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Conserved domains on  [gi|1953345394|ref|XP_038292615|]
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ataxin-2 isoform X4 [Canis lupus familiaris]

Protein Classification

PABP-interacting PAM2 motif-containing protein( domain architecture ID 10627809)

PABP-interacting PAM2 motif-containing protein similar to human polyadenylate-binding protein-interacting protein 2 (PAIP2) that acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.34e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.34e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953345394    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.74e-16

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.74e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953345394  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 665-853 5.81e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 53.89  E-value: 5.81e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  665 KPSTTPTSPRPQAQPSPSM-----------VGHQQPAPVyTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYR 733
Cdd:pfam09770  169 KAAAPAPAPQPAAQPASLPapsrkmmsleeVEAAMRAQA-KKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  734 AVPNMPQQRQEQHHQ-SAMMHPASAAGPPIVATPPaystqyvAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMM 812
Cdd:pfam09770  248 QQPQQPQQHPGQGHPvTILQRPQSPQPDPAQPSIQ-------PQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNP 320

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1953345394  813 APPAHAQPGlvsssatqygahEQTHAMYVSTGSLAQQYAHP 853
Cdd:pfam09770  321 QPGVQPAPA------------HQAHRQQGSFGRQAPIITHP 349
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 606-1015 3.53e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 3.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  606 NTEHKRGPEVTSQGVQTSSPGCKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVG 685
Cdd:pfam03154  127 NDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSV 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  686 HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPiPMTPMPvNQAKTYRAVPNMPQQRQEQHHQSAMMHPASAAGPPIVAT 765
Cdd:pfam03154  207 PPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHP-QRLPSP-HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQT 284

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  766 PPaystqyvAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMA--PPAHAQPGLVSSSATQYGAHEQTHAMYVST 843
Cdd:pfam03154  285 GP-------SHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhtPPSQSQLQSQQPPREQPLPPAPLSMPHIKP 357

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  844 GSLAQQYAHPNATLHPHTPHpqpsatPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMT 923
Cdd:pfam03154  358 PPTTPIPQLPNPQSHKHPPH------LSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQP 431

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  924 PASnTQSPQNSFPTAQQ-TVFTIHPSHVQPAYTNPPHMAHVPqahvQSGMVPSHPTAHAPMMLMTTQPPggpqAALAQSA 1002
Cdd:pfam03154  432 PVL-TQSQSLPPPAASHpPTSGLHQVPSQSPFPQHPFVPGGP----PPITPPSGPPTSTSSAMPGIQPP----SSASVSS 502

                          410
                   ....*....|...
gi 1953345394 1003 LQPIPVSTTAHFP 1015
Cdd:pfam03154  503 SGPVPAAVSCPLP 515
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.34e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.34e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953345394    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.74e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.74e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953345394  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 665-853 5.81e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 53.89  E-value: 5.81e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  665 KPSTTPTSPRPQAQPSPSM-----------VGHQQPAPVyTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYR 733
Cdd:pfam09770  169 KAAAPAPAPQPAAQPASLPapsrkmmsleeVEAAMRAQA-KKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  734 AVPNMPQQRQEQHHQ-SAMMHPASAAGPPIVATPPaystqyvAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMM 812
Cdd:pfam09770  248 QQPQQPQQHPGQGHPvTILQRPQSPQPDPAQPSIQ-------PQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNP 320

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1953345394  813 APPAHAQPGlvsssatqygahEQTHAMYVSTGSLAQQYAHP 853
Cdd:pfam09770  321 QPGVQPAPA------------HQAHRQQGSFGRQAPIITHP 349
PHA03247 PHA03247
large tegument protein UL36; Provisional
 665-1007 9.77e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 9.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  665 KPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQe 744
Cdd:PHA03247  2588 RPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR- 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  745 qhhQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQPGLVS 824
Cdd:PHA03247  2667 ---ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  825 SSATQYGAHEQTHAMYVSTGSLAQQYAHPNAtlhPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASP 904
Cdd:PHA03247  2744 VPAGPATPGGPARPARPPTTAGPPAPAPPAA---PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  905 QQQSaiyhAGLAPTPPSMTPASnTQSPQNSFPTAQQTVFTIHP----SHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAH 980
Cdd:PHA03247  2821 AASP----AGPLPPPTSAQPTA-PPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895

                          330       340
                   ....*....|....*....|....*..
gi 1953345394  981 APMMLMTTQPPGGPQAALAQSALQPIP 1007
Cdd:PHA03247  2896 ESFALPPDQPERPPQPQAPPPPQPQPQ 2922
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 672-785 6.69e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 46.72  E-value: 6.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  672 SPRPQAQPSPS-MVGHQQPAPVYTQpvcfAPNMMYP-VPVSPGVQPLYPIPMTPMPVNQAKTYravPNMPQQRQEQHHQS 749
Cdd:TIGR01628  379 QPRMRQLPMGSpMGGAMGQPPYYGQ----GPQQQFNgQPLGWPRMSMMPTPMGPGGPLRPNGL---APMNAVRAPSRNAQ 451

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1953345394  750 AMMHPASAagPPIVATPPAYSTQyvaySPQQFPNQP 785
Cdd:TIGR01628  452 NAAQKPPM--QPVMYPPNYQSLP----LSQDLPQPQ 481
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 606-1015 3.53e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 3.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  606 NTEHKRGPEVTSQGVQTSSPGCKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVG 685
Cdd:pfam03154  127 NDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSV 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  686 HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPiPMTPMPvNQAKTYRAVPNMPQQRQEQHHQSAMMHPASAAGPPIVAT 765
Cdd:pfam03154  207 PPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHP-QRLPSP-HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQT 284

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  766 PPaystqyvAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMA--PPAHAQPGLVSSSATQYGAHEQTHAMYVST 843
Cdd:pfam03154  285 GP-------SHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhtPPSQSQLQSQQPPREQPLPPAPLSMPHIKP 357

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  844 GSLAQQYAHPNATLHPHTPHpqpsatPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMT 923
Cdd:pfam03154  358 PPTTPIPQLPNPQSHKHPPH------LSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQP 431

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  924 PASnTQSPQNSFPTAQQ-TVFTIHPSHVQPAYTNPPHMAHVPqahvQSGMVPSHPTAHAPMMLMTTQPPggpqAALAQSA 1002
Cdd:pfam03154  432 PVL-TQSQSLPPPAASHpPTSGLHQVPSQSPFPQHPFVPGGP----PPITPPSGPPTSTSSAMPGIQPP----SSASVSS 502

                          410
                   ....*....|...
gi 1953345394 1003 LQPIPVSTTAHFP 1015
Cdd:pfam03154  503 SGPVPAAVSCPLP 515
PHA03247 PHA03247
large tegument protein UL36; Provisional
 416-842 5.27e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  416 PRLSPKTHRPRSPRQNSIGNNPG---GPVLASPQAGIIPAEAVAMPVPAASPTPAS---PASNRAVTPSIEAKDSRLQDQ 489
Cdd:PHA03247  2580 PAVTSRARRPDAPPQSARPRAPVddrGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnepDPHPPPTVPPPERPRDDPAPG 2659

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  490 RQNSPAGNKENMKPNETSPSFSKTENKGISPIVSEHRKQIDDLKKFKNDfRLQPSSTSESMDQLLNKNREGEKSRDLLKD 569
Cdd:PHA03247  2660 RVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP-EPAPHALVSATPLPPGPAAARQASPALPAA 2738

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  570 KIEPNAKDSFIENSSSNCTSGSSKPNSPSISPSIlsntehkRGPEVTSQGVQTSSPGCKQEKDDKEEKKDAAEQVRKSTL 649
Cdd:PHA03247  2739 PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP-------AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  650 NPNAKEFN----PRSFSQPKPSTTPTSPRPQAQPSPSMVG----------------HQQPAPVYTQPVCFAPNMMYPVPV 709
Cdd:PHA03247  2812 LAPAAALPpaasPAGPLPPPTSAQPTAPPPPPGPPPPSLPlggsvapggdvrrrppSRSPAAKPAAPARPPVRRLARPAV 2891

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  710 SPGVQPLYPIPMTPMPVNQaktyravPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQ- 788
Cdd:PHA03247  2892 SRSTESFALPPDQPERPPQ-------PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWl 2964

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953345394  789 --------HVPHYQSQHPhvySPVIQGNARMMAPPAHAQPGLVSSSATQYGAHEQTHAMYVS 842
Cdd:PHA03247  2965 galvpgrvAVPRFRVPQP---APSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVS 3023
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.34e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.34e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953345394    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.74e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.74e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953345394  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 665-853 5.81e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 53.89  E-value: 5.81e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  665 KPSTTPTSPRPQAQPSPSM-----------VGHQQPAPVyTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYR 733
Cdd:pfam09770  169 KAAAPAPAPQPAAQPASLPapsrkmmsleeVEAAMRAQA-KKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  734 AVPNMPQQRQEQHHQ-SAMMHPASAAGPPIVATPPaystqyvAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMM 812
Cdd:pfam09770  248 QQPQQPQQHPGQGHPvTILQRPQSPQPDPAQPSIQ-------PQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNP 320

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1953345394  813 APPAHAQPGlvsssatqygahEQTHAMYVSTGSLAQQYAHP 853
Cdd:pfam09770  321 QPGVQPAPA------------HQAHRQQGSFGRQAPIITHP 349
PHA03247 PHA03247
large tegument protein UL36; Provisional
 665-1007 9.77e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 9.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  665 KPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQe 744
Cdd:PHA03247  2588 RPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR- 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  745 qhhQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQPGLVS 824
Cdd:PHA03247  2667 ---ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  825 SSATQYGAHEQTHAMYVSTGSLAQQYAHPNAtlhPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASP 904
Cdd:PHA03247  2744 VPAGPATPGGPARPARPPTTAGPPAPAPPAA---PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  905 QQQSaiyhAGLAPTPPSMTPASnTQSPQNSFPTAQQTVFTIHP----SHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAH 980
Cdd:PHA03247  2821 AASP----AGPLPPPTSAQPTA-PPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895

                          330       340
                   ....*....|....*....|....*..
gi 1953345394  981 APMMLMTTQPPGGPQAALAQSALQPIP 1007
Cdd:PHA03247  2896 ESFALPPDQPERPPQPQAPPPPQPQPQ 2922
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 658-1012 2.03e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.91  E-value: 2.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  658 PRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPvytqpvcfAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPN 737
Cdd:PRK07764   400 SAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAP--------APAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPA 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  738 MPQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQpLVQHVPHYQ-------SQHPHVYSpvIQGNAR 810
Cdd:PRK07764   472 AAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPE-ILAAVPKRSrktwailLPEATVLG--VRGDTL 548

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  811 MMAppaHAQPGLVSSSATQYGA-------HEQTHA-----MYVSTGSLAQQYAHPNA----TLHPHTPHPQPSATPTGQQ 874
Cdd:PRK07764   549 VLG---FSTGGLARRFASPGNAevlvtalAEELGGdwqveAVVGPAPGAAGGEGPPApassGPPEEAARPAAPAAPAAPA 625

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  875 QSQHGGSHPAPSPVQHHQHQAAQALHL----------ASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPTAQQTVFT 944
Cdd:PRK07764   626 APAPAGAAAAPAEASAAPAPGVAAPEHhpkhvavpdaSDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1953345394  945 IHPSHVQPAYTNPPHMAHVPQA-----HVQSGMVPSHPTAHAPMMLMTT--QPPGGPQAALAQSALQPIPVSTTA 1012
Cdd:PRK07764   706 AATPPAGQADDPAAQPPQAAQGasapsPAADDPVPLPPEPDDPPDPAGApaQPPPPPAPAPAAAPAAAPPPSPPS 780
PHA03247 PHA03247
large tegument protein UL36; Provisional
 664-988 3.93e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 3.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  664 PKPSTTPTSPRPQAQPSPSMVGHQQPAPvytqPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQR- 742
Cdd:PHA03247  2708 PEPAPHALVSATPLPPGPAAARQASPAL----PAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRl 2783

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  743 ------QEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHV-PHYQSQHPHVYSP----VIQGNARM 811
Cdd:PHA03247  2784 trpavaSLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTaPPPPPGPPPPSLPlggsVAPGGDVR 2863

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  812 MAPPAHAQPGLVSSSATQYGAHEQTHAMYVSTGSLAQQyahPNATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHH 891
Cdd:PHA03247  2864 RRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALP---PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  892 QHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSfptaqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQS 970
Cdd:PHA03247  2941 PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA------------PSREAPAsSTPPLTGHSLSRVSSWA 3008

                          330
                   ....*....|....*....
gi 1953345394  971 GMVPSH-PTAHAPMMLMTT 988
Cdd:PHA03247  3009 SSLALHeETDPPPVSLKQT 3027
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 663-888 8.99e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 49.65  E-value: 8.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  663 QPKPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFA-PNMMYPVPVSP--------GVQPLYPIPMTPMPVNQAKtyr 733
Cdd:pfam09770  106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGyEKYKEPEPIPDlqvdaslwGVAPKKAAAPAPAPQPAAQ--- 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  734 AVPNMPQQR-----QEQHHQ-SAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPhvysPVIQG 807
Cdd:pfam09770  183 PASLPAPSRkmmslEEVEAAmRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQP----QQHPG 258

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  808 NARMMA-----PPAHAQPGLVSSSATQYGAHEQTHAMYVSTGSLAQQYAHPNATLHPHTPHPQPSATPT-GQQQSQHGGS 881
Cdd:pfam09770  259 QGHPVTilqrpQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPApAHQAHRQQGS 338


                   ....*..
gi 1953345394  882 HPAPSPV 888
Cdd:pfam09770  339 FGRQAPI 345
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 672-785 6.69e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 46.72  E-value: 6.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  672 SPRPQAQPSPS-MVGHQQPAPVYTQpvcfAPNMMYP-VPVSPGVQPLYPIPMTPMPVNQAKTYravPNMPQQRQEQHHQS 749
Cdd:TIGR01628  379 QPRMRQLPMGSpMGGAMGQPPYYGQ----GPQQQFNgQPLGWPRMSMMPTPMGPGGPLRPNGL---APMNAVRAPSRNAQ 451

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1953345394  750 AMMHPASAagPPIVATPPAYSTQyvaySPQQFPNQP 785
Cdd:TIGR01628  452 NAAQKPPM--QPVMYPPNYQSLP----LSQDLPQPQ 481
PHA03247 PHA03247
large tegument protein UL36; Provisional
 649-1007 7.03e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 7.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  649 LNPNAKEFNPRSFSQPKPSTTPTSPRPQAQ--PSPSMVGHQQPAPVYTQPVCFAPNMMYPVP--VSPGVQPLYPI--PMT 722
Cdd:PHA03247  2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRddPAPGRVSRPRRARRLGRAAQASSPPQRPRRraARPTVGSLTSLadPPP 2703

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  723 PMPVNQAKTYRAVPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHyqsqhphvys 802
Cdd:PHA03247  2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA---------- 2773

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  803 pviqgnARMMAPPAHAQPGLVSSSATQYGAHEQTHAMYVSTGSLAQQYAHPNATLHPHTPHPQPsatPTGQQQSQHGGSH 882
Cdd:PHA03247  2774 ------APAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPP---TSAQPTAPPPPPG 2844

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  883 PAPSPVQHHQHQAAQALHLASPQQQSAIyhagLAPTPPSMTPASNTQSPQNSFPTAQqtvFTIHPSHVQPAYTNPPHMAH 962
Cdd:PHA03247  2845 PPPPSLPLGGSVAPGGDVRRRPPSRSPA----AKPAAPARPPVRRLARPAVSRSTES---FALPPDQPERPPQPQAPPPP 2917

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1953345394  963 VPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIP 1007
Cdd:PHA03247  2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 743-989 8.93e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.57  E-value: 8.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  743 QEQHHQSAMMHPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNA--RMMAPP 815
Cdd:pfam09770   96 EEEQVRFNRQQPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVApkKAAAPA 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  816 AHAQPGLVSSSATQYG----------------AHEQTHAMYVSTGSLAQQYAHPNATLHPHTPHPQPSATPTGQQQSQHG 879
Cdd:pfam09770  175 PAPQPAAQPASLPAPSrkmmsleeveaamraqAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQ 254

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  880 GSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqNSFPTAQQTVFTIHPSHVQPAytnPPH 959
Cdd:pfam09770  255 QHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP-NRLSAARVGYPQNPQPGVQPA---PAH 330

                          250       260       270
                   ....*....|....*....|....*....|
gi 1953345394  960 MAHvPQAHVQSGMVPSHpTAHAPMMLMTTQ 989
Cdd:pfam09770  331 QAH-RQQGSFGRQAPII-THPQQLAQLSEE 358
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 681-905 1.73e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.85  E-value: 1.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  681 PSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPgVQPLYPIPMTPMPVNQaktyravPNMPQQRQeqhhqsammhPASAAGP 760
Cdd:PRK10263   309 PLLNGAPITEPVAVAAAATTATQSWAAPVEP-VTQTPPVASVDVPPAQ-------PTVAWQPV----------PGPQTGE 370

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  761 PIVATPPAystqyvAYSPQQFPNQPLVQHVPHYQSQHPHvyspviqgnarmmAPPAHAQPGLVSSSATQYGAHEQTHAMY 840
Cdd:PRK10263   371 PVIAPAPE------GYPQQSQYAQPAVQYNEPLQQPVQP-------------QQPYYAPAAEQPAQQPYYAPAPEQPAQQ 431

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1953345394  841 vstGSLAQQYAHPNATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQ 905
Cdd:PRK10263   432 ---PYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPE 493
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 662-932 1.80e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.85  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  662 SQPKPSTTPTSPRPQAQPSPsmvGHQQPAPVYT-QPVCFAPNMMYPVPVSPGVQPLYPiPMTPMPVNQAKTYRAVPNMPQ 740
Cdd:PRK10263   345 PVASVDVPPAQPTVAWQPVP---GPQTGEPVIApAPEGYPQQSQYAQPAVQYNEPLQQ-PVQPQQPYYAPAAEQPAQQPY 420

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  741 QRQEQHHQSAMMHPASAAGPPIVATPpaystqyvaysPQQFPNQPLVQHVPHYQSQHPHVySPVIQgNARMMAPPAHAQP 820
Cdd:PRK10263   421 YAPAPEQPAQQPYYAPAPEQPVAGNA-----------WQAEEQQSTFAPQSTYQTEQTYQ-QPAAQ-EPLYQQPQPVEQQ 487

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  821 GLVSSSATQYGAHEQTHAMYVSTgSLAQQYAHPNATLHP-HTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQAL 899
Cdd:PRK10263   488 PVVEPEPVVEETKPARPPLYYFE-EVEEKRAREREQLAAwYQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLAS 566

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1953345394  900 HLaspqqQSAIYHAGLAPTP--PSMTPASN-TQSPQ 932
Cdd:PRK10263   567 GV-----KKATLATGAAATVaaPVFSLANSgGPRPQ 597
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 606-1015 3.53e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 3.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  606 NTEHKRGPEVTSQGVQTSSPGCKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVG 685
Cdd:pfam03154  127 NDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSV 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  686 HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPiPMTPMPvNQAKTYRAVPNMPQQRQEQHHQSAMMHPASAAGPPIVAT 765
Cdd:pfam03154  207 PPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHP-QRLPSP-HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQT 284

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  766 PPaystqyvAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMA--PPAHAQPGLVSSSATQYGAHEQTHAMYVST 843
Cdd:pfam03154  285 GP-------SHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhtPPSQSQLQSQQPPREQPLPPAPLSMPHIKP 357

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  844 GSLAQQYAHPNATLHPHTPHpqpsatPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMT 923
Cdd:pfam03154  358 PPTTPIPQLPNPQSHKHPPH------LSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQP 431

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  924 PASnTQSPQNSFPTAQQ-TVFTIHPSHVQPAYTNPPHMAHVPqahvQSGMVPSHPTAHAPMMLMTTQPPggpqAALAQSA 1002
Cdd:pfam03154  432 PVL-TQSQSLPPPAASHpPTSGLHQVPSQSPFPQHPFVPGGP----PPITPPSGPPTSTSSAMPGIQPP----SSASVSS 502

                          410
                   ....*....|...
gi 1953345394 1003 LQPIPVSTTAHFP 1015
Cdd:pfam03154  503 SGPVPAAVSCPLP 515
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 645-660 5.04e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.04e-03
                           10
                   ....*....|....*.
gi 1953345394  645 RKSTLNPNAKEFNPRS 660
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
PHA03247 PHA03247
large tegument protein UL36; Provisional
 416-842 5.27e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  416 PRLSPKTHRPRSPRQNSIGNNPG---GPVLASPQAGIIPAEAVAMPVPAASPTPAS---PASNRAVTPSIEAKDSRLQDQ 489
Cdd:PHA03247  2580 PAVTSRARRPDAPPQSARPRAPVddrGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnepDPHPPPTVPPPERPRDDPAPG 2659

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  490 RQNSPAGNKENMKPNETSPSFSKTENKGISPIVSEHRKQIDDLKKFKNDfRLQPSSTSESMDQLLNKNREGEKSRDLLKD 569
Cdd:PHA03247  2660 RVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP-EPAPHALVSATPLPPGPAAARQASPALPAA 2738

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  570 KIEPNAKDSFIENSSSNCTSGSSKPNSPSISPSIlsntehkRGPEVTSQGVQTSSPGCKQEKDDKEEKKDAAEQVRKSTL 649
Cdd:PHA03247  2739 PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP-------AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  650 NPNAKEFN----PRSFSQPKPSTTPTSPRPQAQPSPSMVG----------------HQQPAPVYTQPVCFAPNMMYPVPV 709
Cdd:PHA03247  2812 LAPAAALPpaasPAGPLPPPTSAQPTAPPPPPGPPPPSLPlggsvapggdvrrrppSRSPAAKPAAPARPPVRRLARPAV 2891

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  710 SPGVQPLYPIPMTPMPVNQaktyravPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQ- 788
Cdd:PHA03247  2892 SRSTESFALPPDQPERPPQ-------PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWl 2964

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953345394  789 --------HVPHYQSQHPhvySPVIQGNARMMAPPAHAQPGLVSSSATQYGAHEQTHAMYVS 842
Cdd:PHA03247  2965 galvpgrvAVPRFRVPQP---APSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVS 3023
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
650-745 6.30e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.53  E-value: 6.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  650 NPNAKEFN---PRSFSQPKPSTTPtSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPgvqplyPIPMTPMpv 726
Cdd:PRK14971   391 QPSAAAAAspsPSQSSAAAQPSAP-QSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKE------EKKIPVS-- 461

                           90
                   ....*....|....*....
gi 1953345394  727 NQAKTYRAVPNMPQQRQEQ 745
Cdd:PRK14971   462 KVSSLGPSTLRPIQEKAEQ 480
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 710-803 7.77e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 7.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  710 SPGVQPLYPiPMTPMPVNQAKTYRAVPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYST--QYVAYSPQ-QFPNQPL 786
Cdd:PRK10263   746 TPIVEPVQQ-PQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQpqQPVAPQPQyQQPQQPV 824

                           90
                   ....*....|....*..
gi 1953345394  787 VQHVPHYQSQHPHVYSP 803
Cdd:PRK10263   825 APQPQYQQPQQPVAPQP 841
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 801-979 8.45e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.07  E-value: 8.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  801 YSPVIQGNArMMAPPAHAQpglVSSSATQYGAHE-----QTHAMYVSTGSLAQQYAHPNATLHPHTPHP----QPSATPT 871
Cdd:PRK10263   307 YDPLLNGAP-ITEPVAVAA---AATTATQSWAAPvepvtQTPPVASVDVPPAQPTVAWQPVPGPQTGEPviapAPEGYPQ 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953345394  872 GQQQSQHGGSHPAP--------SPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPTAQQTVF 943
Cdd:PRK10263   383 QSQYAQPAVQYNEPlqqpvqpqQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTY 462

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1953345394  944 TIHPSHVQPAYTNPPHMAhvPQAHVQSGMVPSHPTA 979
Cdd:PRK10263   463 QTEQTYQQPAAQEPLYQQ--PQPVEQQPVVEPEPVV 496
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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