|
Name |
Accession |
Description |
Interval |
E-value |
| GT4_PIG-A-like |
cd03796 |
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ... |
16-283 |
1.04e-163 |
|
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.
Pssm-ID: 340827 [Multi-domain] Cd Length: 398 Bit Score: 460.17 E-value: 1.04e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 16 ICMASDFFYPNTGGVEEHIYNLSQCLIKRGHKVVVITHCYEDRVGVRYLTGGLKVYYLPIRVFYSQCALPTMICNIAIVR 95
Cdd:cd03796 2 ICMVSDFFYPNLGGVETHIYQLSQCLIKRGHKVIVITHAYGNRVGVRYLTNGLKVYYLPFKVFYNQSTLPTLFSTFPLLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 96 YILIRERIQIVHGHSAFSVLAHEVSIIGKLMGLKTVFTDHSLFGFADMSAVLTNKYLQMCLCECDHCICVSHTGKENTVL 175
Cdd:cd03796 82 NILIRERIQIVHGHQAFSSLAHEALFHARTLGLKTVFTDHSLFGFADASSILTNKLLRFSLADIDHVICVSHTSKENTVL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 176 RAKVKAHKVSVIPNAVDAYTFTPDPSQRDPNVITVIIVSRLVYRKGVDLMAAVIADMCPRYPNLRFIIGGDGPKMWLLQE 255
Cdd:cd03796 162 RASLDPRIVSVIPNAVDSSDFTPDPSKPDPNKITIVVISRLVYRKGIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEE 241
|
250 260
....*....|....*....|....*...
gi 1949865553 256 VRERKGFQHCVTLLGSLKHSEVRDVLVK 283
Cdd:cd03796 242 MREKYQLQDRVELLGAVPHEEVRDVLVQ 269
|
|
| PIGA |
pfam08288 |
PIGA (GPI anchor biosynthesis); This domain is found on phosphatidylinositol ... |
53-142 |
2.14e-48 |
|
PIGA (GPI anchor biosynthesis); This domain is found on phosphatidylinositol n-acetylglucosaminyltransferase proteins. These proteins are involved in GPI anchor biosynthesis and are associated with disease the paroxysmal nocturnal haemoglobinuria.
Pssm-ID: 400541 Cd Length: 90 Bit Score: 155.88 E-value: 2.14e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 53 HCYEDRVGVRYLTGGLKVYYLPIRVFYSQCALPTMICNIAIVRYILIRERIQIVHGHSAFSVLAHEVSIIGKLMGLKTVF 132
Cdd:pfam08288 1 HAYGDRTGVRYLTNGLKVYYVPFLVIYRQSTFPTVFGTFPLFRNILLRERIDIVHGHGSFSTLAHEAILHARTMGLKTVF 80
|
90
....*....|
gi 1949865553 133 TDHSLFGFAD 142
Cdd:pfam08288 81 TDHSLFGFAD 90
|
|
| GT4_PimA-like |
cd03801 |
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ... |
16-281 |
1.25e-34 |
|
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 128.42 E-value: 1.25e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 16 ICMASDFFYPNTGGVEEHIYNLSQCLIKRGHKVVVITHCYEDRVGVRYLTGGLKVYYLPIRVFYSQCALptmicnIAIVR 95
Cdd:cd03801 2 ILLLSPELPPPVGGAERHVRELARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRL------LRELR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 96 YILIRERIQIVHGHSAFSVLAheVSIIGKLMGLKTVFTDHSLFGF------ADMSAVLTNKYLQmcLCECDHCICVSHTG 169
Cdd:cd03801 76 PLLRLRKFDVVHAHGLLAALL--AALLALLLGAPLVVTLHGAEPGrlllllAAERRLLARAEAL--LRRADAVIAVSEAL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 170 KENTVLRAKVKAHKVSVIPNAVDAYTFTPDPSQR---DPNVITVIIVSRLVYRKGVDLMAAVIADMCPRYPNLRF-IIGG 245
Cdd:cd03801 152 RDELRALGGIPPEKIVVIPNGVDLERFSPPLRRKlgiPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLvIVGG 231
|
250 260 270
....*....|....*....|....*....|....*.
gi 1949865553 246 DGPkmWLLQEVRERKGFQHCVTLLGSLKHSEVRDVL 281
Cdd:cd03801 232 DGP--LRAELEELELGLGDRVRFLGFVPDEELPALY 265
|
|
| GT4_WavL-like |
cd03819 |
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ... |
16-270 |
1.82e-26 |
|
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.
Pssm-ID: 340846 [Multi-domain] Cd Length: 345 Bit Score: 105.90 E-value: 1.82e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 16 ICMASDFFYPntGGVEEHIYNLSQCLIKRGHKVVVITHCYEDRVGVRYLTGGLKVYYLPIRVFYsqcalptmicNIAIVR 95
Cdd:cd03819 1 ILMLTPALEI--GGAETYILDLARALAERGHRVLVVTAGGPLLPRLRQIGIGLPGLKVPLLRAL----------LGNVRL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 96 YILI-RERIQIVHGHSAFSVLAheVSIIGKLMGLKTVFTDHSL----FGFADMS-AVLTNKylqmclcecDHCICVSHTG 169
Cdd:cd03819 69 ARLIrRERIDLIHAHSRAPAWL--GWLASRLTGVPLVTTVHGSylatYHPKDFAlAVRARG---------DRVIAVSELV 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 170 KENTVLRAKVKAHKVSVIPNAVDAYTFTPDPSQR-------DPNVITVIIVSRLVYRKGVDL---MAAVIADMcpryPNL 239
Cdd:cd03819 138 RDHLIEALGVDPERIRVIPNGVDTDRFPPEAEAEeraqlglPEGKPVVGYVGRLSPEKGWLLlvdAAAELKDE----PDF 213
|
250 260 270
....*....|....*....|....*....|.
gi 1949865553 240 RFIIGGDGPKMWLLQEVRERKGFQHCVTLLG 270
Cdd:cd03819 214 RLLVAGDGPERDEIRRLVERLGLRDRVTFTG 244
|
|
| Glyco_transf_4 |
pfam13439 |
Glycosyltransferase Family 4; |
28-192 |
2.93e-23 |
|
Glycosyltransferase Family 4;
Pssm-ID: 463877 [Multi-domain] Cd Length: 169 Bit Score: 93.37 E-value: 2.93e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 28 GGVEEHIYNLSQCLIKRGHKVVVITHCYEDRVGVRYLTgglkVYYLPIRVFYSQCALPTMICNIAIVRYILIRERIQIVH 107
Cdd:pfam13439 1 GGVERYVLELARALARRGHEVTVVTPGGPGPLAEEVVR----VVRVPRVPLPLPPRLLRSLAFLRRLRRLLRRERPDVVH 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 108 GHSAFSvLAHEVSIIGKLMGLKTVFTDHSLF-------GFADMSAVLTNKYLQMCLCECDHCICVSHTGKENTVLRAKVK 180
Cdd:pfam13439 77 AHSPFP-LGLAALAARLRLGIPLVVTYHGLFpdykrlgARLSPLRRLLRRLERRLLRRADRVIAVSEAVADELRRLYGVP 155
|
170
....*....|..
gi 1949865553 181 AHKVSVIPNAVD 192
Cdd:pfam13439 156 PEKIRVIPNGVD 167
|
|
| GT4_UGDG-like |
cd03817 |
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ... |
15-277 |
1.24e-19 |
|
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.
Pssm-ID: 340844 [Multi-domain] Cd Length: 372 Bit Score: 87.33 E-value: 1.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 15 IICMASDFFYPNTGGVEEHIYNLSQCLIKRGHKVVVIT------HCYEDRVGVRYLTGGLKVYYLPIRVFYSQCALPTmi 88
Cdd:cd03817 1 KIAIFTDTYLPQVNGVATSVRNLARALEKRGHEVYVITpsdpgaEDEEEVVRYRSFSIPIRKYHRQHIPFPFKKAVID-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 89 cniaivryILIRERIQIVHGHSAFSV--LAHEvsiIGKLMGLKTVFTDHSL---------FGFADMSAVLTNKYLQMCLc 157
Cdd:cd03817 79 --------RIKELGPDIIHTHTPFSLgkLGLR---IARKLKIPIVHTYHTMyedylhyipKGKLLVKAVVRKLVRRFYN- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 158 ECDHCICVSHtGKENTVLRAKVKAHKVsVIPNAVDAYTFTPDPSQR-------DPNVITVIIVSRLVYRKGVDLMAAVIA 230
Cdd:cd03817 147 HTDAVIAPSE-KIKDTLREYGVKGPIE-VIPNGIDLDKFEKPLNTEerrklglPPDEPILLYVGRLAKEKNIDFLLRAFA 224
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1949865553 231 DMcPRYPNLRFIIGGDGPKMWLLQEVRERKGFQHCVTLLGSLKHSEV 277
Cdd:cd03817 225 EL-KKEPNIKLVIVGDGPEREELKELARELGLADKVIFTGFVPREEL 270
|
|
| GT4_WlbH-like |
cd03798 |
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ... |
22-281 |
4.24e-19 |
|
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.
Pssm-ID: 340828 [Multi-domain] Cd Length: 376 Bit Score: 85.89 E-value: 4.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 22 FFYPNT--GGVEEHIYNLSQCLIKRGHKVVVIT-------------HCYEDRVGVRYLTGGLKVYYLPIRVFYSQCALpt 86
Cdd:cd03798 6 NIYPNAnsPGRGIFVRRQVRALSRRGVDVEVLApapwgpaaarllrKLLGEAVPPRDGRRLLPLKPRLRLLAPLRAPS-- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 87 micnIAIVRYILIRERIQIVHGHSAFS--VLAHevsIIGKLMGLKTVFTDHS--LFGFADMSAVLtnKYLQMCLCECDHC 162
Cdd:cd03798 84 ----LAKLLKRRRRGPPDLIHAHFAYPagFAAA---LLARLYGVPYVVTEHGsdINVFPPRSLLR--KLLRWALRRAARV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 163 ICVSHTGKEnTVLRAKVKAHKVSVIPNAVDAYTFTPDPSQRD--PNVITVIIVSRLVYRKGVDLMAAVIADMCPRYPNLR 240
Cdd:cd03798 155 IAVSKALAE-ELVALGVPRDRVDVIPNGVDPARFQPEDRGLGlpLDAFVILFVGRLIPRKGIDLLLEAFARLAKARPDVV 233
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1949865553 241 FIIGGDGPKMWLLQEVRERKGFQHCVTLLGSLKHSEVRDVL 281
Cdd:cd03798 234 LLIVGDGPLREALRALAEDLGLGDRVTFTGRLPHEQVPAYY 274
|
|
| GT4_GT28_WabH-like |
cd03811 |
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ... |
22-270 |
4.26e-18 |
|
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.
Pssm-ID: 340839 [Multi-domain] Cd Length: 351 Bit Score: 82.79 E-value: 4.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 22 FFYPNT--GGVEEHIYNLSQCLIKRGHKVVVITHC----YEDRVGVRYLTGGLKVYYLPIRVFysqcALPTMICNIaivR 95
Cdd:cd03811 4 FVIPSLsgGGAERVLLNLANALDKRGYDVTLVLLRdegdLDKQLNGDVKLIRLLIRVLKLIKL----GLLKAILKL---K 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 96 YILIRERIQIVHGHSAFSVLaheVSIIGKLMGLKTVFTDHSLFGFADMsavLTNKYLQMCLC--ECDHCICVSHTGKENT 173
Cdd:cd03811 77 RILKRAKPDVVISFLGFATY---IVAKLAAARSKVIAWIHSSLSKLYY---LKKKLLLKLKLykKADKIVCVSKGIKEDL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 174 VLRAKVKAHKVSVIPNAVDAYTFTPDPSQR----DPNVITVIIVSRLVYRKGVDLMAAVIADMCPRYPNLRFIIGGDGPK 249
Cdd:cd03811 151 IRLGPSPPEKIEVIYNPIDIDRIRALAKEPilnePEDGPVILAVGRLDPQKGHDLLIEAFAKLRKKYPDVKLVILGDGPL 230
|
250 260
....*....|....*....|.
gi 1949865553 250 MWLLQEVRERKGFQHCVTLLG 270
Cdd:cd03811 231 REELEKLAKELGLAERVIFLG 251
|
|
| GT4_WbuB-like |
cd03794 |
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ... |
16-284 |
1.39e-17 |
|
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.
Pssm-ID: 340825 [Multi-domain] Cd Length: 391 Bit Score: 81.62 E-value: 1.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 16 ICMASDFFYPNTGGVEEHIYNLSQCLIKRGHKVVVITHCY-----EDRVGVRYLTGGLKVYYLPIRVFYSQCALPTMIC- 89
Cdd:cd03794 2 ILLISQYYPPPKGAAAARVYELAKELVRRGHEVTVLTPSPnyplgRIFAGATETKDGIRVIRVKLGPIKKNGLIRRLLNy 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 90 ---NIAIVRYILIR-ERIQIVHGHSAFSVLAHEVSIIGKLMGLKTVFTDHSLFGFADMSA-VLTNKYL--------QMCL 156
Cdd:cd03794 82 lsfALAALLKLLVReERPDVIIAYSPPITLGLAALLLKKLRGAPFILDVRDLWPESLIALgVLKKGSLlkllkkleRKLY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 157 CECDHCICVSHTGKENtVLRAKVKAHKVSVIPNAVDAYTFTPDPSQR------DPNVITVIIVSRLVYRKGVDLMAAVIA 230
Cdd:cd03794 162 RLADAIIVLSPGLKEY-LLRKGVPKEKIIVIPNWADLEEFKPPPKDElrkklgLDDKFVVVYAGNIGKAQGLETLLEAAE 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1949865553 231 DMcPRYPNLRFIIGGDGPKMWLLQEVRERKGFQHcVTLLGSLKHSEVRDVLVKV 284
Cdd:cd03794 241 RL-KRRPDIRFLFVGDGDEKERLKELAKARGLDN-VTFLGRVPKEEVPELLSAA 292
|
|
| GT4_WbnK-like |
cd03807 |
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ... |
14-270 |
4.22e-16 |
|
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.
Pssm-ID: 340836 [Multi-domain] Cd Length: 362 Bit Score: 77.36 E-value: 4.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 14 HIIcmasdfFYPNTGGVEEHIYNLSQCLIKRGHKVVVITHCYEDRVGVRYLTGGLKVYYLPIRVFYSQCALPTMIcniai 93
Cdd:cd03807 4 HVI------TGLNVGGAETMLLRLLEHMDKSRFEHVVISLTGDGVLGEELLAAGVPVVCLGLSSGKDPGVLLRLA----- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 94 vrYILIRERIQIVHGHSAFSVLAhevSIIGKLM--GLKTVFTDHSLFGFADMSAVLTNKYLQMCLCECDhCICVSHTGKE 171
Cdd:cd03807 73 --KLIRKRNPDVVHTWMYHADLI---GGLAAKLagGVKVIWSVRSSNIPQRLTRLVRKLCLLLSKFSPA-TVANSSAVAE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 172 nTVLRAKVKAHKVSVIPNAVDAYTFTPDPSQRDP---------NVITVIIVSRLVYRKGVDLMAAVIADMCPRYPNLRFI 242
Cdd:cd03807 147 -FHQEQGYAKNKIVVIYNGIDLFKLSPDDASRARarrrlglaeDRRVIGIVGRLHPVKDHSDLLRAAALLVETHPDLRLL 225
|
250 260
....*....|....*....|....*...
gi 1949865553 243 IGGDGPKMWLLQEVRERKGFQHCVTLLG 270
Cdd:cd03807 226 LVGRGPERPNLERLLLELGLEDRVHLLG 253
|
|
| GT4_CapM-like |
cd03808 |
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ... |
26-285 |
1.22e-15 |
|
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.
Pssm-ID: 340837 [Multi-domain] Cd Length: 358 Bit Score: 75.71 E-value: 1.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 26 NTGGVEEHIYNLSQCLIKRGHKVVVITHCYEDRV------GVRYLTggLKVYYLPIRVFYSQCALptmicnIAIVRyILI 99
Cdd:cd03808 8 VDGGFQSFRLPLIKALVKKGYEVHVIAPDGDKLSdelkelGVKVID--IPILRRGINPLKDLKAL------FKLYK-LLK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 100 RERIQIVHGHSAFSVlahevsIIGKLMGL-----KTVFTDHSLfGFADMSavltNKYLQM--CLCE------CDHCICVS 166
Cdd:cd03808 79 KEKPDIVHCHTPKPG------ILGRLAARlagvpKVIYTVHGL-GFVFTE----GKLLRLlyLLLEklallfTDKVIFVN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 167 HTGKENTVLRAKVKAHKVSVIP-NAVDAYTFTPDPSQRDPNVITVIIVSRLVYRKGVDLMAAVIADMCPRYPNLRFIIGG 245
Cdd:cd03808 148 EDDRDLAIKKGIIKKKKTVLIPgSGVDLDRFQYSPESLPSEKVVFLFVARLLKDKGIDELIEAAKILKKKGPNVRFLLVG 227
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1949865553 246 DGPKMWLLQEVRERKGFQHCVTLLGSLkhSEVRDVLVKVS 285
Cdd:cd03808 228 DGELENPSEILIEKLGLEGRIEFLGFR--SDVPELLAESD 265
|
|
| GT4_AmsD-like |
cd03820 |
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ... |
26-274 |
6.14e-15 |
|
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.
Pssm-ID: 340847 [Multi-domain] Cd Length: 351 Bit Score: 73.81 E-value: 6.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 26 NTGGVEEHIYNLSQCLIKRGHKVVVITHCYEDRVGVRYLTGGLKVYYLPIRVFYSQCALPTMICNIAIVRYILIRERIQI 105
Cdd:cd03820 11 NAGGAERVAINLANHLAKKGYDVTIISLDSAEKPPFYELDDNIKIKNLGDRKYSHFKLLLKYFKKVRRLRKYLKNNKPDV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 106 V--HGHSAFSVLAhevsIIGklMGLKTVFTDHSLFgFADMSAVLtnKYLQMCLC--ECDHCICVSHTGKENtvlRAKVKA 181
Cdd:cd03820 91 VisFRTSLLTFLA----LIG--LKSKLIVWEHNNY-EAYNKGLR--RLLLRRLLykRADKIVVLTEADKLK---KYKQPN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 182 HKVSVIPNAVdayTFTPDPSQRDPNVITVIIVSRLVYRKGVDLMAAVIADMCPRYPNLRFIIGGDGPKMWLLQEVRERKG 261
Cdd:cd03820 159 SNVVVIPNPL---SFPSEEPSTNLKSKRILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRIYGDGPEREELEKLIDKLG 235
|
250
....*....|...
gi 1949865553 262 FQHCVTLLGSLKH 274
Cdd:cd03820 236 LEDRVKLLGPTKN 248
|
|
| GT4_ExpE7-like |
cd03823 |
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ... |
20-284 |
1.43e-11 |
|
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).
Pssm-ID: 340850 [Multi-domain] Cd Length: 357 Bit Score: 63.89 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 20 SDFFYPN-TGGVEEHIYNLSQCLIKRGHKVVVITHCYED-------RVGVRYLTGGLKVYYLPIR-------VFYSQCAL 84
Cdd:cd03823 6 NSLYPPQrVGGAEISVHDLAEALVAEGHEVAVLTAGVGPpgqatvaRSVVRYRRAPDETLPLALKrrgyelfETYNPGLR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 85 PtmicniaIVRYILIRERIQIVHGHSaFSVLAHEVSIIGKLMGLKTVFTDHSLFGfadmsavltnkylqmclcECDHCIC 164
Cdd:cd03823 86 R-------LLARLLEDFRPDVVHTHN-LSGLGASLLDAARDLGIPVVHTLHDYWL------------------LCPRQFL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 165 VSHTGK---------ENTVLRAKVKAHKVSVIPNAVDAYTFTPDPSQRDPNVITVIIVSRLVYRKGVDLMAAViADMCPR 235
Cdd:cd03823 140 FKKGGDavlapsrftANLHEANGLFSARISVIPNAVEPDLAPPPRRRPGTERLRFGYIGRLTEEKGIDLLVEA-FKRLPR 218
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1949865553 236 yPNLRFIIGGDGPkmwLLQEVRERKGFQhcVTLLGSLKHSEVRDVLVKV 284
Cdd:cd03823 219 -EDIELVIAGHGP---LSDERQIEGGRR--IAFLGRVPTDDIKDFYEKI 261
|
|
| GT4-like |
cd05844 |
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ... |
163-281 |
6.12e-11 |
|
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Pssm-ID: 340860 [Multi-domain] Cd Length: 365 Bit Score: 62.08 E-value: 6.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 163 ICVSHTGKENtVLRAKVKAHKVSVIPNAVDAYTFTP-DPSQRDPnviTVIIVSRLVYRKGVDLMAAVIADMCPRYPNLRF 241
Cdd:cd05844 148 VAVSGFIRDR-LLARGLPAERIHVHYIGIDPAKFAPrDPAERAP---TILFVGRLVEKKGCDVLIEAFRRLAARHPTARL 223
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1949865553 242 IIGGDGPkmwLLQEVRERKGFQHCVTLLGSLKHSEVRDVL 281
Cdd:cd05844 224 VIAGDGP---LRPALQALAAALGRVRFLGALPHAEVQDWM 260
|
|
| GT4_Bme6-like |
cd03821 |
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ... |
23-273 |
8.48e-11 |
|
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.
Pssm-ID: 340848 [Multi-domain] Cd Length: 377 Bit Score: 61.62 E-value: 8.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 23 FYPNTGGVEEHIYNLSQCLIKRGHKVVVITH--CYEDRVGVRYLTGGLKVYYLPIRVFYSQCALPTMIC-NIAIVRYILI 99
Cdd:cd03821 9 ISPKAGGPVKVVLRLAAALAALGHEVTIVSTgdGYESLVVEENGRYIPPQDGFASIPLLRQGAGRTDFSpGLPNWLRRNL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 100 RErIQIVHGHSAFSVLAHEVSIIGKLMGLKTVFTDH-SLFGFA-DMSAVLTNKYLQMCL------CECDHCICVshtgKE 171
Cdd:cd03821 89 RE-YDVVHIHGVWTYTSLAACKLARRRGIPYVVSPHgMLDPWAlQQKHWKKRIALHLIErrnlnnAALVHFTSE----QE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 172 NTVLRAKVKAHKVSVIPNAVDAYTFTPDPSQRD-----PNVITVIIVSRLVYRKGVDLMAAVIADMCPRYPNLRFIIGGD 246
Cdd:cd03821 164 ADELRRFGLEPPIAVIPNGVDIPEFDPGLRDRRkhnglEDRRIILFLGRIHPKKGLDLLIRAARKLAEQGRDWHLVIAGP 243
|
250 260 270
....*....|....*....|....*....|..
gi 1949865553 247 GP-----KMWLLQEvrerKGFQHCVTLLGSLK 273
Cdd:cd03821 244 DDgaypaFLQLQSS----LGLGDRVTFTGPLY 271
|
|
| GT4_WfcD-like |
cd03795 |
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ... |
22-272 |
7.78e-10 |
|
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.
Pssm-ID: 340826 [Multi-domain] Cd Length: 355 Bit Score: 58.82 E-value: 7.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 22 FFYPNTGGVEEHIYNLSQCLIKRGHKVVVIThCYEDRVGVRYLTGGLKVyylpIRVFYSQCALPTMICNIAIVRYILIRE 101
Cdd:cd03795 8 FYYPDIGGIEQVIYDLAEGLKKKGIEVDVLC-FSKEKETPEKEENGIRI----HRVKSFLNVASTPFSPSYIKRFKKLAK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 102 RIQIVHGHSAFSV--LAHEVSIIGKlmglKTVFTDHSlfgfaDmsaVLTNKYL--------QMCLCECDHCICVSHTGKE 171
Cdd:cd03795 83 EYDIIHYHFPNPLadLLLFFSGAKK----PVVVHWHS-----D---IVKQKKLlklykplmTRFLRRADRIIATSPNYVE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 172 NTVLRAKVKaHKVSVIPNAVDAYTFTPDPSQ----RDPNVITVIIVS--RLVYRKGVD-LMAAViadmcpRYPNLRFIIG 244
Cdd:cd03795 151 TSPTLREFK-NKVRVIPLGIDKNVYNIPRVDfeniKREKKGKKIFLFigRLVYYKGLDyLIEAA------QYLNYPIVIG 223
|
250 260
....*....|....*....|....*...
gi 1949865553 245 GDGPKMWLLQEVRErKGFQHCVTLLGSL 272
Cdd:cd03795 224 GEGPLKPDLEAQIE-LNLLDNVKFLGRV 250
|
|
| Glyco_trans_4_4 |
pfam13579 |
Glycosyl transferase 4-like domain; |
28-190 |
1.54e-09 |
|
Glycosyl transferase 4-like domain;
Pssm-ID: 433325 [Multi-domain] Cd Length: 158 Bit Score: 55.48 E-value: 1.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 28 GGVEEHIYNLSQCLIKRGHKVVVIthCYEDRVGVRYLTG-GLKVYYLPIRVFYSQCALPTMicnIAIVRYILIRERIQIV 106
Cdd:pfam13579 1 GGIGVYVLELARALAALGHEVRVV--TPGGPPGRPELVGdGVRVHRLPVPPRPSPLADLAA---LRRLRRLLRAERPDVV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 107 HGHSAFSVLAheVSIIGKLMGLKTVFTDHSLfGFADMSAVLTNKYLQM---CLCECDHCICVSHTGKEnTVLRAKVKAHK 183
Cdd:pfam13579 76 HAHSPTAGLA--ARLARRRRGVPLVVTVHGL-ALDYGSGWKRRLARALerrLLRRADAVVVVSEAEAE-LLRALGVPAAR 151
|
....*..
gi 1949865553 184 VSVIPNA 190
Cdd:pfam13579 152 VVVVPNG 158
|
|
| Glycosyltransferase_GTB-type |
cd01635 |
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ... |
16-285 |
2.13e-09 |
|
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Pssm-ID: 340816 [Multi-domain] Cd Length: 235 Bit Score: 56.64 E-value: 2.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 16 ICMASDFFYPNTGGVEEHIYNLSQCLIKRGHKVVVITHCYEDrvgvryltgglkvyylpirvfysqcalptmicnIAIVR 95
Cdd:cd01635 1 ILLVTGEYPPLRGGLELHVRALARALAALGHEVTVLALLLLA---------------------------------LRRIL 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 96 YILIRERIQIVHGHSAFSvLAHEVSIIGKLMGLKTVFTDHSLFgfadmsavltnkylqmclcecDHCICVSHTGKENTVL 175
Cdd:cd01635 48 KKLLELKPDVVHAHSPHA-AALAALLAARLLGIPIVVTVHGPD---------------------SLESTRSELLALARLL 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 176 RAKVKAHKVSVipnavdaytftpdpsqrdpnvitviivSRLVYRKGVDLMAAVIADMCPRYPNLRFIIGGDGPKMWLLQE 255
Cdd:cd01635 106 VSLPLADKVSV---------------------------GRLVPEKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEA 158
|
250 260 270
....*....|....*....|....*....|
gi 1949865553 256 VRERKGFQHCVTLLGSLKHSEVRDVLVKVS 285
Cdd:cd01635 159 LAAALGLLERVVIIGGLVDDEVLELLLAAA 188
|
|
| GT4_MtfB-like |
cd03809 |
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ... |
15-249 |
4.02e-09 |
|
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.
Pssm-ID: 340838 [Multi-domain] Cd Length: 362 Bit Score: 56.60 E-value: 4.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 15 IICMASDFFYPNTGGVEEHIYNLSQCLIKRGHKVVVITHCYEDRVGVRYLtgglKVYYLPIRVFYSQCALPTMICNIAIV 94
Cdd:cd03809 1 KILIDGRSLAQRLTGIGRYTRELLKALAKNDPDESVLAVPPLPGELLRLL----REYPELSLGVIKIKLWRELALLRWLQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 95 RYILIRERIQIVHGHSAFSVLahevsiigKLMGLKTVFTDHSLF------GFADMSAVLTNKYLQMCLCECDHCICVSHT 168
Cdd:cd03809 77 ILLPKKDKPDLLHSPHNTAPL--------LLKGCPQVVTIHDLIplrypeFFPKRFRLYYRLLLPISLRRADAIITVSEA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 169 GKENTVLRAKVKAHKVSVIPNAVDAYTFTPDPS--------QRDPnviTVIIVSRLVYRKGVDLMAAVIADMCPRYPNLR 240
Cdd:cd03809 149 TRDDIIKFYGVPPEKIVVIPLGVDPSFFPPESAavliakylLPEP---YFLYVGTLEPRKNHERLLKAFALLKKQGGDLK 225
|
250
....*....|
gi 1949865553 241 -FIIGGDGPK 249
Cdd:cd03809 226 lVIVGGKGWE 235
|
|
| GT4_sucrose_synthase |
cd03800 |
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ... |
25-282 |
1.40e-08 |
|
sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.
Pssm-ID: 340830 [Multi-domain] Cd Length: 398 Bit Score: 54.94 E-value: 1.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 25 PNTGGVEEHIYNLSQCLIKRGHKVVVITHCYEDRVGVR-YLTGGLKVYYLP--IRVFYSQCALPTMICNIA--IVRYILi 99
Cdd:cd03800 18 ADTGGQNVYVLELARALAELGYQVDIFTRRISPADPEVvEIAPGARVIRVPagPPEYLPKEELWPYLEEFAdgLLRFIA- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 100 RERIQ--IVHGHSAFSVLAheVSIIGKLMGLKTVFTDHSLfGfadmsavlTNKYLQM-----------------CLCECD 160
Cdd:cd03800 97 REGGRydLIHSHYWDSGLV--GALLARRLGVPLVHTFHSL-G--------RVKYRHLgaqdtyhpslritaeeqILEAAD 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 161 hCIcVSHTGKENTVLRAKVKAH--KVSVIPNAVDAYTFTPDPSQR--------DPNVITVIIVSRLVYRKGVDLMAAVIA 230
Cdd:cd03800 166 -RV-IASTPQEADELISLYGADpsRINVVPPGVDLERFFPVDRAEarrarlllPPDKPVVLALGRLDPRKGIDTLVRAFA 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1949865553 231 DMCPRYPNLRFIIGGDGPKMWLLQEVRERKGFQHC------VTLLGSLKHSEV------RDVLV 282
Cdd:cd03800 244 QLPELRELANLVLVGGPSDDPLSMDREELAELAEElglidrVRFPGRVSRDDLpelyraADVFV 307
|
|
| GT4_CapH-like |
cd03812 |
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ... |
26-271 |
2.40e-08 |
|
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).
Pssm-ID: 340840 [Multi-domain] Cd Length: 357 Bit Score: 54.22 E-value: 2.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 26 NTGGVEEHIYNLSQCLIKRGHKVVVIthCYEDRVGVRY---LTGGLKVYYLPIRVFYsqcalptMICNIAIVRYILIRER 102
Cdd:cd03812 10 NVGGIETFLMNLYRKLDKSKIEFDFL--ATSDDKGEYDeelEELGGKIFYIPPKKKN-------IIKYFIKLLKLIKKEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 103 IQIVHGHSAFSVLAHEVSIigKLMGLK--------TVFTDHSLfgfaDMSAVLTNKYLQMCLCecDHCICVSHtgKENTV 174
Cdd:cd03812 81 YDIVHVHGSSSNGIILLLA--AKAGVPvriahshnTKDSSIKL----RKIRKNVLKKLIERLS--TKYLACSE--DAGEW 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 175 LRAKVKAHKVSVIPNAVDAYTFTPDPSQRDP--------NVITVIIVSRLVYRKGVDLMAAVIADMCPRYPNLRFIIGGD 246
Cdd:cd03812 151 LFGEVENGKFKVIPNGIDIEKYKFNKEKRRKrrkllileDKLVLGHVGRFNEQKNHSFLIDIFEELKKKNPNVKLVLVGE 230
|
250 260
....*....|....*....|....*
gi 1949865553 247 GPKMWLLQEVRERKGFQHCVTLLGS 271
Cdd:cd03812 231 GELKEKIKEKVKELGLEDKVIFLGF 255
|
|
| GT4-like |
cd03814 |
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
16-273 |
5.07e-08 |
|
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.
Pssm-ID: 340842 [Multi-domain] Cd Length: 365 Bit Score: 53.45 E-value: 5.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 16 ICMASDFFYPNTGGVEEHIYNLSQCLIKRGHKVVVIT----HCYEDRVGVRYLTGGLKvyyLPirvFYSQC--ALPTMic 89
Cdd:cd03814 2 IALVTDTYHPQVNGVVRTLERLVDHLRRRGHEVRVVApgpfDEAESAEGRVVSVPSFP---LP---FYPEYrlALPLP-- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 90 niAIVRYILIRERIQIVHGHSAFsVLAHEVSIIGKLMGLKTVFTDHSLF-------GFADMSAVLTNKYLQMCLCeCDHC 162
Cdd:cd03814 74 --RRVRRLIKEFQPDIIHIATPG-PLGLAALRAARRLGLPVVTSYHTDFpeylsyyTLGPLSWLAWAYLRWFHNP-FDTT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 163 ICVSHTgkentvLRAKVKAH---KVSVIPNAVDAYTFtpDPSQRD---------PNVITVIIVSRLVYRKGVDLMAAVIA 230
Cdd:cd03814 150 LVPSPS------IARELEGHgfeRVRLWPRGVDTELF--HPSRRDaalrrrlgpPGRPLLLYVGRLAPEKNLEALLDADL 221
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1949865553 231 DMCPRYPnLRFIIGGDGPkmwllqevrERKGFQH---CVTLLGSLK 273
Cdd:cd03814 222 PLAASPP-VRLVVVGDGP---------ARAELEArgpDVIFTGFLT 257
|
|
| GT5_Glycogen_synthase_DULL1-like |
cd03791 |
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ... |
27-249 |
1.77e-07 |
|
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.
Pssm-ID: 340822 [Multi-domain] Cd Length: 474 Bit Score: 51.80 E-value: 1.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 27 TGGVEEHIYNLSQCLIKRGHKVVVITHCYED-----------------------RVGVRYLT-GGLKVYYL--------- 73
Cdd:cd03791 15 TGGLGDVAGALPKALAKLGHDVRVILPRYGQipdeldgylrvlglevkvggrgeEVGVFELPvDGVDYYFLdnpeffdrp 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 74 -------------PIR-VFYSQCALpTMICNIAIvryilireRIQIVHGH---SAF-SVLAHEVSIIGKLMGLKTVFTDH 135
Cdd:cd03791 95 glpgppgydypdnAERfAFFSRAAL-ELLRRLGF--------QPDIIHANdwhTALvPAYLKTRYRGPGFKKIKTVFTIH 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 136 SL-----FGFADMSAVLTN----------KYLQMC-----LCECDHCICVSHT-GKE----------NTVLRAKvkAHKV 184
Cdd:cd03791 166 NLayqglFPLDTLAELGLPpelfhidgleFYGQINflkagIVYADRVTTVSPTyAKEiltpeygeglDGVLRAR--AGKL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 185 SVIPNAVD------------AYTFTP-DPSQR---------------DPNVITVIIVSRLVYRKGVDLMAAVIADMCPRy 236
Cdd:cd03791 244 SGILNGIDydewnpatdkliPANYSAnDLEGKaenkaalqkelglpvDPDAPLFGFVGRLTEQKGVDLILDALPELLEE- 322
|
330
....*....|...
gi 1949865553 237 pNLRFIIGGDGPK 249
Cdd:cd03791 323 -GGQLVVLGSGDP 334
|
|
| GlgA |
COG0297 |
Glycogen synthase [Carbohydrate transport and metabolism]; |
27-247 |
5.19e-07 |
|
Glycogen synthase [Carbohydrate transport and metabolism];
Pssm-ID: 440066 [Multi-domain] Cd Length: 476 Bit Score: 50.48 E-value: 5.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 27 TGGVEEHIYNLSQCLIKRGHKVVVITHCY-----------------------EDRVGVRYLTG-GLKVYYL--------- 73
Cdd:COG0297 16 TGGLADVVGALPKALAKLGHDVRVVLPGYpsiddklkdlevvaslevplggrTYYARVLEGPDdGVPVYFIdnpelfdrp 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 74 -------------PIR-VFYSQCALpTMICNIAIvryilireRIQIVHGH---SAF-SVLAHEVSIIGKLMGLKTVFTDH 135
Cdd:COG0297 96 gpygdpdrdypdnAERfAFFSRAAL-ELLKGLDW--------KPDIIHCHdwqTGLiPALLKTRYADDPFKRIKTVFTIH 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 136 SL-----FGFADMSAV-LTNKYLQMCLCECDHCIC--------------VSHT------------GKENtVLRAKvkAHK 183
Cdd:COG0297 167 NLayqgiFPAEILELLgLPPELFTPDGLEFYGQINflkagivyadrvttVSPTyareiqtpefgeGLDG-LLRAR--SGK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 184 VSVIPNAVDAYTFTP--DPS--------------------QR------DPNVITVIIVSRLVYRKGVDLMAAVIADMCPR 235
Cdd:COG0297 244 LSGILNGIDYDVWNPatDPYlpanysaddlegkaankaalQEelglpvDPDAPLIGMVSRLTEQKGLDLLLEALDELLEE 323
|
330
....*....|..
gi 1949865553 236 ypNLRFIIGGDG 247
Cdd:COG0297 324 --DVQLVVLGSG 333
|
|
| GT4_AviGT4-like |
cd03802 |
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ... |
28-281 |
2.71e-06 |
|
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.
Pssm-ID: 340832 [Multi-domain] Cd Length: 333 Bit Score: 48.05 E-value: 2.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 28 GGVEEHIYNLSQCLIKRGHKVVVITHcyEDRVGVRYLtggLKVYYLPIRVfySQCALPTMICNI-AIVRYILIRERIQIV 106
Cdd:cd03802 18 GGTELVVSALTEGLVRRGHEVTLFAP--GDSHTSAPL---VAVIPRALRL--DPIPQESKLAELlEALEVQLRASDFDVI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 107 HGHSAFSVLAHevsiiGKLMGLKTVFTDHSlFGFADMSAVLTNKYLQmclcecdHCICVSHTGKENTVLrakvkAHKVSV 186
Cdd:cd03802 91 HNHSYDWLPPF-----APLIGTPFVTTLHG-PSIPPSLAIYAAEPPV-------NYVSISDAQRAATPP-----IDYLTV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 187 IPNAVDAYTFTPDPSQRDPnvitVIIVSRLVYRKGVDLmAAVIADMCprypNLR-FIIGGDGPKMW--LLQEVRERKGfq 263
Cdd:cd03802 153 VHNGLDPADYRFQPDPEDY----LAFLGRIAPEKGLED-AIRVARRA----GLPlKIAGKVRDEDYfyYLQEPLPGPR-- 221
|
250
....*....|....*...
gi 1949865553 264 hcVTLLGSLKHSEVRDVL 281
Cdd:cd03802 222 --IEFIGEVGHDEKQELL 237
|
|
| Glycos_transf_1 |
pfam00534 |
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ... |
204-281 |
4.43e-06 |
|
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.
Pssm-ID: 425737 [Multi-domain] Cd Length: 158 Bit Score: 45.73 E-value: 4.43e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1949865553 204 DPNVItvIIVSRLVYRKGVDLMAAVIADMCPRYPNLRFIIGGDGPKMWLLQEVRERKGFQHCVTLLGSLKHSEVRDVL 281
Cdd:pfam00534 1 KKKII--LFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELL 76
|
|
| Glyco_trans_1_4 |
pfam13692 |
Glycosyl transferases group 1; |
209-281 |
2.93e-05 |
|
Glycosyl transferases group 1;
Pssm-ID: 463957 [Multi-domain] Cd Length: 138 Bit Score: 42.88 E-value: 2.93e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1949865553 209 TVIIVSRLV-YRKGVDLMAAVIADMCPRYPNLRFIIGGDGPKMWLLQEVRerkGFQHCVTLLGSLKhsEVRDVL 281
Cdd:pfam13692 3 VILFVGRLHpNVKGVDYLLEAVPLLRKRDNDVRLVIVGDGPEEELEELAA---GLEDRVIFTGFVE--DLAELL 71
|
|
| GT4_AmsK-like |
cd03799 |
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ... |
181-281 |
5.95e-05 |
|
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.
Pssm-ID: 340829 [Multi-domain] Cd Length: 350 Bit Score: 43.98 E-value: 5.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 181 AHKVSVIPNAVDAYTFTPDPSQRDPN-VITVIIVSRLVYRKGVDLMAAVIADMCPRYPNLRFIIGGDGPKMWLLQEVRER 259
Cdd:cd03799 147 EKKIIVHRSGIDCNKFRFKPRYLPLDgKIRILTVGRLTEKKGLEYAIEAVAKLAQKYPNIEYQIIGDGDLKEQLQQLIQE 226
|
90 100
....*....|....*....|..
gi 1949865553 260 KGFQHCVTLLGSLKHSEVRDVL 281
Cdd:cd03799 227 LNIGDCVKLLGWKPQEEIIEIL 248
|
|
| GT4_WbdM_like |
cd04951 |
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ... |
28-279 |
2.80e-03 |
|
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.
Pssm-ID: 340857 [Multi-domain] Cd Length: 360 Bit Score: 38.58 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 28 GGVEEHIYNLSQCLIKRGHKVVVIthCYEDRVGVRYLTGGLKVYYLPI-RVFYSqcalptMICNIAIVRYILIRERIQIV 106
Cdd:cd04951 12 GGAEKQTVLLADQMFIRGHDVNIV--YLTGEVEVKPLNNNIIIYNLGMdKNPRS------LLKALLKLKKIISAFKPDVV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 107 HGH----SAFSVLAHEVSIIGKLmglktVFTDHS--LFGFADMSAVLTNKYLqmclceCDHCICVSHTGKENTVLRAKVK 180
Cdd:cd04951 84 HSHmfhaNIFARFLRMLYPIPLL-----ICTAHNknEGGRIRMFIYRLTDFL------CDITTNVSREALDEFIAKKAFS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949865553 181 AHKVSVIPNAVDAYTFTPDPSQRDP---------NVITVIIVSRLVYRKG-VDLMAAvIADMCPRYPNLRFIIGGDGPKM 250
Cdd:cd04951 153 KNKSVPVYNGIDLNKFKKDINVRLKirnklnlknDEFVILNVGRLTEAKDyPNLLLA-ISELILSKNDFKLLIAGDGPLR 231
|
250 260
....*....|....*....|....*....
gi 1949865553 251 WLLQEVRERKGFQHCVTLLGSlkHSEVRD 279
Cdd:cd04951 232 NELERLICNLNLVDRVILLGQ--ISNISE 258
|
|
| |
