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Conserved domains on  [gi|1935093169|ref|XP_037754196|]
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lactosylceramide alpha-2,3-sialyltransferase isoform X2 [Chelonia mydas]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 155-365 1.05e-151

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467711  Cd Length: 211  Bit Score: 426.85  E-value: 1.05e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 155 HCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGAPLSENEYNPQSLFVVVLFKGVD 234
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 235 FSWLQAMVKNEALPLWVRLFFWKQVAEKIPVTPKQFRILNPIIVKETALDILQYPEPRSKFWGWDKNVPTIGVTAVVLAT 314
Cdd:cd23983    81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1935093169 315 HLCDEVSLAGFGYDLHQPNTPLHYYDNLCMAAMEGQTMHNVTTETKFLQKL 365
Cdd:cd23983   161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 155-365 1.05e-151

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 426.85  E-value: 1.05e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 155 HCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGAPLSENEYNPQSLFVVVLFKGVD 234
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 235 FSWLQAMVKNEALPLWVRLFFWKQVAEKIPVTPKQFRILNPIIVKETALDILQYPEPRSKFWGWDKNVPTIGVTAVVLAT 314
Cdd:cd23983    81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1935093169 315 HLCDEVSLAGFGYDLHQPNTPLHYYDNLCMAAMEGQTMHNVTTETKFLQKL 365
Cdd:cd23983   161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 110-370 7.20e-94

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 281.42  E-value: 7.20e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 110 REDINRHEAVF--KYKPPFgfhknsDKLQNLLKLLPEydlPENLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLN 187
Cdd:pfam00777   4 KENFPLGEWIRysEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCN 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 188 DAPIQGYTDHVGNKTTIRMTYPEGAPLS-------ENEYNPQSLFVVVLFKGVDFSWLQAMVKNEALPL-WVRLFFWKQV 259
Cdd:pfam00777  75 LAPTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 260 aeKIPVTPKQFRILNPIIVKETALDILQYPEPRSkfwgwdkNVPTIGVTAVVLATHLCDEVSLAGFGYDLHQPNTPLHYY 339
Cdd:pfam00777 155 --KIPVDPDKVLFLHPDFLRYVANFWLRSHGLKG-------RRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYY 225

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1935093169 340 DNLCMAAMEGQTMHNVTTETKFLQKLIKEGI 370
Cdd:pfam00777 226 DNVLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 155-365 1.05e-151

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 426.85  E-value: 1.05e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 155 HCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGAPLSENEYNPQSLFVVVLFKGVD 234
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 235 FSWLQAMVKNEALPLWVRLFFWKQVAEKIPVTPKQFRILNPIIVKETALDILQYPEPRSKFWGWDKNVPTIGVTAVVLAT 314
Cdd:cd23983    81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1935093169 315 HLCDEVSLAGFGYDLHQPNTPLHYYDNLCMAAMEGQTMHNVTTETKFLQKL 365
Cdd:cd23983   161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 156-365 2.91e-107

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 313.84  E-value: 2.91e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 156 CKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGAPLSENEYNPQSLFVVVLFKGVDF 235
Cdd:cd23967     2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 236 SWLQAMVKNEALPLWVrlFFWKQVAEKIPVTPKQFRILNPIIVKETALDILQYPEPRSKfwgwDKNVPTIGVTAVVLATH 315
Cdd:cd23967    82 LWLQAVIKGKKPNGKG--GFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNGKQ----GKNVPTTGIIAIVMALH 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1935093169 316 LCDEVSLAGFGYDLHQPNTPLHYYDNLCMAAMEGQTMHNVTTETKFLQKL 365
Cdd:cd23967   156 YCDEVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 110-370 7.20e-94

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 281.42  E-value: 7.20e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 110 REDINRHEAVF--KYKPPFgfhknsDKLQNLLKLLPEydlPENLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLN 187
Cdd:pfam00777   4 KENFPLGEWIRysEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCN 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 188 DAPIQGYTDHVGNKTTIRMTYPEGAPLS-------ENEYNPQSLFVVVLFKGVDFSWLQAMVKNEALPL-WVRLFFWKQV 259
Cdd:pfam00777  75 LAPTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 260 aeKIPVTPKQFRILNPIIVKETALDILQYPEPRSkfwgwdkNVPTIGVTAVVLATHLCDEVSLAGFGYDLHQPNTPLHYY 339
Cdd:pfam00777 155 --KIPVDPDKVLFLHPDFLRYVANFWLRSHGLKG-------RRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYY 225

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1935093169 340 DNLCMAAMEGQTMHNVTTETKFLQKLIKEGI 370
Cdd:pfam00777 226 DNVLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 156-365 5.70e-71

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 221.08  E-value: 5.70e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 156 CKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGA---PLSENeyNPQSLFVVVLFKG 232
Cdd:cd23982     2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAqfdPGIEN--DPDTLLVLVPFKP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 233 VDFSWLQAMVKNEALplwVRLFFWKQVAEKIPVTPKQFRILNPIIVKETALDILQYPEPRSKfwgwdKNVPTIGVTAVVL 312
Cdd:cd23982    80 LDFYWLYEILSNEKR---VRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQRKK-----KQKPTTGLLAITL 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1935093169 313 ATHLCDEVSLAGFGY-DLHQPNTPLHYYDNLCMAAMEGqTMHNVTTETKFLQKL 365
Cdd:cd23982   152 ALHLCDEVHIAGFGYpDNGNSNQPIHYYNQITLKSMAN-SGHNLNAEAQAIQRL 204
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 156-365 2.92e-68

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 214.40  E-value: 2.92e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 156 CKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGAPLSENEYNPQSLFVVVLFKGVDF 235
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 236 SWLQAMVKNEAlplwVRLF--FWKQVAEKIPVTPKQFRILNPIIVKETALDILQYPEpRSKFWGwDKNVPTIGVTAVVLA 313
Cdd:cd23981    82 KWLKYIVYKEK----VSASdgFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPF-NNGLMG-RGNIPTLGSVAITMA 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1935093169 314 THLCDEVSLAGFGYDLHQPNTPLHYYDNLCMAAMEGQTMHNVTTETKFLQKL 365
Cdd:cd23981   156 LHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 156-365 8.91e-62

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 197.66  E-value: 8.91e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 156 CKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGAPLSENEYNPQSLFVVVLFKGVDF 235
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 236 SWLQAMVKNEAlplwVRLF-FWKQVAEKIPVTPKQFRILNPIIVKETALDILQYPE--PRSKfwgwDKNVPTIGVTAVVL 312
Cdd:cd23984    82 RWLLDLLMGKK----VSAKgFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKrfPKEK----KPKHPTTGIIAITL 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1935093169 313 ATHLCDEVSLAGFGYDLHQPNTPLHYYDNLCMAAMEGQTMHNVTTETKFLQKL 365
Cdd:cd23984   154 ALHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 84-372 8.10e-44

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 153.57  E-value: 8.10e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169  84 CRPSFVKK-EMDRLFAEKYSVNIFPFV-REDINRHEavF----KYKPPFGF-HKNSDKLQNLLKLLPEYDLPENLKSKH- 155
Cdd:cd23964     1 CPSSLRKKlQKSPWFRERFIPDIKVLLdSEDFNPEE--YnrlsHYKLPFGWgGLNREVVERLLRNLNLTSSRYMFVLRGg 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 156 ---CKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGAPLSENEYNPQS---LFVVVL 229
Cdd:cd23964    79 rprCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLLKHVPQDkdtKYLFIP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 230 FKGVDFSWLQAMVKNEALPLWVRLFFWKQVAEKIPVTPKQFRILNPiivketalDILQYpeprsKFWGW----DKNVPTI 305
Cdd:cd23964   159 FKIRDYDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATNVRLLHP--------DFIRY-----LFNRWlnssTSYRPTT 225

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1935093169 306 GVTAVVLATHLCDEVSLAGFGYDlhqPNTPLHYYDNlcmaAMEGQTM----HNVTTETKFLQKLIKEGIVK 372
Cdd:cd23964   226 GALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDK----TFVKFTVfyanHDFTNERKLWRKLHEEGIIN 289
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 84-372 2.11e-35

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 130.86  E-value: 2.11e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169  84 CRPSFVKKEMDRLFAEKYSVNIFPF-VREDINRHEAVFKYKPPFGFHKNSDK---LQNLLKLLPEYDLPENLKSKHCKRC 159
Cdd:cd23966     1 CRRCVQEGGDSDWFDERFNPSIEPLlTRKNKELPPDVLKWWLSLQSSKNSDLrevLEKLFQVVPGENPYRTRDPNRCRRC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 160 VVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEgaplSENEYNPQSLFVVVLFKGVDFSWLQ 239
Cdd:cd23966    81 AVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPE----SAVDLDPGVHLVLVPFKVLDLQWLI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 240 AMVKNEALplwvrLFFWKQVAEKIPVTPKQFRILNPII---VKETALdilqypEPRSKFwgwdknvPTIGVTAVVLATHL 316
Cdd:cd23966   157 SALTTGEI-----TRTYTPVKRFIKADKDKVLVINPAFikyVHDNWT------EHHGRY-------PSTGFLALIFALHI 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1935093169 317 CDEVSLAGFGYDL----HqpntplHYYDNLCMAAMEGQT-MHNVTTETKFLQKLIKEGIVK 372
Cdd:cd23966   219 CDEVSVFGFGADSkgnwH------HYWEKNRSAGAFRKTgVHDADFESDIIKKLAKEGKIR 273
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 159-365 5.55e-34

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 124.78  E-value: 5.55e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 159 CVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRM-------TYPEGAPLSENEYNPQSLFVVVLFk 231
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVlnskwagFYLRGPRCGCHPLPLEEEVVLILS- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 232 gvDFSWlqamvkneALPLWVRLFFWKQVAEKIPVTPKQFRILNPIIVKetaldilqYPEPRSKFWGwDKNVPTIGVTAVV 311
Cdd:cd19952    80 --RAAA--------ADFKRLKRRKKRHDNAVLLLTDPAPDLLSYVRKR--------LEKLGLKSFF-GGNAPSSGLLAVL 140

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1935093169 312 LATHLCDEVSLAGFGYD-LHQPNTPLHYYDnlCMAAMEGQTMHNVTTETKFLQKL 365
Cdd:cd19952   141 LALQLCDSVDLYGFGVDsGHAPKVPYHYYD--LVEAEEGTAVHSFDLEAELLRAL 193
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 97-372 3.31e-25

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 103.41  E-value: 3.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169  97 FAEKYSVNIFP-FVREDINRHEAVFKY----KPPFGFHKNSDKLQNLLKLLPEYDLPENLKSKHCKRCVVVGSGGILRGL 171
Cdd:cd23979    16 FDEHYDPDISPvWTKENMELPPDVQYWwmmlQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRCRRCAVVGNSGNLRGS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 172 ELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGAplseNEYNPQSLFVVVLFKGVDFSWLQAmvkneALPLWV 251
Cdd:cd23979    96 GYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESA----KNLPANVSFVLVPFKTLDLLWITS-----ALSTGQ 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 252 RLFFWKQVAEKIPVTPKQFRILNPIIVKetaldilqYPEPRskfwgWDKN---VPTIGVTAVVLATHLCDEVSLAGFGYD 328
Cdd:cd23979   167 IRFTYAPVKQFLRVDKDKVQIYNPAFFK--------YIHDR-----WTEHhgrYPSTGMLVLFFALHVCDEVNVYGFGAD 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1935093169 329 lhQPNTPLHYYDNLCMAAMEGQT-MHNVTTETKFLQKLIKEGIVK 372
Cdd:cd23979   234 --SRGNWHHYWENNRYAGEFRKTgVHDADFEAHIIDMLAKAGKIK 276
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 119-372 2.42e-24

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 100.80  E-value: 2.42e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 119 VFKYKPPFGFHKNSDKL-QNLLKLLPEYDLpenLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDH 197
Cdd:cd23963    28 LGDVLYYSYFKKKTFKItKSLYELLPKTSP---FSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKD 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 198 VGNKT---TIrmtypegaplseneyNPQSLFVVVLFKGVDFsWLQAMVK-----NEALpLWVRLFFWK-------QVAEK 262
Cdd:cd23963   105 VGRKTnltTL---------------NPSILKRRYNSLKKNR-DRDKFLNrlkeyNGSI-LWYPKFSFKsstnlllKAARA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 263 IPVTPKQFRIL--NPIivketaldilqYPEPRSKFWGWDKN--VPTIGVTAVVLATHLCDEVSLAGF---GYDLHQPNTP 335
Cdd:cd23963   168 LKKNGLNLTVVysNPE-----------HFLAVQKFWKRRGLekRPSTGLYLVSLALTFCDEIHLYGFwpfPTDPNGRPVP 236

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1935093169 336 LHYYDNlcMAAMEGQTMHNVTTETKFLQKLIKEGIVK 372
Cdd:cd23963   237 YHYYDD--LSPSTKNKVHNMPEEFKLLRELHKKGVLK 271
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 140-365 3.58e-22

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 94.64  E-value: 3.58e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 140 KLLPEYDLPE--NLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIR------MTYPEG 211
Cdd:cd23968    27 LLSLRYPFPEssLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRlinsqiLSKPEF 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 212 APLSENEYNPQSLFVV--VLFKGVDFSWLqamvKNEALPLWVRLFFWKQvaekipVTPKQ-FRILNPIIVKEtALDILQy 288
Cdd:cd23968   107 NFLTDPLYRNVTLLVWdpSSYNVNLEKWY----KKPDFDFFPNYIKYRR------RHPEEpFYLIDPRFLWR-LWDILQ- 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1935093169 289 pepRSKFWGWDKNVPTIGVTAVVLATHLCDEVSLagFGYDLHQPNTPL-HYYDNLCMAAMEGQTMHNVTTETKFLQKL 365
Cdd:cd23968   175 ---EYTPEKIKPNPPSSGFIGIVLMLHLCDWVDV--YEYVPSVRQTDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 132-341 6.35e-22

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 94.56  E-value: 6.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 132 SDKLQNLLKLLP-EYDLPENLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPE 210
Cdd:cd23980    56 NDTIRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPE 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 211 gaplSENEYNPQSLFVVVLFKGVDFSWLQAmvkneALPLWVRLFFWKQVAEKIPVTPKQFRILNPIIVKETaldilqype 290
Cdd:cd23980   136 ----SFRELAQNVSMILVPFKTLDLEWVIS-----ATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYV--------- 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1935093169 291 prskFWGWDKN---VPTIGVTAVVLATHLCDEVSLAGFGYDlhQPNTPLHYYDN 341
Cdd:cd23980   198 ----FDRWLQGhgrYPSTGILSVIFSLHVCDEVDLYGFGAD--SKGNWHHYWEN 245
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 100-372 1.04e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 88.22  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 100 KYSVNIFPFVREDINRHEAVFKYKPpfgfhknsdklqNLLKLLPEYDLpenLKSKHCKRCVVVGSGGILRGLELGHVLNE 179
Cdd:cd23970    27 KKDVRIGQLMHFDYSSHKYVFSISP------------NLRSLLPEVSP---FQNKHYNTCAVVGNSGILTNSQCGNEIDK 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 180 FDIVIRLNDAPIQGYTDHVGNKTTIrmtypegaplseNEYNPQSL--FVVVLFKGVD-FSWLQAMVKNEALPLWVRLFFW 256
Cdd:cd23970    92 SDFVFRCNFAPTEGFEKDVGRKTNL------------TTFNPSILekYYNNLLTIQDrNNFFLSLKKLDGAILWIPAFFF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 257 KQVAekiPVTpkqfRILNPIIVK-------ETAL--DILQYpepRSKFWgWDKNVP----TIGVTAVVLATHLCDEVSLA 323
Cdd:cd23970   160 HTSA---TVT----RTLVDFFVEhrgqlkvQLAWpgNIMQH---VNRYW-KTKHLSpkrlSTGILMYTLASAICEEIHLY 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1935093169 324 GF---GYDLHQPNTPLHYYDNL-CMAAMEGQTMHNVTTETKFLQKLIKEGIVK 372
Cdd:cd23970   229 GFwpfGFDPTGTPLPYHYYDKKgTKFTTKWQESHQLPAEFVLLYKMHGAGVLK 281
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 136-372 4.91e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 86.15  E-value: 4.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 136 QNLLKLLPEYdlpENLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPegapls 215
Cdd:cd23987    47 QNLYELLPRT---SPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP------ 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 216 eneynpqSLFVVVLFKGVDFSWLQAMVK-----NEALpLWVRLFFWKQVAEKIpvtpkqfRILNPIIVKETALDILQYPE 290
Cdd:cd23987   118 -------SVVQRAFEDLVNETWKEKFLQrlqslNGSI-LWIPAFMAKGGEERV-------EWVNDLILKHHINVRTAYPS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 291 PR-----SKFWGWDK---NVPTIGVTAVVLATHLCDEVSLAG---FGYDLHQPNTPLHYYDNLCMAAMEGQTMHNVTTET 359
Cdd:cd23987   183 LRllhavRGYWLTNKvhiKRPTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEF 262

                         250
                  ....*....|...
gi 1935093169 360 KFLQKLIKEGIVK 372
Cdd:cd23987   263 KALKNLHQQGALK 275
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 122-372 4.13e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 84.03  E-value: 4.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 122 YKPPFGFHK-NSDKLQNLLKLLP---EYDLPENLKSKH--CKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYT 195
Cdd:cd23973    43 FNPPFGFMGlNYTLVKEVVELIPkpkEQQLLALSPPGGdgCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 196 DHVGNKTTIRMTYPEGAPLSENEYNPQSLFVVVLFKGV----------DFSWLQAMVKNEALPlwvRLFFWKQVAEKI-- 263
Cdd:cd23973   123 EDVGTRTSFYVHTAHSITSSLMILQKRGFKNIPQDKDIkyilfpegprDYQWLEALLKNKTIP---SGAYYGRRPRSYfs 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 264 -PVTPKQFRILNPiivketalDILQYPEPR--------SKFWGWDKnvPTIGVTAVVLATHLCDEVSLAGFGYDLHQpNT 334
Cdd:cd23973   200 gDFTEDKYLVLHP--------DFLRYVKNRflrsktlkGKYWAIYR--PTTGAFLLLTALHLCDTVSAYGFITEDYR-KY 268

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1935093169 335 PLHYYDnLCMAAMEGQTMHNVTTETKFLQKLIKEGIVK 372
Cdd:cd23973   269 PDHYYD-KKKTKLVFYINHDFRLEKKLWKRLHDEKIIK 305
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 136-372 4.66e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 83.47  E-value: 4.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 136 QNLLKLLPEYdlpENLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNK---TTIRMTYPEGA 212
Cdd:cd23988    47 QNLHSLLPEV---SPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKsdfITMNPSVVQRA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 213 PLSENEYNPQSLFVVVLfkgvdfswlqAMVKNEAlpLWVRLFFWKQvaekipvTPKQFRILNPIIVKETALDILQYPEPR 292
Cdd:cd23988   124 FGGFRNESDREKFVHRL----------SMLNDSV--LWIPAFMVKG-------GEKHVEWVNALILKNKLKVRTAYPSLR 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 293 -----SKFWGWDK---NVPTIGVTAVVLATHLCDEVSLAG---FGYDLHQPNTPLHYYDNLCMAAMEGQTMHNVTTETKF 361
Cdd:cd23988   185 lihavRGYWLTNKvniKRPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSNAGPHRMPLEFKT 264

                         250
                  ....*....|.
gi 1935093169 362 LQKLIKEGIVK 372
Cdd:cd23988   265 LNVLHNRGALK 275
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 136-372 8.40e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 79.77  E-value: 8.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 136 QNLLKLLPEYDlPenLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTT-IRMtypegapl 214
Cdd:cd23969    47 QDLYQLLPEVS-P--LKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNlTTM-------- 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 215 seneyNPQslfvVVL--FKGVDF-SWLQAMVKN----EALPLWVRLFFWKQVAEKIpvtpkqfRILNPIIVKETALDILQ 287
Cdd:cd23969   116 -----NPS----VIPhaYGDLVNaTDKEKFVERlrqlGDSILWIPAFVSKGGEEHV-------QWTNEIILKHKLNVKTA 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 288 YPEPR-----SKFWGWDK---NVPTIGVTAVVLATHLCDEVSLAG---FGYDLHQPNTPLHYYDNLCMAAMEGQtmHNVT 356
Cdd:cd23969   180 YPPLRlnhaiRGYWLTTKfriKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLTTARP--HKMP 257

                         250
                  ....*....|....*.
gi 1935093169 357 TETKFLQKLIKEGIVK 372
Cdd:cd23969   258 EEFRALRSLHQRGALR 273
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 140-325 8.11e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 76.67  E-value: 8.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 140 KLLPEYDLPENLKskHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIR------MTYPEGAP 213
Cdd:cd23985    31 GYLPKKSLREEVG--PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRlinsqlVTTEKHKF 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 214 LSENEYNPQSLFVvvlfkgvdfsWLQAmVKNEALPLWVRL----FF--WKQVAEKIPVTPkqFRILNPI-------IVKE 280
Cdd:cd23985   109 LKDSLYNEGILIV----------WDPA-PYHSDIPEWYKNpdynFFenYKTYRRLNPNQP--FYILHPQmqwelwdIIQE 175

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1935093169 281 TALDILQypeprskfwgwdKNVPTIGVTAVVLATHLCDEVSLAGF 325
Cdd:cd23985   176 NSPEEIQ------------PNPPSSGMLGIILMMTLCDQVDVYEF 208
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 156-340 6.08e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 73.43  E-value: 6.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 156 CKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIR----MTYPEGA--PLSENEYNPQSLFVVVl 229
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRvvshSSLPRLLrnAILLLAGTRAPTVVVF- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 230 fkgvdfsWLQAMVKNEALPLWVRLFfwKQVAEKIP------VTPKQFRILNPIIVKETALDILQypeprSKFW---GWdk 300
Cdd:cd23965    80 -------WGPETKMNKDGAGKYNLL--RSLSKKYPdvefysLTPEKMDYADELFEKETGKSRIK-----SGTWlstGW-- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1935093169 301 nvptigvTAVVLATHLCDEVSLAGF---GYDLHQPN--TPLHYYD 340
Cdd:cd23965   144 -------FTMLLALDVCDEIKVYGMvpeNYCREHPNskVPYHYYE 181
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 136-372 9.39e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 64.97  E-value: 9.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 136 QNLLKLLPEyDLPenLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQgYTDHVGNKT----------TIR 205
Cdd:cd23971    47 EKLFSMLPK-ESP--FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTnlvtanpsilREK 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 206 MTYPEGAPLSENE----YNpQSLFVVVLFkgvdfswlqAMVKNEALPLWVrLFFWKQVAEKIPVTpkqfrILNPiivket 281
Cdd:cd23971   123 FHNLKKRRRPFVErmkvYG-NALLLLPAF---------SYTSNTEPSLRA-LYTLEDFGSPQKVL-----FFNP------ 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 282 aldilQYPEPRSKFW---GWDKNVPTIGVTAVVLATHLCDEVSLAGF---GYDLHQPNTPLHYYDNLcmaaMEGQTMHNV 355
Cdd:cd23971   181 -----EYLRNLSRYWkskGLKARRLSTGLMLVSAALELCENVHLYGFwpfSTDLDGNPISHHYYDNV----LPKKGVHAM 251

                         250
                  ....*....|....*..
gi 1935093169 356 TTETKFLQKLIKEGIVK 372
Cdd:cd23971   252 PEEFLRYLKLHSQGVLR 268
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 155-340 1.61e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 63.73  E-value: 1.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 155 HCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGAPL---SENEYNPQSLFVVVLF- 230
Cdd:cd23976    14 HCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRilrNRNELLNVSQGTVFIFw 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 231 ----------KGVDFSWLQAMvkNEALPlwvrlffwkQVAEKIPVTPKQFRiLNPIIVKETALDilqypEPRSKFW---G 297
Cdd:cd23976    94 gpsnymrrdgKGLVYNNLQLM--NQILP---------KLKVYTITRHKMLQ-FDELFKRETGKD-----RKISNTWlstG 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1935093169 298 WdknvptigvTAVVLATHLCDEVSLAG-----FGYDLHQPNTPLHYYD 340
Cdd:cd23976   157 W---------FTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 152-372 2.91e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 64.00  E-value: 2.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 152 KSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKT--------TIRMTYpegAPLSENEYN--P 221
Cdd:cd23974    80 GRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTsfytfstnTLMNSL---RAYAGVGFNgpP 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 222 QSLFVVVLF---KGVDFSWLQAMVKNEAL---------PlwvRLFFWKQV-AEKipvtpkqFRILNPiivketalDILQY 288
Cdd:cd23974   157 QSKETRYIFlpdHDRDYLLVKAALTHTPIdrgrdkskrP---SKYFGKDVtAEK-------FKIYHP--------DFIRY 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 289 pePRSKF-WG-------WDKNVPTIGVTAVVLATHLCDEVSLAGF---GYDLHQPntplHYYDNlCMAAMEGQTMHNVTT 357
Cdd:cd23974   219 --LRNRFlWSpilntkqRDIYRPSTGAVMLLAALHTCDQVSAYGFmtpDYGKYSD----HYYDK-TYHKVVFYANHDLRL 291

                         250
                  ....*....|....*
gi 1935093169 358 ETKFLQKLIKEGIVK 372
Cdd:cd23974   292 EMQLWQKLHKAGLIK 306
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 156-340 1.82e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 60.25  E-value: 1.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 156 CKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTypEGAPLSENEYNPQSLF-----VVVLF 230
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVV--AHSSVYRVLRRPQEFLnrtpeTTLIF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 231 KGVdfswlQAMVKNEALPLWVRLFfwKQVAEKIP------VTPKQFRILNPIIVKETALDilqypepRSKFWGWdknvPT 304
Cdd:cd23978    79 WGP-----PNKMQKDGKSNLFRII--QRASMTFPnmsafvVSPRRMRQFDDLFRGETGRD-------RKKSHSW----LS 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1935093169 305 IGVTAVVLATHLCDEVSLAG-----FGYDLHQP-NTPLHYYD 340
Cdd:cd23978   141 TGWFTMVIAVELCDNVHVYGmvppnYCSKRPTPkKMPYHYYE 182
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 121-372 2.26e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 60.99  E-value: 2.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 121 KYKPPFGF----HKNSDKLQNLL------KLLPEYDLPENlkskhCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAP 190
Cdd:cd23972    42 QRKVPYGWkglsHQVVASTLSLLndsanaKLFFPRDTPGK-----CIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 191 IQGYTDHVGNKTT---IRMTYPEGAPLSENEYN----PQSlfvvvlfKGVDFSWLQAMVKNealplWVRLffwKQVAEKI 263
Cdd:cd23972   117 IKGFEEDVGTKTSfygFTVNTMKNSLISYWNLGftrtPQG-------QDLQYIFIPSDIRD-----YVML---RSAILGV 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 264 PV------------------TPKQFRILNPiivketalDILQYPEPR---SKF----WGwDKNVPTIGVTAVVLATHLCD 318
Cdd:cd23972   182 PVpegldkgdrphkyfgpeaSAKKFKLLHP--------DFISYLTDRflkSKLlnthYG-HLYMPSTGALMLLTALHTCD 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1935093169 319 EVSLAGFGYDLHQPNTPlHYYDNLcMAAMEGQTMHNVTTETKFLQKLIKEGIVK 372
Cdd:cd23972   253 QVSAYGFITSNYWKFSD-HYYERK-KKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 157-372 3.01e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 60.23  E-value: 3.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 157 KRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPI-QGYTDHVGNKTTIrmtypegapLSENEYNPQSLFVVVLFKGVDF 235
Cdd:cd23989    64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQL---------VTANPSIIDKRFQNLLWSRKSF 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 236 SwlqamvknEALPLWVRLFFWKQVAEKIPVTPKQFRI---LNPIIVKETALdilqYPEPR-----SKFW---GWDKNVPT 304
Cdd:cd23989   135 V--------ESMKVYGRSYIYMPAFSMKTGTDPSLRVyytLADVGANQTVL----FANPNflrnvGKFWkskGVHAKRLS 202

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1935093169 305 IGVTAVVLATHLCDEVSLAG---FGYDLHQPNTPLHYYDNLcmaaMEGQTMHNVTTETKFLQKLIKEGIVK 372
Cdd:cd23989   203 TGLFLVSAALGLCEEVTIYGfwpFSVDLDERTISHHYYDNV----LPDSGFHAMPEEFLQLWHLHKSGVLR 269
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 136-372 6.23e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 59.38  E-value: 6.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 136 QNLLKLLPEydlPENLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQG-YTDHVGNKTTIRMTYPEGAPL 214
Cdd:cd23991    47 ENIFRMFPK---SQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANPSIISI 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 215 SENEYNpqslfvvvlFKGVDFsWLQAMVKNEALPLWVRLFFWKQVAEKIPV--TPKQFR------ILNPIIVKETAldil 286
Cdd:cd23991   124 KYAKLN---------ERRKPF-LETVSVYGDAFLLLPAFSYRSNTALSFKVyyTLEDFKakqkviFFHPIYLKHLA---- 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 287 qypeprsKFW---GWDKNVPTIGVTAVVLATHLCDEVSLAG---FGYDLHQPNTPLHYYDNLcmaaMEGQTMHNVTTETK 360
Cdd:cd23991   190 -------QFWrskGVQVYRLSTGLMITSAALELCEEVKLYGfwpFSKNTEGKPISHHYYDNQ----LPKPGFHSMPKEFY 258

                         250
                  ....*....|..
gi 1935093169 361 FLQKLIKEGIVK 372
Cdd:cd23991   259 QLLQLHSKGILK 270
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 140-367 7.08e-10

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 59.08  E-value: 7.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 140 KLLPEYDLPEnLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYpegaplSENEY 219
Cdd:cd23986    34 KYVPKIPLSK-LHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIIN------SQILT 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 220 NPQSLFV-VVLFKGVdfswlqAMVKNEALPLWVRLFFW------------KQVAEKIPVTPkqFRILNPI-------IVK 279
Cdd:cd23986   107 NPNHHFIdSSLYKDV------ILVAWDPAPYSANLHKWykkpdynlftpyVQYRKRNPNQP--FYILHPKfiwqlwdIIQ 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 280 ETALDILQyPEPrskfwgwdknvPTIGVTAVVLATHLCDEVSLAGFGYDLHQpnTPL-HYYDNLCMAAMEGQTMHNVTTE 358
Cdd:cd23986   179 ENTQEKIQ-PNP-----------PSSGFIGILIMMSMCREVHVYEYIPSVRQ--TDLcHYHERYYDAACTLGAYHPLLYE 244


                  ....*....
gi 1935093169 359 TKFLQKLIK 367
Cdd:cd23986   245 KLLIQRMNK 253
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 156-214 1.76e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 54.48  E-value: 1.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1935093169 156 CKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGAPL 214
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPL 59
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 156-340 5.13e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 50.32  E-value: 5.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 156 CKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPIQGYTDHVGNKTTIRMTYPEGAPLSENeyNPQSLF------VVVL 229
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLK--NPDYFFketnetIYVI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 230 F----------KGVDFSWLQAMVKNEAlplwvrlffwkqvAEKIPVTP-KQFRILNPIIVKETALDILQYPEPRSKFWgw 298
Cdd:cd23975    79 WgpfrnmrkdgKGIVYNMLKKAVESYP-------------QAKIYVTTeKRMSYCDTVFKKETGKDRVQSGSYLSTGW-- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1935093169 299 dknvptigvTAVVLATHLCDEVSLAGFGYDLHQPN-----TPLHYYD 340
Cdd:cd23975   144 ---------FTLILAMDACYGIHVYGMINDTYCKTegyrkVPYHYYE 181
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 128-342 4.24e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 47.91  E-value: 4.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 128 FHKNSDklqnLLKLLPEyDLPenLKSKHCKRCVVVGSGGILRGLELGHVLNEFDIVIRLNDAPI-QGYTDHVGNKTTIRM 206
Cdd:cd23990    43 YHINSE----IFKMFPK-DMP--YSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935093169 207 TYPegaplseneynpqSLFVVVLFKgvdfswlqamvkneaLPLWVRLFF-WKQVAEKIPV----------TPKQFRILNP 275
Cdd:cd23990   116 INP-------------SIITERFHK---------------LEKWRRPFYeVLQVYENASVvlpafyntrnTDVSIRVKYV 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1935093169 276 IIVKETALDIL----QYPEPRSKFW---GWDKNVPTIGVTAVVLATHLCDEVSLAGF-GYDLHQPNTPL--HYYDNL 342
Cdd:cd23990   168 LDDFESQQAVYyfhpQYLLNVSRFWlrqGVRAKRISSGLMLVTAALELCEEVHLYGFwAFPMNPSGIFIthHYYDNV 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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