NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1926999721|ref|XP_036892197|]
View 

annexin A5 [Sturnira hondurensis]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 20-84 6.85e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 97.93  E-value: 6.85e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1926999721  20 DAEALRKAMKGLGTDEETILTLLTSRSNAQRQEITAAFKTLFGRDLLDDLKSELTGKFEKLIVAL 84
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 250-315 8.57e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 8.57e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926999721 250 YLAETLYYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRRNFATSLYSMIKGDTSGDYKKALLLL 315
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 91-156 2.79e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 85.60  E-value: 2.79e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926999721  91 YDAYELKHALKGAGTNEKVLTEIIASRTPEELTAIKKVYEEEYGSNLEDDVVGDTSGYYQRMLVVL 156
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 174-240 6.55e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.05  E-value: 6.55e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1926999721 174 QDAQALfQAGELKWGTDEEKFITIFGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGHLEQLLLAV 240
Cdd:pfam00191   1 YDAELL-RKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 20-84 6.85e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 97.93  E-value: 6.85e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1926999721  20 DAEALRKAMKGLGTDEETILTLLTSRSNAQRQEITAAFKTLFGRDLLDDLKSELTGKFEKLIVAL 84
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 250-315 8.57e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 8.57e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926999721 250 YLAETLYYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRRNFATSLYSMIKGDTSGDYKKALLLL 315
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 91-156 2.79e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 85.60  E-value: 2.79e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926999721  91 YDAYELKHALKGAGTNEKVLTEIIASRTPEELTAIKKVYEEEYGSNLEDDVVGDTSGYYQRMLVVL 156
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
32-84 2.74e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 82.46  E-value: 2.74e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1926999721   32 GTDEETILTLLTSRSNAQRQEITAAFKTLFGRDLLDDLKSELTGKFEKLIVAL 84
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 174-240 6.55e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.05  E-value: 6.55e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1926999721 174 QDAQALfQAGELKWGTDEEKFITIFGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGHLEQLLLAV 240
Cdd:pfam00191   1 YDAELL-RKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
263-315 3.48e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 76.68  E-value: 3.48e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1926999721  263 GTDDHTLIRVIVSRSEIDLFNIRKEFRRNFATSLYSMIKGDTSGDYKKALLLL 315
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
104-156 1.36e-16

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 72.44  E-value: 1.36e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1926999721  104 GTNEKVLTEIIASRTPEELTAIKKVYEEEYGSNLEDDVVGDTSGYYQRMLVVL 156
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
188-240 1.26e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 64.35  E-value: 1.26e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1926999721  188 GTDEEKFITIFGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGHLEQLLLAV 240
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 20-84 6.85e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 97.93  E-value: 6.85e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1926999721  20 DAEALRKAMKGLGTDEETILTLLTSRSNAQRQEITAAFKTLFGRDLLDDLKSELTGKFEKLIVAL 84
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 250-315 8.57e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 8.57e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926999721 250 YLAETLYYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRRNFATSLYSMIKGDTSGDYKKALLLL 315
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 91-156 2.79e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 85.60  E-value: 2.79e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926999721  91 YDAYELKHALKGAGTNEKVLTEIIASRTPEELTAIKKVYEEEYGSNLEDDVVGDTSGYYQRMLVVL 156
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
32-84 2.74e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 82.46  E-value: 2.74e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1926999721   32 GTDEETILTLLTSRSNAQRQEITAAFKTLFGRDLLDDLKSELTGKFEKLIVAL 84
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 174-240 6.55e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.05  E-value: 6.55e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1926999721 174 QDAQALfQAGELKWGTDEEKFITIFGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGHLEQLLLAV 240
Cdd:pfam00191   1 YDAELL-RKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
263-315 3.48e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 76.68  E-value: 3.48e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1926999721  263 GTDDHTLIRVIVSRSEIDLFNIRKEFRRNFATSLYSMIKGDTSGDYKKALLLL 315
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
104-156 1.36e-16

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 72.44  E-value: 1.36e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1926999721  104 GTNEKVLTEIIASRTPEELTAIKKVYEEEYGSNLEDDVVGDTSGYYQRMLVVL 156
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
188-240 1.26e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 64.35  E-value: 1.26e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1926999721  188 GTDEEKFITIFGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGHLEQLLLAV 240
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH