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Conserved domains on  [gi|1926338569|ref|XP_036861815|]
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sulfotransferase 2B1 [Manis javanica]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
57-302 3.75e-101

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 297.72  E-value: 3.75e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569  57 DDDIFIITYPKSGTNWMIEILSLILRDGDPSWTRSVPI---WRRAPWCETILSAFS---------LSDLSSPRLMSSHLP 124
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDTYfdvaegpvrLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 125 IQLFTKAFFNSKAKVIYMSRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLQNFLQGEVQFGSWFDHIKGWIRMQGKENFLF 204
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 205 ITYEELQQDLHGSVQRICQFLGRPLDSEALSSVVVHSAFNAMKANAMSNFTLLPPSLldqrrGAFLRKGVCGDWKNHFTV 284
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 1926338569 285 AQSEAFDRVYREQMRGLP 302
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
57-302 3.75e-101

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 297.72  E-value: 3.75e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569  57 DDDIFIITYPKSGTNWMIEILSLILRDGDPSWTRSVPI---WRRAPWCETILSAFS---------LSDLSSPRLMSSHLP 124
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDTYfdvaegpvrLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 125 IQLFTKAFFNSKAKVIYMSRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLQNFLQGEVQFGSWFDHIKGWIRMQGKENFLF 204
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 205 ITYEELQQDLHGSVQRICQFLGRPLDSEALSSVVVHSAFNAMKANAMSNFTLLPPSLldqrrGAFLRKGVCGDWKNHFTV 284
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 1926338569 285 AQSEAFDRVYREQMRGLP 302
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 59-300 1.80e-18

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 84.97  E-value: 1.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569  59 DIFIITYPKSGTNWMiEILSLILRDGDPSWTRSVPIWRR-----APWCETILSAFSLSDLSSPR---LMSSHLPIQLFTK 130
Cdd:PLN02164   81 DFLVCSYPKTGTTWL-KALTFAIANRSRFDDSSNPLLKRnphefVPYIEIDFPFFPSVDVLKDKgntLFSTHIPYGLLPD 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 131 AFFNSKAKVIYMSRNPRDVVVSLYHY-SKIAGQLKDPGTPDQFLQNFLQGEVQFGSWFDHIKG-WIRMQGKEN-FLFITY 207
Cdd:PLN02164  160 SVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQENPDrILFLKY 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 208 EELQQDLHGSVQRICQFLGRPLDSEALSSVVVHSAFNAMKANAMSNFTLLPPSLLDQRR------GAFLRKGVCGDWKNH 281
Cdd:PLN02164  240 ETMRADPLPYVKRLAEFMGYGFTAEEEEKGVVEKVVKLCSFETLKNLEANKGEKDREDRpavyanSAYFRKGKVGDWQNY 319

                         250
                  ....*....|....*....
gi 1926338569 282 FTVAQSEAFDRVYREQMRG 300
Cdd:PLN02164  320 LTPEMAARIDGLMEEKFKG 338
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
62-238 6.40e-06

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 46.54  E-value: 6.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569  62 IITYPKSGTNWMIEILSLILRDGDPS----------WTRSVPIWRRAPWCETILSAFsLSDLSSP------RLMSSHLPi 125
Cdd:COG4424    11 ICATPRSGSTLLCELLNATGVAGCPGeyfnppfipeWARGFLLGDRDRDPDEYLRAI-RRAGTTPngvfgfKLFWDQLP- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 126 QLFTKAF----FNSKAKVIYMSRnpRDVV---VSLyhysKIA---GQLK----DPGTPDQFLQnFLQGEVQfgSWFDHIK 191
Cdd:COG4424    89 RLLQRALrllaAFPDLKFIHLTR--RDKLaqaVSL----VIAqqtGQWHsdadDALAPTAPPE-YDAEEIA--RLLEALQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1926338569 192 G-------WIRMQGKEnFLFITYEELQQDLHGSVQRICQFLGRPLDSEALSSVV 238
Cdd:COG4424   160 DfearweaWFARTGIT-PLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPAL 212
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
57-302 3.75e-101

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 297.72  E-value: 3.75e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569  57 DDDIFIITYPKSGTNWMIEILSLILRDGDPSWTRSVPI---WRRAPWCETILSAFS---------LSDLSSPRLMSSHLP 124
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDTYfdvaegpvrLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 125 IQLFTKAFFNSKAKVIYMSRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLQNFLQGEVQFGSWFDHIKGWIRMQGKENFLF 204
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 205 ITYEELQQDLHGSVQRICQFLGRPLDSEALSSVVVHSAFNAMKANAMSNFTLLPPSLldqrrGAFLRKGVCGDWKNHFTV 284
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 1926338569 285 AQSEAFDRVYREQMRGLP 302
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 59-300 1.80e-18

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 84.97  E-value: 1.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569  59 DIFIITYPKSGTNWMiEILSLILRDGDPSWTRSVPIWRR-----APWCETILSAFSLSDLSSPR---LMSSHLPIQLFTK 130
Cdd:PLN02164   81 DFLVCSYPKTGTTWL-KALTFAIANRSRFDDSSNPLLKRnphefVPYIEIDFPFFPSVDVLKDKgntLFSTHIPYGLLPD 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 131 AFFNSKAKVIYMSRNPRDVVVSLYHY-SKIAGQLKDPGTPDQFLQNFLQGEVQFGSWFDHIKG-WIRMQGKEN-FLFITY 207
Cdd:PLN02164  160 SVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQENPDrILFLKY 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 208 EELQQDLHGSVQRICQFLGRPLDSEALSSVVVHSAFNAMKANAMSNFTLLPPSLLDQRR------GAFLRKGVCGDWKNH 281
Cdd:PLN02164  240 ETMRADPLPYVKRLAEFMGYGFTAEEEEKGVVEKVVKLCSFETLKNLEANKGEKDREDRpavyanSAYFRKGKVGDWQNY 319

                         250
                  ....*....|....*....
gi 1926338569 282 FTVAQSEAFDRVYREQMRG 300
Cdd:PLN02164  320 LTPEMAARIDGLMEEKFKG 338
Sulfotransfer_3 pfam13469
Sulfotransferase family;
60-230 3.67e-12

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 63.85  E-value: 3.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569  60 IFIITYPKSGTNWMIEILSlilRDGDPSWTRSVpiWRRAPWCETILSAFSLS-------DLSSPRL---MSSHLPIQLFT 129
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLA---AHPDVRPPEET--WFVIPRILALLQAWGKSlealarvPSYARWLcdkSPSHLFHLDLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 130 KAFFnSKAKVIYMSRNPRDVVVSlyhySKIagQLKDPGTPDQFLQNFLQGEVQFGSWFDHIKGWIRMQ---GKENFLFIT 206
Cdd:pfam13469  76 LKAF-PDAKFIHLHRDPVDTVIS----SYC--SLFGFTLSSYSTAFLRDIGLALARWSRAYERLMAARarvPPGRFLDVR 148

                         170       180
                  ....*....|....*....|....
gi 1926338569 207 YEELQQDLHGSVQRICQFLGRPLD 230
Cdd:pfam13469 149 YEDLVADPEGTLRRILEFLGLPWD 172
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
62-238 6.40e-06

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 46.54  E-value: 6.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569  62 IITYPKSGTNWMIEILSLILRDGDPS----------WTRSVPIWRRAPWCETILSAFsLSDLSSP------RLMSSHLPi 125
Cdd:COG4424    11 ICATPRSGSTLLCELLNATGVAGCPGeyfnppfipeWARGFLLGDRDRDPDEYLRAI-RRAGTTPngvfgfKLFWDQLP- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926338569 126 QLFTKAF----FNSKAKVIYMSRnpRDVV---VSLyhysKIA---GQLK----DPGTPDQFLQnFLQGEVQfgSWFDHIK 191
Cdd:COG4424    89 RLLQRALrllaAFPDLKFIHLTR--RDKLaqaVSL----VIAqqtGQWHsdadDALAPTAPPE-YDAEEIA--RLLEALQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1926338569 192 G-------WIRMQGKEnFLFITYEELQQDLHGSVQRICQFLGRPLDSEALSSVV 238
Cdd:COG4424   160 DfearweaWFARTGIT-PLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPAL 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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