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Conserved domains on  [gi|1926283318|ref|XP_036853536|]
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UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 isoform X11 [Manis javanica]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 12-198 4.05e-128

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd06913:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 219  Bit Score: 364.47  E-value: 4.05e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  12 IILPVHNAEPWLDECLRSVLQQDFEGSMELSVFNDASKDKSMTIVEKWKEKLEGSGILVVIGGHDSPSPRGVGYSKNQAV 91
Cdd:cd06913     1 IILPVHNGEQWLDECLESVLQQDFEGTLELSVFNDASTDKSAEIIEKWRKKLEDSGVIVLVGSHNSPSPKGVGYAKNQAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  92 AQSSGPYLCFLDSDDVMMPQRVRLQHEAAVRCPAS--------------------------------VFTSNGPTVIMPT 139
Cdd:cd06913    81 AQSSGRYLCFLDSDDVMMPQRIRLQYEAALQHPNSiigcqvrripedsterytrwintltreqlltqVYTSHGPTVIMPT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1926283318 140 WFCSRAWFSHVGPFDEGGRGVPEDLLFFYNHLRKGGGVIRVDQSLLLYRYHPHAATHAV 198
Cdd:cd06913   161 WFCSREWFSHVGPFDEGGKGVPEDLLFFYEHLRKGGGVYRVDRCLLLYRYHPGATTHSV 219
 
Name Accession Description Interval E-value
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 12-198 4.05e-128

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 364.47  E-value: 4.05e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  12 IILPVHNAEPWLDECLRSVLQQDFEGSMELSVFNDASKDKSMTIVEKWKEKLEGSGILVVIGGHDSPSPRGVGYSKNQAV 91
Cdd:cd06913     1 IILPVHNGEQWLDECLESVLQQDFEGTLELSVFNDASTDKSAEIIEKWRKKLEDSGVIVLVGSHNSPSPKGVGYAKNQAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  92 AQSSGPYLCFLDSDDVMMPQRVRLQHEAAVRCPAS--------------------------------VFTSNGPTVIMPT 139
Cdd:cd06913    81 AQSSGRYLCFLDSDDVMMPQRIRLQYEAALQHPNSiigcqvrripedsterytrwintltreqlltqVYTSHGPTVIMPT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1926283318 140 WFCSRAWFSHVGPFDEGGRGVPEDLLFFYNHLRKGGGVIRVDQSLLLYRYHPHAATHAV 198
Cdd:cd06913   161 WFCSREWFSHVGPFDEGGKGVPEDLLFFYEHLRKGGGVYRVDRCLLLYRYHPGATTHSV 219
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 9-131 2.21e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 90.15  E-value: 2.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318   9 RVSIILPVHNAEPWLDECLRSVLQQDFEgSMELSVFNDASKDKSMTIVEKWKEKLegSGILVVigghDSPSPRGVGYSKN 88
Cdd:COG0463     3 LVSVVIPTYNEEEYLEEALESLLAQTYP-DFEIIVVDDGSTDGTAEILRELAAKD--PRIRVI----RLERNRGKGAARN 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1926283318  89 QAVAQSSGPYLCFLDSDDVMMPQRVRLQHEAAVRCPASVFTSN 131
Cdd:COG0463    76 AGLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGS 118
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 11-172 3.06e-20

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 85.91  E-value: 3.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  11 SIILPVHNAEPWLDECLRSVLQQDFEGsMELSVFNDASKDKSMTIVEKWKEKleGSGILVVIgghdSPSPRGVGYSKNQA 90
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPN-FEIIVVDDGSTDGTVEIAEEYAKK--DPRVRVIR----LPENRGKAGARNAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  91 VAQSSGPYLCFLDSDDVMMPQRVRLQHEAAVRCPASVFTSNGPTVIMPTWFCSRAWFSHV--GPFDEGGRGVPEDLLFFY 168
Cdd:pfam00535  74 LRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLsrLPFFLGLRLLGLNLPFLI 153


                  ....
gi 1926283318 169 NHLR 172
Cdd:pfam00535 154 GGFA 157
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 9-111 3.91e-13

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 68.92  E-value: 3.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318   9 RVSIILPVHNAEPWLDECLRSVLQQDFEgSMELSVFNDASKDKSMTIVEKWKEKLEGSGILVVIGGhdspsprGVGYSKN 88
Cdd:PRK10073    7 KLSIIIPLYNAGKDFRAFMESLIAQTWT-ALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQANA-------GVSVARN 78

                          90       100
                  ....*....|....*....|...
gi 1926283318  89 QAVAQSSGPYLCFLDSDDVMMPQ 111
Cdd:PRK10073   79 TGLAVATGKYVAFPDADDVVYPT 101
 
Name Accession Description Interval E-value
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 12-198 4.05e-128

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 364.47  E-value: 4.05e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  12 IILPVHNAEPWLDECLRSVLQQDFEGSMELSVFNDASKDKSMTIVEKWKEKLEGSGILVVIGGHDSPSPRGVGYSKNQAV 91
Cdd:cd06913     1 IILPVHNGEQWLDECLESVLQQDFEGTLELSVFNDASTDKSAEIIEKWRKKLEDSGVIVLVGSHNSPSPKGVGYAKNQAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  92 AQSSGPYLCFLDSDDVMMPQRVRLQHEAAVRCPAS--------------------------------VFTSNGPTVIMPT 139
Cdd:cd06913    81 AQSSGRYLCFLDSDDVMMPQRIRLQYEAALQHPNSiigcqvrripedsterytrwintltreqlltqVYTSHGPTVIMPT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1926283318 140 WFCSRAWFSHVGPFDEGGRGVPEDLLFFYNHLRKGGGVIRVDQSLLLYRYHPHAATHAV 198
Cdd:cd06913   161 WFCSREWFSHVGPFDEGGKGVPEDLLFFYEHLRKGGGVYRVDRCLLLYRYHPGATTHSV 219
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 12-179 1.28e-28

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 107.98  E-value: 1.28e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  12 IILPVHNAEPWLDECLRSVLQQDFEgSMELSVFNDASKDKSMTIVEKWKEKlegsGILVVIggHDSPSPRGVGYSKNQAV 91
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAQTYP-NFEVIVVDDGSTDGTLEILEEYAKK----DPRVIR--VINEENQGLAAARNAGL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  92 AQSSGPYLCFLDSDDVMMPQRVRLQHEAAVRCPASVFTSngptvIMPTWFCSRAWFSHVGPFDEGGRGVPEDLLFFYNHL 171
Cdd:cd00761    74 KAARGEYILFLDADDLLLPDWLERLVAELLADPEADAVG-----GPGNLLFRRELLEEIGGFDEALLSGEEDDDFLLRLL 148


                  ....*...
gi 1926283318 172 RKGGGVIR 179
Cdd:cd00761   149 RGGKVAFR 156
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 9-131 2.21e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 90.15  E-value: 2.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318   9 RVSIILPVHNAEPWLDECLRSVLQQDFEgSMELSVFNDASKDKSMTIVEKWKEKLegSGILVVigghDSPSPRGVGYSKN 88
Cdd:COG0463     3 LVSVVIPTYNEEEYLEEALESLLAQTYP-DFEIIVVDDGSTDGTAEILRELAAKD--PRIRVI----RLERNRGKGAARN 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1926283318  89 QAVAQSSGPYLCFLDSDDVMMPQRVRLQHEAAVRCPASVFTSN 131
Cdd:COG0463    76 AGLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGS 118
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
9-236 2.62e-21

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 89.67  E-value: 2.62e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318   9 RVSIILPVHNAEPWLDECLRSVLQQDFEgSMELSVFNDASKDKSMTIVEKWKekleGSGILVVigghDSPSPRGVGYSKN 88
Cdd:COG1216     4 KVSVVIPTYNRPELLRRCLESLLAQTYP-PFEVIVVDNGSTDGTAELLAALA----FPRVRVI----RNPENLGFAAARN 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  89 QAVAQSSGPYLCFLDSDDVMMPQRVrlqhEAAVRCPAsvftsngptvimptWFCSRAWFSHVGPFDEGGRGVPEDLLFFY 168
Cdd:COG1216    75 LGLRAAGGDYLLFLDDDTVVEPDWL----ERLLAAAC--------------LLIRREVFEEVGGFDERFFLYGEDVDLCL 136

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1926283318 169 NHLRKGGGVIRVDQSLLlyrYHPHAATHAVLETTMWTHRVRF-LEERVLPHWAAFTIWNAGRQGRWLYR 236
Cdd:COG1216   137 RLRKAGYRIVYVPDAVV---YHLGGASSGPLLRAYYLGRNRLlFLRKHGPRPLLRLALLRGLRLRLRGR 202
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 2-249 6.23e-21

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 90.96  E-value: 6.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318   2 PARGDPARVSIILPVHNAEPWLDECLRSVLQQDF-EGSMELSVFNDASKDKSMTIVEKWKEKLegsGILVVIgghDSPSP 80
Cdd:COG1215    23 RAPADLPRVSVIIPAYNEEAVIEETLRSLLAQDYpKEKLEVIVVDDGSTDETAEIARELAAEY---PRVRVI---ERPEN 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  81 RGVGYSKNQAVAQSSGPYLCFLDSDDVMMPQRVRLQHEAAVRCPASVFTSNGptvimptwFCSRAWFSHVGPFDEGGRGv 160
Cdd:COG1215    97 GGKAAALNAGLKAARGDIVVFLDADTVLDPDWLRRLVAAFADPGVGASGANL--------AFRREALEEVGGFDEDTLG- 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318 161 pEDLLFFYNHLRKGGGVirvdqslllyRYHPHAATHAVLETTM---WTHRVRfleervlphwaaftiWNAGR-QGRWLYR 236
Cdd:COG1215   168 -EDLDLSLRLLRAGYRI----------VYVPDAVVYEEAPETLralFRQRRR---------------WARGGlQLLLKHR 221

                         250
                  ....*....|...
gi 1926283318 237 SLTDRARHKVVAF 249
Cdd:COG1215   222 PLLRPRRLLLFLL 234
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 11-172 3.06e-20

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 85.91  E-value: 3.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  11 SIILPVHNAEPWLDECLRSVLQQDFEGsMELSVFNDASKDKSMTIVEKWKEKleGSGILVVIgghdSPSPRGVGYSKNQA 90
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPN-FEIIVVDDGSTDGTVEIAEEYAKK--DPRVRVIR----LPENRGKAGARNAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  91 VAQSSGPYLCFLDSDDVMMPQRVRLQHEAAVRCPASVFTSNGPTVIMPTWFCSRAWFSHV--GPFDEGGRGVPEDLLFFY 168
Cdd:pfam00535  74 LRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLsrLPFFLGLRLLGLNLPFLI 153


                  ....
gi 1926283318 169 NHLR 172
Cdd:pfam00535 154 GGFA 157
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 9-111 3.91e-13

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 68.92  E-value: 3.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318   9 RVSIILPVHNAEPWLDECLRSVLQQDFEgSMELSVFNDASKDKSMTIVEKWKEKLEGSGILVVIGGhdspsprGVGYSKN 88
Cdd:PRK10073    7 KLSIIIPLYNAGKDFRAFMESLIAQTWT-ALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQANA-------GVSVARN 78

                          90       100
                  ....*....|....*....|...
gi 1926283318  89 QAVAQSSGPYLCFLDSDDVMMPQ 111
Cdd:PRK10073   79 TGLAVATGKYVAFPDADDVVYPT 101
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 1-115 1.37e-11

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 63.37  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318   1 MPARGDPARVSIILPVHNAEPWLDECLRSVLQQDFEGS-MELSVFNDASKDKSMTIVEKWKEKlegsGILVviggHDSPS 79
Cdd:cd06439    22 LPDPAYLPTVTIIIPAYNEEAVIEAKLENLLALDYPRDrLEIIVVSDGSTDGTAEIAREYADK----GVKL----LRFPE 93

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1926283318  80 PRGVGYSKNQAVAQSSGPYLCFLDSDDVMMPQRVRL 115
Cdd:cd06439    94 RRGKAAALNRALALATGEIVVFTDANALLDPDALRL 129
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 11-197 2.21e-11

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 62.26  E-value: 2.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  11 SIILPVHNAEPWLDECLRSVLQQDFEGSmELSVFNDASKDKSMTIVEKWKEKlEGSGILVVIGGHdspsprGVGYSKN-- 88
Cdd:cd04196     1 AVLMATYNGEKYLREQLDSILAQTYKND-ELIISDDGSTDGTVEIIKEYIDK-DPFIIILIRNGK------NLGVARNfe 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  89 QAVAQSSGPYLCFLDSDDVMMPQRVrlqhEAAVRcpaSVFTSNGPTVImptwfCSRAWF-------SHVGPFDEGGRGVP 161
Cdd:cd04196    73 SLLQAADGDYVFFCDQDDIWLPDKL----ERLLK---AFLKDDKPLLV-----YSDLELvdengnpIGESFFEYQKIKPG 140

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1926283318 162 EDL--LFFYN----------------------------------HLRKGGGVIRVDQSLLLYRYHPHAATHA 197
Cdd:cd04196   141 TSFnnLLFQNvvtgctmafnrellelalpfpdadvimhdwwlalLASAFGKVVFLDEPLILYRQHGNNVVGA 212
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 11-190 1.00e-10

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 60.25  E-value: 1.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  11 SIILPVHNAEPWLDECLRSVLQQDFEgSMELSVFNDASKDKSMTIVEKWKEKlegsgILVVIGGHDspspRGVGYSKNQA 90
Cdd:cd06433     1 SIITPTYNQAETLEETIDSVLSQTYP-NIEYIVIDGGSTDGTVDIIKKYEDK-----ITYWISEPD----KGIYDAMNKG 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  91 VAQSSGPYLCFLDSDDVMMP----QRVRLQHEA----AVRCPASVFTSNGPTVIM-------------------PTWFCS 143
Cdd:cd06433    71 IALATGDIIGFLNSDDTLLPgallAVVAAFAEHpevdVVYGDVLLVDENGRVIGRrrpppfldkfllygmpichQATFFR 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1926283318 144 RAWFSHVGPFDEGGRgVPEDLLFFYNHLRKGGGVIRVDQSLLLYRYH 190
Cdd:cd06433   151 RSLFEKYGGFDESYR-IAADYDLLLRLLLAGKIFKYLPEVLAAFRLG 196
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 12-108 1.23e-10

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 59.55  E-value: 1.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  12 IILPVHNAEPWLDECLRSVLQQDFEgSMELSVFNDASKDKSMTIVEKWKEKLEGSGILVVIGGHdspspRGVGYSKNQAV 91
Cdd:cd06423     1 IIVPAYNEEAVIERTIESLLALDYP-KLEVIVVDDGSTDDTLEILEELAALYIRRVLVVRDKEN-----GGKAGALNAGL 74

                          90
                  ....*....|....*..
gi 1926283318  92 AQSSGPYLCFLDSDDVM 108
Cdd:cd06423    75 RHAKGDIVVVLDADTIL 91
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 12-190 1.38e-10

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 59.11  E-value: 1.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  12 IILPVHNAEPWLDECLRSVLQQDFEgSMELSVFNDASKDKSmtiVEKWKEKLEGsgilVVIggHDSPSPRGVGYSKNQAV 91
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLLAQTYP-DFEVIVVDNASTDGS---VELLRELFPE----VRL--IRNGENLGFGAGNNQGI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  92 AQSSGPYLCFLDSDDVMMPQRVRLQHEAAVRCP-ASVFTSNGPTVIMptwFCSRAWFSHVGPFDEGGRGVPEDLLFFYnH 170
Cdd:cd04186    71 REAKGDYVLLLNPDTVVEPGALLELLDAAEQDPdVGIVGPKVSGAFL---LVRREVFEEVGGFDEDFFLYYEDVDLCL-R 146

                         170       180
                  ....*....|....*....|
gi 1926283318 171 LRKGGGVIRVDQSLLLYRYH 190
Cdd:cd04186   147 ARLAGYRVLYVPQAVIYHHG 166
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 9-105 1.34e-09

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 57.63  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318   9 RVSIILPVHNAEPWLDECLRSVLQQDFE-GSMELSVFNDASKDKSMTIVEKWKEKLEgsgILVVIgghDSPSpRGVGYSK 87
Cdd:cd02525     1 FVSIIIPVRNEEKYIEELLESLLNQSYPkDLIEIIVVDGGSTDGTREIVQEYAAKDP---RIRLI---DNPK-RIQSAGL 73

                          90
                  ....*....|....*...
gi 1926283318  88 NQAVAQSSGPYLCFLDSD 105
Cdd:cd02525    74 NIGIRNSRGDIIIRVDAH 91
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 9-110 6.32e-09

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 54.90  E-value: 6.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318   9 RVSIILPVHNA-EPWLDECLRSVLQQDFEgSMELSVFNDASKDKSMTIVEKWKEKLEgSGILVVIgghdSPSPRGVGYSK 87
Cdd:cd04184     2 LISIVMPVYNTpEKYLREAIESVRAQTYP-NWELCIADDASTDPEVKRVLKKYAAQD-PRIKVVF----REENGGISAAT 75

                          90       100
                  ....*....|....*....|...
gi 1926283318  88 NQAVAQSSGPYLCFLDSDDVMMP 110
Cdd:cd04184    76 NSALELATGEFVALLDHDDELAP 98
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 12-105 2.57e-07

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 50.26  E-value: 2.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  12 IILPVHNAE----PWLDEcLRSVLQQDFEGSMELSVFNDASKDKSMTIVEKWKEKLegSGILVVIgghDSPSPRGVGYSK 87
Cdd:cd04188     1 VVIPAYNEEkrlpPTLEE-AVEYLEERPSFSYEIIVVDDGSKDGTAEVARKLARKN--PALIRVL---TLPKNRGKGGAV 74

                          90
                  ....*....|....*...
gi 1926283318  88 NQAVAQSSGPYLCFLDSD 105
Cdd:cd04188    75 RAGMLAARGDYILFADAD 92
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 12-175 4.58e-06

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 46.42  E-value: 4.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  12 IILPVHNAEPWLDECLRSVLQQ---DFEgsmeLSVFNDASKDKSMTIVEKWKeklegsgilvviggHDSPSP------RG 82
Cdd:cd06420     1 LIITTYNRPEALELVLKSVLNQsilPFE----VIIADDGSTEETKELIEEFK--------------SQFPIPikhvwqED 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  83 VGYSK----NQAVAQSSGPYLCFLDSDDVMMPQRVRLQHEAAVRcpaSVFTSnGPTVIMPTWF-----------CSRAWF 147
Cdd:cd06420    63 EGFRKakirNKAIAAAKGDYLIFIDGDCIPHPDFIADHIELAEP---GVFLS-GSRVLLNEKLtergirgcnmsFWKKDL 138

                         170       180
                  ....*....|....*....|....*....
gi 1926283318 148 SHVGPFDEGGRG-VPEDLLFFYNHLRKGG 175
Cdd:cd06420   139 LAVNGFDEEFTGwGGEDSELVARLLNSGI 167
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
10-118 2.95e-05

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 44.98  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  10 VSIILPVHNAEPWLDECLRSVLQQDFEgSMELSVFNDASKdkSMTIVEKWKEKLEGSGILVVIGGHDSpsprGVGYSKNQ 89
Cdd:PRK10018    7 ISIYMPTWNRQQLAIRAIKSVLRQDYS-NWEMIIVDDCST--SWEQLQQYVTALNDPRITYIHNDINS----GACAVRNQ 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1926283318  90 AVAQSSGPYLCFLDSDDVMMPQR--VRLQHE 118
Cdd:PRK10018   80 AIMLAQGEYITGIDDDDEWTPNRlsVFLAHK 110
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 7-110 4.80e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 43.90  E-value: 4.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318   7 PARVSIILPVHNAEPWLDECLRSVLQQDFeGSMELSVFNDASKDKSMTIVEKWKEKLEGSGILVVIGGHDsPSPRGVGYS 86
Cdd:pfam13641   1 PPDVSVVVPAFNEDSVLGRVLEAILAQPY-PPVEVVVVVNPSDAETLDVAEEIAARFPDVRLRVIRNARL-LGPTGKSRG 78

                          90       100
                  ....*....|....*....|....
gi 1926283318  87 KNQAVAQSSGPYLCFLDSDDVMMP 110
Cdd:pfam13641  79 LNHGFRAVKSDLVVLHDDDSVLHP 102
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 12-117 1.23e-04

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 42.18  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  12 IILPVHNAEPWLDECLRSVLQQDFEG-SMELSVFNDASKDKSMTIVEKWKEKLEGSGILVvigghdSPSPRGVGYSKNQA 90
Cdd:cd04179     1 VVIPAYNEEENIPELVERLLAVLEEGyDYEIIVVDDGSTDGTAEIARELAARVPRVRVIR------LSRNFGKGAAVRAG 74

                          90       100
                  ....*....|....*....|....*..
gi 1926283318  91 VAQSSGPYLCFLDSDdvmmpqrvrLQH 117
Cdd:cd04179    75 FKAARGDIVVTMDAD---------LQH 92
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 10-166 6.04e-04

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 40.63  E-value: 6.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  10 VSIILPVHNAEPWLDECLRSvLQQDFEGSMELSVFNDASKDKSMTIVEKwkeklegSGILVVigghdsPSPRGVGYSKNQ 89
Cdd:cd02522     1 LSIIIPTLNEAENLPRLLAS-LRRLNPLPLEIIVVDGGSTDGTVAIARS-------AGVVVI------SSPKGRARQMNA 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  90 AVAQSSGPYLCFLDSdDVMMPQRVRLQHEAAVRCPASV-------FTSNGPTV----IMPTW--------------FCSR 144
Cdd:cd02522    67 GAAAARGDWLLFLHA-DTRLPPDWDAAIIETLRADGAVagafrlrFDDPGPRLrlleLGANLrsrlfglpygdqglFIRR 145

                         170       180
                  ....*....|....*....|....
gi 1926283318 145 AWFSHVGPFDEggrgVP--EDLLF 166
Cdd:cd02522   146 ELFEELGGFPE----LPlmEDVEL 165
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 11-105 8.27e-04

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 40.52  E-value: 8.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  11 SIILPVHNAEPWLDECLRSVLQ-----QDFEGSM--ELSVFNDASKDKSMTIVEK-WKEKL-EGSGILVVigghDSPSPR 81
Cdd:PTZ00260   73 SIVIPAYNEEDRLPKMLKETIKylesrSRKDPKFkyEIIIVNDGSKDKTLKVAKDfWRQNInPNIDIRLL----SLLRNK 148

                          90       100
                  ....*....|....*....|....
gi 1926283318  82 GVGYSKNQAVAQSSGPYLCFLDSD 105
Cdd:PTZ00260  149 GKGGAVRIGMLASRGKYILMVDAD 172
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 12-111 1.16e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 39.58  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  12 IILPVHNAEPWLDECLRSVLQQDF-EGSMELSVFNDASKDKSMTIVEKWKEKleGSGILVVIgghdSPSPRGVGYSKN-- 88
Cdd:cd04192     1 VVIAARNEAENLPRLLQSLSALDYpKEKFEVILVDDHSTDGTVQILEFAAAK--PNFQLKIL----NNSRVSISGKKNal 74

                          90       100
                  ....*....|....*....|....
gi 1926283318  89 -QAVAQSSGPYLCFLDSDDVMMPQ 111
Cdd:cd04192    75 tTAIKAAKGDWIVTTDADCVVPSN 98
Glucosylceramide_synthase cd02520
Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid ...
 10-209 5.38e-03

Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; UDP-glucose:N-acylsphingosine D-glucosyltransferase (glucosylceramide synthase or ceramide glucosyltransferase) catalyzes the first glycosylation step of glycosphingolipid synthesis. Its product, glucosylceramide, serves as the core of more than 300 glycosphingolipids (GSL). GSLs are a group of membrane components that have the lipid portion embedded in the outer plasma membrane leaflet and the sugar chains extended to the outer environment. Several lines of evidence suggest the importance of GSLs in various cellular processes such as differentiation, adhesion, proliferation, and cell-cell recognition. In pathogenic fungus Cryptococcus neoformans, glucosylceramide serves as an antigen that elicits an antibody response in patients and it is essential for fungal growth in host extracellular environment.


Pssm-ID: 133012 [Multi-domain]  Cd Length: 196  Bit Score: 37.19  E-value: 5.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  10 VSIILPVHNAEPWLDECLRSVLQQDFEGSMELSVFNDASkDKSMTIVEKWKEKLEGSGILVVIGGHDSPSPRGVGySKNQ 89
Cdd:cd02520     3 VSILKPLCGVDPNLYENLESFFQQDYPKYEILFCVQDED-DPAIPVVRKLIAKYPNVDARLLIGGEKVGINPKVN-NLIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926283318  90 AVAQSSGPYLCFLDSDDVMMP---QRV--RLQHE--AAVRCPASVftsnGPTVIMptwfcSRAWFSHVGPFDEGGRGVPE 162
Cdd:cd02520    81 GYEEARYDILVISDSDISVPPdylRRMvaPLMDPgvGLVTCLCAF----GKSMAL-----RREVLDAIGGFEAFADYLAE 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1926283318 163 DlLFFYNHLRKGGGVIRVDqslllyryhPHAATHAVLETTM---WTHRVR 209
Cdd:cd02520   152 D-YFLGKLIWRLGYRVVLS---------PYVVMQPLGSTSLasfWRRQLR 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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