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Conserved domains on  [gi|1907069608|ref|XP_036022090|]
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protein FAM178B isoform X6 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CANIN super family cl20731
Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the ...
 1-176 6.13e-81

Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the SMC5-SMC6 complex localization factor 2 (SFL2, also known as NSE6 and FAM178A)) which bridges the interaction between SMC6 and SFL1 (NSE5), being responsible for targeting the SMC5/6 complex to double-strand DNA breaks (DSBs) repair sites. It is suggested to be a regulatory element in SMC5/6 complex dynamics by locking its coiled-coiled arms together, thus being named as Coiled-coil And Nse INteracting (CANIN) domain. This domain is essential for the interaction with NSE5. It forms a U-shaped structure that seems to be structurally conserved in eukaryotes.


The actual alignment was detected with superfamily member pfam14816:

Pssm-ID: 464331  Cd Length: 375  Bit Score: 249.98  E-value: 6.13e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069608   1 MHFWCPSLQEVKEVFSSLGAYNPALYPQGPFQHS--ARVLESEASL--------DSQDPPQEVALDIKLNYIYKFLTLCL 70
Cdd:pfam14816 190 FHVWCPSLADVTEVFLNMGARFPSLFPLGPLQPSfnERDLLSEAQLseneqqnaGSVSPPFETLPEINLSNILKFLSLCT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069608  71 LVRPVSYTDASILDLMELLCRAGLDVGLCLLPKTDLQQLLLLLLERIQEWPGKLQPLCCALSWVSDHHHNLLALVQFFLD 150
Cdd:pfam14816 270 LAQPDAYTDEELLLLLELLCRIGLDVGLRLLPKTDFQQLLLLLLENIQDWPTKLPELCCALSDLSDHHHNLLALVQLFPD 349

                         170       180
                  ....*....|....*....|....*.
gi 1907069608 151 VTPRGRQLRSQLSLVIIARMLGQQES 176
Cdd:pfam14816 350 VTSRGRQLRRHLSLVIIAKLLDQQET 375
 
Name Accession Description Interval E-value
CANIN pfam14816
Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the ...
 1-176 6.13e-81

Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the SMC5-SMC6 complex localization factor 2 (SFL2, also known as NSE6 and FAM178A)) which bridges the interaction between SMC6 and SFL1 (NSE5), being responsible for targeting the SMC5/6 complex to double-strand DNA breaks (DSBs) repair sites. It is suggested to be a regulatory element in SMC5/6 complex dynamics by locking its coiled-coiled arms together, thus being named as Coiled-coil And Nse INteracting (CANIN) domain. This domain is essential for the interaction with NSE5. It forms a U-shaped structure that seems to be structurally conserved in eukaryotes.


Pssm-ID: 464331  Cd Length: 375  Bit Score: 249.98  E-value: 6.13e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069608   1 MHFWCPSLQEVKEVFSSLGAYNPALYPQGPFQHS--ARVLESEASL--------DSQDPPQEVALDIKLNYIYKFLTLCL 70
Cdd:pfam14816 190 FHVWCPSLADVTEVFLNMGARFPSLFPLGPLQPSfnERDLLSEAQLseneqqnaGSVSPPFETLPEINLSNILKFLSLCT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069608  71 LVRPVSYTDASILDLMELLCRAGLDVGLCLLPKTDLQQLLLLLLERIQEWPGKLQPLCCALSWVSDHHHNLLALVQFFLD 150
Cdd:pfam14816 270 LAQPDAYTDEELLLLLELLCRIGLDVGLRLLPKTDFQQLLLLLLENIQDWPTKLPELCCALSDLSDHHHNLLALVQLFPD 349

                         170       180
                  ....*....|....*....|....*.
gi 1907069608 151 VTPRGRQLRSQLSLVIIARMLGQQES 176
Cdd:pfam14816 350 VTSRGRQLRRHLSLVIIAKLLDQQET 375
 
Name Accession Description Interval E-value
CANIN pfam14816
Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the ...
 1-176 6.13e-81

Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the SMC5-SMC6 complex localization factor 2 (SFL2, also known as NSE6 and FAM178A)) which bridges the interaction between SMC6 and SFL1 (NSE5), being responsible for targeting the SMC5/6 complex to double-strand DNA breaks (DSBs) repair sites. It is suggested to be a regulatory element in SMC5/6 complex dynamics by locking its coiled-coiled arms together, thus being named as Coiled-coil And Nse INteracting (CANIN) domain. This domain is essential for the interaction with NSE5. It forms a U-shaped structure that seems to be structurally conserved in eukaryotes.


Pssm-ID: 464331  Cd Length: 375  Bit Score: 249.98  E-value: 6.13e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069608   1 MHFWCPSLQEVKEVFSSLGAYNPALYPQGPFQHS--ARVLESEASL--------DSQDPPQEVALDIKLNYIYKFLTLCL 70
Cdd:pfam14816 190 FHVWCPSLADVTEVFLNMGARFPSLFPLGPLQPSfnERDLLSEAQLseneqqnaGSVSPPFETLPEINLSNILKFLSLCT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069608  71 LVRPVSYTDASILDLMELLCRAGLDVGLCLLPKTDLQQLLLLLLERIQEWPGKLQPLCCALSWVSDHHHNLLALVQFFLD 150
Cdd:pfam14816 270 LAQPDAYTDEELLLLLELLCRIGLDVGLRLLPKTDFQQLLLLLLENIQDWPTKLPELCCALSDLSDHHHNLLALVQLFPD 349

                         170       180
                  ....*....|....*....|....*.
gi 1907069608 151 VTPRGRQLRSQLSLVIIARMLGQQES 176
Cdd:pfam14816 350 VTSRGRQLRRHLSLVIIAKLLDQQET 375
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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