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Conserved domains on  [gi|1907162924|ref|XP_036020966|]
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volume-regulated anion channel subunit LRRC8D isoform X1 [Mus musculus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-385 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 618.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924   1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPANSKAHTppgnadittevp 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLD------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924  81 rmetatHQDQNGQTTTNDVAFGTSAVTPDIPlqathphaestlpnqeakkekrDPTGRKTNLDFQQYVFINQMCYHLALP 160
Cdd:pfam12534  69 ------DSYANSLSPTQSAPTVSSPSASMIP----------------------EPKGRKTNLDRQQYVFINQVCYEKALH 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 161 WYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVS 240
Cdd:pfam12534 121 WYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VS 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 241 TSSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAK 319
Cdd:pfam12534 200 SSSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLK 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907162924 320 FIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 385
Cdd:pfam12534 280 FLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
562-826 5.16e-37

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 144.31  E-value: 5.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 562 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKmmNVAEL 641
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLL--LLLLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 642 ELQNCELERIPHAIFSLSNLQELDLKSNNirtieeiiSFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLES 721
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 722 LPTAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQL 801
Cdd:COG4886   151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                         250       260
                  ....*....|....*....|....*
gi 1907162924 802 TQLELKGNCLDRLPaQLGQCRMLKK 826
Cdd:COG4886   231 ETLDLSNNQLTDLP-ELGNLTNLEE 254
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-385 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 618.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924   1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPANSKAHTppgnadittevp 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLD------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924  81 rmetatHQDQNGQTTTNDVAFGTSAVTPDIPlqathphaestlpnqeakkekrDPTGRKTNLDFQQYVFINQMCYHLALP 160
Cdd:pfam12534  69 ------DSYANSLSPTQSAPTVSSPSASMIP----------------------EPKGRKTNLDRQQYVFINQVCYEKALH 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 161 WYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVS 240
Cdd:pfam12534 121 WYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VS 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 241 TSSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAK 319
Cdd:pfam12534 200 SSSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLK 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907162924 320 FIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 385
Cdd:pfam12534 280 FLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
562-826 5.16e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 144.31  E-value: 5.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 562 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKmmNVAEL 641
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLL--LLLLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 642 ELQNCELERIPHAIFSLSNLQELDLKSNNirtieeiiSFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLES 721
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 722 LPTAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQL 801
Cdd:COG4886   151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                         250       260
                  ....*....|....*....|....*
gi 1907162924 802 TQLELKGNCLDRLPaQLGQCRMLKK 826
Cdd:COG4886   231 ETLDLSNNQLTDLP-ELGNLTNLEE 254
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 637-792 3.21e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 78.29  E-value: 3.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 637 NVAELELQNCELERIPHaIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKivaippsITHVKNLES----- 711
Cdd:cd21340    25 NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNR-------ISVVEGLENltnle 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 712 -LYFSNNKL---ESL---PTAVFSLQK-LRCLDVSYNNISTIpIEIGLLQNLQHLHITGNKVDILPKQ---LFKCVKLRT 780
Cdd:cd21340    94 eLHIENQRLppgEKLtfdPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELldlLSSWPSLRE 172

                         170
                  ....*....|..
gi 1907162924 781 LNLGQNCIASLP 792
Cdd:cd21340   173 LDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 572-826 2.96e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 2.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 572 LNSENNKMIGLESLRELRHLKILHVKSNLT--KVPSNITDvaphLTKLVIHNDGTKLLVLNSLKKMMNVAELEL----QN 645
Cdd:PLN00113  123 LNLSNNNFTGSIPRGSIPNLETLDLSNNMLsgEIPNDIGS----FSSLKVLDLGGNVLVGKIPNSLTNLTSLEFltlaSN 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 646 CELERIPHAIFSLSNLQELDLKSNNI-----RTIEEIISFQHLKRLtclklWHNKIVAIPPSITHVKNLESLYFSNNKLE 720
Cdd:PLN00113  199 QLVGQIPRELGQMKSLKWIYLGYNNLsgeipYEIGGLTSLNHLDLV-----YNNLTGPIPSSLGNLKNLQYLFLYQNKLS 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 721 -SLPTAVFSLQKLRCLDVSYNNIS-TIPIEIGLLQNLQHLHITGN--------------KVDIL-----------PKQLF 773
Cdd:PLN00113  274 gPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNnftgkipvaltslpRLQVLqlwsnkfsgeiPKNLG 353

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907162924 774 KCVKLRTLNLGQNCIAS-LPEKISQLTQLTQLELKGNCLD-RLPAQLGQCRMLKK 826
Cdd:PLN00113  354 KHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRR 408
LRR_8 pfam13855
Leucine rich repeat;
637-696 1.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.40e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907162924 637 NVAELELQNCELERI-PHAIFSLSNLQELDLKSNNIRTIEEiISFQHLKRLTCLKLWHNKI 696
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-385 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 618.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924   1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPANSKAHTppgnadittevp 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLD------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924  81 rmetatHQDQNGQTTTNDVAFGTSAVTPDIPlqathphaestlpnqeakkekrDPTGRKTNLDFQQYVFINQMCYHLALP 160
Cdd:pfam12534  69 ------DSYANSLSPTQSAPTVSSPSASMIP----------------------EPKGRKTNLDRQQYVFINQVCYEKALH 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 161 WYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVS 240
Cdd:pfam12534 121 WYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VS 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 241 TSSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAK 319
Cdd:pfam12534 200 SSSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLK 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907162924 320 FIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 385
Cdd:pfam12534 280 FLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
562-826 5.16e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 144.31  E-value: 5.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 562 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKmmNVAEL 641
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLL--LLLLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 642 ELQNCELERIPHAIFSLSNLQELDLKSNNirtieeiiSFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLES 721
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 722 LPTAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQL 801
Cdd:COG4886   151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                         250       260
                  ....*....|....*....|....*
gi 1907162924 802 TQLELKGNCLDRLPaQLGQCRMLKK 826
Cdd:COG4886   231 ETLDLSNNQLTDLP-ELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
489-773 1.68e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 1.68e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 489 DLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTafsflrdHLRCLHVKFTDVAEIPAWVYLLKNLRELYL 568
Cdd:COG4886    71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT-------NLESLDLSGNQLTDLPEELANLTNLKELDL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 569 ignlnsENNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDVaPHLTKLVIHNdgTKLLVL-NSLKKMMNVAELELQN 645
Cdd:COG4886   144 ------SNNQLTDLpEPLGNLTNLKSLDLSNNqLTDLPEELGNL-TNLKELDLSN--NQITDLpEPLGNLTNLEELDLSG 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 646 CELERIPHAIFSLSNLQELDLKSNNIRTIEEIisfQHLKRLTCLKLWHNKIVAIPPSiTHVKNLESLYFSNNKLESLPTA 725
Cdd:COG4886   215 NQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLK 290

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1907162924 726 VFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLF 773
Cdd:COG4886   291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
406-818 8.92e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 8.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 406 SFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHVSRNAQDKQELHLFMLSGVPD 485
Cdd:COG4886    11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 486 AVFDLTDLDVLKLELIPEakipakISQMTNLQELHLCHCPAKVEQTAFSFLRdHLRCLHVKFTDVAEIPAWVYLLKNLRE 565
Cdd:COG4886    91 DLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTNLKS 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 566 LYLignlnsENNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDvAPHLTKLVIhnDGTKLLVL-NSLKKMMNVAELE 642
Cdd:COG4886   164 LDL------SNNQLTDLpEELGNLTNLKELDLSNNqITDLPEPLGN-LTNLEELDL--SGNQLTDLpEPLANLTNLETLD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 643 LQNCELERIPhAIFSLSNLQELDLKSNNIRTIEEIisfQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLESL 722
Cdd:COG4886   235 LSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL---ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 723 PTAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQLT 802
Cdd:COG4886   311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390

                         410
                  ....*....|....*.
gi 1907162924 803 QLELKGNCLDRLPAQL 818
Cdd:COG4886   391 LLLLTTTAGVLLLTLA 406
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 637-792 3.21e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 78.29  E-value: 3.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 637 NVAELELQNCELERIPHaIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKivaippsITHVKNLES----- 711
Cdd:cd21340    25 NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNR-------ISVVEGLENltnle 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 712 -LYFSNNKL---ESL---PTAVFSLQK-LRCLDVSYNNISTIpIEIGLLQNLQHLHITGNKVDILPKQ---LFKCVKLRT 780
Cdd:cd21340    94 eLHIENQRLppgEKLtfdPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELldlLSSWPSLRE 172

                         170
                  ....*....|..
gi 1907162924 781 LNLGQNCIASLP 792
Cdd:cd21340   173 LDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 641-815 3.85e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 78.29  E-value: 3.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 641 LELQNCELERIPhAIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVAIPPsITHVKNLESLYFSNNK-- 718
Cdd:cd21340     7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRis 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 719 -LESLPtavfSLQKLRCLDVSYNNIS----------TIpieIGLLQNLQHLHITGNKVDILpKQLFKCVKLRTLNLGQNC 787
Cdd:cd21340    82 vVEGLE----NLTNLEELHIENQRLPpgekltfdprSL---AALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQ 153

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1907162924 788 IASLPE---KISQLTQLTQLELKGNCLDRLP 815
Cdd:cd21340   154 ISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 572-826 2.96e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 2.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 572 LNSENNKMIGLESLRELRHLKILHVKSNLT--KVPSNITDvaphLTKLVIHNDGTKLLVLNSLKKMMNVAELEL----QN 645
Cdd:PLN00113  123 LNLSNNNFTGSIPRGSIPNLETLDLSNNMLsgEIPNDIGS----FSSLKVLDLGGNVLVGKIPNSLTNLTSLEFltlaSN 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 646 CELERIPHAIFSLSNLQELDLKSNNI-----RTIEEIISFQHLKRLtclklWHNKIVAIPPSITHVKNLESLYFSNNKLE 720
Cdd:PLN00113  199 QLVGQIPRELGQMKSLKWIYLGYNNLsgeipYEIGGLTSLNHLDLV-----YNNLTGPIPSSLGNLKNLQYLFLYQNKLS 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 721 -SLPTAVFSLQKLRCLDVSYNNIS-TIPIEIGLLQNLQHLHITGN--------------KVDIL-----------PKQLF 773
Cdd:PLN00113  274 gPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNnftgkipvaltslpRLQVLqlwsnkfsgeiPKNLG 353

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907162924 774 KCVKLRTLNLGQNCIAS-LPEKISQLTQLTQLELKGNCLD-RLPAQLGQCRMLKK 826
Cdd:PLN00113  354 KHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRR 408
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
587-818 6.80e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 6.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 587 ELRhLKILhvksNLTKVPSNITDvapHLTKLVIHNDGTKLLVLNSlkkMMNVAELELQNCELERIPHAIfsLSNLQELDL 666
Cdd:PRK15370  182 ELR-LKIL----GLTTIPACIPE---QITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIPATL--PDTIQEMEL 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 667 KSNNIRTIEEiisfqHL-KRLTCLKLWHNKIVAIPpsithvknleslyfsnnklESLPtavfslQKLRCLDVSYNNISTI 745
Cdd:PRK15370  249 SINRITELPE-----RLpSALQSLDLFHNKISCLP-------------------ENLP------EELRYLSVYDNSIRTL 298

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907162924 746 PIEigLLQNLQHLHITGNKVDILPKQLfkCVKLRTLNLGQNCIASLPEKISqlTQLTQLELKGNCLDRLPAQL 818
Cdd:PRK15370  299 PAH--LPSGITHLNVQSNSLTALPETL--PPGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETL 365
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 468-824 2.04e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 2.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 468 NAQDKQELHLF--MLSG-VPDAVFDLTDLDVLKL-ELIPEAKIPAKISQMTNLQELHLchcpakveqtaFSflrdhlrcl 543
Cdd:PLN00113  258 NLKNLQYLFLYqnKLSGpIPPSIFSLQKLISLDLsDNSLSGEIPELVIQLQNLEILHL-----------FS--------- 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 544 hVKFTdvAEIPAWVYLLKNLRELYLIGN-LNSENNKMIGLESlrelrHLKILHVKSN-LT-KVPSNITDvAPHLTKLVIH 620
Cdd:PLN00113  318 -NNFT--GKIPVALTSLPRLQVLQLWSNkFSGEIPKNLGKHN-----NLTVLDLSTNnLTgEIPEGLCS-SGNLFKLILF 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 621 NDGTKLLVLNSLKKMMNVAELELQNCELE-RIPHAIFSLSNLQELDLKSNNIrtieeiisfqhLKRLTCLKlWhnkivai 699
Cdd:PLN00113  389 SNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL-----------QGRINSRK-W------- 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 700 ppsitHVKNLESLYFSNNK-LESLPTAvFSLQKLRCLDVSYNNIS-TIPIEIGLLQNLQHLHITGNKVD-ILPKQLFKCV 776
Cdd:PLN00113  450 -----DMPSLQMLSLARNKfFGGLPDS-FGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCK 523

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907162924 777 KLRTLNLGQNCIA-SLPEKISQLTQLTQLELKGNCLD-RLPAQLGQCRML 824
Cdd:PLN00113  524 KLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 683-826 1.36e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 683 LKRLTCLKLWHNKIVAIP---------------------PSITHVKNLESLYFSNNKLESLPtAVFSLQKLRCLDVSYNN 741
Cdd:cd21340     1 LKRITHLYLNDKNITKIDnlslcknlkvlylydnkitkiENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 742 ISTIpieIGL--LQNLQHLHI------TGNKVDILPKQLFKCVK-LRTLNLGQNCIASLpEKISQLTQLTQLELKGNCLD 812
Cdd:cd21340    80 ISVV---EGLenLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155

                         170
                  ....*....|....*..
gi 1907162924 813 RLPAQ---LGQCRMLKK 826
Cdd:cd21340   156 DLEELldlLSSWPSLRE 172
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 641-809 6.10e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.50  E-value: 6.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 641 LELQNCELERIPHAIFSLSNLQELDLKSNNI--RTIEEIIS-FQHLKRLTCLKLWHNKI-----VAIPPSITHVKNLESL 712
Cdd:COG5238   190 NQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 713 YFSNNKL-----ESLPTAVFSLQKLRCLDVSYNNISTiPIEIGLLQNLQHLHItgnkvdilpkqlfkcvkLRTLNLGQNC 787
Cdd:COG5238   270 YLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQGNKT-----------------LHTLNLAYNG 331

                         170       180
                  ....*....|....*....|....*..
gi 1907162924 788 IA-----SLPEKISQLTQLTQLELKGN 809
Cdd:COG5238   332 IGaqgaiALAKALQENTTLHSLDLSDN 358
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 541-736 1.75e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 541 RCLHVKFTD--VAEIPAwVYLLKNLRELYL-------IGNLNS---------ENNKMIGLESLRELRHLKILHVKSNltk 602
Cdd:cd21340     3 RITHLYLNDknITKIDN-LSLCKNLKVLYLydnkitkIENLEFltnlthlylQNNQIEKIENLENLVNLKKLYLGGN--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 603 vpsNITdvaphltklvihndgtkllVLNSLKKMMNVAELELQN------CELERIPHAIFSLSN-LQELDLKSNNIRTIE 675
Cdd:cd21340    79 ---RIS-------------------VVEGLENLTNLEELHIENqrlppgEKLTFDPRSLAALSNsLRVLNISGNNIDSLE 136

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907162924 676 EiisFQHLKRLTCLKLWHNKI---VAIPPSITHVKNLESLYFSNNKLESLP----TAVFSLQKLRCLD 736
Cdd:cd21340   137 P---LAPLRNLEQLDASNNQIsdlEELLDLLSSWPSLRELDLTGNPVCKKPkyrdKIILASKSLEVLD 201
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 650-819 1.10e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.62  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 650 RIPHAIFSLSNLQELDLKSNNIR-TIEEIIsFQHLKRLTCLKLWHNKIVAIPPSiTHVKNLESLYFSNNKLE-SLPTAVF 727
Cdd:PLN00113   84 KISSAIFRLPYIQTINLSNNQLSgPIPDDI-FTTSSSLRYLNLSNNNFTGSIPR-GSIPNLETLDLSNNMLSgEIPNDIG 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 728 SLQKLRCLDVSYNNIS-TIPIEIGLLQNLQHLHITGNK-VDILPKQLFKCVKLRTLNLGQNCIA-SLPEKISQLTQLTQL 804
Cdd:PLN00113  162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHL 241

                         170
                  ....*....|....*.
gi 1907162924 805 ELKGNCLD-RLPAQLG 819
Cdd:PLN00113  242 DLVYNNLTgPIPSSLG 257
LRR_8 pfam13855
Leucine rich repeat;
637-696 1.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.40e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907162924 637 NVAELELQNCELERI-PHAIFSLSNLQELDLKSNNIRTIEEiISFQHLKRLTCLKLWHNKI 696
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
685-742 2.81e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.81e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 685 RLTCLKLWHNKIVAIPPSI-THVKNLESLYFSNNKLESLPTAVFS-LQKLRCLDVSYNNI 742
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 637-815 4.75e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 53.73  E-value: 4.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924  637 NVAELELQNCELERIPHAIFSLSNLQELDL-KSNNIRTIEEIISFQHLKRL---TCLKLwhnkiVAIPPSITHVKNLESL 712
Cdd:PLN03210   612 NLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIPDLSMATNLETLklsDCSSL-----VELPSSIQYLNKLEDL 686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924  713 YFSN-NKLESLPTAVfSLQKLRCLDV-------SYNNIST--------------IPIEIGlLQNLQHLHItgnkVDILPK 770
Cdd:PLN03210   687 DMSRcENLEILPTGI-NLKSLYRLNLsgcsrlkSFPDISTniswldldetaieeFPSNLR-LENLDELIL----CEMKSE 760

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924  771 QLFKCVKLRT------------LNLGQN-CIASLPEKISQLTQLTQLELKgNC--LDRLP 815
Cdd:PLN03210   761 KLWERVQPLTplmtmlspsltrLFLSDIpSLVELPSSIQNLHKLEHLEIE-NCinLETLP 819
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
661-817 5.25e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 53.63  E-value: 5.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 661 LQELDLKSNNIRTIEEIISfqhlkrlTCLKLW--HNKIVAIPpsiTHVKNLESLYFSNNKLESLPTAVFSLQKL------ 732
Cdd:PRK15387  304 LQELSVSDNQLASLPALPS-------ELCKLWayNNQLTSLP---TLPSGLQELSVSDNQLASLPTLPSELYKLwaynnr 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 733 -----------RCLDVSYNNISTIPIeigLLQNLQHLHITGNKVDILPkqlFKCVKLRTLNLGQNCIASLPEKISQLTQL 801
Cdd:PRK15387  374 ltslpalpsglKELIVSGNRLTSLPV---LPSELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSE 447

                         170
                  ....*....|....*.
gi 1907162924 802 TQLELKGNCLDRLPAQ 817
Cdd:PRK15387  448 TTVNLEGNPLSERTLQ 463
LRR_8 pfam13855
Leucine rich repeat;
708-765 6.15e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 6.15e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 708 NLESLYFSNNKLESLPTAVFS-LQKLRCLDVSYNNISTI-PIEIGLLQNLQHLHITGNKV 765
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
659-719 1.00e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.00e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907162924 659 SNLQELDLKSNNIRTIEEIiSFQHLKRLTCLKLWHNKIVAIPP-SITHVKNLESLYFSNNKL 719
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 745-819 3.78e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 3.78e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907162924 745 IPIEIGLLQNLQHLHITGNKVD-ILPKQLFKCVKLRTLNLGQNCI-ASLPEKISQLTQLTQLELKGNCLD-RLPAQLG 819
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
597-828 3.80e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.46  E-value: 3.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 597 KSNLTKVPsnitDVAP-HLTKLVIHNDGtkllvLNSLKKMM-NVAELELQNCELERIPhaiFSLSNLQELDLKSNnirti 674
Cdd:PRK15387  210 ESGLTTLP----DCLPaHITTLVIPDNN-----LTSLPALPpELRTLEVSGNQLTSLP---VLPPGLLELSIFSN----- 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 675 eeiiSFQHLKRLTC--LKLW--HNKIVAIPpsiTHVKNLESLYFSNNKLESLPTAVFSLQKLRcldvSYNN-ISTIPIei 749
Cdd:PRK15387  273 ----PLTHLPALPSglCKLWifGNQLTSLP---VLPPGLQELSVSDNQLASLPALPSELCKLW----AYNNqLTSLPT-- 339

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907162924 750 gLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNlgqNCIASLPEKISQLTQLTqleLKGNCLDRLPAQLGQCRMLKKSG 828
Cdd:PRK15387  340 -LPSGLQELSVSDNQLASLPTLPSELYKLWAYN---NRLTSLPALPSGLKELI---VSGNRLTSLPVLPSELKELMVSG 411
PLN03150 PLN03150
hypothetical protein; Provisional
 699-763 4.19e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 4.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907162924 699 IPPSITHVKNLESLYFSNNKLE-SLPTAVFSLQKLRCLDVSYNNIS-TIPIEIGLLQNLQHLHITGN 763
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
753-809 4.39e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.39e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907162924 753 QNLQHLHITGNKVDILPKQLFK-CVKLRTLNLGQNCIASLPEK-ISQLTQLTQLELKGN 809
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 583-817 7.40e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 7.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 583 ESLRELRHLKILHVKSNLTKVpSNITDVAPHLTklviHNDGTKLLVLnslkKMMNVAELELQnceLERIPHAIFSLSNLQ 662
Cdd:cd00116    17 ELLPKLLCLQVLRLEGNTLGE-EAAKALASALR----PQPSLKELCL----SLNETGRIPRG---LQSLLQGLTKGCGLQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 663 ELDLkSNN---IRTIEEIISFQHLKRLTCLKLWHN-------KIVAipPSITHVK-NLESLYFSNNKL-----ESLPTAV 726
Cdd:cd00116    85 ELDL-SDNalgPDGCGVLESLLRSSSLQELKLNNNglgdrglRLLA--KGLKDLPpALEKLVLGRNRLegascEALAKAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 727 FSLQKLRCLDVSYNNISTIPIEI---GL--LQNLQHLHITGNKV-DILPKQLFKCVK----LRTLNLGQNCIAS------ 790
Cdd:cd00116   162 RANRDLKELNLANNGIGDAGIRAlaeGLkaNCNLEVLDLNNNGLtDEGASALAETLAslksLEVLNLGDNNLTDagaaal 241

                         250       260
                  ....*....|....*....|....*..
gi 1907162924 791 LPEKISQLTQLTQLELKGNCLDRLPAQ 817
Cdd:cd00116   242 ASALLSPNISLLTLSLSCNDITDDGAK 268
LRR_9 pfam14580
Leucine-rich repeat;
640-746 8.35e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 43.98  E-value: 8.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 640 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVAIPPSITHV-KNLESLYFSNNK 718
Cdd:pfam14580  23 ELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLD---GFPLLRRLKTLLLNNNRICRIGEGLGEAlPNLTELILTNNN 99

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907162924 719 LESL----PTAvfSLQKLRCLDVSYNNISTIP 746
Cdd:pfam14580 100 LQELgdldPLA--SLKKLTFLSLLRNPVTNKP 129
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 485-789 1.34e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 45.64  E-value: 1.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924  485 DAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCpakveqtafsflrdhlrclhvkfTDVAEIPAWVYLLKNLR 564
Cdd:PLN03210   628 DGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDC-----------------------SSLVELPSSIQYLNKLE 684

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924  565 ELYLIGNLNSENNKM-IGLESLRELRhlkiLHVKSNLTKVPsnitDVAPHLTKLVIhnDGTKLLVLNSLKKMMNVAELEL 643
Cdd:PLN03210   685 DLDMSRCENLEILPTgINLKSLYRLN----LSGCSRLKSFP----DISTNISWLDL--DETAIEEFPSNLRLENLDELIL 754

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924  644 qnCELE----------RIPHAIFSLSNLQELDLkSNNIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLY 713
Cdd:PLN03210   755 --CEMKseklwervqpLTPLMTMLSPSLTRLFL-SDIPSLVELPSSIQNLHKLEHLEIENCINLETLPTGINLESLESLD 831

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924  714 FSN-NKLESLP---TAVFSLQklrcldVSYNNISTIPIEIGLLQNLQHLHITG-NKVDILPKQLFKCVKLRTLNLgQNCI 788
Cdd:PLN03210   832 LSGcSRLRTFPdisTNISDLN------LSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHLETVDF-SDCG 904


                   .
gi 1907162924  789 A 789
Cdd:PLN03210   905 A 905
LRR_8 pfam13855
Leucine rich repeat;
730-786 8.39e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 8.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907162924 730 QKLRCLDVSYNNISTIPIEIGL-LQNLQHLHITGNKVDILPKQLFKC-VKLRTLNLGQN 786
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 707-744 2.78e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 2.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907162924 707 KNLESLYFSNNKLESLPtAVFSLQKLRCLDVSYNNIST 744
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNKIT 37
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 510-696 6.83e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 6.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 510 ISQMTNLQELHLCHCPakVEQTAFSFLRDHLRclhvkftDVAEipawvyllkNLRELYLIGNlNSENNKMIGL-ESLREL 588
Cdd:cd00116   104 LLRSSSLQELKLNNNG--LGDRGLRLLAKGLK-------DLPP---------ALEKLVLGRN-RLEGASCEALaKALRAN 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162924 589 RHLKILHVKSNltkvpsNITDVA-PHLTKLVIHNDGTKLLVLNSLKkmmnvaeLELQNCELerIPHAIFSLSNLQELDLK 667
Cdd:cd00116   165 RDLKELNLANN------GIGDAGiRALAEGLKANCNLEVLDLNNNG-------LTDEGASA--LAETLASLKSLEVLNLG 229

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1907162924 668 SNNIRT--IEEIISfQHLKRLTCLK---LWHNKI 696
Cdd:cd00116   230 DNNLTDagAAALAS-ALLSPNISLLtlsLSCNDI 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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