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Conserved domains on  [gi|1907162095|ref|XP_036020888|]
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toll-like receptor 6 isoform X1 [Mus musculus]

Protein Classification

toll-like receptor( domain architecture ID 11471523)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
652-791 7.30e-31

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 117.81  E-value: 7.30e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  652 QFHAFVSYSEHDsaWVKNELLPNLEKD--DIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYF 729
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKlrGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907162095  730 AHHNLFHEGSDNLILILLEPILQnNIPSRYHKLRALMaQRTYLEWPTEKGKRglFWANLRAS 791
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-313 2.16e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 2.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  50 SNRNLTHVPKDLP--PRTKALSLSQNSISELRmPDISFLSELRVLRLSHNRIRSLDFHVFLFNQdLEYLDVSHNRLQNIS 127
Cdd:COG4886   121 SGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 128 C--CPMASLRHLDLSFNDFDVLPvcKEFGNLTKLTFLGLSAAKFRQLDLLpvAHL-HLSCilLDLVSYHIKgGETESLQI 204
Cdd:COG4886   199 EplGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL--GNLtNLEE--LDLSNNQLT-DLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 205 PNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFF 284
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250       260
                  ....*....|....*....|....*....
gi 1907162095 285 WPRPVEYLNIYNLTITERIDREEFTYSET 313
Cdd:COG4886   352 LLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
262-542 8.30e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 8.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 262 LLNVTLQHIETTWKCSVKLFQFFWPRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAE 341
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 342 MNIKMLSISDTPFIHmvcppSPSSFTFLNFTQNVFTDsVFQGCSTLKRLQTLILQRNGLKNFFKvALmtKNMSSLETLDV 421
Cdd:COG4886    96 TNLTELDLSGNEELS-----NLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPE-PL--GNLTNLKSLDL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 422 SLNSLNShaYDRTCAWAESILVLNLSSNMLT--GSVFRCLPpKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDL 499
Cdd:COG4886   167 SNNQLTD--LPEELGNLTNLKELDLSNNQITdlPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1907162095 500 PGCGAFSSLSVLVIDHNSVSHPSEDFfqSCQNIRSLTAGNNPF 542
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRRCT smart00082
Leucine rich repeat C-terminal domain;
540-594 6.38e-08

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 6.38e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907162095  540 NPFQCTCELRDFVKnigWVAREVVEGWPDSYRCDYPESSKGtALRDFHMSPLSCD 594
Cdd:smart00082   1 NPFICDCELRWLLR---WLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
652-791 7.30e-31

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 117.81  E-value: 7.30e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  652 QFHAFVSYSEHDsaWVKNELLPNLEKD--DIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYF 729
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKlrGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907162095  730 AHHNLFHEGSDNLILILLEPILQnNIPSRYHKLRALMaQRTYLEWPTEKGKRglFWANLRAS 791
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 653-727 5.42e-18

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 82.03  E-value: 5.42e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907162095 653 FHAFVSYSEHDS-AWVKNELLPNLEKDDIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYEL 727
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDEL 76
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-313 2.16e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 2.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  50 SNRNLTHVPKDLP--PRTKALSLSQNSISELRmPDISFLSELRVLRLSHNRIRSLDFHVFLFNQdLEYLDVSHNRLQNIS 127
Cdd:COG4886   121 SGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 128 C--CPMASLRHLDLSFNDFDVLPvcKEFGNLTKLTFLGLSAAKFRQLDLLpvAHL-HLSCilLDLVSYHIKgGETESLQI 204
Cdd:COG4886   199 EplGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL--GNLtNLEE--LDLSNNQLT-DLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 205 PNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFF 284
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250       260
                  ....*....|....*....|....*....
gi 1907162095 285 WPRPVEYLNIYNLTITERIDREEFTYSET 313
Cdd:COG4886   352 LLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
262-542 8.30e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 8.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 262 LLNVTLQHIETTWKCSVKLFQFFWPRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAE 341
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 342 MNIKMLSISDTPFIHmvcppSPSSFTFLNFTQNVFTDsVFQGCSTLKRLQTLILQRNGLKNFFKvALmtKNMSSLETLDV 421
Cdd:COG4886    96 TNLTELDLSGNEELS-----NLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPE-PL--GNLTNLKSLDL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 422 SLNSLNShaYDRTCAWAESILVLNLSSNMLT--GSVFRCLPpKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDL 499
Cdd:COG4886   167 SNNQLTD--LPEELGNLTNLKELDLSNNQITdlPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1907162095 500 PGCGAFSSLSVLVIDHNSVSHPSEDFfqSCQNIRSLTAGNNPF 542
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
87-144 1.60e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.60e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907162095  87 SELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNIS---CCPMASLRHLDLSFNDF 144
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-540 5.65e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 5.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  50 SNRNLT-HVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHN-----------RIRSLDFHVFLFNQ------ 111
Cdd:PLN00113  126 SNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnsltNLTSLEFLTLASNQlvgqip 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 112 -------DLEYLDVSHNRLQN---ISCCPMASLRHLDLSFNDFdVLPVCKEFGNLTKLTFLGLSAAKFRqlDLLPVAHLH 181
Cdd:PLN00113  206 relgqmkSLKWIYLGYNNLSGeipYEIGGLTSLNHLDLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFS 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 182 LS-CILLDLVSYHIKGGETE-SLQIPNTTVLHLvFHPNSLFSVQVNM-SVNALGHLQLSNIKLNDENCQRL-----MTFL 253
Cdd:PLN00113  283 LQkLISLDLSDNSLSGEIPElVIQLQNLEILHL-FSNNFTGKIPVALtSLPRLQVLQLWSNKFSGEIPKNLgkhnnLTVL 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 254 SELTRgptllNVTLQHIETTwkCSVKlfqffwprpveylNIYNLTITERIDREEFTYSETALKSLmiEHVKNQVFLFSKE 333
Cdd:PLN00113  362 DLSTN-----NLTGEIPEGL--CSSG-------------NLFKLILFSNSLEGEIPKSLGACRSL--RRVRLQDNSFSGE 419

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 334 aLYSVFAEMnikmlsisdtPFIHmvcppspssftFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNglkNFFKVALMTKNM 413
Cdd:PLN00113  420 -LPSEFTKL----------PLVY-----------FLDISNNNLQGRINSRKWDMPSLQMLSLARN---KFFGGLPDSFGS 474

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 414 SSLETLDVSLNSLnSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPP--KVKVLDL-HNNRIMSIPKDVTHLQALQELN 490
Cdd:PLN00113  475 KRLENLDLSRNQF-SGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSckKLVSLDLsHNQLSGQIPASFSEMPVLSQLD 553

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907162095 491 VASNSLT-DLP-GCGAFSSLSVLVIDHNSV--SHPSEDFFQSCQNirSLTAGNN 540
Cdd:PLN00113  554 LSQNQLSgEIPkNLGNVESLVQVNISHNHLhgSLPSTGAFLAINA--SAVAGNI 605
LRRCT smart00082
Leucine rich repeat C-terminal domain;
540-594 6.38e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 6.38e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907162095  540 NPFQCTCELRDFVKnigWVAREVVEGWPDSYRCDYPESSKGtALRDFHMSPLSCD 594
Cdd:smart00082   1 NPFICDCELRWLLR---WLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-151 4.82e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 4.82e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  89 LRVLRLSHNRIRSLDFHVFLFNqdLEYLDVSHNRLQNI-------SCCPmaSLRHLDLSFNdfdvlPVCK 151
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRN--LEQLDASNNQISDLeelldllSSWP--SLRELDLTGN-----PVCK 182
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
390-500 2.34e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 2.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 390 LQTLILQRNglknffKVALMTKNM-SSLETLDV---SLNSLNSHAydrtcawAESILVLNLSSNMLTG------------ 453
Cdd:PRK15370  264 LQSLDLFHN------KISCLPENLpEELRYLSVydnSIRTLPAHL-------PSGITHLNVQSNSLTAlpetlppglktl 330

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907162095 454 --------SVFRCLPPKVKVLDLHNNRIMSIPKdvTHLQALQELNVASNSLTDLP 500
Cdd:PRK15370  331 eagenaltSLPASLPPELQVLDVSKNQITVLPE--TLPPTITTLDVSRNALTNLP 383
LRR_8 pfam13855
Leucine rich repeat;
461-516 7.21e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 7.21e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 461 PKVKVLDLHNNRIMSIPKDV-THLQALQELNVASNSLTDLPGcGAFS---SLSVLVIDHN 516
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 380-500 6.24e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 6.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 380 VFQGCSTLKRLQTLILQRNGL---KNFFKVALMTKNMSSLETLDVSLNSLNShayDRTCAWAE------SILVLNLSSNM 450
Cdd:cd00116   100 VLESLLRSSSLQELKLNNNGLgdrGLRLLAKGLKDLPPALEKLVLGRNRLEG---ASCEALAKalranrDLKELNLANNG 176

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907162095 451 LTGSVFRCLPP------KVKVLDLHNNRIMS-----IPKDVTHLQALQELNVASNSLTDLP 500
Cdd:cd00116   177 IGDAGIRALAEglkancNLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAG 237
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
652-791 7.30e-31

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 117.81  E-value: 7.30e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  652 QFHAFVSYSEHDsaWVKNELLPNLEKD--DIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYF 729
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKlrGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907162095  730 AHHNLFHEGSDNLILILLEPILQnNIPSRYHKLRALMaQRTYLEWPTEKGKRglFWANLRAS 791
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 653-727 5.42e-18

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 82.03  E-value: 5.42e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907162095 653 FHAFVSYSEHDS-AWVKNELLPNLEKDDIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYEL 727
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDEL 76
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 656-732 2.21e-17

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 78.51  E-value: 2.21e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907162095 656 FVSYSEHDSAWVKnELLPNLEKDDIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYFAHH 732
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA 77
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-313 2.16e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 2.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  50 SNRNLTHVPKDLP--PRTKALSLSQNSISELRmPDISFLSELRVLRLSHNRIRSLDFHVFLFNQdLEYLDVSHNRLQNIS 127
Cdd:COG4886   121 SGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 128 C--CPMASLRHLDLSFNDFDVLPvcKEFGNLTKLTFLGLSAAKFRQLDLLpvAHL-HLSCilLDLVSYHIKgGETESLQI 204
Cdd:COG4886   199 EplGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL--GNLtNLEE--LDLSNNQLT-DLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 205 PNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFF 284
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250       260
                  ....*....|....*....|....*....
gi 1907162095 285 WPRPVEYLNIYNLTITERIDREEFTYSET 313
Cdd:COG4886   352 LLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
262-542 8.30e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 8.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 262 LLNVTLQHIETTWKCSVKLFQFFWPRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAE 341
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 342 MNIKMLSISDTPFIHmvcppSPSSFTFLNFTQNVFTDsVFQGCSTLKRLQTLILQRNGLKNFFKvALmtKNMSSLETLDV 421
Cdd:COG4886    96 TNLTELDLSGNEELS-----NLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPE-PL--GNLTNLKSLDL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 422 SLNSLNShaYDRTCAWAESILVLNLSSNMLT--GSVFRCLPpKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDL 499
Cdd:COG4886   167 SNNQLTD--LPEELGNLTNLKELDLSNNQITdlPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1907162095 500 PGCGAFSSLSVLVIDHNSVSHPSEDFfqSCQNIRSLTAGNNPF 542
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
343-556 9.95e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 9.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 343 NIKMLSISDTPFIHMvcPPSPSSFT---FLNFTQNVFTDsVFQGCSTLKRLQTLILQRNGLKNFFKVAlmtKNMSSLETL 419
Cdd:COG4886   114 NLESLDLSGNQLTDL--PEELANLTnlkELDLSNNQLTD-LPEPLGNLTNLKSLDLSNNQLTDLPEEL---GNLTNLKEL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 420 DVSLNSLNShaYDRTCAWAESILVLNLSSNMLT---GSVFRClpPKVKVLDLHNNRIMSIPkDVTHLQALQELNVASNSL 496
Cdd:COG4886   188 DLSNNQITD--LPEPLGNLTNLEELDLSGNQLTdlpEPLANL--TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 497 TDLPGCGAFSSLSVLVIDHNSVSHPSEDFFQSCQNIRSLTAGNNPFQCTCELRDFVKNIG 556
Cdd:COG4886   263 TDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-274 1.53e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  50 SNRNLTHVPKDLPPRT--KALSLSQNSISELrMPDISFLSELRVLRLSHNRIRSLDfhvFLFN-QDLEYLDVSHNRLQNI 126
Cdd:COG4886   190 SNNQITDLPEPLGNLTnlEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP---ELGNlTNLEELDLSNNQLTDL 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 127 S-CCPMASLRHLDLSFNDFDVLpvckEFGNLTKLTFLGLSAAKFRQLDLLPVAHLHLSCILLDLVSYHIKGGETESLQIP 205
Cdd:COG4886   266 PpLANLTNLKTLDLSNNQLTDL----KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907162095 206 NTTVLhLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTW 274
Cdd:COG4886   342 LSLSL-LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
LRR_8 pfam13855
Leucine rich repeat;
87-144 1.60e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.60e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907162095  87 SELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNIS---CCPMASLRHLDLSFNDF 144
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-540 5.65e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 5.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  50 SNRNLT-HVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHN-----------RIRSLDFHVFLFNQ------ 111
Cdd:PLN00113  126 SNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnsltNLTSLEFLTLASNQlvgqip 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 112 -------DLEYLDVSHNRLQN---ISCCPMASLRHLDLSFNDFdVLPVCKEFGNLTKLTFLGLSAAKFRqlDLLPVAHLH 181
Cdd:PLN00113  206 relgqmkSLKWIYLGYNNLSGeipYEIGGLTSLNHLDLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFS 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 182 LS-CILLDLVSYHIKGGETE-SLQIPNTTVLHLvFHPNSLFSVQVNM-SVNALGHLQLSNIKLNDENCQRL-----MTFL 253
Cdd:PLN00113  283 LQkLISLDLSDNSLSGEIPElVIQLQNLEILHL-FSNNFTGKIPVALtSLPRLQVLQLWSNKFSGEIPKNLgkhnnLTVL 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 254 SELTRgptllNVTLQHIETTwkCSVKlfqffwprpveylNIYNLTITERIDREEFTYSETALKSLmiEHVKNQVFLFSKE 333
Cdd:PLN00113  362 DLSTN-----NLTGEIPEGL--CSSG-------------NLFKLILFSNSLEGEIPKSLGACRSL--RRVRLQDNSFSGE 419

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 334 aLYSVFAEMnikmlsisdtPFIHmvcppspssftFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNglkNFFKVALMTKNM 413
Cdd:PLN00113  420 -LPSEFTKL----------PLVY-----------FLDISNNNLQGRINSRKWDMPSLQMLSLARN---KFFGGLPDSFGS 474

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 414 SSLETLDVSLNSLnSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPP--KVKVLDL-HNNRIMSIPKDVTHLQALQELN 490
Cdd:PLN00113  475 KRLENLDLSRNQF-SGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSckKLVSLDLsHNQLSGQIPASFSEMPVLSQLD 553

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907162095 491 VASNSLT-DLP-GCGAFSSLSVLVIDHNSV--SHPSEDFFQSCQNirSLTAGNN 540
Cdd:PLN00113  554 LSQNQLSgEIPkNLGNVESLVQVNISHNHLhgSLPSTGAFLAINA--SAVAGNI 605
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-165 2.63e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  66 KALSLSQNsiselrmPDISFLSELRVLRLSHNRIRSLDFHVFLFNQdLEYLDVSHNRLQNI--SCCPMASLRHLDLSFND 143
Cdd:COG4886    99 TELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTN-LKELDLSNNQLTDLpePLGNLTNLKSLDLSNNQ 170

                          90       100
                  ....*....|....*....|..
gi 1907162095 144 FDVLPvcKEFGNLTKLTFLGLS 165
Cdd:COG4886   171 LTDLP--EELGNLTNLKELDLS 190
LRRCT smart00082
Leucine rich repeat C-terminal domain;
540-594 6.38e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 6.38e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907162095  540 NPFQCTCELRDFVKnigWVAREVVEGWPDSYRCDYPESSKGtALRDFHMSPLSCD 594
Cdd:smart00082   1 NPFICDCELRWLLR---WLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-173 1.03e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095   1 MVKSLWDSLCNMSQDRKPIVGSFHFVCALALIVGSMTPFSNELESMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRM 80
Cdd:COG4886    10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  81 PDISFLSELRVLRLSHNRIrsldfhvFLFNQDLEYLDVSHNRLQNI--SCCPMASLRHLDLSFNDFDVLPvcKEFGNLTK 158
Cdd:COG4886    90 TDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLpeELANLTNLKELDLSNNQLTDLP--EPLGNLTN 160

                         170
                  ....*....|....*
gi 1907162095 159 LTFLGLSAAKFRQLD 173
Cdd:COG4886   161 LKSLDLSNNQLTDLP 175
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-151 4.82e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 4.82e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  89 LRVLRLSHNRIRSLDFHVFLFNqdLEYLDVSHNRLQNI-------SCCPmaSLRHLDLSFNdfdvlPVCK 151
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRN--LEQLDASNNQISDLeelldllSSWP--SLRELDLTGN-----PVCK 182
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
390-500 2.34e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 2.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 390 LQTLILQRNglknffKVALMTKNM-SSLETLDV---SLNSLNSHAydrtcawAESILVLNLSSNMLTG------------ 453
Cdd:PRK15370  264 LQSLDLFHN------KISCLPENLpEELRYLSVydnSIRTLPAHL-------PSGITHLNVQSNSLTAlpetlppglktl 330

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907162095 454 --------SVFRCLPPKVKVLDLHNNRIMSIPKdvTHLQALQELNVASNSLTDLP 500
Cdd:PRK15370  331 eagenaltSLPASLPPELQVLDVSKNQITVLPE--TLPPTITTLDVSRNALTNLP 383
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
40-148 4.67e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 4.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  40 SNELESMVD---------YSNRN-LTHVPKDLPPRTKALSLSQNSISEL--RMPdisflSELRVLRLSHNRIRSLDFHVf 107
Cdd:PRK15370  208 NNELKSLPEnlqgniktlYANSNqLTSIPATLPDTIQEMELSINRITELpeRLP-----SALQSLDLFHNKISCLPENL- 281

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1907162095 108 lfNQDLEYLDVSHNRLQNISCCPMASLRHLDLSFNDFDVLP 148
Cdd:PRK15370  282 --PEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALP 320
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 362-540 7.50e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 7.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 362 SPSSFTFLNFTQNVFTDSVFQGcsTLKRLQTLILQRNGLKNffKVALMTKNMSSLETLDVSLNSLNSHAyDRTCAWAESI 441
Cdd:PLN00113  116 TSSSLRYLNLSNNNFTGSIPRG--SIPNLETLDLSNNMLSG--EIPNDIGSFSSLKVLDLGGNVLVGKI-PNSLTNLTSL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 442 LVLNLSSNMLTGSVFRCLPpKVKVLDL----HNNRIMSIPKDVTHLQALQELNVASNSLTDL--PGCGAFSSLSVLVIDH 515
Cdd:PLN00113  191 EFLTLASNQLVGQIPRELG-QMKSLKWiylgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPipSSLGNLKNLQYLFLYQ 269

                         170       180
                  ....*....|....*....|....*
gi 1907162095 516 NSVSHPSEDFFQSCQNIRSLTAGNN 540
Cdd:PLN00113  270 NKLSGPIPPSIFSLQKLISLDLSDN 294
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 405-516 7.63e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 7.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 405 KVALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIM-SIPKDVTHL 483
Cdd:PLN00113   84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSgEIPNDIGSF 163

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1907162095 484 QALQELNVASNSLT-DLPG-CGAFSSLSVLVIDHN 516
Cdd:PLN00113  164 SSLKVLDLGGNVLVgKIPNsLTNLTSLEFLTLASN 198
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
51-148 8.13e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 8.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  51 NRNLTHVPKDLPPRTKALSLSQNSISELrmPDiSFLSELRVLRLSHNRIRSLDFhvfLFNQDLEYLDVSHNRLQNISCCP 130
Cdd:PRK15370  313 SNSLTALPETLPPGLKTLEAGENALTSL--PA-SLPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPENL 386

                          90
                  ....*....|....*...
gi 1907162095 131 MASLRHLDLSFNDFDVLP 148
Cdd:PRK15370  387 PAALQIMQASRNNLVRLP 404
LRR_8 pfam13855
Leucine rich repeat;
63-123 1.54e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.54e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907162095  63 PRTKALSLSQNSISELRmpDISF--LSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRL 123
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD--DGAFkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
388-544 2.41e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 388 KRLQTLILQRNGLKNffkvalMTKNM-SSLETLDVSLNSLNShaydRTCAWAESILVLNLSSNMLTGSVFRcLPPKVKVL 466
Cdd:PRK15370  199 EQITTLILDNNELKS------LPENLqGNIKTLYANSNQLTS----IPATLPDTIQEMELSINRITELPER-LPSALQSL 267

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907162095 467 DLHNNRIMSIPKDVThlQALQELNVASNSLTDLPGcGAFSSLSVLVIDHNSVSHPSEDFfqsCQNIRSLTAGNNPFQC 544
Cdd:PRK15370  268 DLFHNKISCLPENLP--EELRYLSVYDNSIRTLPA-HLPSGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTS 339
LRR_8 pfam13855
Leucine rich repeat;
461-516 7.21e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 7.21e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 461 PKVKVLDLHNNRIMSIPKDV-THLQALQELNVASNSLTDLPGcGAFS---SLSVLVIDHN 516
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
47-148 1.20e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  47 VDYSNRNLTHVPKDLPPRTKALSLSQNSISELrmPDiSFLSELRVLRLSHNRIRSLDFH-------VFLFNQ-------- 111
Cdd:PRK15370  246 MELSINRITELPERLPSALQSLDLFHNKISCL--PE-NLPEELRYLSVYDNSIRTLPAHlpsgithLNVQSNsltalpet 322

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1907162095 112 ---DLEYLDVSHNRLqniSCCPMA---SLRHLDLSFNDFDVLP 148
Cdd:PRK15370  323 lppGLKTLEAGENAL---TSLPASlppELQVLDVSKNQITVLP 362
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-171 1.35e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095  50 SNRNLTHVPK-DLPPRTKALSLSQNSISelRMPDISFLSELRVLRLSHNRIRSLDF------------------------ 104
Cdd:cd21340    10 NDKNITKIDNlSLCKNLKVLYLYDNKIT--KIENLEFLTNLTHLYLQNNQIEKIENlenlvnlkklylggnrisvvegle 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 105 --------HV----------FLFNQD--------LEYLDVSHNRLQNISCC-PMASLRHLDLSFNDF----DVLPVCKEF 153
Cdd:cd21340    88 nltnleelHIenqrlppgekLTFDPRslaalsnsLRVLNISGNNIDSLEPLaPLRNLEQLDASNNQIsdleELLDLLSSW 167

                         170       180
                  ....*....|....*....|.
gi 1907162095 154 GNLTKLTFLG---LSAAKFRQ 171
Cdd:cd21340   168 PSLRELDLTGnpvCKKPKYRD 188
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 380-500 6.24e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 6.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 380 VFQGCSTLKRLQTLILQRNGL---KNFFKVALMTKNMSSLETLDVSLNSLNShayDRTCAWAE------SILVLNLSSNM 450
Cdd:cd00116   100 VLESLLRSSSLQELKLNNNGLgdrGLRLLAKGLKDLPPALEKLVLGRNRLEG---ASCEALAKalranrDLKELNLANNG 176

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907162095 451 LTGSVFRCLPP------KVKVLDLHNNRIMS-----IPKDVTHLQALQELNVASNSLTDLP 500
Cdd:cd00116   177 IGDAGIRALAEglkancNLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAG 237
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 369-542 2.34e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 369 LNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKNmsSLETLDVSLNSLNSHAYDRTCAwAESILVLNLSS 448
Cdd:PLN00113  313 LHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHN--NLTVLDLSTNNLTGEIPEGLCS-SGNLFKLILFS 389

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 449 NMLTGSVFRCLPP--KVKVLDLHNNRIM-SIPKDVTHLQALQELNVASNSLT--------DLPgcgafsSLSVLVIDHNS 517
Cdd:PLN00113  390 NSLEGEIPKSLGAcrSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwDMP------SLQMLSLARNK 463

                         170       180
                  ....*....|....*....|....*
gi 1907162095 518 VSHPSEDFFQScQNIRSLTAGNNPF 542
Cdd:PLN00113  464 FFGGLPDSFGS-KRLENLDLSRNQF 487
PLN03150 PLN03150
hypothetical protein; Provisional
 385-510 5.74e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 5.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907162095 385 STLKRLQTLILQRNGLKNFFKVALmtKNMSSLETLDVSLNSLNSHAYDrTCAWAESILVLNLSSNMLTGSVfrclPPKVK 464
Cdd:PLN03150  439 SKLRHLQSINLSGNSIRGNIPPSL--GSITSLEVLDLSYNSFNGSIPE-SLGQLTSLRILNLNGNSLSGRV----PAALG 511

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907162095 465 VLDLHNNRimsipkdvthlqalqeLNVASNS-LTDLPG---CGAFSSLSV 510
Cdd:PLN03150  512 GRLLHRAS----------------FNFTDNAgLCGIPGlraCGPHLSVGA 545
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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