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Conserved domains on  [gi|1907151128|ref|XP_036019040|]
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uncharacterized protein LOC381484 isoform X3 [Mus musculus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 32-143 6.63e-65

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd16097:

Pssm-ID: 472250  Cd Length: 111  Bit Score: 194.70  E-value: 6.63e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  32 KVIQPEKSVSVRAGGLATLNCTVTSLIPVGPMRWYRGVGHRRNLIYSYTGEHFPRITNVSDATKRRNLDFSIRISDVTFA 111
Cdd:cd16097     1 QVIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISNITPA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907151128 112 DADTYYCVKFQKGPSEsDIEIQSGGGTELLVL 143
Cdd:cd16097    81 DAGTYYCVKFRKGSPD-DVEFKSGAGTELSVR 111
 
Name Accession Description Interval E-value
IgV_SIRP cd16097
Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...
 32-143 6.63e-65

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409516  Cd Length: 111  Bit Score: 194.70  E-value: 6.63e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  32 KVIQPEKSVSVRAGGLATLNCTVTSLIPVGPMRWYRGVGHRRNLIYSYTGEHFPRITNVSDATKRRNLDFSIRISDVTFA 111
Cdd:cd16097     1 QVIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISNITPA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907151128 112 DADTYYCVKFQKGPSEsDIEIQSGGGTELLVL 143
Cdd:cd16097    81 DAGTYYCVKFRKGSPD-DVEFKSGAGTELSVR 111
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 35-143 5.99e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 64.40  E-value: 5.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  35 QPEKSVSVRAGGLATLNCTVTSLI--PVGPMRWYR---GVGHRRNLIYSYTGEHFPRITN-VSDATKRRNLDFSIRISDV 108
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRqppGKGPTFLIAYYSNGSEEGVKKGrFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1907151128 109 TFADADTYYCVKFQKGpsesdiEIQSGGGTELLVL 143
Cdd:pfam07686  81 TLSDSGTYTCAVIPSG------EGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 38-133 9.02e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 9.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128   38 KSVSVRAGGLATLNCTVTSLIPVGpMRWYRGVGhrRNLIYSytgehfPRITnvsdaTKRRNLDFSIRISDVTFADADTYY 117
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPE-VTWYKQGG--KLLAES------GRFS-----VSRSGSTSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|....*..
gi 1907151128  118 C-VKFQKGPSESDIEIQ 133
Cdd:smart00410  68 CaATNSSGSASSGTTLT 84
 
Name Accession Description Interval E-value
IgV_SIRP cd16097
Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...
 32-143 6.63e-65

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409516  Cd Length: 111  Bit Score: 194.70  E-value: 6.63e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  32 KVIQPEKSVSVRAGGLATLNCTVTSLIPVGPMRWYRGVGHRRNLIYSYTGEHFPRITNVSDATKRRNLDFSIRISDVTFA 111
Cdd:cd16097     1 QVIQPEKSVSVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISNITPA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907151128 112 DADTYYCVKFQKGPSEsDIEIQSGGGTELLVL 143
Cdd:cd16097    81 DAGTYYCVKFRKGSPD-DVEFKSGAGTELSVR 111
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 33-142 2.73e-21

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 83.54  E-value: 2.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  33 VIQPEKSVSVRAGGLATLNCTVTSLIPVGPMRWYRGV-GHRRNLIYSYTGEHFPRITNVSD---ATKRRNLDFSIRISDV 108
Cdd:cd00099     1 VTQSPRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKpGQGPEFLIYLSSSKGKTKGGVPGrfsGSRDGTSSFSLTISNL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907151128 109 TFADADTYYCVKFQKGpseSDIEIQSGGGTELLV 142
Cdd:cd00099    81 QPEDSGTYYCAVSESG---GTDKLTFGSGTRLTV 111
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 35-143 5.99e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 64.40  E-value: 5.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  35 QPEKSVSVRAGGLATLNCTVTSLI--PVGPMRWYR---GVGHRRNLIYSYTGEHFPRITN-VSDATKRRNLDFSIRISDV 108
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRqppGKGPTFLIAYYSNGSEEGVKKGrFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1907151128 109 TFADADTYYCVKFQKGpsesdiEIQSGGGTELLVL 143
Cdd:pfam07686  81 TLSDSGTYTCAVIPSG------EGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 38-133 9.02e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 9.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128   38 KSVSVRAGGLATLNCTVTSLIPVGpMRWYRGVGhrRNLIYSytgehfPRITnvsdaTKRRNLDFSIRISDVTFADADTYY 117
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPE-VTWYKQGG--KLLAES------GRFS-----VSRSGSTSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|....*..
gi 1907151128  118 C-VKFQKGPSESDIEIQ 133
Cdd:smart00410  68 CaATNSSGSASSGTTLT 84
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 33-142 5.44e-07

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 46.11  E-value: 5.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  33 VIQPEKSVSVRAGGLATLNCTVTSlIPVGPMRWYR---GvGHRRNLIYSYTGEhfpriTNVSDATKRRNLD-----FSIR 104
Cdd:cd04983     1 VTQSPQSLSVQEGENVTLNCNYST-STFYYLFWYRqypG-QGPQFLIYISSDS-----GNKKKGRFSATLDksrksSSLH 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907151128 105 ISDVTFADADTYYCVKFQKGPSEsdiEIQSGGGTELLV 142
Cdd:cd04983    74 ISAAQLSDSAVYFCALSESGGTG---KLTFGKGTRLTV 108
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 32-133 1.07e-06

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 45.26  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  32 KVIQPEKSVSVRAGGLATLNCTVTSLIPVGPM--RWYRgvGHRRNLIYSY------TGEHFP----RITNVSDATKRRNL 99
Cdd:cd05713     2 SVIGPTEPILALVGEDAELPCHLSPKMSAEHMevRWFR--SQFSPVVHLYrdgqdqEEEQMPeyrgRTELLKDAIAEGSV 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1907151128 100 dfSIRISDVTFADADTYYCVkFQKGPS--ESDIEIQ 133
Cdd:cd05713    80 --ALRIHNVRPSDEGQYTCF-FRSGSFyeEATLELK 112
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 33-142 2.60e-06

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 44.30  E-value: 2.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  33 VIQPEKSVSVRAGGLATLNCTVTSLIPVGPMRWYRGVGHR--RNLIYSYTGehfpRITNVSD--ATKRRNLDFSIRISDV 108
Cdd:cd04980     3 MTQSPASLSVSPGERVTISCKASQSISSNYLAWYQQKPGQapKLLIYYAST----LHSGVPSrfSGSGSGTDFTLTISSV 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907151128 109 TFADADTYYCVKFQKGPsesdieIQSGGGTELLV 142
Cdd:cd04980    79 EPEDAAVYYCQQGYTFP------YTFGGGTKLEI 106
IGv smart00406
Immunoglobulin V-Type;
48-118 1.65e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 41.21  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128   48 ATLNCTV-TSLIPVGPMRWYR---GVG----HRRNLIYS-YTGEHFP-RITNVSDATKRrnlDFSIRISDVTFADADTYY 117
Cdd:smart00406   2 VTLSCKFsGSTFSSYYVSWVRqppGKGlewlGYIGSNGSsYYQESYKgRFTISKDTSKN---DVSLTISNLRVEDTGTYY 78


                   .
gi 1907151128  118 C 118
Cdd:smart00406  79 C 79
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 35-119 2.43e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 41.03  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  35 QPEKSVSVRAGGLATLNCTVTSLIPVGPMRWYRGVGhrRNLIYSYTGEHFPRITNvsdatkrrnldFSIRISDVTFADAD 114
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGG--TLIESLKVKHDNGRTTQ-----------SSLLISNVTKEDAG 67


                  ....*
gi 1907151128 115 TYYCV 119
Cdd:pfam00047  68 TYTCV 72
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 32-119 1.29e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 38.70  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  32 KVIQPEKSVSVRAGGLATLNCTVTSlIPVGPMRWYRGvghrrnliysytGEhfPRITNVSDATKRRNLDFSIRISDVTFA 111
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATG-SPPPTITWYKN------------GE--PISSGSTRSRSLSGSNSTLTISNVTRS 67


                  ....*...
gi 1907151128 112 DADTYYCV 119
Cdd:pfam13927  68 DAGTYTCV 75
IgV_1_Necl_like cd05717
First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the ...
 38-132 1.45e-03

First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the V-set of Ig superfamily (IgSF) domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 (CADM3)), Necl-2 (CADM1), Necl-3 (CADM2), and similar proteins. At least five nectin-like molecules have been identified (Necl-1 to Necl-5). They all have an extracellular region containing three Ig-like domains, a transmembrane region, and a cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1, Necl-2, and Necl-3 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue, and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Necl-3 accumulates in central and peripheral nervous system tissue and has been shown to selectively interact with oligodendrocytes. This group also contains Class-I MHC-restricted T-cell-associated molecule (CRTAM), whose expression pattern is consistent with its expression in Class-I MHC-restricted T-cells.


Pssm-ID: 409382  Cd Length: 94  Bit Score: 36.34  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  38 KSVSVRAGGLATLNCtVTSLIPVGPMRWYRGVGHRrnliySYTGEHFP------RITNVSDAtkrrnlDFSIRISDVTFA 111
Cdd:cd05717     4 QDVTVVEGETLTLKC-QVSLRDDSSLQWLNPNGQT-----IYFNDKRAlrdsryQLLNHSAS------ELSISVSNVTLS 71

                          90       100
                  ....*....|....*....|.
gi 1907151128 112 DADTYYCVKFQKGPSESDIEI 132
Cdd:cd05717    72 DEGVYTCLHYTDPVSTKKVTV 92
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 33-142 3.46e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 35.72  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  33 VIQPEKSVSVRAGGLATLNCTVTSLIPVgpMRWYRgvgHRRN-----LIYSYTGEHfPRITNVS----DATKRRNLDFSI 103
Cdd:cd05899     1 VTQSPRYLIKRRGQSVTLRCSQKSGHDN--MYWYR---QDPGkglqlLFYSYGGGL-NEEGDLPgdrfSASRPSLTRSSL 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907151128 104 RISDVTFADADTYYCVKFQKGPSEsdiEIQSGGGTELLV 142
Cdd:cd05899    75 TIKSAEPEDSAVYLCASSLGGGAD---EAYFGPGTRLTV 110
I-set pfam07679
Immunoglobulin I-set domain;
32-119 3.95e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 34.93  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  32 KVIQPEKSVSVRAGGLATLNCTVTSlIPVGPMRWYRGvGHRRNliysyTGEHFpRITNVSDatkrrnlDFSIRISDVTFA 111
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTVTG-TPDPEVSWFKD-GQPLR-----SSDRF-KVTYEGG-------TYTLTISNVQPD 66


                  ....*...
gi 1907151128 112 DADTYYCV 119
Cdd:pfam07679  67 DSGKYTCV 74
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 34-119 6.56e-03

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 34.68  E-value: 6.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151128  34 IQPEKSVSVRAGGLATLNCTVTSLIPVGPMRWYRGVGHRRNLIYSYTGEHFPRITNVSDATKRRNldFSIRISDVTFADA 113
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPGGRISLTDDPDNGV--FTVTLNQLRKEDA 78


                  ....*.
gi 1907151128 114 DTYYCV 119
Cdd:cd05716    79 GWYWCG 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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