Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.
:
Pssm-ID: 461383 Cd Length: 208 Bit Score: 342.77 E-value: 2.60e-116
Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.
Pssm-ID: 461383 Cd Length: 208 Bit Score: 342.77 E-value: 2.60e-116
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
359-523
4.11e-10
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 62.48 E-value: 4.11e-10
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.
Pssm-ID: 468478 [Multi-domain] Cd Length: 440 Bit Score: 56.07 E-value: 3.41e-08
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
382-493
1.25e-05
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 47.84 E-value: 1.25e-05
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
301-431
2.62e-04
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.
Pssm-ID: 468201 [Multi-domain] Cd Length: 684 Bit Score: 43.85 E-value: 2.62e-04
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins ...
382-508
2.67e-04
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 360 amino acids in length.
Pssm-ID: 434493 [Multi-domain] Cd Length: 176 Bit Score: 42.12 E-value: 2.67e-04
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
392-547
1.00e-03
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 41.68 E-value: 1.00e-03
Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.
Pssm-ID: 461383 Cd Length: 208 Bit Score: 342.77 E-value: 2.60e-116
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
359-523
4.11e-10
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 62.48 E-value: 4.11e-10
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.
Pssm-ID: 468478 [Multi-domain] Cd Length: 440 Bit Score: 56.07 E-value: 3.41e-08
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
382-493
1.25e-05
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 47.84 E-value: 1.25e-05
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
301-431
2.62e-04
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.
Pssm-ID: 468201 [Multi-domain] Cd Length: 684 Bit Score: 43.85 E-value: 2.62e-04
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins ...
382-508
2.67e-04
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 360 amino acids in length.
Pssm-ID: 434493 [Multi-domain] Cd Length: 176 Bit Score: 42.12 E-value: 2.67e-04
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins ...
382-514
3.78e-04
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 360 amino acids in length.
Pssm-ID: 434493 [Multi-domain] Cd Length: 176 Bit Score: 41.35 E-value: 3.78e-04
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
392-547
1.00e-03
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 41.68 E-value: 1.00e-03
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins ...
391-547
1.12e-03
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 360 amino acids in length.
Pssm-ID: 434493 [Multi-domain] Cd Length: 176 Bit Score: 40.19 E-value: 1.12e-03
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins ...
391-515
2.71e-03
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 360 amino acids in length.
Pssm-ID: 434493 [Multi-domain] Cd Length: 176 Bit Score: 39.04 E-value: 2.71e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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