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Conserved domains on  [gi|1907067605|ref|XP_036018422|]
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membrane cofactor protein isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 64-235 3.33e-19

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 83.93  E-value: 3.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605  64 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 143
Cdd:PHA02927   44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605 144 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 223
Cdd:PHA02927  119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                         170
                  ....*....|..
gi 1907067605 224 hNTWSNsPPECK 235
Cdd:PHA02927  193 -GEWSD-PPTCQ 202
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 64-235 3.33e-19

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 83.93  E-value: 3.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605  64 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 143
Cdd:PHA02927   44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605 144 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 223
Cdd:PHA02927  119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                         170
                  ....*....|..
gi 1907067605 224 hNTWSNsPPECK 235
Cdd:PHA02927  193 -GEWSD-PPTCQ 202
Sushi pfam00084
Sushi repeat (SCR repeat);
109-168 4.17e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.52  E-value: 4.17e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605 109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGddeaYWNGYPPHC 168
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDG----TWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 173-235 3.80e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 51.69  E-value: 3.80e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907067605 173 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPECK 235
Cdd:cd00033     1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNE-----GYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 173-234 1.21e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.52  E-value: 1.21e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907067605  173 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPEC 234
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDP-----GYTLIGSSTITCLENGTWSPPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 64-235 3.33e-19

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 83.93  E-value: 3.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605  64 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 143
Cdd:PHA02927   44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605 144 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 223
Cdd:PHA02927  119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                         170
                  ....*....|..
gi 1907067605 224 hNTWSNsPPECK 235
Cdd:PHA02927  193 -GEWSD-PPTCQ 202
Sushi pfam00084
Sushi repeat (SCR repeat);
109-168 4.17e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.52  E-value: 4.17e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605 109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGddeaYWNGYPPHC 168
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDG----TWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 173-235 3.80e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 51.69  E-value: 3.80e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907067605 173 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPECK 235
Cdd:cd00033     1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNE-----GYTLVGSSTITCTENGGWSPPPPTCE 57
PHA02639 PHA02639
EEV host range protein; Provisional
 103-235 1.23e-08

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 54.67  E-value: 1.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605 103 GCIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVlKGDDEAYWNGYPPHCEKIYCLPPPKIKNG 182
Cdd:PHA02639   16 GVKSIYCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCI-KDKNNAIWSNKAPFCMLKECNDPPSIING 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907067605 183 ThTLTDINVFKYHEAVSYSCDPTPGPdKFSLVGTSMIFCAGHNTWSNSPPECK 235
Cdd:PHA02639   95 K-IYNKREMYKVGDEIYYVCNEHKGV-QYSLVGNEKITCIQDKSWKPDPPICK 145
Sushi pfam00084
Sushi repeat (SCR repeat);
173-234 3.68e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.65  E-value: 3.68e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907067605 173 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPTpgpdkFSLVGTSMIFCAGHNTWSNSPPEC 234
Cdd:pfam00084   1 CPPPPDIPNGKVSATK-NEYNYGASVSYECDPG-----YRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 109-169 4.23e-08

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 48.61  E-value: 4.23e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907067605 109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDdeayWNGYPPHCE 169
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG----WSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 173-234 1.21e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.52  E-value: 1.21e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907067605  173 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPEC 234
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDP-----GYTLIGSSTITCLENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 109-168 6.53e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 45.21  E-value: 6.53e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605  109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDdeayWNGYPPHC 168
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT----WSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 104-234 3.21e-06

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.86  E-value: 3.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605 104 CIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEG-----YYVVGMSVLHCvlkgDDEAYWNGYPPHCEKIYClPPPK 178
Cdd:PHA02817   19 CDLNKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIIC----EKDGKWNKEFPVCKIIRC-RFPA 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907067605 179 IKNG-THTLTDINVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPEC 234
Cdd:PHA02817   94 LQNGfVNGIPDSKKFYYESEVSFSCKP-----GFVLIGTKYSVCGINSSWIPKVPIC 145
PHA02639 PHA02639
EEV host range protein; Provisional
 64-234 2.82e-05

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 44.27  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605  64 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNHTWVPISDAGCIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCME---- 139
Cdd:PHA02639   40 YEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAIWSNKAPFCMLKECNDPPSIINGKIYNKREMYKVGDEIYYVCNEhkgv 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605 140 GYYVVGMSVLHCVlkgdDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDINVFKYHEAVSYSCDptpgpDKFSLVGTSMI 219
Cdd:PHA02639  120 QYSLVGNEKITCI----QDKSWKPDPPICKMINCRFPALQNGYINGIPSNKKFYYKTRVGFSCK-----SGFDLVGEKYS 190

                         170
                  ....*....|....*
gi 1907067605 220 FCAGHNTWSNSPPEC 234
Cdd:PHA02639  191 TCNINATWFPSIPTC 205
PHA02831 PHA02831
EEV host range protein; Provisional
 64-234 7.58e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 39.98  E-value: 7.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605  64 YAVGEKIEYKCKKGYlylspYLMIATCEpNHTWVpiSDAGCI-KVQCtmlQDPSF---GKVYYIDGSFSWGARAKFTC-- 137
Cdd:PHA02831   40 YEENENLEYKCNNNF-----DKVFVTCN-NGSWS--TKNMCIgKRNC---KDPVTilnGYIKNKKDQYSFGDSVTYACkv 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605 138 --MEGYYVVGMSVLHCVlkgddEAYWNGYPPHCEKIYClPPPKIKNGThtltdINVFK----YHEAVSYSCDptpgpDKF 211
Cdd:PHA02831  109 nkLEKYSIVGNETVKCI-----NKQWVPKYPVCKLIRC-KYPALQNGF-----LNVFEkkfyYGDIVNFKCK-----KGF 172

                         170       180
                  ....*....|....*....|...
gi 1907067605 212 SLVGTSMIFCAGHNTWSNSPPEC 234
Cdd:PHA02831  173 ILLGSSVSTCDINSIWYPGIPKC 195
PHA02817 PHA02817
EEV Host range protein; Provisional
 168-249 8.09e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 39.54  E-value: 8.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067605 168 CEKIYCLPPPKIKNGtHTLTDINVFKYHEAVSYSCDPTPGPDKFSLVGTSMIFCAGHNTWSNSPPECKG-RWSSLAIRNG 246
Cdd:PHA02817   19 CDLNKCCYPPSIKNG-YIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEKNIICEKDGKWNKEFPVCKIiRCRFPALQNG 97


                  ...
gi 1907067605 247 RVD 249
Cdd:PHA02817   98 FVN 100
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 45-98 1.02e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.29  E-value: 1.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907067605  45 CELPRPFEAMELKGTpKLFYAVGEKIEYKCKKGYLYLSPylMIATCEPNHTWVP 98
Cdd:cd00033     1 CPPPPVPENGTVTGS-KGSYSYGSTVTYSCNEGYTLVGS--STITCTENGGWSP 51
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 45-98 6.09e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 34.42  E-value: 6.09e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907067605   45 CELPRPFEAMELKGTPKLFYaVGEKIEYKCKKGYLYLSPYlmIATCEPNHTWVP 98
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYS-YGDTVTYSCDPGYTLIGSS--TITCLENGTWSP 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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