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Conserved domains on  [gi|1907203005|ref|XP_036017748|]
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plexin-A3 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 595-1138 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


:

Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 927.37  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  595 QIPFLDYRTYAVRVLFPGIEAHPVLKELDTPP-------NVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVA 667
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVtndgrrtNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  668 SLTMVALQSRLDYATGLLKQLLADLIEKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQ 747
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVESKN-PKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQ 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  748 QMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPK 827
Cdd:pfam08337  160 QVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQRPS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  828 AEDMDLEWRQGRMARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPkqvsaynmansftftrslsryesllraa 907
Cdd:pfam08337  240 IDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP---------------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  908 sspdslrsrapmltpdqeagtKLWHLVRNHDHTDHREG-DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHrgS 986
Cdd:pfam08337  292 ---------------------KYWHLVKPSDEGDQRKKsERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPN--S 348

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  987 ALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEH 1066
Cdd:pfam08337  349 ALPLAVKYLFDFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEH 428

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907203005 1067 RLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTK 1138
Cdd:pfam08337  429 RLGKDSPSNKLLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 325-425 9.51e-44

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238586  Cd Length: 99  Bit Score: 153.73  E-value: 9.51e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  325 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTnTCQVINDTAMLCKAPGIFLGhPQPRAQGEHPDEFG 404
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKT-SCKVRNSTLMTCPAPSLALL-NRSPEPGERPVEFG 78

                           90       100
                   ....*....|....*....|.
gi 1907203005  405 FLLDHVQAARSLNRSSFTYYP 425
Cdd:cd01181     79 LDGDNVQSLLILNRTSFSYYP 99
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 142-236 1.04e-33

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 124.74  E-value: 1.04e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  142 PRITQIHPLTGPKEGGTRVTIVGENLGL--TSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPsPPPGPAELCVGD 219
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLrkNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNP-VFNGPVEVTVGH 79

                           90
                   ....*....|....*..
gi 1907203005  220 CSadFRTQSQQLYSFVT 236
Cdd:cd01180     80 GS--FRTESSEGFSFVD 94
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 2-86 1.78e-29

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


:

Pssm-ID: 465619  Cd Length: 94  Bit Score: 112.76  E-value: 1.78e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005    2 QPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEfGDTELDFSVVWDGDFPIDKPPSF 81
Cdd:pfam18020   11 REITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGSS-GELPATFYVTWNGGHRLDNPANL 89


                   ....*
gi 1907203005   82 RALLY 86
Cdd:pfam18020   90 QVVLY 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 237-323 2.66e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238584  Cd Length: 85  Bit Score: 106.15  E-value: 2.66e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  237 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGECQFVRRDAEAIVCISPVSTLgPSQSPITLAIDHANIsNTG 316
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAS-PGEAPVKVLIDGARR-LAP 78


                   ....*..
gi 1907203005  317 VIYTYTQ 323
Cdd:cd01179     79 LVFTYTE 85
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 90-139 1.99e-10

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 57.33  E-value: 1.99e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907203005   90 AQRPSCGLCLKADpRFNCGWCISEHRCQLRAHCPAPKSNWMHPSQKGARC 139
Cdd:pfam01437    3 SQYTSCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKC 51
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 427-510 4.84e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.69  E-value: 4.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  427 PSFEPLGPS-GVLDvkPGSHVVLKGKNLipaaaGSSRLNYTVLIGGQPCALT-VSDTQLLCDSPSQT--GRQPVMVLVGG 502
Cdd:cd00603      1 PVITSISPSsGPLS--GGTRLTITGSNL-----GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPAAAtpGEGPVEVTVDG 73


                   ....*...
gi 1907203005  503 LEFWLGTL 510
Cdd:cd00603     74 ANVSARVL 81
 
Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 595-1138 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 927.37  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  595 QIPFLDYRTYAVRVLFPGIEAHPVLKELDTPP-------NVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVA 667
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVtndgrrtNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  668 SLTMVALQSRLDYATGLLKQLLADLIEKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQ 747
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVESKN-PKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQ 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  748 QMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPK 827
Cdd:pfam08337  160 QVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQRPS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  828 AEDMDLEWRQGRMARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPkqvsaynmansftftrslsryesllraa 907
Cdd:pfam08337  240 IDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP---------------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  908 sspdslrsrapmltpdqeagtKLWHLVRNHDHTDHREG-DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHrgS 986
Cdd:pfam08337  292 ---------------------KYWHLVKPSDEGDQRKKsERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPN--S 348

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  987 ALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEH 1066
Cdd:pfam08337  349 ALPLAVKYLFDFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEH 428

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907203005 1067 RLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTK 1138
Cdd:pfam08337  429 RLGKDSPSNKLLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 595-1167 0e+00

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 750.41  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  595 QIPFLDYRTYAVRVLFPGIEAHPVLKEL----DTPPNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLT 670
Cdd:cd12790      1 GIPFLDYRTYAMRVLFPGIEDHPVLRELeverDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  671 MVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQME 750
Cdd:cd12790     81 MVVLQSKMEYATDILKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  751 KGPIdaitgearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncDSItqakdklldtvykgipysqrpkaed 830
Cdd:cd12790    161 KGPI------------------------------------------------DAI------------------------- 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  831 mdlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraassp 910
Cdd:cd12790        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  911 dslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPL 990
Cdd:cd12790    168 ---------------------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPL 208

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  991 AIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGK 1070
Cdd:cd12790    209 AIKYMFDFLDEQADQHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGK 288

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005 1071 DSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRD 1150
Cdd:cd12790    289 DSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEED 368

                          570
                   ....*....|....*..
gi 1907203005 1151 ASCRKHKLRQKLEQIIT 1167
Cdd:cd12790    369 EFARKQRLAYKLEQVIN 385
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 325-425 9.51e-44

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 153.73  E-value: 9.51e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  325 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTnTCQVINDTAMLCKAPGIFLGhPQPRAQGEHPDEFG 404
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKT-SCKVRNSTLMTCPAPSLALL-NRSPEPGERPVEFG 78

                           90       100
                   ....*....|....*....|.
gi 1907203005  405 FLLDHVQAARSLNRSSFTYYP 425
Cdd:cd01181     79 LDGDNVQSLLILNRTSFSYYP 99
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 142-236 1.04e-33

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 124.74  E-value: 1.04e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  142 PRITQIHPLTGPKEGGTRVTIVGENLGL--TSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPsPPPGPAELCVGD 219
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLrkNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNP-VFNGPVEVTVGH 79

                           90
                   ....*....|....*..
gi 1907203005  220 CSadFRTQSQQLYSFVT 236
Cdd:cd01180     80 GS--FRTESSEGFSFVD 94
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 2-86 1.78e-29

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 112.76  E-value: 1.78e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005    2 QPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEfGDTELDFSVVWDGDFPIDKPPSF 81
Cdd:pfam18020   11 REITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGSS-GELPATFYVTWNGGHRLDNPANL 89


                   ....*
gi 1907203005   82 RALLY 86
Cdd:pfam18020   90 QVVLY 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 237-323 2.66e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 106.15  E-value: 2.66e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  237 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGECQFVRRDAEAIVCISPVSTLgPSQSPITLAIDHANIsNTG 316
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAS-PGEAPVKVLIDGARR-LAP 78


                   ....*..
gi 1907203005  317 VIYTYTQ 323
Cdd:cd01179     79 LVFTYTE 85
IPT smart00429
ig-like, plexins, transcription factors;
237-322 2.11e-16

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 75.53  E-value: 2.11e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005   237 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGE--CQFVRRDAEAIVCISPVSTLGPSQSPI-TLAIDHANIS 313
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEapCTFSPSSSTAIVCKTPPYHNIPGSVPVrTVGLRNGGVP 81


                    ....*....
gi 1907203005   314 NTGVIYTYT 322
Cdd:smart00429   82 SSPQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
142-232 2.43e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 69.37  E-value: 2.43e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005   142 PRITQIHPLTGPKEGGTRVTIVGENLG-LTSREVGLRVAGVRCNSIPTeyvSAERIVCEMeeslvPSPPPGPAEL---CV 217
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKsISVVFVEVGVGEAPCTFSPS---SSTAIVCKT-----PPYHNIPGSVpvrTV 73

                            90
                    ....*....|....*
gi 1907203005   218 GDCSADFRTQSQQLY 232
Cdd:smart00429   74 GLRNGGVPSSPQPFT 88
IPT smart00429
ig-like, plexins, transcription factors;
324-424 1.27e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 67.45  E-value: 1.27e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005   324 DPTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIEttntCQVIND--TAMLCKAPgiflghPQPRAQGEHP- 400
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP----CTFSPSssTAIVCKTP------PYHNIPGSVPv 70

                            90       100
                    ....*....|....*....|....
gi 1907203005   401 DEFGFLLDHVQAarslNRSSFTYY 424
Cdd:smart00429   71 RTVGLRNGGVPS----SPQPFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 142-231 3.18e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.23  E-value: 3.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  142 PRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIpteYVSAERIVCEmeeslVPSPPPGPAELCVGDCS 221
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVI---SVSSTTIVCT-----TPPGTSGLVNVSVTVGG 72

                           90
                   ....*....|
gi 1907203005  222 ADFRTQSQQL 231
Cdd:pfam01833   73 GGISSSPLTF 82
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 237-321 5.70e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 5.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  237 PTFDRVSPSRGPASGGTRLTISGISLDAGSR-VTVIIRDGECQFVRRDAEAIVCISPVSTlgPSQSPITLAIDHANISNT 315
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSdLKVTIGGTPCTVISVSSTTIVCTTPPGT--SGLVNVSVTVGGGGISSS 78


                   ....*.
gi 1907203005  316 GVIYTY 321
Cdd:pfam01833   79 PLTFTY 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 90-139 1.99e-10

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 57.33  E-value: 1.99e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907203005   90 AQRPSCGLCLKADpRFNCGWCISEHRCQLRAHCPAPKSNWMHPSQKGARC 139
Cdd:pfam01437    3 SQYTSCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKC 51
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
90-131 1.66e-09

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 54.47  E-value: 1.66e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907203005    90 AQRPSCGLCLKADPrFNCGWCISEHRCQLRAHCPAPKSNWMH 131
Cdd:smart00423    3 SKYTSCSECLLARD-PYCAWCSSQGRCTSGERCDSRRQNWLS 43
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 427-510 4.84e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.69  E-value: 4.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  427 PSFEPLGPS-GVLDvkPGSHVVLKGKNLipaaaGSSRLNYTVLIGGQPCALT-VSDTQLLCDSPSQT--GRQPVMVLVGG 502
Cdd:cd00603      1 PVITSISPSsGPLS--GGTRLTITGSNL-----GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPAAAtpGEGPVEVTVDG 73


                   ....*...
gi 1907203005  503 LEFWLGTL 510
Cdd:cd00603     74 ANVSARVL 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 443-513 1.59e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 44.36  E-value: 1.59e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907203005  443 GSHVVLKGKNLipaaaGSSRLNYTVLIGGQPCA-LTVSDTQLLCDSPSQT-GRQPVMVLVGGLEFWLGTLHIT 513
Cdd:pfam01833   16 GTTITITGSNF-----GTDSSDLKVTIGGTPCTvISVSSTTIVCTTPPGTsGLVNVSVTVGGGGISSSPLTFT 83
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 325-423 3.70e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 40.51  E-value: 3.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  325 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEpRVRAKYRGIETTNTcqVINDTAMLCKAPgiflghpqPRAQGEHPdefg 404
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSS-DLKVTIGGTPCTVI--SVSSTTIVCTTP--------PGTSGLVN---- 65

                           90
                   ....*....|....*....
gi 1907203005  405 FLLDHVQAARSLNRSSFTY 423
Cdd:pfam01833   66 VSVTVGGGGISSSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
426-496 4.54e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.48  E-value: 4.54e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907203005   426 DPSFEPLGPSGVLdVKPGSHVVLKGKNLIPAAAGSSRLNYtvliGGQPCALT-VSDTQLLCDSPSQT---GRQPV 496
Cdd:smart00429    1 DPVITRISPTSGP-VSGGTEITLCGKNLKSISVVFVEVGV----GEAPCTFSpSSSTAIVCKTPPYHnipGSVPV 70
 
Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 595-1138 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 927.37  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  595 QIPFLDYRTYAVRVLFPGIEAHPVLKELDTPP-------NVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVA 667
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPVtndgrrtNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  668 SLTMVALQSRLDYATGLLKQLLADLIEKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQ 747
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVESKN-PKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQ 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  748 QMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPK 827
Cdd:pfam08337  160 QVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQRPS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  828 AEDMDLEWRQGRMARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPkqvsaynmansftftrslsryesllraa 907
Cdd:pfam08337  240 IDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP---------------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  908 sspdslrsrapmltpdqeagtKLWHLVRNHDHTDHREG-DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHrgS 986
Cdd:pfam08337  292 ---------------------KYWHLVKPSDEGDQRKKsERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPN--S 348

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  987 ALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEH 1066
Cdd:pfam08337  349 ALPLAVKYLFDFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEH 428

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907203005 1067 RLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTK 1138
Cdd:pfam08337  429 RLGKDSPSNKLLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 595-1167 0e+00

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 750.41  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  595 QIPFLDYRTYAVRVLFPGIEAHPVLKEL----DTPPNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLT 670
Cdd:cd12790      1 GIPFLDYRTYAMRVLFPGIEDHPVLRELeverDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  671 MVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQME 750
Cdd:cd12790     81 MVVLQSKMEYATDILKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  751 KGPIdaitgearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncDSItqakdklldtvykgipysqrpkaed 830
Cdd:cd12790    161 KGPI------------------------------------------------DAI------------------------- 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  831 mdlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraassp 910
Cdd:cd12790        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  911 dslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPL 990
Cdd:cd12790    168 ---------------------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPL 208

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  991 AIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGK 1070
Cdd:cd12790    209 AIKYMFDFLDEQADQHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGK 288

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005 1071 DSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRD 1150
Cdd:cd12790    289 DSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEED 368

                          570
                   ....*....|....*..
gi 1907203005 1151 ASCRKHKLRQKLEQIIT 1167
Cdd:cd12790    369 EFARKQRLAYKLEQVIN 385
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
 595-1166 0e+00

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 546.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  595 QIPFLDYRTYAVRVLFPGIEAHPVLKELDTP----PNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLT 670
Cdd:cd12205      1 GIPFLDFREYIIRVLFPGVNDHPVLLSKFVHgsrrPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNVASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  671 MVALQSRLDYATGLLKQLLADLIEKNLeSKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQME 750
Cdd:cd12205     81 MVALQGKMEYATEILFDLLTDLIEKSV-SKKHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGEPLFLLYKALKQQIE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  751 KGPidaitgearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlnCDSItqakdklldtvykgipysqrpkaed 830
Cdd:cd12205    160 KGP------------------------------------------------VDAI------------------------- 166

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  831 mdlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraassp 910
Cdd:cd12205        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  911 dslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRgsALPL 990
Cdd:cd12205    167 ---------------------------------------KLIPEIFLTRLLSTKGTLQKFVDDLFESILSVPQR--SLPP 205

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  991 AIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGK 1070
Cdd:cd12205    206 AIKYLFDFLDEQARKHGISDPDVLHAWKTNSLPLRFWVNIIKNPDFVFDVNKTPTVDSCLSVIAQTFMDACSTSEHKLGK 285

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005 1071 DSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRD 1150
Cdd:cd12205    286 DSPSNKLLFAKDIPRYREMVANFYRDISNLPPVSDEEMNSYLAELSESHSGEFNTNVALSELYIYAVKYGDQLLEALEDD 365

                          570
                   ....*....|....*.
gi 1907203005 1151 ASCRKHKLRQKLEQII 1166
Cdd:cd12205    366 REARVQQLADKLSQVA 381
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
 596-1169 3.90e-138

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 423.96  E-value: 3.90e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  596 IPFLDYRTYAVRVLFPGIEAHP--VLKELDTP----PNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASL 669
Cdd:cd12787      2 IPFLDYKTYAERVFFPGHKDGPldVMIKLDIPeprrPTVEQGLYQLSNLLNSKLFLINFIHTLENQREFSARDRVYVASL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  670 TMVALQSRLDYATGLLKQLLADLIEKNLeSKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQM 749
Cdd:cd12787     82 LTVALHGKLEYYTDIMRTLLLDLLAQYV-VKN-PKLMLRRTETVVEKLLTNWMSICLYQFLRDSAGEPLYMLFRAIKHQV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  750 EKGPIDAITGearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncdsitqakdklldtvykgipysqrpkae 829
Cdd:cd12787    160 DKGPVDAVTG---------------------------------------------------------------------- 169

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  830 dmdlewrqgrmariilqdedittkiecdwKRvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraass 909
Cdd:cd12787    170 -----------------------------KR------------------------------------------------- 171

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  910 pdslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHrgsALP 989
Cdd:cd12787    172 ---------------------------------------AKAIPEIYLTRLLSMKGTLQKFVDDFFQSILSPGR---PVP 209

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  990 LAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLG 1069
Cdd:cd12787    210 PAVKYFFDLLDEQAEKHGIQDEDTIHIWKTNSLPLRFWVNILKNPQFIFDVHVSDNVDASLSVIAQTFMDACTRTEHKLG 289

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005 1070 KDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDR 1149
Cdd:cd12787    290 RDSPSNKLLYAREIPRYKKMVERYYADIRQMVPASDQEMNSHLAELSRNYTDSLNTLVALHELYQYIQKYYDQIINALEE 369

                          570       580
                   ....*....|....*....|
gi 1907203005 1150 DASCRKHKLRQKLEQIITLV 1169
Cdd:cd12787    370 DPAAQKMQLAFRLQQIAAAV 389
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
 596-1169 1.47e-132

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 410.54  E-value: 1.47e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  596 IPFLDYRTYAVRVLFPGI------------------------EAHPVLKELDTP----PNVEKALRLFGQLLHSRAFLLT 647
Cdd:cd12788      3 IPFLEYKHFVTRTFFPKCsslyeeryvlpsqennsqgprqvpETHPLLQEWKIPescrPNMEEGITLFSTLLNNKHFLVT 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  648 FIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNlESKNhPKLLLRRTESVAEKMLTNWFTFLLH 727
Cdd:cd12788     83 FVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDAS-ASKN-PKLMLRRTESVVEKMLTNWMSICMY 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  728 KFLKECAGEPLFLLYCAIKQQMEKGPIDAITgearyslsedklirqqidyktltlhcvcpesegsaqvpvKVLncdsitq 807
Cdd:cd12788    161 SYLRETVGEPFFLLLCAIKQQINKGSIDAIK---------------------------------------KVL------- 194

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  808 akdklldtvykgipysqrpkaedmdlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynm 887
Cdd:cd12788        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  888 ansftftrslsryesllraasspdslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgskmvSEIYLTRLLATKGTL 967
Cdd:cd12788    195 -----------------------------------------------------------------PEIYLTRLLSTKGTL 209

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  968 QKFVDDLFETVFSTahRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITD 1047
Cdd:cd12788    210 QKFLDDLFQAILSI--PEDRPPLAVKYFFDFLEEQAEKRGITDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHMD 287

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005 1048 ACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLS 1127
Cdd:cd12788    288 ACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYQQIQEMPPLSEQEMNAHLAEESRKYRNEFNTNV 367

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|..
gi 1907203005 1128 ALSELYFYVTKYRQEILTSLDRDASCRKHKLRQKLEQIITLV 1169
Cdd:cd12788    368 AMAEIYKYAKRYRAQIVSALESNPTARRTQLQHKFEQVIALM 409
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 596-1171 5.41e-132

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 407.88  E-value: 5.41e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  596 IPFLDYRTYAVRVLFPGIEAHPVLKELDTP----PNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLTM 671
Cdd:cd12793      2 IPFLDYRMYAERIFFPGHRESPLRRDLDVPecrrQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLLT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  672 VALQSRLDYATGLLKQLLADLIEKNLeSKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEK 751
Cdd:cd12793     82 VALHGKLEYFTDILKTLLNDLVEQYV-AKN-PKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDK 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  752 GPIDAITGEARyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncdsitqakdklldtvykgipysqrpkaedm 831
Cdd:cd12793    160 GPVDAVTGKER--------------------------------------------------------------------- 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  832 dlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraasspd 911
Cdd:cd12793        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  912 slrsrapmltpdqeagtklwhlvrnhdhtdhregdrgSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHrgsALPLA 991
Cdd:cd12793    171 -------------------------------------AKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSR---PVPLA 210

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  992 IKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKD 1071
Cdd:cd12793    211 VKYFFDLLDEQALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRD 290

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005 1072 SPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRDA 1151
Cdd:cd12793    291 SPINKLLYARDIPRYKQMVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDS 370

                          570       580
                   ....*....|....*....|
gi 1907203005 1152 SCRKHKLRQKLEQIITLVSS 1171
Cdd:cd12793    371 TAQKMQLGYRLQQIAAAVEN 390
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 596-1169 8.70e-130

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 402.30  E-value: 8.70e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  596 IPFLDYRTYAVRVLFPGIEAHPVLKELDTP------PNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASL 669
Cdd:cd12791      2 IPFLDYRTYAERVFFPGHGGCPLQPSLEGDgeegrrATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  670 TMVALQSRLDYATGLLKQLLADLIEKNLeSKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQM 749
Cdd:cd12791     82 LSLALHGKLEYLTDIMKTLLGDLAAHYV-HKN-PKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKYQV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  750 EKGPIDAITGEaryslsedklirqqidyktltlhcvcpesegsaqvpvkvlncdsitqakdklldtvykgipysqrpkae 829
Cdd:cd12791    160 DKGPVDAVTGK--------------------------------------------------------------------- 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  830 dmdlewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraass 909
Cdd:cd12791        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  910 pdslRSRApmltpdqeagtklwhlvrnhdhtdhregdrgsKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTahrGSALP 989
Cdd:cd12791    171 ----RERA--------------------------------KAIPEIYLTRLLSMKGTLQKFVDDTFQAILSV---NRPVP 211

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  990 LAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLG 1069
Cdd:cd12791    212 IAVKYLFDFLDELAEKHGIEDPETLHIWKTNSLLLRFWVNTLKNPQFIFDVRVSDNVDAILAVIAQTFIDSCTISEHKVG 291

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005 1070 KDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDR 1149
Cdd:cd12791    292 RDSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALTELSGNYTSAPHCLVALQELYNHIHRYYDQIISALEE 371

                          570       580
                   ....*....|....*....|
gi 1907203005 1150 DASCRKHKLRQKLEQIITLV 1169
Cdd:cd12791    372 DPVGQKMQLACRLQQIAALV 391
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
 595-1165 3.73e-124

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 387.44  E-value: 3.73e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  595 QIPFLDYRTYAVRVLF----PGIEAHPVLKELDTP----PNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTV 666
Cdd:cd12792      1 RIPFLDYKTYTDRVFFlpskDGANDVMITGKLDIPearrATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  667 ASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNhPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIK 746
Cdd:cd12792     81 ASLLTVALHGKLEYYTDIMRTLLLELMEQYVHSKN-PKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIK 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  747 QQMEKGPIDAitgearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncdsitqakdklldtvykgipysqrp 826
Cdd:cd12792    160 HQVEKGPVDA---------------------------------------------------------------------- 169

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  827 kaedmdlewRQGRMARiilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllra 906
Cdd:cd12792    170 ---------VQKKKER---------------------------------------------------------------- 176

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  907 asspdslrsrapmltpdqeagtklwhlvrnhdhtdhregdrgSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTahrGS 986
Cdd:cd12792    177 ------------------------------------------TKAITEIYLTRLLSVKGTLQQFVDNFFRSVLCS---GA 211

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  987 ALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEH 1066
Cdd:cd12792    212 VVPPAVKYFFDFLDEQAEKHDIVDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTEH 291

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005 1067 RLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTS 1146
Cdd:cd12792    292 KLSRDSPSNKLLYAKEISTYKKMVDDYYKGIRQMVPVSDQDMNTHLAEISRAHTDKLNTQVALHQLYQYASKYYDEIINS 371

                          570
                   ....*....|....*....
gi 1907203005 1147 LDRDASCRKHKLRQKLEQI 1165
Cdd:cd12792    372 LEEDPAAQSKQLTLRLQQI 390
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
 596-1169 6.89e-99

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 319.89  E-value: 6.89e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  596 IPFLDYRTYAVRVLFPGIEAHPVLKELDTPPN-----VEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLT 670
Cdd:cd12789      4 VPFLDYKHFALRTFFPESGGFTHIFTRDDPHDrdqtdKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLFASFL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  671 MVALQSRLDYATGLLKQLLADLIEKNleSKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQME 750
Cdd:cd12789     84 TIALQTKLVYLTEILEVLTKDLMDQS--SNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKIN 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  751 KGPIDAItgearyslsedklirqqidyktltlhcvcpesegsaqvpvkvlncdsitqakdklldtvykgipysqRPKAED 830
Cdd:cd12789    162 KGPVDVI-------------------------------------------------------------------KFKVKE 174

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  831 MDLewrqgrmariilqdedittkiecdwkrvnslahyqvtdgslvalvpkqvsaynmansftftrslsryesllraassp 910
Cdd:cd12789    175 MYL----------------------------------------------------------------------------- 177

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  911 dslrsrapmltpdqeagTKLwhlvrnhdhtdhregdrgskmvseiyltrlLATKGTLQKFVDDLFETVFSTAHrgSALPL 990
Cdd:cd12789    178 -----------------TKL------------------------------LSTKVAIHSVVEKLFRSIWSLPN--NKAPV 208

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  991 AIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGK 1070
Cdd:cd12789    209 AIKYFFDFLDAQAENKKITDPDVLHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHLDGCLSVIAQAFMDSFSLSEQHLGK 288

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005 1071 DSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRD 1150
Cdd:cd12789    289 EAPTNKLLYAKDIPQYKEEVKSYYKAIRDLPPLSSSELEEFLTQESKKHENEFNEEVALMEIYKYIVKYFDEILNKLERE 368

                          570
                   ....*....|....*....
gi 1907203005 1151 ASCRkhKLRQKLEQIITLV 1169
Cdd:cd12789    369 RGLE--EVQKQLLHVKALF 385
Plexin_RBD pfam20170
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ...
 765-877 5.31e-61

Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.


Pssm-ID: 466321  Cd Length: 113  Bit Score: 203.58  E-value: 5.31e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  765 LSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMARII 844
Cdd:pfam20170    1 LSEDKLLREQIDYKTLTLNVIFEEGEVSESVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHGRGGRLI 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1907203005  845 LQDEDITTKIECDWKRVNSLAHYQVTDGSLVAL 877
Cdd:pfam20170   81 LQDEDSTSKVEGGWKKLNTLAHYKVPDGATLAL 113
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 325-425 9.51e-44

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 153.73  E-value: 9.51e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  325 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTnTCQVINDTAMLCKAPGIFLGhPQPRAQGEHPDEFG 404
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKT-SCKVRNSTLMTCPAPSLALL-NRSPEPGERPVEFG 78

                           90       100
                   ....*....|....*....|.
gi 1907203005  405 FLLDHVQAARSLNRSSFTYYP 425
Cdd:cd01181     79 LDGDNVQSLLILNRTSFSYYP 99
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 142-236 1.04e-33

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 124.74  E-value: 1.04e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  142 PRITQIHPLTGPKEGGTRVTIVGENLGL--TSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPsPPPGPAELCVGD 219
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLrkNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNP-VFNGPVEVTVGH 79

                           90
                   ....*....|....*..
gi 1907203005  220 CSadFRTQSQQLYSFVT 236
Cdd:cd01180     80 GS--FRTESSEGFSFVD 94
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 2-86 1.78e-29

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 112.76  E-value: 1.78e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005    2 QPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEfGDTELDFSVVWDGDFPIDKPPSF 81
Cdd:pfam18020   11 REITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDSITCQEHQFSYSGSS-GELPATFYVTWNGGHRLDNPANL 89


                   ....*
gi 1907203005   82 RALLY 86
Cdd:pfam18020   90 QVVLY 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 237-323 2.66e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 106.15  E-value: 2.66e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  237 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGECQFVRRDAEAIVCISPVSTLgPSQSPITLAIDHANIsNTG 316
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAS-PGEAPVKVLIDGARR-LAP 78


                   ....*..
gi 1907203005  317 VIYTYTQ 323
Cdd:cd01179     79 LVFTYTE 85
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 142-235 5.29e-22

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 91.36  E-value: 5.29e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  142 PRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIPteyVSAERIVCEMEESlvPSPPPGPAELCVGDCS 221
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLN---VSSTEIVCRTPAA--ATPGEGPVEVTVDGAN 75

                           90
                   ....*....|....
gi 1907203005  222 ADFRTQSQQLYSFV 235
Cdd:cd00603     76 VSARVLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 237-323 6.45e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.81  E-value: 6.45e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  237 PTFDRVSPSRGPASGGTRLTISGISLDAGS-RVTVIIRDGECQFVRRDAEAIVCISPVSTLGPSQsPITLAIDHANIS-- 313
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSpRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEG-PVEVTVDGANVSar 79

                           90
                   ....*....|.
gi 1907203005  314 -NTGVIYTYTQ 323
Cdd:cd00603     80 vLSNTTFTYVE 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 237-323 1.20e-16

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 75.96  E-value: 1.20e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  237 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDG-ECQFVRRDAEAIVC-ISPVSTLGPSQSPITLAIDHANISN 314
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGvPCSVLSVSSTAIVCtTPPYANPGPGPVEVTVDRGNGGITS 80


                   ....*....
gi 1907203005  315 TGVIYTYTQ 323
Cdd:cd00102     81 SPLTFTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
237-322 2.11e-16

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 75.53  E-value: 2.11e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005   237 PTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGE--CQFVRRDAEAIVCISPVSTLGPSQSPI-TLAIDHANIS 313
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEapCTFSPSSSTAIVCKTPPYHNIPGSVPVrTVGLRNGGVP 81


                    ....*....
gi 1907203005   314 NTGVIYTYT 322
Cdd:smart00429   82 SSPQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
142-232 2.43e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 69.37  E-value: 2.43e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005   142 PRITQIHPLTGPKEGGTRVTIVGENLG-LTSREVGLRVAGVRCNSIPTeyvSAERIVCEMeeslvPSPPPGPAEL---CV 217
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKsISVVFVEVGVGEAPCTFSPS---SSTAIVCKT-----PPYHNIPGSVpvrTV 73

                            90
                    ....*....|....*
gi 1907203005   218 GDCSADFRTQSQQLY 232
Cdd:smart00429   74 GLRNGGVPSSPQPFT 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 142-236 2.66e-14

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 69.41  E-value: 2.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  142 PRITQIHPLTGPKEGGTRVTIVGENLGLTSRevgLRV---AGVRCNSIPteyVSAERIVCEMEESlvPSPPPGPAELCVG 218
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN---LRVtfgGGVPCSVLS---VSSTAIVCTTPPY--ANPGPGPVEVTVD 72

                           90
                   ....*....|....*...
gi 1907203005  219 DCSaDFRTQSQQLYSFVT 236
Cdd:cd00102     73 RGN-GGITSSPLTFTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
324-424 1.27e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 67.45  E-value: 1.27e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005   324 DPTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIEttntCQVIND--TAMLCKAPgiflghPQPRAQGEHP- 400
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP----CTFSPSssTAIVCKTP------PYHNIPGSVPv 70

                            90       100
                    ....*....|....*....|....
gi 1907203005   401 DEFGFLLDHVQAarslNRSSFTYY 424
Cdd:smart00429   71 RTVGLRNGGVPS----SPQPFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 142-231 3.18e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.23  E-value: 3.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  142 PRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIpteYVSAERIVCEmeeslVPSPPPGPAELCVGDCS 221
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVI---SVSSTTIVCT-----TPPGTSGLVNVSVTVGG 72

                           90
                   ....*....|
gi 1907203005  222 ADFRTQSQQL 231
Cdd:pfam01833   73 GGISSSPLTF 82
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 325-425 1.12e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 62.09  E-value: 1.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  325 PTVTHLEPTWSIINGSTSITVSGTHLLTVQePRVRAKYRGIettnTCQVI--NDTAMLCKAPgiflGHPQPraqGEHPDE 402
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGS-PRVRVTVGGV----PCKVLnvSSTEIVCRTP----AAATP---GEGPVE 68

                           90       100
                   ....*....|....*....|...
gi 1907203005  403 FGFLLDHVQaARSLNRSSFTYYP 425
Cdd:cd00603     69 VTVDGANVS-ARVLSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 237-321 5.70e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 5.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  237 PTFDRVSPSRGPASGGTRLTISGISLDAGSR-VTVIIRDGECQFVRRDAEAIVCISPVSTlgPSQSPITLAIDHANISNT 315
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSdLKVTIGGTPCTVISVSSTTIVCTTPPGT--SGLVNVSVTVGGGGISSS 78


                   ....*.
gi 1907203005  316 GVIYTY 321
Cdd:pfam01833   79 PLTFTY 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 90-139 1.99e-10

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 57.33  E-value: 1.99e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907203005   90 AQRPSCGLCLKADpRFNCGWCISEHRCQLRAHCPAPKSNWMHPSQKGARC 139
Cdd:pfam01437    3 SQYTSCSSCLAAR-DPYCGWCSSEGRCVRRSACGAPEGNCEEWEQASSKC 51
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
90-131 1.66e-09

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 54.47  E-value: 1.66e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907203005    90 AQRPSCGLCLKADPrFNCGWCISEHRCQLRAHCPAPKSNWMH 131
Cdd:smart00423    3 SKYTSCSECLLARD-PYCAWCSSQGRCTSGERCDSRRQNWLS 43
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 943-1098 9.03e-09

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 57.89  E-value: 9.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  943 REGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRgsaLPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCL 1022
Cdd:cd04519    104 ESKESCEIDTKLPVGEDLEENLENLLELVNKLVDRILSSLDR---LPPELRYVFKILREFLAERFPEEPDEAYQAVSGFL 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005 1023 PLRFWVNVIKNPQFvFDIHKNSITD---ACLSVVAQTFMDSCSTSEhrlgkdsPSNKLLYAKD----IPNYKSWVERYYR 1095
Cdd:cd04519    181 FLRFICPAIVSPEL-FGLVPDEPSEqarRNLTLISKVLQSLANGVE-------FGDKEPFMKPlndfIKSNKPKLKQFLD 252


                   ...
gi 1907203005 1096 DIA 1098
Cdd:cd04519    253 ELS 255
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 325-425 3.21e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 52.08  E-value: 3.21e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  325 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRakyrgIETTNTCQVI--NDTAMLCKAPGIFLGHPQPRAqgehpde 402
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVT-----FGGGVPCSVLsvSSTAIVCTTPPYANPGPGPVE------- 68

                           90       100
                   ....*....|....*....|...
gi 1907203005  403 fgFLLDHVQAARSLNRSSFTYYP 425
Cdd:cd00102     69 --VTVDRGNGGITSSPLTFTYVP 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 427-510 4.84e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.69  E-value: 4.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  427 PSFEPLGPS-GVLDvkPGSHVVLKGKNLipaaaGSSRLNYTVLIGGQPCALT-VSDTQLLCDSPSQT--GRQPVMVLVGG 502
Cdd:cd00603      1 PVITSISPSsGPLS--GGTRLTITGSNL-----GSGSPRVRVTVGGVPCKVLnVSSTEIVCRTPAAAtpGEGPVEVTVDG 73


                   ....*...
gi 1907203005  503 LEFWLGTL 510
Cdd:cd00603     74 ANVSARVL 81
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 428-502 6.53e-06

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 45.29  E-value: 6.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  428 SFEPL-GP-SGvldvkpGSHVVLKGKNLipaAAGSSRlnyTVLIGGQPCALT-VSDTQLLCDSPSQT--GRQPVMVLVGG 502
Cdd:cd01179      5 SLSPSyGPqSG------GTRLTITGKHL---NAGSSV---RVTVGGQPCKILsVSSSQIVCLTPPSAspGEAPVKVLIDG 72
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 443-513 1.59e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 44.36  E-value: 1.59e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907203005  443 GSHVVLKGKNLipaaaGSSRLNYTVLIGGQPCA-LTVSDTQLLCDSPSQT-GRQPVMVLVGGLEFWLGTLHIT 513
Cdd:pfam01833   16 GTTITITGSNF-----GTDSSDLKVTIGGTPCTvISVSSTTIVCTTPPGTsGLVNVSVTVGGGGISSSPLTFT 83
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 237-309 3.46e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 43.46  E-value: 3.46e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907203005  237 PTFDRVSPSRGPASGGTRLTISGISLD---AGSRVTVIIRDGECQFVR---RDAEAIVCISPVSTLGPSQSPITLAIDH 309
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGlrkNDVRHGVRVGGVPCNPEPpeySSSEKIVCTTGPAGNPVFNGPVEVTVGH 79
RasGAP_RASA3 cd05134
Ras-GTPase Activating Domain of RASA3; RASA3 (or GAP1_IP4BP) is a member of the GAP1 family ...
 964-1099 4.24e-05

Ras-GTPase Activating Domain of RASA3; RASA3 (or GAP1_IP4BP) is a member of the GAP1 family and has been shown to specifically bind 1,3,4,5-tetrakisphosphate (IP4). Thus, RASA3 may function as an IP4 receptor. The members of GAP1 family are characterized by a conserved domain structure comprising N-terminal tandem C2 domains, a highly conserved central RasGAP domain, and a C-terminal pleckstrin-homology domain that is associated with a Bruton's tyrosine kinase motif. Purified RASA3 stimulates GAP activity on Ras with about a five-fold lower potency than p120RasGAP, but shows no GAP-stimulating activity at all against Rac or Rab3A.


Pssm-ID: 213336  Cd Length: 269  Bit Score: 46.56  E-value: 4.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  964 KGTLQKFVDDLFETVFSTahrGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQfVFDI--- 1040
Cdd:cd05134    131 RENLRQYVDRIFRVITKS---GVSCPTVMCDIFFSLRESAAKRFQVDPDVRYTAVSSFIFLRFFAPAILSPN-LFQLtph 206

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907203005 1041 HKNSITDACLSVVAQTFMDSCSTSEHRlgkdSPSNKLLYAKDIpnYKSWVERYYRDIAK 1099
Cdd:cd05134    207 HPDPQTSRTLTLISKTIQTLGSLSKSK----SANFKESYMAAF--YDYFNEQKYADAVK 259
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 325-423 3.70e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 40.51  E-value: 3.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907203005  325 PTVTHLEPTWSIINGSTSITVSGTHLLTVQEpRVRAKYRGIETTNTcqVINDTAMLCKAPgiflghpqPRAQGEHPdefg 404
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSS-DLKVTIGGTPCTVI--SVSSTTIVCTTP--------PGTSGLVN---- 65

                           90
                   ....*....|....*....
gi 1907203005  405 FLLDHVQAARSLNRSSFTY 423
Cdd:pfam01833   66 VSVTVGGGGISSSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
426-496 4.54e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.48  E-value: 4.54e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907203005   426 DPSFEPLGPSGVLdVKPGSHVVLKGKNLIPAAAGSSRLNYtvliGGQPCALT-VSDTQLLCDSPSQT---GRQPV 496
Cdd:smart00429    1 DPVITRISPTSGP-VSGGTEITLCGKNLKSISVVFVEVGV----GEAPCTFSpSSSTAIVCKTPPYHnipGSVPV 70
RasGAP_GAP1_like cd05128
Ras-GTPase Activating Domain of GAP1 and similar proteins; The GAP1 family of Ras ...
 964-1035 2.24e-03

Ras-GTPase Activating Domain of GAP1 and similar proteins; The GAP1 family of Ras GTPase-activating proteins includes GAP1(m) (or RASA2), GAP1_IP4BP (or RASA3), Ca2+ -promoted Ras inactivator (CAPRI, or RASAL4), and Ras GTPase activating-like proteins (RASAL) or RASAL1. The members are characterized by a conserved domain structure comprising N-terminal tandem C2 domains, a highly conserved central RasGAP domain, and a C-terminal pleckstrin homology domain that is associated with a Bruton's tyrosine kinase motif. While this domain structure is conserved, a small change in the function of each individual domain and the interaction between domains has a marked effect on the regulation of each protein.


Pssm-ID: 213330  Cd Length: 269  Bit Score: 41.47  E-value: 2.24e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907203005  964 KGTLQKFVDDLFETVFSTAHRgsaLPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQ 1035
Cdd:cd05128    131 LANLRGYVERVFKAITSSARR---CPTLMCEIFSDLRESAAQRFPDNEDVPYTAVSGFIFLRFFAPAILNPK 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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