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Conserved domains on  [gi|1907137313|ref|XP_036016112|]
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inactive serine protease PAMR1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 128-234 9.44e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 123.29  E-value: 9.44e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137313 128 CGQVLRASKGQILL-----ESYPLNAHCEWTIHARPGFIIQLRFGMLSLEFDYMCQYDYVEVRDGDNSDSPIIKRFCGNE 202
Cdd:cd00041     1 CGGTLTASTSGTISspnypNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907137313 203 RPAPIRSTGSSLHVLFHSDGSKNFDGFHAVFE 234
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 280-342 6.22e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 51.69  E-value: 6.22e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907137313 280 CSDLGGPVNGYKKITEGPgllnerhVKIGTVVSFFCNGSYVLSGNEKRTCQQNGEWSGKQPVC 342
Cdd:cd00033     1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 240-272 1.17e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.17e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907137313 240 SSSPCFHDGTCLlDTTGSFKCACLAGYTGQRCE 272
Cdd:cd00054     7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 128-234 9.44e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 123.29  E-value: 9.44e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137313 128 CGQVLRASKGQILL-----ESYPLNAHCEWTIHARPGFIIQLRFGMLSLEFDYMCQYDYVEVRDGDNSDSPIIKRFCGNE 202
Cdd:cd00041     1 CGGTLTASTSGTISspnypNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907137313 203 RPAPIRSTGSSLHVLFHSDGSKNFDGFHAVFE 234
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
128-233 1.78e-30

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 112.00  E-value: 1.78e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137313 128 CGQVLRASKGQILL----ESYPLNAHCEWTIHARPGFIIQLRFGMLSLEFDYMCQYDYVEVRDGDNSDSPIIKRFCGNER 203
Cdd:pfam00431   1 CGGVLTDSSGSISSpnypNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1907137313 204 PAPIRSTGSSLHVLFHSDGSKNFDGFHAVF 233
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 142-233 2.60e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 108.63  E-value: 2.60e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137313  142 ESYPLNAHCEWTIHARPGFIIQLRFGMLSLEFDYMCQYDYVEVRDGDNSDSPIIKRFCGNERPAP-IRSTGSSLHVLFHS 220
Cdd:smart00042  10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNSLTLTFVS 89

                           90
                   ....*....|...
gi 1907137313  221 DGSKNFDGFHAVF 233
Cdd:smart00042  90 DSSVQKRGFSARY 102
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 280-342 6.22e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 51.69  E-value: 6.22e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907137313 280 CSDLGGPVNGYKKITEGPgllnerhVKIGTVVSFFCNGSYVLSGNEKRTCQQNGEWSGKQPVC 342
Cdd:cd00033     1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 280-342 1.49e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.60  E-value: 1.49e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907137313  280 CSDLGGPVNGYKKITEGPgllnerhVKIGTVVSFFCNGSYVLSGNEKRTCQQNGEWSGKQPVC 342
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT-------YSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
307-342 5.88e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.65  E-value: 5.88e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907137313 307 IGTVVSFFCNGSYVLSGNEKRTCQQNGEWSGKQPVC 342
Cdd:pfam00084  21 YGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 240-272 1.17e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.17e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907137313 240 SSSPCFHDGTCLlDTTGSFKCACLAGYTGQRCE 272
Cdd:cd00054     7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
PHA02639 PHA02639
EEV host range protein; Provisional
 306-347 2.06e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 39.65  E-value: 2.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907137313 306 KIGTVVSFFCNGSYVLSGNEKRTC---QQNGEWSGKQPVCMKDRC 347
Cdd:PHA02639   41 EIGKLIEYTCNTDYALIGDRFRTCikdKNNAIWSNKAPFCMLKEC 85
EGF_CA smart00179
Calcium-binding EGF-like domain;
240-272 4.61e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.53  E-value: 4.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907137313  240 SSSPCFHDGTCLlDTTGSFKCACLAGYT-GQRCE 272
Cdd:smart00179   7 SGNPCQNGGTCV-NTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 239-270 9.42e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 33.51  E-value: 9.42e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907137313 239 CSSSPCFHDGTClLDTTGSFKCACLAGYTGQR 270
Cdd:pfam00008   1 CAPNPCSNGGTC-VDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 128-234 9.44e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 123.29  E-value: 9.44e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137313 128 CGQVLRASKGQILL-----ESYPLNAHCEWTIHARPGFIIQLRFGMLSLEFDYMCQYDYVEVRDGDNSDSPIIKRFCGNE 202
Cdd:cd00041     1 CGGTLTASTSGTISspnypNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907137313 203 RPAPIRSTGSSLHVLFHSDGSKNFDGFHAVFE 234
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
128-233 1.78e-30

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 112.00  E-value: 1.78e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137313 128 CGQVLRASKGQILL----ESYPLNAHCEWTIHARPGFIIQLRFGMLSLEFDYMCQYDYVEVRDGDNSDSPIIKRFCGNER 203
Cdd:pfam00431   1 CGGVLTDSSGSISSpnypNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1907137313 204 PAPIRSTGSSLHVLFHSDGSKNFDGFHAVF 233
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 142-233 2.60e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 108.63  E-value: 2.60e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137313  142 ESYPLNAHCEWTIHARPGFIIQLRFGMLSLEFDYMCQYDYVEVRDGDNSDSPIIKRFCGNERPAP-IRSTGSSLHVLFHS 220
Cdd:smart00042  10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNSLTLTFVS 89

                           90
                   ....*....|...
gi 1907137313  221 DGSKNFDGFHAVF 233
Cdd:smart00042  90 DSSVQKRGFSARY 102
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 280-342 6.22e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 51.69  E-value: 6.22e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907137313 280 CSDLGGPVNGYKKITEGPgllnerhVKIGTVVSFFCNGSYVLSGNEKRTCQQNGEWSGKQPVC 342
Cdd:cd00033     1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 280-342 1.49e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.60  E-value: 1.49e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907137313  280 CSDLGGPVNGYKKITEGPgllnerhVKIGTVVSFFCNGSYVLSGNEKRTCQQNGEWSGKQPVC 342
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT-------YSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
307-342 5.88e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.65  E-value: 5.88e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907137313 307 IGTVVSFFCNGSYVLSGNEKRTCQQNGEWSGKQPVC 342
Cdd:pfam00084  21 YGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 240-272 1.17e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.17e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907137313 240 SSSPCFHDGTCLlDTTGSFKCACLAGYTGQRCE 272
Cdd:cd00054     7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
PHA02639 PHA02639
EEV host range protein; Provisional
 306-347 2.06e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 39.65  E-value: 2.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907137313 306 KIGTVVSFFCNGSYVLSGNEKRTC---QQNGEWSGKQPVCMKDRC 347
Cdd:PHA02639   41 EIGKLIEYTCNTDYALIGDRFRTCikdKNNAIWSNKAPFCMLKEC 85
EGF_CA smart00179
Calcium-binding EGF-like domain;
240-272 4.61e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.53  E-value: 4.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907137313  240 SSSPCFHDGTCLlDTTGSFKCACLAGYT-GQRCE 272
Cdd:smart00179   7 SGNPCQNGGTCV-NTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 239-270 9.42e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 33.51  E-value: 9.42e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907137313 239 CSSSPCFHDGTClLDTTGSFKCACLAGYTGQR 270
Cdd:pfam00008   1 CAPNPCSNGGTC-VDTPGGYTCICPEGYTGKR 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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