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Conserved domains on  [gi|1907119433|ref|XP_036015996|]
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cilia- and flagella-associated protein 298 isoform X1 [Mus musculus]

Protein Classification

CFAP298 family protein( domain architecture ID 10567415)

CFAP298 family protein is a DUF2870 domain-containing protein; similar to Homo sapiens Cilia- and flagella-associated protein 298 that plays a role in motile cilium function, possibly by acting on outer dynein arm assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CFAP298 pfam11069
Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which ...
 145-239 1.15e-56

Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which includes a group of cilia- and flagella-associated protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role in cilia motility and polarization. Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26).


:

Pssm-ID: 463214  Cd Length: 95  Bit Score: 175.53  E-value: 1.15e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907119433 145 AQLWWAAKELRRTKKLSDYVGKNEKTKIIVKIQQRGQGAPAREPVISSEEHKQLMLFYHRRQEELKKLEENDDDSCLNSP 224
Cdd:pfam11069   1 AQLWWAGKEMQRGKKLSDYIGKNEKTKIIVKLQKKGSGAPGREPVVSEEEQKAMMAYYYRKQEELKKLEEDDDDSYLNSE 80

                          90
                  ....*....|....*
gi 1907119433 225 WADNTALKRHFHGVK 239
Cdd:pfam11069  81 WADPRGLKRQLHGLN 95
 
Name Accession Description Interval E-value
CFAP298 pfam11069
Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which ...
 145-239 1.15e-56

Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which includes a group of cilia- and flagella-associated protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role in cilia motility and polarization. Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26).


Pssm-ID: 463214  Cd Length: 95  Bit Score: 175.53  E-value: 1.15e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907119433 145 AQLWWAAKELRRTKKLSDYVGKNEKTKIIVKIQQRGQGAPAREPVISSEEHKQLMLFYHRRQEELKKLEENDDDSCLNSP 224
Cdd:pfam11069   1 AQLWWAGKEMQRGKKLSDYIGKNEKTKIIVKLQKKGSGAPGREPVVSEEEQKAMMAYYYRKQEELKKLEEDDDDSYLNSE 80

                          90
                  ....*....|....*
gi 1907119433 225 WADNTALKRHFHGVK 239
Cdd:pfam11069  81 WADPRGLKRQLHGLN 95
 
Name Accession Description Interval E-value
CFAP298 pfam11069
Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which ...
 145-239 1.15e-56

Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which includes a group of cilia- and flagella-associated protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role in cilia motility and polarization. Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26).


Pssm-ID: 463214  Cd Length: 95  Bit Score: 175.53  E-value: 1.15e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907119433 145 AQLWWAAKELRRTKKLSDYVGKNEKTKIIVKIQQRGQGAPAREPVISSEEHKQLMLFYHRRQEELKKLEENDDDSCLNSP 224
Cdd:pfam11069   1 AQLWWAGKEMQRGKKLSDYIGKNEKTKIIVKLQKKGSGAPGREPVVSEEEQKAMMAYYYRKQEELKKLEEDDDDSYLNSE 80

                          90
                  ....*....|....*
gi 1907119433 225 WADNTALKRHFHGVK 239
Cdd:pfam11069  81 WADPRGLKRQLHGLN 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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