NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907102640|ref|XP_036014641|]
View 

sacsin isoform X6 [Mus musculus]

Protein Classification

DnaJ and HEPN domain-containing protein( domain architecture ID 10245166)

DnaJ and HEPN domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
HEPN smart00748
Higher Eukarytoes and Prokaryotes Nucleotide-binding domain;
4241-4357 6.09e-22

Higher Eukarytoes and Prokaryotes Nucleotide-binding domain;


:

Pssm-ID: 214800  Cd Length: 113  Bit Score: 93.52  E-value: 6.09e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102640  4241 LRQARANFSAARNDLHKNANEWVCFKCYLSTKLALIAADYAVRGKSDKDVKPTALAQKIEEYSQQLEGLTNDVHTLEAYG 4320
Cdd:smart00748    1 LRRAKRFLEAAKLDLEKGFYDLAAFLSQQAAELALKALLLALGGEPPKTHSLRELLSELEKLLRLPEFIDEIRECLNLLE 80
                            90       100       110
                    ....*....|....*....|....*....|....*..
gi 1907102640  4321 VDSLKTRYPDLLPfpqiPNDRFTSEVAMRVMECTACI 4357
Cdd:smart00748   81 EAYIKSRYPDAGE----PLEWYTKEDAEELLKCAEEI 113
DnaJ super family cl02542
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
4112-4147 1.11e-03

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


The actual alignment was detected with superfamily member pfam00226:

Pssm-ID: 413365 [Multi-domain]  Cd Length: 63  Bit Score: 40.15  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907102640 4112 ESERKKIIRRLYLKWHPDKNPENHDiANEVFKHLQN 4147
Cdd:pfam00226   14 DEEIKKAYRKLALKYHPDKNPGDPE-AEEKFKEINE 48
 
Name Accession Description Interval E-value
HEPN smart00748
Higher Eukarytoes and Prokaryotes Nucleotide-binding domain;
4241-4357 6.09e-22

Higher Eukarytoes and Prokaryotes Nucleotide-binding domain;


Pssm-ID: 214800  Cd Length: 113  Bit Score: 93.52  E-value: 6.09e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102640  4241 LRQARANFSAARNDLHKNANEWVCFKCYLSTKLALIAADYAVRGKSDKDVKPTALAQKIEEYSQQLEGLTNDVHTLEAYG 4320
Cdd:smart00748    1 LRRAKRFLEAAKLDLEKGFYDLAAFLSQQAAELALKALLLALGGEPPKTHSLRELLSELEKLLRLPEFIDEIRECLNLLE 80
                            90       100       110
                    ....*....|....*....|....*....|....*..
gi 1907102640  4321 VDSLKTRYPDLLPfpqiPNDRFTSEVAMRVMECTACI 4357
Cdd:smart00748   81 EAYIKSRYPDAGE----PLEWYTKEDAEELLKCAEEI 113
HEPN COG2250
HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];
4241-4367 4.20e-06

HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];


Pssm-ID: 441851  Cd Length: 121  Bit Score: 48.79  E-value: 4.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102640 4241 LRQARANFSAARNDLHKNANEWVCFKCYLSTKLALIAADYAVRGKSDK--DVkpTALAQKIEEYSQQLEGLTNDVHTLEA 4318
Cdd:COG2250      1 LRRAERDLEAAELLLEEGRYDLACFHAQQAAEKALKALLLALGGEPPKthDL--RELLELLEKLLPEPEELRDLLRLLDK 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1907102640 4319 YGVDSlktRYPDLLPfpqIPNDRFTSEVAMRVMECTACIIIKLENFIQQ 4367
Cdd:COG2250     79 AYIPA---RYPDALP---EGPEEYTREEAEEALELAEEVLEFVEKLLKE 121
HEPN pfam05168
HEPN domain;
4237-4354 4.90e-06

HEPN domain;


Pssm-ID: 398711  Cd Length: 117  Bit Score: 48.39  E-value: 4.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102640 4237 ARRWLRQARANFSAARNDLHKNANEWVCFKCYLSTKLALIAAdYAVRGKSDK---DVkpTALAQKIEEYSQQLEGLTNDV 4313
Cdd:pfam05168    1 AEDWLRRAEEDLEAAELLLEEGDYDWACFHAQQAAEKALKAL-LLKLGGDPPkthDL--RELLGELKKGLGLPEELREIL 77
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1907102640 4314 HTLEAYGVDSlktRYPDLLPfpqipndrFTSEVAMRVMECT 4354
Cdd:pfam05168   78 DELEKAYIES---RYPDADE--------GTEEDAEEALKDA 107
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
4112-4147 1.11e-03

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 40.15  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907102640 4112 ESERKKIIRRLYLKWHPDKNPENHDiANEVFKHLQN 4147
Cdd:pfam00226   14 DEEIKKAYRKLALKYHPDKNPGDPE-AEEKFKEINE 48
PRK14281 PRK14281
chaperone protein DnaJ; Provisional
4099-4160 1.67e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 237657 [Multi-domain]  Cd Length: 397  Bit Score: 44.03  E-value: 1.67e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907102640 4099 EVTSVVEQAWKlpeSERKKIIRRLYLKWHPDKNPENHDI------ANEVFKHLQNEinrlEKQAFLDQ 4160
Cdd:PRK14281     7 EVLGVSRSADK---DEIKKAYRKLALKYHPDKNPDNKEAeehfkeVNEAYEVLSND----DKRRRYDQ 67
DnaJ smart00271
DnaJ molecular chaperone homology domain;
4112-4150 1.82e-03

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 39.53  E-value: 1.82e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907102640  4112 ESERKKIIRRLYLKWHPDKNPENHDIANEVFKhlqnEIN 4150
Cdd:smart00271   15 LDEIKKAYRKLALKYHPDKNPGDKEEAEEKFK----EIN 49
 
Name Accession Description Interval E-value
HEPN smart00748
Higher Eukarytoes and Prokaryotes Nucleotide-binding domain;
4241-4357 6.09e-22

Higher Eukarytoes and Prokaryotes Nucleotide-binding domain;


Pssm-ID: 214800  Cd Length: 113  Bit Score: 93.52  E-value: 6.09e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102640  4241 LRQARANFSAARNDLHKNANEWVCFKCYLSTKLALIAADYAVRGKSDKDVKPTALAQKIEEYSQQLEGLTNDVHTLEAYG 4320
Cdd:smart00748    1 LRRAKRFLEAAKLDLEKGFYDLAAFLSQQAAELALKALLLALGGEPPKTHSLRELLSELEKLLRLPEFIDEIRECLNLLE 80
                            90       100       110
                    ....*....|....*....|....*....|....*..
gi 1907102640  4321 VDSLKTRYPDLLPfpqiPNDRFTSEVAMRVMECTACI 4357
Cdd:smart00748   81 EAYIKSRYPDAGE----PLEWYTKEDAEELLKCAEEI 113
HEPN COG2250
HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];
4241-4367 4.20e-06

HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];


Pssm-ID: 441851  Cd Length: 121  Bit Score: 48.79  E-value: 4.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102640 4241 LRQARANFSAARNDLHKNANEWVCFKCYLSTKLALIAADYAVRGKSDK--DVkpTALAQKIEEYSQQLEGLTNDVHTLEA 4318
Cdd:COG2250      1 LRRAERDLEAAELLLEEGRYDLACFHAQQAAEKALKALLLALGGEPPKthDL--RELLELLEKLLPEPEELRDLLRLLDK 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1907102640 4319 YGVDSlktRYPDLLPfpqIPNDRFTSEVAMRVMECTACIIIKLENFIQQ 4367
Cdd:COG2250     79 AYIPA---RYPDALP---EGPEEYTREEAEEALELAEEVLEFVEKLLKE 121
HEPN pfam05168
HEPN domain;
4237-4354 4.90e-06

HEPN domain;


Pssm-ID: 398711  Cd Length: 117  Bit Score: 48.39  E-value: 4.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102640 4237 ARRWLRQARANFSAARNDLHKNANEWVCFKCYLSTKLALIAAdYAVRGKSDK---DVkpTALAQKIEEYSQQLEGLTNDV 4313
Cdd:pfam05168    1 AEDWLRRAEEDLEAAELLLEEGDYDWACFHAQQAAEKALKAL-LLKLGGDPPkthDL--RELLGELKKGLGLPEELREIL 77
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1907102640 4314 HTLEAYGVDSlktRYPDLLPfpqipndrFTSEVAMRVMECT 4354
Cdd:pfam05168   78 DELEKAYIES---RYPDADE--------GTEEDAEEALKDA 107
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
4112-4147 1.11e-03

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 40.15  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907102640 4112 ESERKKIIRRLYLKWHPDKNPENHDiANEVFKHLQN 4147
Cdd:pfam00226   14 DEEIKKAYRKLALKYHPDKNPGDPE-AEEKFKEINE 48
PRK14281 PRK14281
chaperone protein DnaJ; Provisional
4099-4160 1.67e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 237657 [Multi-domain]  Cd Length: 397  Bit Score: 44.03  E-value: 1.67e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907102640 4099 EVTSVVEQAWKlpeSERKKIIRRLYLKWHPDKNPENHDI------ANEVFKHLQNEinrlEKQAFLDQ 4160
Cdd:PRK14281     7 EVLGVSRSADK---DEIKKAYRKLALKYHPDKNPDNKEAeehfkeVNEAYEVLSND----DKRRRYDQ 67
DnaJ smart00271
DnaJ molecular chaperone homology domain;
4112-4150 1.82e-03

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 39.53  E-value: 1.82e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907102640  4112 ESERKKIIRRLYLKWHPDKNPENHDIANEVFKhlqnEIN 4150
Cdd:smart00271   15 LDEIKKAYRKLALKYHPDKNPGDKEEAEEKFK----EIN 49
PRK14282 PRK14282
chaperone protein DnaJ; Provisional
4112-4160 2.56e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 184603 [Multi-domain]  Cd Length: 369  Bit Score: 43.63  E-value: 2.56e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907102640 4112 ESERKKIIRRLYLKWHPDKNPENHDIANEVFKHLQNEINRL---EKQAFLDQ 4160
Cdd:PRK14282    18 QEEIKRAYKRLVKEWHPDRHPENRKEAEQKFKEIQEAYEVLsdpQKRAMYDR 69
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
4112-4150 5.35e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 42.44  E-value: 5.35e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907102640 4112 ESERKKIIRRLYLKWHPDKNPENHDiANEVFKhlqnEIN 4150
Cdd:PRK10767    18 EDEIKKAYRKLAMKYHPDRNPGDKE-AEEKFK----EIK 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH