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Conserved domains on  [gi|1907102076|ref|XP_036014585|]
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leucine-rich repeat and calponin homology domain-containing protein 1 isoform X9 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_LRCH1 cd21270
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 446-557 7.67e-71

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 1; Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1), also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. LRCH1 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409119  Cd Length: 112  Bit Score: 223.58  E-value: 7.67e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 446 EEKELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLG 525
Cdd:cd21270     1 EERELTEQLRENIETRLKVSLPEDLGAALMDGVVLCHLVNHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKIG 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907102076 526 VPEADLCSPYDILQLDFRHIRKTVDTLLALGE 557
Cdd:cd21270    81 VPEADLCSPYDILQLNLRGIRKTVETLLALGE 112
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-106 1.55e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 1.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076   2 ELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPPELVDLP-LVKFDFSCNKVLVIPVCFREMKQLQVLLLENNPLQS 80
Cdd:COG4886   140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                          90       100
                  ....*....|....*....|....*.
gi 1907102076  81 PPAQICTKGKVhifKYLSIQACQIKT 106
Cdd:COG4886   220 LPEPLANLTNL---ETLDLSNNQLTD 242
 
Name Accession Description Interval E-value
CH_LRCH1 cd21270
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 446-557 7.67e-71

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 1; Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1), also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. LRCH1 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409119  Cd Length: 112  Bit Score: 223.58  E-value: 7.67e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 446 EEKELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLG 525
Cdd:cd21270     1 EERELTEQLRENIETRLKVSLPEDLGAALMDGVVLCHLVNHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKIG 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907102076 526 VPEADLCSPYDILQLDFRHIRKTVDTLLALGE 557
Cdd:cd21270    81 VPEADLCSPYDILQLNLRGIRKTVETLLALGE 112
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-106 1.55e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 1.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076   2 ELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPPELVDLP-LVKFDFSCNKVLVIPVCFREMKQLQVLLLENNPLQS 80
Cdd:COG4886   140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                          90       100
                  ....*....|....*....|....*.
gi 1907102076  81 PPAQICTKGKVhifKYLSIQACQIKT 106
Cdd:COG4886   220 LPEPLANLTNL---ETLDLSNNQLTD 242
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 448-537 1.88e-13

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 66.57  E-value: 1.88e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076  448 KELVEQLRESIEMRLKVTLhEDLGAALMDGVVLCHLANHVRPRSVASIHVPspavPKLSMAKCRRNVENFLEACRKLGvP 527
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPV-TNFSSDLKDGVALCALLNSLSPGLVDKKKVA----ASLSRFKKIENINLALSFAEKLG-G 74

                           90
                   ....*....|
gi 1907102076  528 EADLCSPYDI 537
Cdd:smart00033  75 KVVLFEPEDL 84
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 444-531 6.37e-08

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 51.13  E-value: 6.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 444 MREEKELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVasihvpSPAVPKLSMAKCRRNVENFLE-ACR 522
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRVTNFTTDLRDGLALCALLNKLAPGLV------DKKKLNKSEFDKLENINLALDvAEK 74


                  ....*....
gi 1907102076 523 KLGVPEADL 531
Cdd:pfam00307  75 KLGVPKVLI 83
LRR_8 pfam13855
Leucine rich repeat;
1-78 8.43e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 8.43e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907102076   1 MELDVSCNEITALPQQI-GQLKSLRELNVRRNYLKVLPPElvdlplvkfdfscnkvlvipvCFREMKQLQVLLLENNPL 78
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPG---------------------AFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
3-116 3.56e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.53  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076   3 LDVSCNEITALPQQIGQlkSLRELNVRRNYLKVLPPELVDlPLVKFDFSCNKVLVIPVCFRemKQLQVLLLENNPLQSPP 82
Cdd:PRK15370  267 LDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS-GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLP 341

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907102076  83 AQICTKGKVhifkyLSIQACQIKTSDSLYLPTIE 116
Cdd:PRK15370  342 ASLPPELQV-----LDVSKNQITVLPETLPPTIT 370
SCP1 COG5199
Calponin [Cytoskeleton];
441-555 3.28e-03

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 38.75  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 441 MEQMREEKELVEQLREsIEMRLKVTLHE------DLGAALMDGVVLCHLANHVRPrsvASIHVPSPAVPKLSMakcrRNV 514
Cdd:COG5199     2 VNTKNRCPGMDKQQKE-VTLWIETVLGEkfeppgDLLSLLKDGVRLCRILNEASP---LDIKYKESKMPFVQM----ENI 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1907102076 515 ENFLEACRKLGVPEADLCSPYDILQLdfRHIRKTVDTLLAL 555
Cdd:COG5199    74 SSFINGLKKLRVPEYELFQTNDLFEA--KDLRQVVICLYSL 112
 
Name Accession Description Interval E-value
CH_LRCH1 cd21270
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 446-557 7.67e-71

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 1; Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1), also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. LRCH1 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409119  Cd Length: 112  Bit Score: 223.58  E-value: 7.67e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 446 EEKELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLG 525
Cdd:cd21270     1 EERELTEQLRENIETRLKVSLPEDLGAALMDGVVLCHLVNHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKIG 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907102076 526 VPEADLCSPYDILQLDFRHIRKTVDTLLALGE 557
Cdd:cd21270    81 VPEADLCSPYDILQLNLRGIRKTVETLLALGE 112
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
 449-557 1.26e-59

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 193.67  E-value: 1.26e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 449 ELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE 528
Cdd:cd21205     1 EQIEQLRKSIESRLKVTLPDDLGEALMDGVVLCHLANHVRPRSVPSIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE 80

                          90       100
                  ....*....|....*....|....*....
gi 1907102076 529 ADLCSPYDILQldFRHIRKTVDTLLALGE 557
Cdd:cd21205    81 ERLCSPGDILE--EKGLVRVAVTVQALLQ 107
CH_LRCH2 cd21271
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 445-539 4.14e-54

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2; Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) may play a role in the organization of the cytoskeleton. It contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409120  Cd Length: 111  Bit Score: 179.35  E-value: 4.14e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 445 REEKELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKL 524
Cdd:cd21271     1 REELELIEQLRENIESRLKVILPEDLGAALMDGVVLCHLANHIRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLDACRKL 80

                          90
                  ....*....|....*
gi 1907102076 525 GVPEADLCSPYDILQ 539
Cdd:cd21271    81 GVPEDKLCLPHHILE 95
CH_LRCH3 cd21272
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 449-555 1.13e-49

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409121  Cd Length: 109  Bit Score: 167.47  E-value: 1.13e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 449 ELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE 528
Cdd:cd21272     1 ELIEQLRKNIESRLKVSLPSDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRRIGVPQ 80

                          90       100
                  ....*....|....*....|....*...
gi 1907102076 529 ADLCSPYDILQLD-FRHIRKTVDTLLAL 555
Cdd:cd21272    81 EQLCLPLHILEEKgLSQVAVTVQALLEL 108
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 446-554 9.68e-46

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 156.98  E-value: 9.68e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 446 EEKELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLG 525
Cdd:cd21273     1 DEKELRAQLRKTLESRLKVTLPEDLAEALSNGAVLCQLANQLRPRSVSIIHVPSPAVPKLSKAKCRKNVENFIEACRKMG 80

                          90       100
                  ....*....|....*....|....*....
gi 1907102076 526 VPEADLCSPYDILQLDFRHIRKTVDTLLA 554
Cdd:cd21273    81 VPEVDLCSPSDVLLQGPAAVLRTVLALLA 109
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 451-557 8.38e-20

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 84.70  E-value: 8.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 451 VEQLRESIEMRLKVTLH---EDLGAALMDGVVLCHLANHVRPRSVASIHVPSpavpkLSMAKCRRNVENFLEACRKLGVP 527
Cdd:cd00014     1 EEELLKWINEVLGEELPvsiTDLFESLRDGVLLCKLINKLSPGSIPKINKKP-----KSPFKKRENINLFLNACKKLGLP 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 1907102076 528 EADLCSPYDILQLdfRHIRKTVDTLLALGE 557
Cdd:cd00014    76 ELDLFEPEDLYEK--GNLKKVLGTLWALAL 103
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-106 1.55e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 1.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076   2 ELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPPELVDLP-LVKFDFSCNKVLVIPVCFREMKQLQVLLLENNPLQS 80
Cdd:COG4886   140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                          90       100
                  ....*....|....*....|....*.
gi 1907102076  81 PPAQICTKGKVhifKYLSIQACQIKT 106
Cdd:COG4886   220 LPEPLANLTNL---ETLDLSNNQLTD 242
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 448-537 1.88e-13

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 66.57  E-value: 1.88e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076  448 KELVEQLRESIEMRLKVTLhEDLGAALMDGVVLCHLANHVRPRSVASIHVPspavPKLSMAKCRRNVENFLEACRKLGvP 527
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPV-TNFSSDLKDGVALCALLNSLSPGLVDKKKVA----ASLSRFKKIENINLALSFAEKLG-G 74

                           90
                   ....*....|
gi 1907102076  528 EADLCSPYDI 537
Cdd:smart00033  75 KVVLFEPEDL 84
CH_VAV cd21201
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ...
 469-552 2.16e-13

calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins.


Pssm-ID: 409050  Cd Length: 117  Bit Score: 66.89  E-value: 2.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 469 DLGAALMDGVVLCHLANHVRPRSVaSIHVPSPAvPKLSMAKCRRNVENFLEACR-KLGVPEADLCSPYDILQLdfRHIRK 547
Cdd:cd21201    31 DLAQALRDGVLLCQLLNRLSPGSV-DDREINLR-PQMSQFLCLKNIRTFLQACRtVFGLRSADLFEPEDLYDV--TNFGK 106


                  ....*
gi 1907102076 548 TVDTL 552
Cdd:cd21201   107 VIRTL 111
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-106 2.40e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 2.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076   2 ELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPPELVDLP-LVKFDFSCNKVLVIPVCFREMKQLQVLLLENNPLQS 80
Cdd:COG4886   117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTnLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITD 196

                          90       100
                  ....*....|....*....|....*...
gi 1907102076  81 PPAQI--CTKgkvhiFKYLSIQACQIKT 106
Cdd:COG4886   197 LPEPLgnLTN-----LEELDLSGNQLTD 219
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 468-556 1.85e-11

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 61.17  E-value: 1.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 468 EDLGAALMDGVVLCHLANHVRPRSVASIHVPSpavpklsMA-KCRRNVENFLEACRKLGVPEADLCSPYDILQLdfRHIR 546
Cdd:cd21207    26 KDYEDVLKDGVILCKLINILKPGSVKKINTSK-------MAfKLMENIENFLTACKGYGVPKTDLFQTVDLYEK--KNIP 96

                          90
                  ....*....|
gi 1907102076 547 KTVDTLLALG 556
Cdd:cd21207    97 QVTNCLFALG 106
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-82 9.39e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 9.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076   2 ELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPPELVDLP-LVKFDFSCNKVLVIPVcFREMKQLQVLLLENNPLQS 80
Cdd:COG4886   186 ELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTnLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTD 264


                  ..
gi 1907102076  81 PP 82
Cdd:COG4886   265 LP 266
CH_VAV1 cd21262
calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the ...
 469-559 3.94e-10

calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV1 protein.


Pssm-ID: 409111  Cd Length: 120  Bit Score: 57.64  E-value: 3.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 469 DLGAALMDGVVLCHLANHVRPRSVASIHVpsPAVPKLSMAKCRRNVENFLEAC-RKLGVPEADLCSPYDIlqLDFRHIRK 547
Cdd:cd21262    31 DLAQALRDGVLLCQLLNNLLPHAVNLREI--NLRPQMSQFLCLKNIRTFLSTCcEKFGLRKSELFEAFDL--FDVRDFGK 106

                          90
                  ....*....|..
gi 1907102076 548 TVDTLLALGEKP 559
Cdd:cd21262   107 VIDTLSILSWTP 118
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 452-531 4.54e-10

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 56.99  E-value: 4.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 452 EQLRESIEMRLKVTLHE-DLGAALMDGVVLCHLANHVRPRSVASIHvpSPAVPKLSMakcrRNVENFLEACRKLGVPEAD 530
Cdd:cd21210     3 QEAREWIEEVLGEKLAQgDLLDALKDGVVLCKLANRILPADIRKYK--ESKMPFVQM----ENISAFLNAARKLGVPEND 76


                  .
gi 1907102076 531 L 531
Cdd:cd21210    77 L 77
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 448-556 2.38e-09

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 55.74  E-value: 2.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 448 KELVEQLRESIEMRLKVTLHEDLGA-----ALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSM-AKC----------- 510
Cdd:cd21204     1 EEALLPMKEDLAEWLNDLLGDDLTPdnfldELRNGVVLCQLAQKIQEAAEKAREAGKKNGPPPSYkLKCnenakpgsffa 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907102076 511 RRNVENFLEACRKLGVPEADLCSPYDILQldFRHIRKTVDTLLALG 556
Cdd:cd21204    81 RDNVANFLRWCRKLGVDEVLLFESEDLVL--HKNPRQVLLCLLELA 124
CH_AtKIN14-like cd21203
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ...
 468-555 3.23e-09

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409052 [Multi-domain]  Cd Length: 112  Bit Score: 54.73  E-value: 3.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 468 EDLGAALMDGVVLCHLANHVRPRSVASI--HVPSPAVPKLSMAKCRRNVENFLEACRKLGVPeadLCSPYDILQLDFRHI 545
Cdd:cd21203    24 EEFRLCLRDGVVLCKLLNKLQPGAVPKVveSPDDPDGAAGSAFQYFENVRNFLVAIEEMGLP---TFEASDLEQGGGGSR 100

                          90
                  ....*....|
gi 1907102076 546 RKTVDTLLAL 555
Cdd:cd21203   101 PRVVDCILAL 110
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 468-556 5.26e-08

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 51.57  E-value: 5.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 468 EDLGAALMDGVVLCHLANHVRPRSVASI-HVPSPAVpklsmakCRRNVENFLEACRKLGVPEADLCSPYDILQL------ 540
Cdd:cd21208    20 DDFRESLEDGILLCELINAIKPGSIKKInRLPTPIA-------GLDNLNLFLKACEDLGLKDSQLFDPTDLQDLsnrria 92

                          90       100
                  ....*....|....*....|...
gi 1907102076 541 -------DFRHIRKTVDTLLALG 556
Cdd:cd21208    93 thvrkkeDERRLKNVAITLYWLG 115
CH_VAV3 cd21264
calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously ...
 469-555 5.40e-08

calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously expressed and functions as a phosphorylation-dependent guanine nucleotide exchange factor (GEF) for RhoA, RhoG, and Rac1. Its function has been implicated in the hematopoietic, bone, cerebellar, and cardiovascular systems. VAV3 is essential in axon guidance in neurons that control blood pressure and respiration. It is overexpressed in prostate cancer cells and it plays a role in regulating androgen receptor transcriptional activity. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV3 protein.


Pssm-ID: 409113  Cd Length: 117  Bit Score: 51.50  E-value: 5.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 469 DLGAALMDGVVLCHLANHVRPRSV--ASIHVPspavPKLSMAKCRRNVENFLEA-CRKLGVPEADLCSPYDIlqLDFRHI 545
Cdd:cd21264    31 DLAQTLRDGVLLCQLLNNLRPHSInlKEINLR----PQMSQFLCLKNIRTFLSAcCETFGMRKSELFEAFDL--FDVRDF 104

                          90
                  ....*....|
gi 1907102076 546 RKTVDTLLAL 555
Cdd:cd21264   105 GKVIETLSKL 114
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 444-531 6.37e-08

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 51.13  E-value: 6.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 444 MREEKELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVasihvpSPAVPKLSMAKCRRNVENFLE-ACR 522
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRVTNFTTDLRDGLALCALLNKLAPGLV------DKKKLNKSEFDKLENINLALDvAEK 74


                  ....*....
gi 1907102076 523 KLGVPEADL 531
Cdd:pfam00307  75 KLGVPKVLI 83
CH_PIX cd21202
calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak ...
 458-552 7.76e-07

calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak Interactive eXchange factor (PIX) proteins are Rho guanine nucleotide exchange factors (GEFs), which activate small GTPases by exchanging bound GDP for free GTP. They act as GEFs for both Cdc42 and Rac1, and have been implicated in cell motility, adhesion, neurite outgrowth, and cell polarity. Vertebrates contain two proteins from the PIX family, alpha-PIX and beta-PIX. Alpha-PIX, also called Rho guanine nucleotide exchange factor 6 (ARHGEF6), is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Beta-PIX, also called Rho guanine nucleotide exchange factor 7 (ARHGEF7), plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Both alpha-PIX and beta-PIX contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409051 [Multi-domain]  Cd Length: 114  Bit Score: 47.91  E-value: 7.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 458 IEMRLKVTLHED---LGAALMDGVVLCHLANHVRPRSVASIHvPSPavpkLSMAKCRRNVENFLEACRKLGVPEADLCSP 534
Cdd:cd21202    15 LESPKKETIEDPerfLSESLKNGVVLCRLVNRLKPGTVEKIY-DEP----TTEEECLYNFESFLKACQELGILAEEIFDP 89

                          90
                  ....*....|....*....
gi 1907102076 535 YDILQ-LDFRHIRKTVDTL 552
Cdd:cd21202    90 NDLYSgGNFQKVLSTLERL 108
CH_CNN cd21211
calponin homology (CH) domain found in the calponin family; Calponin is an actin ...
 452-558 3.72e-06

calponin homology (CH) domain found in the calponin family; Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of non-muscle cells. There are three calponin isoforms, calponin-1, -2, -3. All of them are actin-binding proteins with functions in inhibiting actin-activated myosin ATPase and stabilizing the actin cytoskeleton. Calponin-1 is specifically expressed in smooth muscle cells and plays a role in fine-tuning smooth muscle contractility. Calponin-2 is expressed in both smooth muscle and non-muscle cells and regulates multiple actin cytoskeleton-based functions. Calponin-3 is expressed in the brain and participates in actin cytoskeleton-based activities in embryonic development and myogenesis. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409060 [Multi-domain]  Cd Length: 108  Bit Score: 46.15  E-value: 3.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 452 EQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLsmakcrRNVENFLEACRKLGVPEADL 531
Cdd:cd21211     6 AELRTWIEGVTGLSIGPNFQKGLKDGIILCELINKLQPGSVKKINESMQNWHQL------ENIGNFIKAIVSYGMKPHDI 79

                          90       100
                  ....*....|....*....|....*..
gi 1907102076 532 CSPYDILQLDfrHIRKTVDTLLALGEK 558
Cdd:cd21211    80 FEANDLFENG--NMTQVQVTLLALAGK 104
CH_LMO7 cd21277
calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 ...
 468-543 4.03e-06

calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 (LMO-7), also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409126 [Multi-domain]  Cd Length: 116  Bit Score: 45.98  E-value: 4.03e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907102076 468 EDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSmakcrrNVENFLEACRKLGVPEADLCSPYDILQLDFR 543
Cdd:cd21277    20 KDFRSALENGVLLCDLINKIKPGIIKKINRLSTPIAGLD------NINVFLKACEKLGLKEAQLFHPGDLQDLSTR 89
CH_CNN1 cd21282
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ...
 452-555 5.71e-06

calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409131 [Multi-domain]  Cd Length: 108  Bit Score: 45.25  E-value: 5.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 452 EQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLsmakcrRNVENFLEACRKLGVPEADL 531
Cdd:cd21282     6 EELRVWIEGVTGRRIGDNFMDGLKDGVILCELINKLQPGSVRKINESTQNWHKL------ENIGNFIKAIMHYGVKPHDI 79

                          90       100
                  ....*....|....*....|....
gi 1907102076 532 CSPYDILQlDFRHIrKTVDTLLAL 555
Cdd:cd21282    80 FEANDLFE-NTNHT-QVQSTLIAL 101
LRR_8 pfam13855
Leucine rich repeat;
1-78 8.43e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 8.43e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907102076   1 MELDVSCNEITALPQQI-GQLKSLRELNVRRNYLKVLPPElvdlplvkfdfscnkvlvipvCFREMKQLQVLLLENNPL 78
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPG---------------------AFSGLPSLRYLDLSGNRL 61
CH_VAV2 cd21263
calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely ...
 469-552 1.39e-05

calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV2 protein.


Pssm-ID: 409112  Cd Length: 119  Bit Score: 44.56  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 469 DLGAALMDGVVLCHLANHVRPRSVASIHVPSPavPKLSMAKCRRNVENFLEACR-KLGVPEADLCSPYDIlqLDFRHIRK 547
Cdd:cd21263    31 DLAQALRDGVLLCQLLHNLSPGSIDLKDINFR--PQMSQFLCLKNIRTFLKVCHdKFGLRNSELFDPFDL--FDVRDFGK 106


                  ....*
gi 1907102076 548 TVDTL 552
Cdd:cd21263   107 VISAL 111
CH_alphaPIX cd21265
calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak ...
 468-564 2.54e-05

calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak Interactive eXchange factor (alpha-PIX), also called PAK-interacting exchange factor alpha, Rho guanine nucleotide exchange factor 6 (ARHGEF6), Rac/Cdc42 guanine nucleotide exchange factor 6, or Cool (Cloned out of Library)-2, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Alpha-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409114  Cd Length: 117  Bit Score: 43.66  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 468 EDLGAALMDGVVLCHLANHVRPRSVASiHVPSPAvpklSMAKCRRNVENFLEACRKLGVpeaDLCSPYDILQLDfrHIRK 547
Cdd:cd21265    29 EFLKSSLKDGVVLCKLIERLLPGSVEK-YCLEPK----TEADCIGNIKEFLKGCAALKV---ETFEPDDLYTGE--NFSK 98

                          90
                  ....*....|....*..
gi 1907102076 548 TVDTLLALGEKPPQSTS 564
Cdd:cd21265    99 VLSTLLAVNKATEDRPS 115
CH_CNN3 cd21284
calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic ...
 452-555 5.74e-05

calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409133 [Multi-domain]  Cd Length: 111  Bit Score: 42.58  E-value: 5.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 452 EQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLsmakcrRNVENFLEACRKLGVPEADL 531
Cdd:cd21284     8 EELRNWIEEVTGMSIGENFQKGLKDGVILCELINKLQPGSIRKINESKLNWHQL------ENIGNFIKAIQAYGMKPHDI 81

                          90       100
                  ....*....|....*....|....
gi 1907102076 532 CSPYDILQLDfrHIRKTVDTLLAL 555
Cdd:cd21284    82 FEANDLFENG--NMTQVQTTLLAL 103
CH_TAGLN2 cd21280
calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis ...
 443-537 6.26e-05

calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409129 [Multi-domain]  Cd Length: 137  Bit Score: 43.33  E-value: 6.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 443 QMREEKELVEQLRESIEMRLKvtlhedlgaalmDGVVLCHLANHVRPRSVAsihvPSPAVPKLSMA-KCRRNVENFLEAC 521
Cdd:cd21280    20 QCGKQVGRPQPGRENFQNWLK------------DGTVLCHLINSLYPKGQA----PVKKIQASTMAfKQMEQISQFLQAA 83

                          90
                  ....*....|....*.
gi 1907102076 522 RKLGVPEADLCSPYDI 537
Cdd:cd21280    84 ERYGINTTDIFQTVDL 99
CH_TAGLN3 cd21281
calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal ...
 474-556 7.75e-05

calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409130 [Multi-domain]  Cd Length: 119  Bit Score: 42.64  E-value: 7.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 474 LMDGVVLCHLANHVRPRSvasiHVPSPAVPKLSMA-KCRRNVENFLEACRKLGVPEADLCSPYDILQ-LDFRHIRKtvdT 551
Cdd:cd21281    34 LMDGTILCRLINSLYPPG----KEPIKKISETKMAfKQMEKISQFLQAAEAYGVITTDIFQTVDLWEgKDMAAVQR---T 106


                  ....*
gi 1907102076 552 LLALG 556
Cdd:cd21281   107 LMALG 111
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
3-116 3.56e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.53  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076   3 LDVSCNEITALPQQIGQlkSLRELNVRRNYLKVLPPELVDlPLVKFDFSCNKVLVIPVCFRemKQLQVLLLENNPLQSPP 82
Cdd:PRK15370  267 LDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS-GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLP 341

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907102076  83 AQICTKGKVhifkyLSIQACQIKTSDSLYLPTIE 116
Cdd:PRK15370  342 ASLPPELQV-----LDVSKNQITVLPETLPPTIT 370
CH_CNN2 cd21283
calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral ...
 452-539 3.80e-04

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409132 [Multi-domain]  Cd Length: 109  Bit Score: 40.30  E-value: 3.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 452 EQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLsmakcrRNVENFLEACRKLGVPEADL 531
Cdd:cd21283     6 AELRTWIEGLTGRSIGPDFQKGLKDGVILCELMNKLQPGSVPKINRSMQNWHQL------ENLSNFIKAMVSYGMKPVDL 79


                  ....*...
gi 1907102076 532 CSPYDILQ 539
Cdd:cd21283    80 FEANDLFE 87
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
6-106 4.04e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 4.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076   6 SCNEITALPQQIGQLKSLRELNVRRNylkvlpPELVDLP-LVKFDFSCNKVLVIPVCFREMKQLQVLLLENNPLQSPPAQ 84
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTnLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP 154

                          90       100
                  ....*....|....*....|....
gi 1907102076  85 I--CTKgkvhiFKYLSIQACQIKT 106
Cdd:COG4886   155 LgnLTN-----LKSLDLSNNQLTD 173
CH_LIMCH1 cd21278
calponin homology (CH) domain found in LIM and calponin homology domains-containing protein 1; ...
 468-550 5.67e-04

calponin homology (CH) domain found in LIM and calponin homology domains-containing protein 1; LIM and calponin homology domains-containing protein 1 (LIMCH1) acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. LIMCH1 contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409127 [Multi-domain]  Cd Length: 118  Bit Score: 39.85  E-value: 5.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 468 EDLGAALMDGVVLCHLANHVRPRSVASIH-VPSPaVPKLSmakcrrNVENFLEACRKLGVPEADLCSPYDILQLDFRHIR 546
Cdd:cd21278    20 KDFRSGLENGILLCELLNAIKPGLVKKINrLPTP-IAGLD------NITLFLRGCKELGLKESQLFDPGDLQDTSNRVTI 92


                  ....
gi 1907102076 547 KTVD 550
Cdd:cd21278    93 KSSD 96
CH_betaPIX cd21266
calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak ...
 470-555 6.55e-04

calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak Interactive eXchange factor (beta-PIX), also called PAK-interacting exchange factor beta, Rho guanine nucleotide exchange factor 7 (ARHGEF7), p85, or Cool (Cloned out of Library)-1, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Beta-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409115  Cd Length: 112  Bit Score: 39.52  E-value: 6.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 470 LGAALMDGVVLCHLANHVRPRSVASIHvPSPAvpklSMAKCRRNVENFLEACRKLGVPEADlcsPYDILQldFRHIRKTV 549
Cdd:cd21266    29 LQASLKDGVVLCRLLERLLPGSIDKVY-PEPR----TESECLSNIREFLRGCGALRLETFD---ANDLYQ--GQNFNKVL 98


                  ....*.
gi 1907102076 550 DTLLAL 555
Cdd:cd21266    99 SSLVAL 104
CH_PLS_FIM_rpt1 cd21217
first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes ...
 467-526 1.66e-03

first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes plastin and fimbrin. Plastin has three isoforms, plastin-1, -2, and -3, which are all actin-bundling proteins. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, LC64P, or lymphocyte cytosolic protein 1 (LCP-1), plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Fimbrin has been found in plants and fungi. Arabidopsis thaliana fimbrin (AtFIM) includes fimbrin-1, -2, -3, -4, and -5; they cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Fungal fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409066 [Multi-domain]  Cd Length: 114  Bit Score: 38.32  E-value: 1.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907102076 467 HEDLGAALMDGVVLCHLANHVRPRSVA--SIHVPSPavpkLSMAKCRRNVENFLEACRKLGV 526
Cdd:cd21217    30 GDDLFEALRDGVLLCKLINKIVPGTIDerKLNKKKP----KNIFEATENLNLALNAAKKIGC 87
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 451-528 2.43e-03

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 37.98  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 451 VEQLRESIEMRLKVTLH--EDLGAALMDGVVLCHLANHVRPRSVASIHVPSpavPKLSMakcrRNVEN---FLEACRKLG 525
Cdd:cd21206    10 LEEAKQWIEACLNEELPptTEFEEELRNGVVLAKLANKFAPKLVPLKKIYD---VGLQF----RHTDNinhFLRALKKIG 82


                  ...
gi 1907102076 526 VPE 528
Cdd:cd21206    83 LPK 85
SCP1 COG5199
Calponin [Cytoskeleton];
441-555 3.28e-03

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 38.75  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907102076 441 MEQMREEKELVEQLREsIEMRLKVTLHE------DLGAALMDGVVLCHLANHVRPrsvASIHVPSPAVPKLSMakcrRNV 514
Cdd:COG5199     2 VNTKNRCPGMDKQQKE-VTLWIETVLGEkfeppgDLLSLLKDGVRLCRILNEASP---LDIKYKESKMPFVQM----ENI 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1907102076 515 ENFLEACRKLGVPEADLCSPYDILQLdfRHIRKTVDTLLAL 555
Cdd:COG5199    74 SSFINGLKKLRVPEYELFQTNDLFEA--KDLRQVVICLYSL 112
CH_jitterbug-like_rpt3 cd21185
third calponin homology (CH) domain found in Drosophila melanogaster protein jitterbug and ...
 476-527 7.90e-03

third calponin homology (CH) domain found in Drosophila melanogaster protein jitterbug and similar proteins; Protein jitterbug (Jbug) is an actin-meshwork organizing protein. It is required to maintain the shape and cell orientation of the Drosophila notum epithelium during flight muscle attachment to tendon cells. Jbug contains three copies of the CH domain. This model corresponds to the third CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409034  Cd Length: 98  Bit Score: 36.13  E-value: 7.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907102076 476 DGVVLCHLANhvrprsvaSIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVP 527
Cdd:cd21185    28 DGRLLCGLVN--------ALGGSVPGWPNLDPEESENNIQRGLEAGKSLGVE 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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