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Conserved domains on  [gi|1907085546|ref|XP_036013040|]
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tubulin epsilon and delta complex protein 1 isoform X1 [Mus musculus]

Protein Classification

DUF4509 domain-containing protein( domain architecture ID 10633163)

DUF4509 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TEDC1 pfam14970
Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and ...
 1-91 6.69e-46

Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and delta complex protein 1 (TEDC1). This complex is required for centriole maintenance and it is a component of several ciliary structures. It acts as a positive regulator of hedgehog signalling, which play key roles in embryonic development and in cancers. Additionally, this protein may play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F.


:

Pssm-ID: 464414  Cd Length: 161  Bit Score: 150.95  E-value: 6.69e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907085546   1 MGRLRFRWRCLISSQQEQCILLSKIHLYTQGCHSQQSLGHLSVAETEMLRDPESGQQLLQALESENIRLEAALEWRRREL 80
Cdd:pfam14970  71 NGKLRFQWRSLYSLQQERCKLLHKIHSYTQGCSGLPSLGHLSVSETALLRDPELLKQLLQLLEKENSRLEALLEWKRKEH 150

                          90
                  ....*....|.
gi 1907085546  81 VFWQWMDTVLD 91
Cdd:pfam14970 151 VFWQWMESVLD 161
COG4913 super family cl25907
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
109-180 8.59e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


The actual alignment was detected with superfamily member COG4913:

Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.20  E-value: 8.59e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907085546  109 EISEGGLGELESVKQELQALQEELREVSEpRRAAWEARVGGLGQGPEWSNSR-KALQEAVQQELAALQGSWEQ 180
Cdd:COG4913    331 QIRGNGGDRLEQLEREIERLERELEERER-RRARLEALLAALGLPLPASAEEfAALRAEAAALLEALEEELEA 402
 
Name Accession Description Interval E-value
TEDC1 pfam14970
Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and ...
 1-91 6.69e-46

Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and delta complex protein 1 (TEDC1). This complex is required for centriole maintenance and it is a component of several ciliary structures. It acts as a positive regulator of hedgehog signalling, which play key roles in embryonic development and in cancers. Additionally, this protein may play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F.


Pssm-ID: 464414  Cd Length: 161  Bit Score: 150.95  E-value: 6.69e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907085546   1 MGRLRFRWRCLISSQQEQCILLSKIHLYTQGCHSQQSLGHLSVAETEMLRDPESGQQLLQALESENIRLEAALEWRRREL 80
Cdd:pfam14970  71 NGKLRFQWRSLYSLQQERCKLLHKIHSYTQGCSGLPSLGHLSVSETALLRDPELLKQLLQLLEKENSRLEALLEWKRKEH 150

                          90
                  ....*....|.
gi 1907085546  81 VFWQWMDTVLD 91
Cdd:pfam14970 151 VFWQWMESVLD 161
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
109-180 8.59e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.20  E-value: 8.59e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907085546  109 EISEGGLGELESVKQELQALQEELREVSEpRRAAWEARVGGLGQGPEWSNSR-KALQEAVQQELAALQGSWEQ 180
Cdd:COG4913    331 QIRGNGGDRLEQLEREIERLERELEERER-RRARLEALLAALGLPLPASAEEfAALRAEAAALLEALEEELEA 402
 
Name Accession Description Interval E-value
TEDC1 pfam14970
Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and ...
 1-91 6.69e-46

Tubulin epsilon and delta complex protein 1; This family represents the tubulin epsilon and delta complex protein 1 (TEDC1). This complex is required for centriole maintenance and it is a component of several ciliary structures. It acts as a positive regulator of hedgehog signalling, which play key roles in embryonic development and in cancers. Additionally, this protein may play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F.


Pssm-ID: 464414  Cd Length: 161  Bit Score: 150.95  E-value: 6.69e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907085546   1 MGRLRFRWRCLISSQQEQCILLSKIHLYTQGCHSQQSLGHLSVAETEMLRDPESGQQLLQALESENIRLEAALEWRRREL 80
Cdd:pfam14970  71 NGKLRFQWRSLYSLQQERCKLLHKIHSYTQGCSGLPSLGHLSVSETALLRDPELLKQLLQLLEKENSRLEALLEWKRKEH 150

                          90
                  ....*....|.
gi 1907085546  81 VFWQWMDTVLD 91
Cdd:pfam14970 151 VFWQWMESVLD 161
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
109-180 8.59e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.20  E-value: 8.59e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907085546  109 EISEGGLGELESVKQELQALQEELREVSEpRRAAWEARVGGLGQGPEWSNSR-KALQEAVQQELAALQGSWEQ 180
Cdd:COG4913    331 QIRGNGGDRLEQLEREIERLERELEERER-RRARLEALLAALGLPLPASAEEfAALRAEAAALLEALEEELEA 402
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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