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Conserved domains on  [gi|1907078541|ref|XP_036011969|]
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coiled-coil domain-containing protein 138 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 80-211 3.16e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.89  E-value: 3.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078541   80 KLQYETTAQKKFAEELQKREQFLAEREQLLFSHETALSKIKGVKEEVLTRFQILKEQHGTEIEHLTEALKEKNKENKRMR 159
Cdd:TIGR02168  807 ELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLE 886

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907078541  160 SSFDTLRELNDNLRKQLNEVSEENKKMEIQAKRVQARLDNLQRKYEFMTVQR 211
Cdd:TIGR02168  887 EALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRI 938
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 80-211 3.16e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.89  E-value: 3.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078541   80 KLQYETTAQKKFAEELQKREQFLAEREQLLFSHETALSKIKGVKEEVLTRFQILKEQHGTEIEHLTEALKEKNKENKRMR 159
Cdd:TIGR02168  807 ELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLE 886

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907078541  160 SSFDTLRELNDNLRKQLNEVSEENKKMEIQAKRVQARLDNLQRKYEFMTVQR 211
Cdd:TIGR02168  887 EALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRI 938
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
65-205 1.68e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.20  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078541  65 HEINQIYDELyhihMKLQYETTAQKKFAEELQKREQFLAEREQLLFSHETALSKIKGVKEEVLTRFQILKEqhgtEIEHL 144
Cdd:PRK03918  207 REINEISSEL----PELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKK----EIEEL 278

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907078541 145 TEALKEKnKENKRMRSSFDTLRELNDNLRKQLNEVSEENKKMEIQAKRVQARLDNLQRKYE 205
Cdd:PRK03918  279 EEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEE 338
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 72-210 3.36e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 40.48  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078541  72 DELYHIHMKLQYETTAQKKFAE-------ELQKREQFLAEREQLLFSH---ETALSKIKGVKEEVLTRFQIL-KEQHGTE 140
Cdd:pfam05483 377 DQLKIITMELQKKSSELEEMTKfknnkevELEELKKILAEDEKLLDEKkqfEKIAEELKGKEQELIFLLQAReKEIHDLE 456

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907078541 141 IEHLTEALKEKN--KENKRMRSSFDTLRELNDNLRKQLNEVSEENKK-------MEIQAKRVQARLDNLQRKYEFMTVQ 210
Cdd:pfam05483 457 IQLTAIKTSEEHylKEVEDLKTELEKEKLKNIELTAHCDKLLLENKEltqeasdMTLELKKHQEDIINCKKQEERMLKQ 535
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 80-211 3.16e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.89  E-value: 3.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078541   80 KLQYETTAQKKFAEELQKREQFLAEREQLLFSHETALSKIKGVKEEVLTRFQILKEQHGTEIEHLTEALKEKNKENKRMR 159
Cdd:TIGR02168  807 ELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLE 886

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907078541  160 SSFDTLRELNDNLRKQLNEVSEENKKMEIQAKRVQARLDNLQRKYEFMTVQR 211
Cdd:TIGR02168  887 EALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRI 938
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
65-205 1.68e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.20  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078541  65 HEINQIYDELyhihMKLQYETTAQKKFAEELQKREQFLAEREQLLFSHETALSKIKGVKEEVLTRFQILKEqhgtEIEHL 144
Cdd:PRK03918  207 REINEISSEL----PELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKK----EIEEL 278

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907078541 145 TEALKEKnKENKRMRSSFDTLRELNDNLRKQLNEVSEENKKMEIQAKRVQARLDNLQRKYE 205
Cdd:PRK03918  279 EEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEE 338
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 85-202 3.32e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 3.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078541   85 TTAQKKFAEELQKREQFLAEREQLlfshETALSKIKGVKEEVLTRF-QILKEQHGTEIEHLTEALKEKNKENKRMRSSFD 163
Cdd:TIGR02168  382 ETLRSKVAQLELQIASLNNEIERL----EARLERLEDRRERLQQEIeELLKKLEEAELKELQAELEELEEELEELQEELE 457

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1907078541  164 TLRELNDNLRKQLNEVSEENKKMEIQAKRVQARLDNLQR 202
Cdd:TIGR02168  458 RLEEALEELREELEEAEQALDAAERELAQLQARLDSLER 496
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 72-210 3.36e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 40.48  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907078541  72 DELYHIHMKLQYETTAQKKFAE-------ELQKREQFLAEREQLLFSH---ETALSKIKGVKEEVLTRFQIL-KEQHGTE 140
Cdd:pfam05483 377 DQLKIITMELQKKSSELEEMTKfknnkevELEELKKILAEDEKLLDEKkqfEKIAEELKGKEQELIFLLQAReKEIHDLE 456

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907078541 141 IEHLTEALKEKN--KENKRMRSSFDTLRELNDNLRKQLNEVSEENKK-------MEIQAKRVQARLDNLQRKYEFMTVQ 210
Cdd:pfam05483 457 IQLTAIKTSEEHylKEVEDLKTELEKEKLKNIELTAHCDKLLLENKEltqeasdMTLELKKHQEDIINCKKQEERMLKQ 535
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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