|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
192-351 |
8.16e-79 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 266.07 E-value: 8.16e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 192 DPGKLAAPGSAP--HGHGEGARRQEQPSNNPGQPTLQ----PLPPSHKQHpAQHHPSITSLNRNSLTNRRNQSPAPPAAL 265
Cdd:pfam06484 203 DPDEEFSPNSYLvrTGSGPQSAPSEQPPNFQNHSRLRtpppPLPPPHKQN-QHHHPSINSLNRSSLTNRRNPSPAPTASL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 266 PAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSS 345
Cdd:pfam06484 282 PAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPY 361
|
....*.
gi 1907188997 346 KYCSWR 351
Cdd:pfam06484 362 KYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
819-1178 |
1.03e-40 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 154.23 E-value: 1.03e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 819 VSSIMGNGRRrsiscpscnGQADGNKLLA----PVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSN 892
Cdd:cd14953 1 VSTVAGSGTA---------GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 893 PAHRYY----LATDPvTGDLYVSDTNTRRIYRpksLTGAKDLTknaeVVAGTGEqclpfdeARCGDGGKAVEATLMSPKG 968
Cdd:cd14953 72 AAAQFNtpsgVAVDA-AGNLYVADTGNHRIRK---ITPDGVVS----TLAGTGT-------AGFSDDGGATAAQFNYPTG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 969 MAIDKNGLIYFVDGT--MIRKVDQNGIISTLLGSNDLTSAR--PLTcdtsmhisQVRLEWPTDLAINPMDNsIYVLD--N 1042
Cdd:cd14953 137 VAVDAAGNLYVADTGnhRIRKITPDGVVTTVAGTGGAGYAGdgPAT--------AAQFNNPTGVAVDAAGN-LYVADrgN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1043 NVVLQITENRQVRIAAGRPmhcqvpGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVA 1122
Cdd:cd14953 208 HRIRKITPDGVVTTVAGTG------TAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVA 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907188997 1123 GIPSEcdckndancdcyQSGD-GYAKDAKLNAPSSLAASPDGTLYIADLGNIRIRAV 1178
Cdd:cd14953 279 GGGAG------------FSGDgGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2295-2372 |
6.80e-40 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 142.75 E-value: 6.80e-40
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907188997 2295 EEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLR 2372
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1132-2072 |
9.65e-32 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 136.42 E-value: 9.65e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1132 NDANCDCYQSGDGYAKDAKLNAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQ 1211
Cdd:COG3209 109 AAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGA 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1212 YTVSLVTGDYLYNFSYSNDNDVTAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYH 1291
Cdd:COG3209 189 VTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1292 GNSGLLATK---SDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMV 1368
Cdd:COG3209 269 ASGAGLDAStgtGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTT 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1369 QDQLRNSYQIGYDGSLRIFYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLR 1448
Cdd:COG3209 349 VGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTA 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1449 VNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDSQGR 1528
Cdd:COG3209 429 GGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGG 508
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1529 IVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDY 1608
Cdd:COG3209 509 TTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGT 588
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1609 NEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFicTIRYRQIGPLIDRQIFRFS 1688
Cdd:COG3209 589 ATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTG 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1689 EDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIK 1768
Cdd:COG3209 667 TGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1769 EIQYEifRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSSSA 1848
Cdd:COG3209 747 TSTTT--TTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSG 824
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1849 RLTPL-----RYDLRDRITRLgdvqyrldEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTviYRYDGLGRRVSSKTSLG 1923
Cdd:COG3209 825 GGTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATDPGTTES--YTYDANGNLTSRTDGGT 894
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1924 QHLQFFYADLtyPTRITHvynhSSSEITSLYYDLQGHlfameissgdefyiaSDNTGTPLAVFSSNGLMLKQIQYTAYGE 2003
Cdd:COG3209 895 TTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGN 953
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907188997 2004 IYFDSNVDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDPAPfNLYMFRNNNP 2072
Cdd:COG3209 954 LLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNP 1016
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
1998-2072 |
3.18e-09 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 55.58 E-value: 3.18e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907188997 1998 YTAYGEIYFDSNVDFQLvIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDpAPFNLYMFRNNNP 2072
Cdd:TIGR03696 1 YDPYGEVLSESGAAPNP-LRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-----PIGLG-GGLNLYAYVGNNP 68
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
848-1126 |
1.11e-08 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 58.49 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 848 PVALACGIDGSLYVGDF--NYVRRIFP-SGNVTsvlelrnkdfRHSSNPAHRYY-LATDPvTGDLYVSDTNTRRIYRpks 923
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT----------EYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGR--- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 924 LTGAkdlTKNAEVVAGTGEQCLPFdearcgdggkaveatlmspkGMAIDKNGLIYFVDGT--MIRKVD-QNGIISTLLGS 1000
Cdd:COG4257 85 IDPK---TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPLP 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1001 NDLTSARPLTCD--------------------TSMHISQVRLE----WPTDLAINPmDNSIYVLD--NNVVLQITEnrqv 1054
Cdd:COG4257 142 TGGAGPYGIAVDpdgnlwvtdfganaigridpDTGTLTEYALPtpgaGPRGLAVDP-DGNLWVADtgSGRIGRFDP---- 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907188997 1055 riAAGRpmhcqvpgveypVGKHAVQTTLESATAIAVSYSGVLYITETDekkINRIRQVTTDGEISLVAgIPS 1126
Cdd:COG4257 217 --KTGT------------VTEYPLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELTEYV-LPS 270
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
449-479 |
1.43e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 52.13 E-value: 1.43e-08
10 20 30
....*....|....*....|....*....|.
gi 1907188997 449 AMETLCTDSKDNEGDGLIDCMDPDCCLQSSC 479
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
899-1182 |
3.34e-05 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 49.46 E-value: 3.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 899 LATDPVTGDLYVSDTNTRRIYrpksltgAKDLTKNAEV-VAGTGEQCL---PFDEArcgdggkaveaTLMSPKGMAID-K 973
Cdd:PLN02919 573 LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFEDA-----------TFNRPQGLAYNaK 634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 974 NGLIYFVD--GTMIRKVD-QNGIISTLLGS----NDLTSARPLTcdtsmhiSQVrLEWPTDLAINPMDNSIYV------- 1039
Cdd:PLN02919 635 KNLLYVADteNHALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDVCFEPVNEKVYIamagqhq 706
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1040 ------LD-------------------------------------NNVVLQITENRQVR-----------IAAGRPMhcq 1065
Cdd:PLN02919 707 iweyniSDgvtrvfsgdgyernlngssgtstsfaqpsgislspdlKELYIADSESSSIRaldlktggsrlLAGGDPT--- 783
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1066 VPGVEYPVGKH---AVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTtdGEISLVAGIPsecdckndancdcyQSG 1142
Cdd:PLN02919 784 FSDNLFKFGDHdgvGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTG--------------KAG 847
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1907188997 1143 --DGYAKDAKLNAPSSLAASPDGTLYIADLGNIRIRAVSKNK 1182
Cdd:PLN02919 848 fkDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1147-1273 |
7.15e-05 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 46.93 E-value: 7.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1147 KDAKLNAPSSLAASPDGTLYIADLGNIRIRAVSKN-KPLLN-------SMNFYE---VASPTDQELYI----------FD 1205
Cdd:cd05819 3 GPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDgNFITSfgsfgsgDGQFNEpagVAVDSDGNLYVadtgnhriqkFD 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907188997 1206 INGTHQYTVSlVTGDYLYNFSY------SNDNDVtAVTDSNGNtlRIrrdpnrmpvRVVSPDNQVIwLTIGTNG 1273
Cdd:cd05819 83 PDGNFLASFG-GSGDGDGEFNGprgiavDSSGNI-YVADTGNH--RI---------QKFDPDGEFL-TTFGSGG 142
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
413-446 |
4.82e-04 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.54 E-value: 4.82e-04
10 20 30
....*....|....*....|....*....|....*.
gi 1907188997 413 NEgC--PGLCNSNGRCTLDQNGWHCVCQPGWRGAGC 446
Cdd:cd00054 3 DE-CasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| EGF |
pfam00008 |
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
420-443 |
1.16e-03 |
|
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Pssm-ID: 394967 Cd Length: 31 Bit Score: 38.13 E-value: 1.16e-03
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1295-1326 |
9.01e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 36.04 E-value: 9.01e-03
10 20 30
....*....|....*....|....*....|..
gi 1907188997 1295 GLLATKSDETGWTTFFDYDSEGRLTNVTFPTG 1326
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| EGF |
smart00181 |
Epidermal growth factor-like domain; |
416-443 |
9.03e-03 |
|
Epidermal growth factor-like domain;
Pssm-ID: 214544 Cd Length: 35 Bit Score: 35.96 E-value: 9.03e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
192-351 |
8.16e-79 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 266.07 E-value: 8.16e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 192 DPGKLAAPGSAP--HGHGEGARRQEQPSNNPGQPTLQ----PLPPSHKQHpAQHHPSITSLNRNSLTNRRNQSPAPPAAL 265
Cdd:pfam06484 203 DPDEEFSPNSYLvrTGSGPQSAPSEQPPNFQNHSRLRtpppPLPPPHKQN-QHHHPSINSLNRSSLTNRRNPSPAPTASL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 266 PAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSS 345
Cdd:pfam06484 282 PAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPY 361
|
....*.
gi 1907188997 346 KYCSWR 351
Cdd:pfam06484 362 KYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
819-1178 |
1.03e-40 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 154.23 E-value: 1.03e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 819 VSSIMGNGRRrsiscpscnGQADGNKLLA----PVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSN 892
Cdd:cd14953 1 VSTVAGSGTA---------GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 893 PAHRYY----LATDPvTGDLYVSDTNTRRIYRpksLTGAKDLTknaeVVAGTGEqclpfdeARCGDGGKAVEATLMSPKG 968
Cdd:cd14953 72 AAAQFNtpsgVAVDA-AGNLYVADTGNHRIRK---ITPDGVVS----TLAGTGT-------AGFSDDGGATAAQFNYPTG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 969 MAIDKNGLIYFVDGT--MIRKVDQNGIISTLLGSNDLTSAR--PLTcdtsmhisQVRLEWPTDLAINPMDNsIYVLD--N 1042
Cdd:cd14953 137 VAVDAAGNLYVADTGnhRIRKITPDGVVTTVAGTGGAGYAGdgPAT--------AAQFNNPTGVAVDAAGN-LYVADrgN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1043 NVVLQITENRQVRIAAGRPmhcqvpGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVA 1122
Cdd:cd14953 208 HRIRKITPDGVVTTVAGTG------TAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVA 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907188997 1123 GIPSEcdckndancdcyQSGD-GYAKDAKLNAPSSLAASPDGTLYIADLGNIRIRAV 1178
Cdd:cd14953 279 GGGAG------------FSGDgGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2295-2372 |
6.80e-40 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 142.75 E-value: 6.80e-40
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907188997 2295 EEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLR 2372
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
899-1179 |
4.14e-38 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 146.52 E-value: 4.14e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 899 LATDPvTGDLYVSDTNTRRIYRpksltgakdLTKNAEV--VAGTGEqclpfdEARCGDGGKAveATLMSPKGMAIDKNGL 976
Cdd:cd14953 28 VAVDA-AGNLYVADRGNHRIRK---------ITPDGVVttVAGTGT------AGFADGGGAA--AQFNTPSGVAVDAAGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 977 IYFVDGT--MIRKVDQNGIISTLLGsndlTSARPLTCDTSMhiSQVRLEWPTDLAINPMDNsIYVLD--NNVVLQITENR 1052
Cdd:cd14953 90 LYVADTGnhRIRKITPDGVVSTLAG----TGTAGFSDDGGA--TAAQFNYPTGVAVDAAGN-LYVADtgNHRIRKITPDG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1053 QVRIAAGRPmhcqVPGveYPVGKHAVQTTLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVAGIPSEcdckn 1132
Cdd:cd14953 163 VVTTVAGTG----GAG--YAGDGPATAAQFNNPTGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTGTA----- 228
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1907188997 1133 dancdcYQSGDGYAKDAKLNAPSSLAASPDGTLYIADLGNIRIRAVS 1179
Cdd:cd14953 229 ------GFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKIT 269
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1132-2072 |
9.65e-32 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 136.42 E-value: 9.65e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1132 NDANCDCYQSGDGYAKDAKLNAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQ 1211
Cdd:COG3209 109 AAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGA 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1212 YTVSLVTGDYLYNFSYSNDNDVTAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYH 1291
Cdd:COG3209 189 VTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1292 GNSGLLATK---SDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMV 1368
Cdd:COG3209 269 ASGAGLDAStgtGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTT 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1369 QDQLRNSYQIGYDGSLRIFYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLR 1448
Cdd:COG3209 349 VGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTA 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1449 VNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDSQGR 1528
Cdd:COG3209 429 GGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGG 508
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1529 IVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDY 1608
Cdd:COG3209 509 TTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGT 588
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1609 NEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFicTIRYRQIGPLIDRQIFRFS 1688
Cdd:COG3209 589 ATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTG 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1689 EDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIK 1768
Cdd:COG3209 667 TGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1769 EIQYEifRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSSSA 1848
Cdd:COG3209 747 TSTTT--TTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSG 824
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1849 RLTPL-----RYDLRDRITRLgdvqyrldEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTviYRYDGLGRRVSSKTSLG 1923
Cdd:COG3209 825 GGTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATDPGTTES--YTYDANGNLTSRTDGGT 894
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1924 QHLQFFYADLtyPTRITHvynhSSSEITSLYYDLQGHlfameissgdefyiaSDNTGTPLAVFSSNGLMLKQIQYTAYGE 2003
Cdd:COG3209 895 TTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGN 953
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907188997 2004 IYFDSNVDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDPAPfNLYMFRNNNP 2072
Cdd:COG3209 954 LLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNP 1016
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
936-1179 |
1.49e-31 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 127.65 E-value: 1.49e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 936 VVAGTGeqclpfdeARCGDGGKAVEATLMSPKGMAIDKNGLIYFVDGT--MIRKVDQNGIISTLLG------SNDLTSAr 1007
Cdd:cd14953 3 TVAGSG--------TAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGnhRIRKITPDGVVTTVAGtgtagfADGGGAA- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1008 pltcdtsmhisqVRLEWPTDLAINPMDNsIYVLD--NNVVLQITENRQVRIAAGrpmhcqVPGVEYPVGKHAVQTTLESA 1085
Cdd:cd14953 74 ------------AQFNTPSGVAVDAAGN-LYVADtgNHRIRKITPDGVVSTLAG------TGTAGFSDDGGATAAQFNYP 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1086 TAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVAGIPSEcdckndancdcYQSGDGYAKDAKLNAPSSLAASPDGTL 1165
Cdd:cd14953 135 TGVAVDAAGNLYVADTGN---HRIRKITPDGVVTTVAGTGGA-----------GYAGDGPATAAQFNNPTGVAVDAAGNL 200
|
250
....*....|....
gi 1907188997 1166 YIADLGNIRIRAVS 1179
Cdd:cd14953 201 YVADRGNHRIRKIT 214
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
838-1176 |
2.75e-19 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 90.07 E-value: 2.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 838 GQADGnKLLAPVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSNPAHryyLATDPvTGDLYVSDTNT 915
Cdd:cd05819 1 GTGPG-ELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 916 RRIYRpksltgakdLTKNAEVVAGTGeqclpfdearcGDGGKAVEatLMSPKGMAIDKNGLIYFVDgTM---IRKVDQNG 992
Cdd:cd05819 76 HRIQK---------FDPDGNFLASFG-----------GSGDGDGE--FNGPRGIAVDSSGNIYVAD-TGnhrIQKFDPDG 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 993 IISTLLGSNDLTSARpltcdtsmhisqvrLEWPTDLAINPmDNSIYVLDnnvvlqiTENRQVRI--AAGRPMHcQVPGVE 1070
Cdd:cd05819 133 EFLTTFGSGGSGPGQ--------------FNGPTGVAVDS-DGNIYVAD-------TGNHRIQVfdPDGNFLT-TFGSTG 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1071 YPVGKhavqttLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISlvagipsecdckndancdcYQSGDGYAKDAK 1150
Cdd:cd05819 190 TGPGQ------FNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGF-------------------GGNGNFLGSDGQ 241
|
330 340
....*....|....*....|....*.
gi 1907188997 1151 LNAPSSLAASPDGTLYIADLGNIRIR 1176
Cdd:cd05819 242 FNRPSGLAVDSDGNLYVADTGNNRIQ 267
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
837-1109 |
7.22e-16 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 80.06 E-value: 7.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 837 NGQADGNkLLAPVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSNPahrYYLATDPvTGDLYVSDTN 914
Cdd:cd05819 47 FGSGDGQ-FNEPAGVAVDSDGNLYVADTgnHRIQKFDPDGNFLASFGGSGDGDGEFNGP---RGIAVDS-SGNIYVADTG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 915 TRRIYRpksltgakdLTKNAEVVAGTGeqclpfdearcgdGGKAVEATLMSPKGMAIDKNGLIYFVDGT--MIRKVDQNG 992
Cdd:cd05819 122 NHRIQK---------FDPDGEFLTTFG-------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 993 IISTLLGSNDLTSARpltcdtsmhisqvrLEWPTDLAINPMDNsIYVLD--NNVVLQITENRQVRIAAGRPMhCQVPGVE 1070
Cdd:cd05819 180 NFLTTFGSTGTGPGQ--------------FNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNGNFL-GSDGQFN 243
|
250 260 270
....*....|....*....|....*....|....*....
gi 1907188997 1071 YPVGkhavqttlesataIAVSYSGVLYITETDEKKINRI 1109
Cdd:cd05819 244 RPSG-------------LAVDSDGNLYVADTGNNRIQVF 269
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
1998-2072 |
3.18e-09 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 55.58 E-value: 3.18e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907188997 1998 YTAYGEIYFDSNVDFQLvIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDpAPFNLYMFRNNNP 2072
Cdd:TIGR03696 1 YDPYGEVLSESGAAPNP-LRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-----PIGLG-GGLNLYAYVGNNP 68
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
848-1126 |
1.11e-08 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 58.49 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 848 PVALACGIDGSLYVGDF--NYVRRIFP-SGNVTsvlelrnkdfRHSSNPAHRYY-LATDPvTGDLYVSDTNTRRIYRpks 923
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT----------EYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGR--- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 924 LTGAkdlTKNAEVVAGTGEQCLPFdearcgdggkaveatlmspkGMAIDKNGLIYFVDGT--MIRKVD-QNGIISTLLGS 1000
Cdd:COG4257 85 IDPK---TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPLP 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1001 NDLTSARPLTCD--------------------TSMHISQVRLE----WPTDLAINPmDNSIYVLD--NNVVLQITEnrqv 1054
Cdd:COG4257 142 TGGAGPYGIAVDpdgnlwvtdfganaigridpDTGTLTEYALPtpgaGPRGLAVDP-DGNLWVADtgSGRIGRFDP---- 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907188997 1055 riAAGRpmhcqvpgveypVGKHAVQTTLESATAIAVSYSGVLYITETDekkINRIRQVTTDGEISLVAgIPS 1126
Cdd:COG4257 217 --KTGT------------VTEYPLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELTEYV-LPS 270
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
449-479 |
1.43e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 52.13 E-value: 1.43e-08
10 20 30
....*....|....*....|....*....|.
gi 1907188997 449 AMETLCTDSKDNEGDGLIDCMDPDCCLQSSC 479
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
963-1273 |
1.99e-08 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 58.05 E-value: 1.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 963 LMSPKGMAIDKNGLIYFVD--GTMIRKVDQNGIISTLLGSNDltsarpltcdtsmhISQVRLEWPTDLAINPMDNsIYVL 1040
Cdd:cd14957 17 FNTPRGIAVDSAGNIYVADtgNNRIQVFTSSGVYSYSIGSGG--------------TGSGQFNSPYGIAVDSNGN-IYVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1041 DNNvvlqitENR-QVRIAAGrpmhcqvpGVEYPVGKHAVQTT-LESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEI 1118
Cdd:cd14957 82 DTD------NNRiQVFNSSG--------VYQYSIGTGGSGDGqFNGPYGIAVDSNGNIYVADTGN---HRIQVFTSSGTF 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1119 slvagipsecdckndancdCYQSGDGYAKDAKLNAPSSLAASPDGTLYIADLGNIRIRavsknkpllnsmnfyevasptd 1198
Cdd:cd14957 145 -------------------SYSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ---------------------- 183
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907188997 1199 qelyIFDINGTHQYTV-SLVTGDYLynFSYSNDNDVtavtDSNGNTLRIRRDPNRmpVRVVSPDNqVIWLTIGTNG 1273
Cdd:cd14957 184 ----VFTSSGTFQYTFgSSGSGPGQ--FSDPYGIAV----DSDGNIYVADTGNHR--IQVFTSSG-AYQYSIGTSG 246
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
899-1175 |
2.14e-08 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 57.60 E-value: 2.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 899 LATDPvTGDLYVSDTNTRRIYRpksltgakdltknaeVVAGTGEQ-CLPFDEarcgdggkaveatLMSPKGMAIDKNGLI 977
Cdd:cd14952 15 VAVDA-AGNVYVADSGNNRVLK---------------LAAGSTTQtVLPFTG-------------LYQPQGVAVDAAGTV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 978 YFVDGtmirkvDQNGIISTLLGSNDLTsARPLTcdtsmhisqvRLEWPTDLAINPMDNsIYVLDNnvvlqiTENRQVRIA 1057
Cdd:cd14952 66 YVTDF------GNNRVLKLAAGSTTQT-VLPFT----------GLNDPTGVAVDAAGN-VYVADT------GNNRVLKLA 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1058 AGRPMHCQVPgveypvgkhavQTTLESATAIAVSYSGVLYITETDEkkiNRIRQvttdgeisLVAGipsecdckndANCD 1137
Cdd:cd14952 122 AGSNTQTVLP-----------FTGLSNPDGVAVDGAGNVYVTDTGN---NRVLK--------LAAG----------STTQ 169
|
250 260 270
....*....|....*....|....*....|....*...
gi 1907188997 1138 CYQSGDGyakdakLNAPSSLAASPDGTLYIADLGNIRI 1175
Cdd:cd14952 170 TVLPFTG------LNSPSGVAVDTAGNVYVTDHGNNRV 201
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
906-1180 |
1.45e-06 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 52.28 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 906 GDLYVSDTNTRRIyrpksltgakdltknaEVVAGTGEQCLPFDEARCGDGGkaveatLMSPKGMAIDKNGLIYFVDGT-- 983
Cdd:cd14956 24 DNVYVADARNGRI----------------QVFDKDGTFLRRFGTTGDGPGQ------FGRPRGLAVDKDGWLYVADYWgd 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 984 MIRKVDQNGIISTLLGSNdltSARPLTCDTsmhisqvrlewPTDLAINPmDNSIYVLD--NNVVLQITENRQVRIAAGRP 1061
Cdd:cd14956 82 RIQVFTLTGELQTIGGSS---GSGPGQFNA-----------PRGVAVDA-DGNLYVADfgNQRIQKFDPDGSFLRQWGGT 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1062 mhcqvpgvEYPVGKhavqttLESATAIAVSYSGVLYITETdekKINRIRQVTTDGEISLVAGIPSecdckndancdcyqS 1141
Cdd:cd14956 147 --------GIEPGS------FNYPRGVAVDPDGTLYVADT---YNDRIQVFDNDGAFLRKWGGRG--------------T 195
|
250 260 270
....*....|....*....|....*....|....*....
gi 1907188997 1142 GDGyakdaKLNAPSSLAASPDGTLYIADLGNIRIRAVSK 1180
Cdd:cd14956 196 GPG-----QFNYPYGIAIDPDGNVFVADFGNNRIQKFTA 229
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
897-1176 |
5.04e-06 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 50.40 E-value: 5.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 897 YYLATDPvTGDLYVSDTNTRRIYRpksltgakdltknaeVVAGTGEqclpFDEARCGDGGkaveatlmSPKGMAIDKNGL 976
Cdd:COG4257 20 RDVAVDP-DGAVWFTDQGGGRIGR---------------LDPATGE----FTEYPLGGGS--------GPHGIAVDPDGN 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 977 IYFVDGT--MIRKVD-QNGIISTLLGSNDLTSarpltcdtsmhisqvrlewPTDLAINPmDNSIYVLD--NNVVLQIT-E 1050
Cdd:COG4257 72 LWFTDNGnnRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGNLWFTDqgGNRIGRLDpA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1051 NRQVRiaagrpmhcqvpgvEYPVGKHAVQTTlesatAIAVSYSGVLYITETdekKINRIRQVTTD-GEISLvagipsecd 1129
Cdd:COG4257 132 TGEVT--------------EFPLPTGGAGPY-----GIAVDPDGNLWVTDF---GANAIGRIDPDtGTLTE--------- 180
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1907188997 1130 ckndancdcyqsgdgYAKDAKLNAPSSLAASPDGTLYIADLGNIRIR 1176
Cdd:COG4257 181 ---------------YALPTPGAGPRGLAVDPDGNLWVADTGSGRIG 212
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
845-1106 |
1.82e-05 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 48.74 E-value: 1.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 845 LLAPVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLElrnkdFRHSSNPAHryyLATDPVtGDLYVSDTNTRRIyrpk 922
Cdd:cd14952 51 LYQPQGVAVDAAGTVYVTDFgnNRVLKLAAGSTTQTVLP-----FTGLNDPTG---VAVDAA-GNVYVADTGNNRV---- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 923 sltgakdltknAEVVAGTGEQC-LPFdearcgdggkaveATLMSPKGMAIDKNGLIYFVDGtmirkvDQNGIISTLLGSN 1001
Cdd:cd14952 118 -----------LKLAAGSNTQTvLPF-------------TGLSNPDGVAVDGAGNVYVTDT------GNNRVLKLAAGST 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1002 DLTsARPLTCDTSmhisqvrlewPTDLAINPMDNsIYVLDNNvvlqitENRQVRIAAGRPMHCQVP--GVEYPVGkhavq 1079
Cdd:cd14952 168 TQT-VLPFTGLNS----------PSGVAVDTAGN-VYVTDHG------NNRVLKLAAGSTTPTVLPftGLNGPLG----- 224
|
250 260
....*....|....*....|....*..
gi 1907188997 1080 ttlesataIAVSYSGVLYITETDEKKI 1106
Cdd:cd14952 225 --------VAVDAAGNVYVADRGNDRV 243
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
899-1182 |
3.34e-05 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 49.46 E-value: 3.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 899 LATDPVTGDLYVSDTNTRRIYrpksltgAKDLTKNAEV-VAGTGEQCL---PFDEArcgdggkaveaTLMSPKGMAID-K 973
Cdd:PLN02919 573 LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFEDA-----------TFNRPQGLAYNaK 634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 974 NGLIYFVD--GTMIRKVD-QNGIISTLLGS----NDLTSARPLTcdtsmhiSQVrLEWPTDLAINPMDNSIYV------- 1039
Cdd:PLN02919 635 KNLLYVADteNHALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDVCFEPVNEKVYIamagqhq 706
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1040 ------LD-------------------------------------NNVVLQITENRQVR-----------IAAGRPMhcq 1065
Cdd:PLN02919 707 iweyniSDgvtrvfsgdgyernlngssgtstsfaqpsgislspdlKELYIADSESSSIRaldlktggsrlLAGGDPT--- 783
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1066 VPGVEYPVGKH---AVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTtdGEISLVAGIPsecdckndancdcyQSG 1142
Cdd:PLN02919 784 FSDNLFKFGDHdgvGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTG--------------KAG 847
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1907188997 1143 --DGYAKDAKLNAPSSLAASPDGTLYIADLGNIRIRAVSKNK 1182
Cdd:PLN02919 848 fkDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1147-1273 |
7.15e-05 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 46.93 E-value: 7.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1147 KDAKLNAPSSLAASPDGTLYIADLGNIRIRAVSKN-KPLLN-------SMNFYE---VASPTDQELYI----------FD 1205
Cdd:cd05819 3 GPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDgNFITSfgsfgsgDGQFNEpagVAVDSDGNLYVadtgnhriqkFD 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907188997 1206 INGTHQYTVSlVTGDYLYNFSY------SNDNDVtAVTDSNGNtlRIrrdpnrmpvRVVSPDNQVIwLTIGTNG 1273
Cdd:cd05819 83 PDGNFLASFG-GSGDGDGEFNGprgiavDSSGNI-YVADTGNH--RI---------QKFDPDGEFL-TTFGSGG 142
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1141-1181 |
8.68e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 47.14 E-value: 8.68e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1907188997 1141 SGDGYAKDAKLNAPSSLAASPDGTLYIADLGNIRIRAVSKN 1181
Cdd:cd14953 12 FSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPD 52
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
844-1101 |
2.28e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 45.36 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 844 KLLAPVALACGIDGSLYVGDFnYVRRI--F-PSGNVTSVLElRNKDFRHSSNPAHryyLATDpvTGDLYVSDTNTRRIYr 920
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFdPDGKFLKYFP-EKKDRVKLISPAG---LAID--DGKLYVSDVKKHKVI- 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 921 pksltgakdltknaeVVAGTGEQCLPFdearcGDGGKAvEATLMSPKGMAIDKNGLIYFVD--GTMIRKVDQNG-IISTL 997
Cdd:cd14963 126 ---------------VFDLEGKLLLEF-----GKPGSE-PGELSYPNGIAVDEDGNIYVADsgNGRIQVFDKNGkFIKEL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 998 LGSNDLTSArpltcdtsmhisqvrLEWPTDLAINPmDNSIYVLDN--NVVLQITENRQVRIAAGRpmhcqvPGVEypvgk 1075
Cdd:cd14963 185 NGSPDGKSG---------------FVNPRGIAVDP-DGNLYVVDNlsHRVYVFDEQGKELFTFGG------RGKD----- 237
|
250 260
....*....|....*....|....*.
gi 1907188997 1076 havQTTLESATAIAVSYSGVLYITET 1101
Cdd:cd14963 238 ---DGQFNLPNGLFIDDDGRLYVTDR 260
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
413-446 |
4.82e-04 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.54 E-value: 4.82e-04
10 20 30
....*....|....*....|....*....|....*.
gi 1907188997 413 NEgC--PGLCNSNGRCTLDQNGWHCVCQPGWRGAGC 446
Cdd:cd00054 3 DE-CasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| EGF |
pfam00008 |
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
420-443 |
1.16e-03 |
|
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Pssm-ID: 394967 Cd Length: 31 Bit Score: 38.13 E-value: 1.16e-03
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
956-1175 |
1.44e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 42.96 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 956 GKAVEATLMSPKGMAIDKNGLIYFVDGT--MIRKVDQNGIISTLLGSNDLtsarpltcdtsmhisQVRlewPTDLAINPM 1033
Cdd:cd14962 49 GNAGPNRFVSPIGVAIDANGNLYVSDAElgKVFVFDRDGKFLRAIGAGAL---------------FKR---PTGIAVDPA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1034 DNSIYVLDnnvvlqiTENRQVRI--AAGRPMHcQVPgveyPVGKHAVQttLESATAIAVSYSGVLYITETDEKKINRI-- 1109
Cdd:cd14962 111 GKRLYVVD-------TLAHKVKVfdLDGRLLF-DIG----KRGSGPGE--FNLPTDLAVDRDGNLYVTDTMNFRVQIFda 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1110 --RQVTTDGEISLVAG---IPSECDCKNDAN---CDCYQS---------------GDGYAKDAKLNAPSSLAASPDGTLY 1166
Cdd:cd14962 177 dgKFLRSFGERGDGPGsfaRPKGIAVDSEGNiyvVDAAFDnvqifnpegellltvGGPGSGPGEFYLPSGIAIDKDDRIY 256
|
....*....
gi 1907188997 1167 IADLGNIRI 1175
Cdd:cd14962 257 VVDQFNRRI 265
|
|
| EGF |
cd00053 |
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
417-445 |
1.48e-03 |
|
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.
Pssm-ID: 238010 Cd Length: 36 Bit Score: 38.23 E-value: 1.48e-03
10 20
....*....|....*....|....*....
gi 1907188997 417 PGLCNSNGRCTLDQNGWHCVCQPGWRGAG 445
Cdd:cd00053 5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1503-1543 |
2.27e-03 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 37.57 E-value: 2.27e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1907188997 1503 YSSTGQ-IASIQRGTTSEKVDYDSQGRIVSRVFADGKTWSYT 1543
Cdd:TIGR01643 1 YDAAGRlTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
851-994 |
2.36e-03 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 42.19 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 851 LACGIDGSLYVGDFNYVR------RIFPSGNVTSVLElrnkDFrHSSN-----PAHRYylatdpvtgdLYVSDTNTRRIY 919
Cdd:COG3386 98 GVVDPDGRLYFTDMGEYLptgalyRVDPDGSLRVLAD----GL-TFPNgiafsPDGRT----------LYVADTGAGRIY 162
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907188997 920 R-PKSLTGAkdLTkNAEVVAgtgeqclpfdEARCGDGGkaveatlmsPKGMAIDKNGLIY--FVDGTMIRKVDQNGII 994
Cdd:COG3386 163 RfDLDADGT--LG-NRRVFA----------DLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDGEL 218
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
843-920 |
3.82e-03 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 41.54 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 843 NKLLAPVALACGIDGSLYVGDF--NYVRRIFP-SGNVTSvlelrnkdFRHSSNPAHRYYLATDPvTGDLYVSDTNTRRIY 919
Cdd:COG4257 185 TPGAGPRGLAVDPDGNLWVADTgsGRIGRFDPkTGTVTE--------YPLPGGGARPYGVAVDG-DGRVWFAESGANRIV 255
|
.
gi 1907188997 920 R 920
Cdd:COG4257 256 R 256
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1150-1246 |
4.47e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 41.51 E-value: 4.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907188997 1150 KLNAPSSLAASPDGTLYIADLGNIRIRAVSKN----------KPLLNSM----------NFYeVASPTDQELYIFDINGT 1209
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADLYNGRIQVFDPDgkflkyfpekKDRVKLIspaglaiddgKLY-VSDVKKHKVIVFDLEGK 132
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1907188997 1210 HQYTVSLVtGDYLYNFSYSN----DNDVT-AVTDSNGNtlRI 1246
Cdd:cd14963 133 LLLEFGKP-GSEPGELSYPNgiavDEDGNiYVADSGNG--RI 171
|
|
| hEGF |
pfam12661 |
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ... |
420-441 |
4.70e-03 |
|
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.
Pssm-ID: 463660 Cd Length: 22 Bit Score: 36.54 E-value: 4.70e-03
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1295-1326 |
9.01e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 36.04 E-value: 9.01e-03
10 20 30
....*....|....*....|....*....|..
gi 1907188997 1295 GLLATKSDETGWTTFFDYDSEGRLTNVTFPTG 1326
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
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|
| EGF |
smart00181 |
Epidermal growth factor-like domain; |
416-443 |
9.03e-03 |
|
Epidermal growth factor-like domain;
Pssm-ID: 214544 Cd Length: 35 Bit Score: 35.96 E-value: 9.03e-03
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