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Conserved domains on  [gi|1907070233|ref|XP_036009288|]
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protein dispatched homolog 1 isoform X4 [Mus musculus]

Protein Classification

RND transporter family protein( domain architecture ID 1001856)

resistance-nodulation-cell division (RND) transporter family protein

Gene Ontology:  GO:0016020|GO:0055085
PubMed:  10941792
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MMPL super family cl34072
Predicted exporter protein, RND superfamily [General function prediction only];
302-941 1.51e-43

Predicted exporter protein, RND superfamily [General function prediction only];


The actual alignment was detected with superfamily member COG1033:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 171.20  E-value: 1.51e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  302 FQDYLLMD-TVYPAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPFMNLTALIILvGIGADD 379
Cdd:COG1033    212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  380 A-FVLcdvwnyTKFDKPRAETS---EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMV 455
Cdd:COG1033    289 GiHLL------NRYREERRKGLdkrEALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSL 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  456 TWLPAVIVLheryllniftcFRKPQPQaydkscwavlcqkcRRVLFAVSEASRIFfeKVLPCIVIKFRYLWLIWFLALTV 535
Cdd:COG1033    363 TLLPALLSL-----------LPRPKPK--------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAV 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  536 GGAYIVcvnPKMKLPSLELSEfqvFRSSHPFeRYDAEFkklfmFERVHHGEelhMPITVIwgvspedsgdplnpkskgeL 615
Cdd:COG1033    416 VSLYGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------V 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  616 TLDSTFNIASPASQAWILHFCQKLRNQTFFHQTeqQDFTScFIETFKQWMENQDCDEPALypccshcsfPYKQEVfelcI 695
Cdd:COG1033    462 DTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESREL----L 525

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  696 KKAIMELDRSTGYHLNNktpgprFdINDTIRAVVLefqSTFLFTLAYEKMQQFYKEVDSWISHELssAPEGLSrgWFVS- 774
Cdd:COG1033    526 AQLLLLLSSPPGDDLSR------F-VDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTg 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  775 -NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGL 853
Cdd:COG1033    592 sAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGI 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  854 SVDFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 931
Cdd:COG1033    672 GVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLL 751

                          650
                   ....*....|
gi 1907070233  932 FQCLCRCLGP 941
Cdd:COG1033    752 LPALLLLLDP 761
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
302-941 1.51e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 171.20  E-value: 1.51e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  302 FQDYLLMD-TVYPAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPFMNLTALIILvGIGADD 379
Cdd:COG1033    212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  380 A-FVLcdvwnyTKFDKPRAETS---EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMV 455
Cdd:COG1033    289 GiHLL------NRYREERRKGLdkrEALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSL 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  456 TWLPAVIVLheryllniftcFRKPQPQaydkscwavlcqkcRRVLFAVSEASRIFfeKVLPCIVIKFRYLWLIWFLALTV 535
Cdd:COG1033    363 TLLPALLSL-----------LPRPKPK--------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAV 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  536 GGAYIVcvnPKMKLPSLELSEfqvFRSSHPFeRYDAEFkklfmFERVHHGEelhMPITVIwgvspedsgdplnpkskgeL 615
Cdd:COG1033    416 VSLYGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------V 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  616 TLDSTFNIASPASQAWILHFCQKLRNQTFFHQTeqQDFTScFIETFKQWMENQDCDEPALypccshcsfPYKQEVfelcI 695
Cdd:COG1033    462 DTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESREL----L 525

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  696 KKAIMELDRSTGYHLNNktpgprFdINDTIRAVVLefqSTFLFTLAYEKMQQFYKEVDSWISHELssAPEGLSrgWFVS- 774
Cdd:COG1033    526 AQLLLLLSSPPGDDLSR------F-VDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTg 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  775 -NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGL 853
Cdd:COG1033    592 sAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGI 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  854 SVDFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 931
Cdd:COG1033    672 GVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLL 751

                          650
                   ....*....|
gi 1907070233  932 FQCLCRCLGP 941
Cdd:COG1033    752 LPALLLLLDP 761
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 241-921 1.35e-22

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 104.74  E-value: 1.35e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  241 DFMTPKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGITTVTGIEFGIKHSLFQDYLLM---DTVYPAIAI 317
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  318 AIVLLIM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFNFEFFPFMNLTALIILvGIGADDAFVLC 384
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  385 DVWNYTkfdkpRAETS--EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 462
Cdd:pfam02460  301 AAWQRT-----TATLSvkKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIM 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  463 VLHERYLLNIFTCFRKPqPQAYDKSCWAVLCQKCRRVLfAVSEASRIFFEKVLPCI----VIKFRYLWLIWFLALTVGGa 538
Cdd:pfam02460  376 AICAKPEAEGRHCLFVW-ATSSPQRIDSEGSEPDKSHN-IEQLKSRFFLDIYCPFLlnpsVRVCMLVLFVVYIAIAIYG- 452

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  539 yivCVNPKMklpslELSEFQVFRSSHPFERYDAEFKKLFMfervHHGEELHMPItviwgvspEDSGDPLNPKSKGEL--- 615
Cdd:pfam02460  453 ---CVNIKE-----GLEPDKLVLEDSPLVEYLSLREKHFW----PEGLQIQVAV--------NNPPNLTIPESRDRMnem 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  616 --TLDSTFNIASP-ASQAWILHFCQKLRNQTFFhqtEQQDF-TSCFIETFKQWMEnqdcdepalYPCCSHCSfpykqevf 691
Cdd:pfam02460  513 vdEFENTPYSLGPnSTLFWLREYENFLSTLNME---EEEDEeKEWSYGNLPSFLK---------APGNSHWA-------- 572

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  692 elcikkaimeldrstGYHLNNKTpGPRFdindtiravvlefqSTFLFTLAYEKMQQFYKEVDS---W--ISHELSSapeg 766
Cdd:pfam02460  573 ---------------GDLVWDDN-TTMV--------------TKFRFTLAGKGLSTWNDRTRAlqeWrsIADQYPE---- 618

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  767 LSRGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVT 846
Cdd:pfam02460  619 FNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMIT 698

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907070233  847 ISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAIAMAALTTFVagAMMMPSTVLAYTQLGTF--MMLVM 921
Cdd:pfam02460  699 IIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTIL--GVLVLLFVPSYMVVVFFktVFLVV 773
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 784-961 1.05e-10

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 66.56  E-value: 1.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  784 SLSDGTLIAMGLSVAVAFSVMLL---TTWNIIISLyaIVSIAGTIFVTVGSLVLLGwELNVlesvtISVA-----VGLSV 855
Cdd:TIGR03480  266 TVSEGATVAGLLSFVLVLVLLWLalrSPRLVFAVL--VTLIVGLILTAAFATLAVG-HLNL-----ISVAfavlfIGLGV 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  856 DFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWaFATF-FF 932
Cdd:TIGR03480  338 DFAIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTLtVL 416

                          170       180
                   ....*....|....*....|....*....
gi 1907070233  933 QCLCRCLGPQGTCGQIPFPTKLQCSPFSH 961
Cdd:TIGR03480  417 PALLRLLRPPRRRKPPGYATLAPLDAFLR 445
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
302-941 1.51e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 171.20  E-value: 1.51e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  302 FQDYLLMD-TVYPAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPFMNLTALIILvGIGADD 379
Cdd:COG1033    212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  380 A-FVLcdvwnyTKFDKPRAETS---EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMV 455
Cdd:COG1033    289 GiHLL------NRYREERRKGLdkrEALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSL 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  456 TWLPAVIVLheryllniftcFRKPQPQaydkscwavlcqkcRRVLFAVSEASRIFfeKVLPCIVIKFRYLWLIWFLALTV 535
Cdd:COG1033    363 TLLPALLSL-----------LPRPKPK--------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAV 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  536 GGAYIVcvnPKMKLPSLELSEfqvFRSSHPFeRYDAEFkklfmFERVHHGEelhMPITVIwgvspedsgdplnpkskgeL 615
Cdd:COG1033    416 VSLYGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------V 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  616 TLDSTFNIASPASQAWILHFCQKLRNQTFFHQTeqQDFTScFIETFKQWMENQDCDEPALypccshcsfPYKQEVfelcI 695
Cdd:COG1033    462 DTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESREL----L 525

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  696 KKAIMELDRSTGYHLNNktpgprFdINDTIRAVVLefqSTFLFTLAYEKMQQFYKEVDSWISHELssAPEGLSrgWFVS- 774
Cdd:COG1033    526 AQLLLLLSSPPGDDLSR------F-VDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTg 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  775 -NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGL 853
Cdd:COG1033    592 sAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGI 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  854 SVDFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 931
Cdd:COG1033    672 GVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLL 751

                          650
                   ....*....|
gi 1907070233  932 FQCLCRCLGP 941
Cdd:COG1033    752 LPALLLLLDP 761
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 241-921 1.35e-22

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 104.74  E-value: 1.35e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  241 DFMTPKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGITTVTGIEFGIKHSLFQDYLLM---DTVYPAIAI 317
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  318 AIVLLIM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFNFEFFPFMNLTALIILvGIGADDAFVLC 384
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  385 DVWNYTkfdkpRAETS--EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 462
Cdd:pfam02460  301 AAWQRT-----TATLSvkKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIM 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  463 VLHERYLLNIFTCFRKPqPQAYDKSCWAVLCQKCRRVLfAVSEASRIFFEKVLPCI----VIKFRYLWLIWFLALTVGGa 538
Cdd:pfam02460  376 AICAKPEAEGRHCLFVW-ATSSPQRIDSEGSEPDKSHN-IEQLKSRFFLDIYCPFLlnpsVRVCMLVLFVVYIAIAIYG- 452

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  539 yivCVNPKMklpslELSEFQVFRSSHPFERYDAEFKKLFMfervHHGEELHMPItviwgvspEDSGDPLNPKSKGEL--- 615
Cdd:pfam02460  453 ---CVNIKE-----GLEPDKLVLEDSPLVEYLSLREKHFW----PEGLQIQVAV--------NNPPNLTIPESRDRMnem 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  616 --TLDSTFNIASP-ASQAWILHFCQKLRNQTFFhqtEQQDF-TSCFIETFKQWMEnqdcdepalYPCCSHCSfpykqevf 691
Cdd:pfam02460  513 vdEFENTPYSLGPnSTLFWLREYENFLSTLNME---EEEDEeKEWSYGNLPSFLK---------APGNSHWA-------- 572

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  692 elcikkaimeldrstGYHLNNKTpGPRFdindtiravvlefqSTFLFTLAYEKMQQFYKEVDS---W--ISHELSSapeg 766
Cdd:pfam02460  573 ---------------GDLVWDDN-TTMV--------------TKFRFTLAGKGLSTWNDRTRAlqeWrsIADQYPE---- 618

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  767 LSRGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVT 846
Cdd:pfam02460  619 FNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMIT 698

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907070233  847 ISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAIAMAALTTFVagAMMMPSTVLAYTQLGTF--MMLVM 921
Cdd:pfam02460  699 IIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTIL--GVLVLLFVPSYMVVVFFktVFLVV 773
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
779-932 1.33e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 85.30  E-value: 1.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  779 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 858
Cdd:COG1033    210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYG 289

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907070233  859 VHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVA-GAMM-MPSTVLAytQLGTFMMLVMCVSWAFATFFF 932
Cdd:COG1033    290 IHLLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGfLSLLfSDIPPIR--DFGIVAAIGVLLAFLTSLTLL 365
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
314-468 7.21e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 82.99  E-value: 7.21e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  314 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPfMNLTALIILVGIGADDAFVLcdVWNYTKF 392
Cdd:COG1033    612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFgLMG--LLGIPLNI-ATAVVASIALGIGVDYTIHF--LSRYREE 686

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907070233  393 DKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY 468
Cdd:COG1033    687 RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 313-477 3.91e-14

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 71.08  E-value: 3.91e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  313 PAIAIAIVLLIMCVYTKSMfiTLMTMFAIISSLIVSyflyrvvfnfEFFPFmnltaliILVGIGADDAFVLCDVWNYTKF 392
Cdd:pfam12349    6 FGLGLAGVIIVLASVASSL--GLCAYFGLPLTLIIS----------EVIPF-------LVLAIGVDNIFLLVKAVVRTPR 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  393 DKPraeTSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHER----Y 468
Cdd:pfam12349   67 SLD---VSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRrlesN 143


                   ....*....
gi 1907070233  469 LLNIFTCFR 477
Cdd:pfam12349  144 RLDVACCIR 152
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 784-961 1.05e-10

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 66.56  E-value: 1.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  784 SLSDGTLIAMGLSVAVAFSVMLL---TTWNIIISLyaIVSIAGTIFVTVGSLVLLGwELNVlesvtISVA-----VGLSV 855
Cdd:TIGR03480  266 TVSEGATVAGLLSFVLVLVLLWLalrSPRLVFAVL--VTLIVGLILTAAFATLAVG-HLNL-----ISVAfavlfIGLGV 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  856 DFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWaFATF-FF 932
Cdd:TIGR03480  338 DFAIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTLtVL 416

                          170       180
                   ....*....|....*....|....*....
gi 1907070233  933 QCLCRCLGPQGTCGQIPFPTKLQCSPFSH 961
Cdd:TIGR03480  417 PALLRLLRPPRRRKPPGYATLAPLDAFLR 445
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 258-464 7.19e-10

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 63.70  E-value: 7.19e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  258 SMLFSPTEKgESMMNIYLDNFENWNSSDGIT-TVTG--IEFGIKHSLFQDYLLMDTVYPAIAIAIVLLImcVY---TKSM 331
Cdd:TIGR00921  519 QVQLKQGEP-KVQGRKILRDVQHEHPPPGVKvGVTGlpVAFAEMHELVNEGMRRMTIAGAILVLMILLA--VFrnpIKAV 595

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  332 FiTLMTMFAIISSLIVSYFLYRVVFnfeffpFMNLTALI-ILVGIGADDAFVLCDvwnytKFDKPRAETS--EAVSVTLQ 408
Cdd:TIGR00921  596 F-PLIAIGSGILWAIGLMGLRGIPS------FLAMATTIsIILGLGMDYSIHLAE-----RYFEERKEHGpkEAITHTME 663

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907070233  409 HAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL 464
Cdd:TIGR00921  664 RTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 261-888 7.60e-10

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 63.77  E-value: 7.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  261 FSPTEKGESMM---NIYLDNFENWNSSDGITTVTgieFGIKHSLfQDYLLMDTVYPAIAIAIVLLIMCVYT--------- 328
Cdd:TIGR00917  522 VNKTNKTEKAVaweKAFIQLAKDELLPMVQATIS---FSAERSI-EDELKRESTADVITIAISYLVMFAYIsltlgdspr 597

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  329 -KSMFITLMTMFAIISSLIVsyfLYRVVFNFEFFPFMNLTALIILV--------GIGADDAFVLCDVWNYTKF------- 392
Cdd:TIGR00917  598 lKSLYVTSKVLLGLSGILIV---MLSVLGSVGVFSAVGLKSTLIIMevipflvlAVGVDNIFILVFFYFYLEYfyrqvgv 674

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  393 DKPRAETSE-AVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL----HER 467
Cdd:TIGR00917  675 DNEQELTLErRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLdfkrTED 754

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  468 YLLNIFTCFRKPQPqayDKSCWAVLCQKCRRVLFavseasrIFFEKVLPCIVIK--FRYLWLIWFLALTVGG-AYIVCVN 544
Cdd:TIGR00917  755 KRVDCFPCIKTSKS---SISAEKGSGQRKAGLLT-------RYFKEVYAPVLLHwiVKIVVIAFFVGLLMAGiALSTRVE 824

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  545 P----KMKLPSleLSEFQVFRSShpferydaefkklfMFERVHHGEELHMPI------TVIWGVSPEDSGDPLNPKSKGE 614
Cdd:TIGR00917  825 IgldqQIVLPQ--DSYLQIYFAS--------------LTPLLEVGPPFYIVIkgdynyTDFESQNKLCTMGGCDKDSIVN 888

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  615 LTLDSTFnIASPASqAWILHF-----------CQKLRNQTFFHQTEQQDFtSCFIET-----------FKQWMENQDCDE 672
Cdd:TIGR00917  889 VFNNLSY-IAKPAS-SWLDDYlvwlspqasccCRKFTNGTFCNGPDPQCF-RCADLSsdaqgrpsttqFKEKLPWFLNAL 965

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  673 PAlyPCCSHCSFPYKQEVFELCIKKAIMELDRSTGYHLNNKTpgpRFDINDTIRAvVLEFQSTFLFTLAYE--KMQQFYK 750
Cdd:TIGR00917  966 PS--ADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTPLNT---QVDFINAMRA-AQEFAAKVSRSSKMEvyPYSVFYV 1039

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  751 evdswishelssapeglsrgwfvsnleFYDLQDSLSDGTLIAMGLSVAVAFSV-MLLTTWNIIISLYAIVSIAGTIFVTV 829
Cdd:TIGR00917 1040 ---------------------------FFEQYLTIWKTAIINLSIALGAIFIVcLFLLQLNALSVVNLIMSVGMAVVFCV 1092

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907070233  830 GSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAI 888
Cdd:TIGR00917 1093 GIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSV 1151
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 777-915 5.76e-09

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 60.55  E-value: 5.76e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  777 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLV--------LLGWELNVLESVT-- 846
Cdd:COG2409    507 VNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVpl 586

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  847 --ISVAVGLSVDfavhYGV--------AYRLAPDPdREGkVIFSLSRMGSAIAMAAL---TTFVAgamMMPSTVLAYTQL 913
Cdd:COG2409    587 llFVILFGLGMD----YEVflvsrireEYDRGGGT-REA-VIRGLARTGRVITSAALimaAVFAA---FATSPLVFLKQI 657


                   ..
gi 1907070233  914 GT 915
Cdd:COG2409    658 GF 659
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 780-916 1.17e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 55.38  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  780 DLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGwELNVLE----SVTISVAVGLSV 855
Cdd:pfam03176  135 DLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILA-HILGIGlstfALNLLVVLLIAV 213

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907070233  856 --DFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTtfVAGAMMmpstVLAYTQLGTF 916
Cdd:pfam03176  214 gtDYALFLVSRYReeLRAGEDREEAVIRAVRGTGKVVTAAGLT--VAIAML----ALSFARLPVF 272
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
335-487 2.33e-07

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 55.66  E-value: 2.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  335 LMTMFAIISSLIVSYFLyRVVFN---FEFFPFMNLtaliilvGIGADDAFVLCDVWNYTKfdkPRAETSEAVSVTLQHAA 411
Cdd:TIGR00918  435 LLVALSVAAGLGLCALL-GISFNaatTQVLPFLAL-------GVGVDDVFLLAHAFSETG---QNIPFEERTGECLKRTG 503

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  412 LSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL----HERYLLNIFTCFRKP-------- 479
Cdd:TIGR00918  504 ASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLdlrrREDRRLDIFCCFFSPcsarviqi 583


                   ....*...
gi 1907070233  480 QPQAYDKS 487
Cdd:TIGR00918  584 EPQAYADG 591
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 314-464 2.05e-06

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 52.31  E-value: 2.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  314 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSyflyrvvfnFEFFPFM----NL--TALIIL-VGIGADDAFVLCdv 386
Cdd:TIGR03480  276 LLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILT---------AAFATLAvghlNLisVAFAVLfIGLGVDFAIQFS-- 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  387 wnyTKFDKPR---AETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIV 463
Cdd:TIGR03480  345 ---LRYREERfrgGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLR 421


                   .
gi 1907070233  464 L 464
Cdd:TIGR03480  422 L 422
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 314-509 2.69e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 51.76  E-value: 2.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  314 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSlivsyflyrVVFNFEFFPFM-------NLTALIILVGIGAD-DAFVLcd 385
Cdd:TIGR00921  200 AISGILVVLVLLLDFKRWWRPLLPLVIILFG---------VAWVLGIMGWLgiplyatTLLAVPMLIGVGIDyGIQTL-- 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  386 vwnyTKFDKPRAE---TSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 462
Cdd:TIGR00921  269 ----NRYEEERDIgraKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1907070233  463 VL--HERYLLNIFTCFRKPQPQAYDKSCWAVLCQKCRRVLFAVSEASRI 509
Cdd:TIGR00921  345 QSidIGREKVKKEIIAIGGKSSEIEEELSKVLSITVRHPVPALVAALII 393
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 314-481 6.32e-06

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 50.74  E-value: 6.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  314 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFNFEF-----FPFMNLTALIIlvGIGADDAFVLcdVWN 388
Cdd:TIGR00833  180 ATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLigvnaQTTVLLTALVI--GAGTDYAVFL--TGR 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  389 YTKFDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY 468
Cdd:TIGR00833  256 YHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGRE 335

                          170
                   ....*....|...
gi 1907070233  469 LLniftcFRKPQP 481
Cdd:TIGR00833  336 GL-----MKPGRK 343
COG4258 COG4258
Predicted exporter [General function prediction only];
848-932 1.43e-05

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 49.47  E-value: 1.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  848 SVAVGLSVDFAVHYGVAYRLAPDPDREgkviFSLSRMGSAIAMAALTTFVAGAMMM--PSTVLAytQLGTFMMLVMCVSW 925
Cdd:COG4258    310 SSLIGVAVDYSLHYLTHRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLfsPFPGLR--QLGVFAAAGLLAAA 383


                   ....*..
gi 1907070233  926 AFATFFF 932
Cdd:COG4258    384 LTTLLWL 390
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 314-464 1.53e-05

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 48.83  E-value: 1.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  314 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSL-----IVSYFLYRVVFNFEFFPFMNLTalIILVGIGADDAFVLcdvwn 388
Cdd:pfam03176  149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLgaaqgLVAILAHILGIGLSTFALNLLV--VLLIAVGTDYALFL----- 221

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907070233  389 YTKFDKPRAE---TSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL 464
Cdd:pfam03176  222 VSRYREELRAgedREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 778-930 3.57e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 48.29  E-value: 3.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  778 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDF 857
Cdd:TIGR00921  558 FAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDY 637

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907070233  858 AVHygVAYRLAPDPDREGKV---IFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGtFMMLVMCVSWAFATF 930
Cdd:TIGR00921  638 SIH--LAERYFEERKEHGPKeaiTHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG-LVQGIGVLSSLTAAL 710
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 779-931 9.34e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 46.75  E-value: 9.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  779 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 858
Cdd:TIGR00921  185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907070233  859 VHYGVAYRlapDPDREGK-----VIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 931
Cdd:TIGR00921  265 IQTLNRYE---EERDIGRakgeaIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLV 339
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 778-916 2.40e-04

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 45.53  E-value: 2.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  778 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVlESVTISVAV----GL 853
Cdd:COG2409    160 AADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDV-SSFAPNLLTmlglGV 238

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907070233  854 SVDFAVHYgVA-YR--LAPDPDREGKVIFSLSRMGSAIAMAALTtfVAGAMMmpstVLAYTQLGTF 916
Cdd:COG2409    239 GIDYALFL-VSrYReeLRAGEDREEAVARAVATAGRAVLFSGLT--VAIALL----GLLLAGLPFL 297
COG4258 COG4258
Predicted exporter [General function prediction only];
793-895 6.02e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 44.46  E-value: 6.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  793 MGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHygvayrLAPDPD 872
Cdd:COG4258    645 LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALF------FTEGLL 718

                           90       100
                   ....*....|....*....|...
gi 1907070233  873 REGkvifSLSRMGSAIAMAALTT 895
Cdd:COG4258    719 DKG----ELARTLLSILLAALTT 737
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
790-905 1.04e-03

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 43.72  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  790 LIAMGLSVAVAF---SVMLLTTWNIIISLYAIVSIAGTIFvtvGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYr 866
Cdd:TIGR00918  968 LLSISVVLACTFlvcALLLLNPWTAGLIVLVLALMTVELF---GMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGF- 1043

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1907070233  867 LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPS 905
Cdd:TIGR00918 1044 LTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGS 1082
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 314-464 1.88e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 42.45  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  314 AIAIAIVLLIMcVYtKS---MFITLMT-MFAIISSLIVSYFLYRVvfnFEFFPFMNLTALIILVGIGADDA-FVLcdvwn 388
Cdd:COG2409    178 TLPVALVVLLL-VF-RSlvaALLPLLTaGLAVGVALGLLALLAAF---TDVSSFAPNLLTMLGLGVGIDYAlFLV----- 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  389 yTKFdkpRAE------TSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 462
Cdd:COG2409    248 -SRY---REElragedREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALL 323


                   ..
gi 1907070233  463 VL 464
Cdd:COG2409    324 AL 325
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 297-464 6.56e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 40.90  E-value: 6.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  297 IKHSLFQDYLLMdtVypAIAIAIVLLIMCVYTKSMFI----TLMTMFAIISSLIVSYFLY---RVVFNFE------FFPF 363
Cdd:COG2409    511 ISDALADDLPLV--I--PVVLGLIFLLLLLLFRSVVAplkaVLTNLLSLGAALGVLVLVFqhgWLLLGFTpgpldsFVPL 586

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070233  364 MnltALIILVGIGAD-DAFVLCDVW-NYTKfdkpRAETSEAVSVTLQH-------AALSMFVTsFttaAAFyanYVSNIT 434
Cdd:COG2409    587 L---LFVILFGLGMDyEVFLVSRIReEYDR----GGGTREAVIRGLARtgrvitsAALIMAAV-F---AAF---ATSPLV 652

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1907070233  435 AIRCFGVYAGTAILVNYVLMVTWL-PAVIVL 464
Cdd:COG2409    653 FLKQIGFGLAVGVLLDAFVVRMLLvPALMAL 683
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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