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Conserved domains on  [gi|1907070231|ref|XP_036009287|]
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protein dispatched homolog 1 isoform X3 [Mus musculus]

Protein Classification

RND transporter family protein( domain architecture ID 1001856)

resistance-nodulation-cell division (RND) transporter family protein

Gene Ontology:  GO:0016020|GO:0055085
PubMed:  10941792
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MMPL super family cl34072
Predicted exporter protein, RND superfamily [General function prediction only];
495-1134 1.91e-43

Predicted exporter protein, RND superfamily [General function prediction only];


The actual alignment was detected with superfamily member COG1033:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 171.20  E-value: 1.91e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  495 FQDYLLMD-TVYPAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPFMNLTALIILvGIGADD 572
Cdd:COG1033    212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  573 A-FVLcdvwnyTKFDKPRAETS---EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMV 648
Cdd:COG1033    289 GiHLL------NRYREERRKGLdkrEALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSL 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  649 TWLPAVIVLheryllniftcFRKPQPQaydkscwavlcqkcRRVLFAVSEASRIFfeKVLPCIVIKFRYLWLIWFLALTV 728
Cdd:COG1033    363 TLLPALLSL-----------LPRPKPK--------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAV 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  729 GGAYIVcvnPKMKLPSLELSEfqvFRSSHPFeRYDAEFkklfmFERVHHGEelhMPITVIwgvspedsgdplnpkskgeL 808
Cdd:COG1033    416 VSLYGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------V 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  809 TLDSTFNIASPASQAWILHFCQKLRNQTFFHQTeqQDFTScFIETFKQWMENQDCDEPALypccshcsfPYKQEVfelcI 888
Cdd:COG1033    462 DTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESREL----L 525

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  889 KKAIMELDRSTGYHLNNktpgprFdINDTIRAVVLefqSTFLFTLAYEKMQQFYKEVDSWISHELssAPEGLSrgWFVS- 967
Cdd:COG1033    526 AQLLLLLSSPPGDDLSR------F-VDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTg 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  968 -NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGL 1046
Cdd:COG1033    592 sAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGI 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231 1047 SVDFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 1124
Cdd:COG1033    672 GVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLL 751

                          650
                   ....*....|
gi 1907070231 1125 FQCLCRCLGP 1134
Cdd:COG1033    752 LPALLLLLDP 761
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
495-1134 1.91e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 171.20  E-value: 1.91e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  495 FQDYLLMD-TVYPAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPFMNLTALIILvGIGADD 572
Cdd:COG1033    212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  573 A-FVLcdvwnyTKFDKPRAETS---EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMV 648
Cdd:COG1033    289 GiHLL------NRYREERRKGLdkrEALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSL 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  649 TWLPAVIVLheryllniftcFRKPQPQaydkscwavlcqkcRRVLFAVSEASRIFfeKVLPCIVIKFRYLWLIWFLALTV 728
Cdd:COG1033    363 TLLPALLSL-----------LPRPKPK--------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAV 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  729 GGAYIVcvnPKMKLPSLELSEfqvFRSSHPFeRYDAEFkklfmFERVHHGEelhMPITVIwgvspedsgdplnpkskgeL 808
Cdd:COG1033    416 VSLYGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------V 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  809 TLDSTFNIASPASQAWILHFCQKLRNQTFFHQTeqQDFTScFIETFKQWMENQDCDEPALypccshcsfPYKQEVfelcI 888
Cdd:COG1033    462 DTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESREL----L 525

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  889 KKAIMELDRSTGYHLNNktpgprFdINDTIRAVVLefqSTFLFTLAYEKMQQFYKEVDSWISHELssAPEGLSrgWFVS- 967
Cdd:COG1033    526 AQLLLLLSSPPGDDLSR------F-VDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTg 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  968 -NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGL 1046
Cdd:COG1033    592 sAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGI 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231 1047 SVDFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 1124
Cdd:COG1033    672 GVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLL 751

                          650
                   ....*....|
gi 1907070231 1125 FQCLCRCLGP 1134
Cdd:COG1033    752 LPALLLLLDP 761
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 434-1114 3.51e-23

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 107.06  E-value: 3.51e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  434 DFMTPKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGITTVTGIEFGIKHSLFQDYLLM---DTVYPAIAI 510
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  511 AIVLLIM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFNFEFFPFMNLTALIILvGIGADDAFVLC 577
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  578 DVWNYTkfdkpRAETS--EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 655
Cdd:pfam02460  301 AAWQRT-----TATLSvkKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIM 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  656 VLHERYLLNIFTCFRKPqPQAYDKSCWAVLCQKCRRVLfAVSEASRIFFEKVLPCI----VIKFRYLWLIWFLALTVGGa 731
Cdd:pfam02460  376 AICAKPEAEGRHCLFVW-ATSSPQRIDSEGSEPDKSHN-IEQLKSRFFLDIYCPFLlnpsVRVCMLVLFVVYIAIAIYG- 452

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  732 yivCVNPKMklpslELSEFQVFRSSHPFERYDAEFKKLFMfervHHGEELHMPItviwgvspEDSGDPLNPKSKGEL--- 808
Cdd:pfam02460  453 ---CVNIKE-----GLEPDKLVLEDSPLVEYLSLREKHFW----PEGLQIQVAV--------NNPPNLTIPESRDRMnem 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  809 --TLDSTFNIASP-ASQAWILHFCQKLRNQTFFhqtEQQDF-TSCFIETFKQWMEnqdcdepalYPCCSHCSfpykqevf 884
Cdd:pfam02460  513 vdEFENTPYSLGPnSTLFWLREYENFLSTLNME---EEEDEeKEWSYGNLPSFLK---------APGNSHWA-------- 572

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  885 elcikkaimeldrstGYHLNNKTpGPRFdindtiravvlefqSTFLFTLAYEKMQQFYKEVDS---W--ISHELSSapeg 959
Cdd:pfam02460  573 ---------------GDLVWDDN-TTMV--------------TKFRFTLAGKGLSTWNDRTRAlqeWrsIADQYPE---- 618

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  960 LSRGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVT 1039
Cdd:pfam02460  619 FNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMIT 698

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907070231 1040 ISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAIAMAALTTFVagAMMMPSTVLAYTQLGTF--MMLVM 1114
Cdd:pfam02460  699 IIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTIL--GVLVLLFVPSYMVVVFFktVFLVV 773
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 977-1154 1.25e-10

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 66.56  E-value: 1.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  977 SLSDGTLIAMGLSVAVAFSVMLL---TTWNIIISLyaIVSIAGTIFVTVGSLVLLGwELNVlesvtISVA-----VGLSV 1048
Cdd:TIGR03480  266 TVSEGATVAGLLSFVLVLVLLWLalrSPRLVFAVL--VTLIVGLILTAAFATLAVG-HLNL-----ISVAfavlfIGLGV 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231 1049 DFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWaFATF-FF 1125
Cdd:TIGR03480  338 DFAIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTLtVL 416

                          170       180
                   ....*....|....*....|....*....
gi 1907070231 1126 QCLCRCLGPQGTCGQIPFPTKLQCSPFSH 1154
Cdd:TIGR03480  417 PALLRLLRPPRRRKPPGYATLAPLDAFLR 445
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
495-1134 1.91e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 171.20  E-value: 1.91e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  495 FQDYLLMD-TVYPAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPFMNLTALIILvGIGADD 572
Cdd:COG1033    212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  573 A-FVLcdvwnyTKFDKPRAETS---EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMV 648
Cdd:COG1033    289 GiHLL------NRYREERRKGLdkrEALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSL 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  649 TWLPAVIVLheryllniftcFRKPQPQaydkscwavlcqkcRRVLFAVSEASRIFfeKVLPCIVIKFRYLWLIWFLALTV 728
Cdd:COG1033    363 TLLPALLSL-----------LPRPKPK--------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAV 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  729 GGAYIVcvnPKMKLPSLELSEfqvFRSSHPFeRYDAEFkklfmFERVHHGEelhMPITVIwgvspedsgdplnpkskgeL 808
Cdd:COG1033    416 VSLYGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------V 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  809 TLDSTFNIASPASQAWILHFCQKLRNQTFFHQTeqQDFTScFIETFKQWMENQDCDEPALypccshcsfPYKQEVfelcI 888
Cdd:COG1033    462 DTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESREL----L 525

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  889 KKAIMELDRSTGYHLNNktpgprFdINDTIRAVVLefqSTFLFTLAYEKMQQFYKEVDSWISHELssAPEGLSrgWFVS- 967
Cdd:COG1033    526 AQLLLLLSSPPGDDLSR------F-VDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTg 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  968 -NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGL 1046
Cdd:COG1033    592 sAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGI 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231 1047 SVDFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 1124
Cdd:COG1033    672 GVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLL 751

                          650
                   ....*....|
gi 1907070231 1125 FQCLCRCLGP 1134
Cdd:COG1033    752 LPALLLLLDP 761
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 434-1114 3.51e-23

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 107.06  E-value: 3.51e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  434 DFMTPKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGITTVTGIEFGIKHSLFQDYLLM---DTVYPAIAI 510
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  511 AIVLLIM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFNFEFFPFMNLTALIILvGIGADDAFVLC 577
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  578 DVWNYTkfdkpRAETS--EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 655
Cdd:pfam02460  301 AAWQRT-----TATLSvkKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIM 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  656 VLHERYLLNIFTCFRKPqPQAYDKSCWAVLCQKCRRVLfAVSEASRIFFEKVLPCI----VIKFRYLWLIWFLALTVGGa 731
Cdd:pfam02460  376 AICAKPEAEGRHCLFVW-ATSSPQRIDSEGSEPDKSHN-IEQLKSRFFLDIYCPFLlnpsVRVCMLVLFVVYIAIAIYG- 452

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  732 yivCVNPKMklpslELSEFQVFRSSHPFERYDAEFKKLFMfervHHGEELHMPItviwgvspEDSGDPLNPKSKGEL--- 808
Cdd:pfam02460  453 ---CVNIKE-----GLEPDKLVLEDSPLVEYLSLREKHFW----PEGLQIQVAV--------NNPPNLTIPESRDRMnem 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  809 --TLDSTFNIASP-ASQAWILHFCQKLRNQTFFhqtEQQDF-TSCFIETFKQWMEnqdcdepalYPCCSHCSfpykqevf 884
Cdd:pfam02460  513 vdEFENTPYSLGPnSTLFWLREYENFLSTLNME---EEEDEeKEWSYGNLPSFLK---------APGNSHWA-------- 572

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  885 elcikkaimeldrstGYHLNNKTpGPRFdindtiravvlefqSTFLFTLAYEKMQQFYKEVDS---W--ISHELSSapeg 959
Cdd:pfam02460  573 ---------------GDLVWDDN-TTMV--------------TKFRFTLAGKGLSTWNDRTRAlqeWrsIADQYPE---- 618

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  960 LSRGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVT 1039
Cdd:pfam02460  619 FNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMIT 698

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907070231 1040 ISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAIAMAALTTFVagAMMMPSTVLAYTQLGTF--MMLVM 1114
Cdd:pfam02460  699 IIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTIL--GVLVLLFVPSYMVVVFFktVFLVV 773
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
972-1125 1.59e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 85.30  E-value: 1.59e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  972 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 1051
Cdd:COG1033    210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYG 289

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907070231 1052 VHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVA-GAMM-MPSTVLAytQLGTFMMLVMCVSWAFATFFF 1125
Cdd:COG1033    290 IHLLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGfLSLLfSDIPPIR--DFGIVAAIGVLLAFLTSLTLL 365
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
507-661 8.63e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 82.99  E-value: 8.63e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  507 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPfMNLTALIILVGIGADDAFVLcdVWNYTKF 585
Cdd:COG1033    612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFgLMG--LLGIPLNI-ATAVVASIALGIGVDYTIHF--LSRYREE 686

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907070231  586 DKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY 661
Cdd:COG1033    687 RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 506-670 1.84e-14

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 72.23  E-value: 1.84e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  506 PAIAIAIVLLIMCVYTKSMfiTLMTMFAIISSLIVSyflyrvvfnfEFFPFmnltaliILVGIGADDAFVLCDVWNYTKF 585
Cdd:pfam12349    6 FGLGLAGVIIVLASVASSL--GLCAYFGLPLTLIIS----------EVIPF-------LVLAIGVDNIFLLVKAVVRTPR 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  586 DKPraeTSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHER----Y 661
Cdd:pfam12349   67 SLD---VSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRrlesN 143


                   ....*....
gi 1907070231  662 LLNIFTCFR 670
Cdd:pfam12349  144 RLDVACCIR 152
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 977-1154 1.25e-10

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 66.56  E-value: 1.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  977 SLSDGTLIAMGLSVAVAFSVMLL---TTWNIIISLyaIVSIAGTIFVTVGSLVLLGwELNVlesvtISVA-----VGLSV 1048
Cdd:TIGR03480  266 TVSEGATVAGLLSFVLVLVLLWLalrSPRLVFAVL--VTLIVGLILTAAFATLAVG-HLNL-----ISVAfavlfIGLGV 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231 1049 DFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWaFATF-FF 1125
Cdd:TIGR03480  338 DFAIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTLtVL 416

                          170       180
                   ....*....|....*....|....*....
gi 1907070231 1126 QCLCRCLGPQGTCGQIPFPTKLQCSPFSH 1154
Cdd:TIGR03480  417 PALLRLLRPPRRRKPPGYATLAPLDAFLR 445
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 451-657 8.48e-10

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 63.70  E-value: 8.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  451 SMLFSPTEKgESMMNIYLDNFENWNSSDGIT-TVTG--IEFGIKHSLFQDYLLMDTVYPAIAIAIVLLImcVY---TKSM 524
Cdd:TIGR00921  519 QVQLKQGEP-KVQGRKILRDVQHEHPPPGVKvGVTGlpVAFAEMHELVNEGMRRMTIAGAILVLMILLA--VFrnpIKAV 595

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  525 FiTLMTMFAIISSLIVSYFLYRVVFnfeffpFMNLTALI-ILVGIGADDAFVLCDvwnytKFDKPRAETS--EAVSVTLQ 601
Cdd:TIGR00921  596 F-PLIAIGSGILWAIGLMGLRGIPS------FLAMATTIsIILGLGMDYSIHLAE-----RYFEERKEHGpkEAITHTME 663

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907070231  602 HAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL 657
Cdd:TIGR00921  664 RTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 454-1081 1.04e-09

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 63.39  E-value: 1.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  454 FSPTEKGESMM---NIYLDNFENWNSSDGITTVTgieFGIKHSLfQDYLLMDTVYPAIAIAIVLLIMCVYT--------- 521
Cdd:TIGR00917  522 VNKTNKTEKAVaweKAFIQLAKDELLPMVQATIS---FSAERSI-EDELKRESTADVITIAISYLVMFAYIsltlgdspr 597

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  522 -KSMFITLMTMFAIISSLIVsyfLYRVVFNFEFFPFMNLTALIILV--------GIGADDAFVLCDVWNYTKF------- 585
Cdd:TIGR00917  598 lKSLYVTSKVLLGLSGILIV---MLSVLGSVGVFSAVGLKSTLIIMevipflvlAVGVDNIFILVFFYFYLEYfyrqvgv 674

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  586 DKPRAETSE-AVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL----HER 660
Cdd:TIGR00917  675 DNEQELTLErRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLdfkrTED 754

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  661 YLLNIFTCFRKPQPqayDKSCWAVLCQKCRRVLFavseasrIFFEKVLPCIVIK--FRYLWLIWFLALTVGG-AYIVCVN 737
Cdd:TIGR00917  755 KRVDCFPCIKTSKS---SISAEKGSGQRKAGLLT-------RYFKEVYAPVLLHwiVKIVVIAFFVGLLMAGiALSTRVE 824

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  738 P----KMKLPSleLSEFQVFRSShpferydaefkklfMFERVHHGEELHMPI------TVIWGVSPEDSGDPLNPKSKGE 807
Cdd:TIGR00917  825 IgldqQIVLPQ--DSYLQIYFAS--------------LTPLLEVGPPFYIVIkgdynyTDFESQNKLCTMGGCDKDSIVN 888

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  808 LTLDSTFnIASPASqAWILHF-----------CQKLRNQTFFHQTEQQDFtSCFIET-----------FKQWMENQDCDE 865
Cdd:TIGR00917  889 VFNNLSY-IAKPAS-SWLDDYlvwlspqasccCRKFTNGTFCNGPDPQCF-RCADLSsdaqgrpsttqFKEKLPWFLNAL 965

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  866 PAlyPCCSHCSFPYKQEVFELCIKKAIMELDRSTGYHLNNKTpgpRFDINDTIRAvVLEFQSTFLFTLAYE--KMQQFYK 943
Cdd:TIGR00917  966 PS--ADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTPLNT---QVDFINAMRA-AQEFAAKVSRSSKMEvyPYSVFYV 1039

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  944 evdswishelssapeglsrgwfvsnleFYDLQDSLSDGTLIAMGLSVAVAFSV-MLLTTWNIIISLYAIVSIAGTIFVTV 1022
Cdd:TIGR00917 1040 ---------------------------FFEQYLTIWKTAIINLSIALGAIFIVcLFLLQLNALSVVNLIMSVGMAVVFCV 1092

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907070231 1023 GSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAI 1081
Cdd:TIGR00917 1093 GIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSV 1151
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 970-1108 6.78e-09

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 60.55  E-value: 6.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  970 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLV--------LLGWELNVLESVT-- 1039
Cdd:COG2409    507 VNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVpl 586

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231 1040 --ISVAVGLSVDfavhYGV--------AYRLAPDPdREGkVIFSLSRMGSAIAMAAL---TTFVAgamMMPSTVLAYTQL 1106
Cdd:COG2409    587 llFVILFGLGMD----YEVflvsrireEYDRGGGT-REA-VIRGLARTGRVITSAALimaAVFAA---FATSPLVFLKQI 657


                   ..
gi 1907070231 1107 GT 1108
Cdd:COG2409    658 GF 659
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 973-1109 1.37e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 55.38  E-value: 1.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  973 DLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGwELNVLE----SVTISVAVGLSV 1048
Cdd:pfam03176  135 DLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILA-HILGIGlstfALNLLVVLLIAV 213

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907070231 1049 --DFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTtfVAGAMMmpstVLAYTQLGTF 1109
Cdd:pfam03176  214 gtDYALFLVSRYReeLRAGEDREEAVIRAVRGTGKVVTAAGLT--VAIAML----ALSFARLPVF 272
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
528-680 3.56e-07

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 55.27  E-value: 3.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  528 LMTMFAIISSLIVSYFLyRVVFN---FEFFPFMNLtaliilvGIGADDAFVLCDVWNYTKfdkPRAETSEAVSVTLQHAA 604
Cdd:TIGR00918  435 LLVALSVAAGLGLCALL-GISFNaatTQVLPFLAL-------GVGVDDVFLLAHAFSETG---QNIPFEERTGECLKRTG 503

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  605 LSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL----HERYLLNIFTCFRKP-------- 672
Cdd:TIGR00918  504 ASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLdlrrREDRRLDIFCCFFSPcsarviqi 583


                   ....*...
gi 1907070231  673 QPQAYDKS 680
Cdd:TIGR00918  584 EPQAYADG 591
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 507-657 2.40e-06

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 52.31  E-value: 2.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  507 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSyflyrvvfnFEFFPFM----NL--TALIIL-VGIGADDAFVLCdv 579
Cdd:TIGR03480  276 LLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILT---------AAFATLAvghlNLisVAFAVLfIGLGVDFAIQFS-- 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  580 wnyTKFDKPR---AETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIV 656
Cdd:TIGR03480  345 ---LRYREERfrgGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLR 421


                   .
gi 1907070231  657 L 657
Cdd:TIGR03480  422 L 422
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 507-702 3.15e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 51.76  E-value: 3.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  507 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSlivsyflyrVVFNFEFFPFM-------NLTALIILVGIGAD-DAFVLcd 578
Cdd:TIGR00921  200 AISGILVVLVLLLDFKRWWRPLLPLVIILFG---------VAWVLGIMGWLgiplyatTLLAVPMLIGVGIDyGIQTL-- 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  579 vwnyTKFDKPRAE---TSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 655
Cdd:TIGR00921  269 ----NRYEEERDIgraKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1907070231  656 VL--HERYLLNIFTCFRKPQPQAYDKSCWAVLCQKCRRVLFAVSEASRI 702
Cdd:TIGR00921  345 QSidIGREKVKKEIIAIGGKSSEIEEELSKVLSITVRHPVPALVAALII 393
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 507-674 7.40e-06

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 50.74  E-value: 7.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  507 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFNFEF-----FPFMNLTALIIlvGIGADDAFVLcdVWN 581
Cdd:TIGR00833  180 ATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLigvnaQTTVLLTALVI--GAGTDYAVFL--TGR 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  582 YTKFDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY 661
Cdd:TIGR00833  256 YHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGRE 335

                          170
                   ....*....|...
gi 1907070231  662 LLniftcFRKPQP 674
Cdd:TIGR00833  336 GL-----MKPGRK 343
COG4258 COG4258
Predicted exporter [General function prediction only];
1041-1125 1.68e-05

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 49.47  E-value: 1.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231 1041 SVAVGLSVDFAVHYGVAYRLAPDPDREgkviFSLSRMGSAIAMAALTTFVAGAMMM--PSTVLAytQLGTFMMLVMCVSW 1118
Cdd:COG4258    310 SSLIGVAVDYSLHYLTHRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLfsPFPGLR--QLGVFAAAGLLAAA 383


                   ....*..
gi 1907070231 1119 AFATFFF 1125
Cdd:COG4258    384 LTTLLWL 390
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 507-657 1.78e-05

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 48.83  E-value: 1.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  507 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSL-----IVSYFLYRVVFNFEFFPFMNLTalIILVGIGADDAFVLcdvwn 581
Cdd:pfam03176  149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLgaaqgLVAILAHILGIGLSTFALNLLV--VLLIAVGTDYALFL----- 221

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907070231  582 YTKFDKPRAE---TSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL 657
Cdd:pfam03176  222 VSRYREELRAgedREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 971-1123 4.18e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 48.29  E-value: 4.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  971 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDF 1050
Cdd:TIGR00921  558 FAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDY 637

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907070231 1051 AVHygVAYRLAPDPDREGKV---IFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGtFMMLVMCVSWAFATF 1123
Cdd:TIGR00921  638 SIH--LAERYFEERKEHGPKeaiTHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG-LVQGIGVLSSLTAAL 710
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 972-1124 1.09e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 46.75  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  972 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 1051
Cdd:TIGR00921  185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907070231 1052 VHYGVAYRlapDPDREGK-----VIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 1124
Cdd:TIGR00921  265 IQTLNRYE---EERDIGRakgeaIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLV 339
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 971-1109 2.80e-04

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 45.53  E-value: 2.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  971 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVlESVTISVAV----GL 1046
Cdd:COG2409    160 AADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDV-SSFAPNLLTmlglGV 238

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907070231 1047 SVDFAVHYgVA-YR--LAPDPDREGKVIFSLSRMGSAIAMAALTtfVAGAMMmpstVLAYTQLGTF 1109
Cdd:COG2409    239 GIDYALFL-VSrYReeLRAGEDREEAVARAVATAGRAVLFSGLT--VAIALL----GLLLAGLPFL 297
COG4258 COG4258
Predicted exporter [General function prediction only];
986-1088 7.02e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 44.46  E-value: 7.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  986 MGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHygvayrLAPDPD 1065
Cdd:COG4258    645 LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALF------FTEGLL 718

                           90       100
                   ....*....|....*....|...
gi 1907070231 1066 REGkvifSLSRMGSAIAMAALTT 1088
Cdd:COG4258    719 DKG----ELARTLLSILLAALTT 737
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
983-1098 1.46e-03

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 43.33  E-value: 1.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  983 LIAMGLSVAVAF---SVMLLTTWNIIISLYAIVSIAGTIFvtvGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYr 1059
Cdd:TIGR00918  968 LLSISVVLACTFlvcALLLLNPWTAGLIVLVLALMTVELF---GMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGF- 1043

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1907070231 1060 LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPS 1098
Cdd:TIGR00918 1044 LTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGS 1082
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 507-657 2.19e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 42.45  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  507 AIAIAIVLLIMcVYtKS---MFITLMT-MFAIISSLIVSYFLYRVvfnFEFFPFMNLTALIILVGIGADDA-FVLcdvwn 581
Cdd:COG2409    178 TLPVALVVLLL-VF-RSlvaALLPLLTaGLAVGVALGLLALLAAF---TDVSSFAPNLLTMLGLGVGIDYAlFLV----- 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  582 yTKFdkpRAE------TSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 655
Cdd:COG2409    248 -SRY---REElragedREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALL 323


                   ..
gi 1907070231  656 VL 657
Cdd:COG2409    324 AL 325
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 490-657 7.64e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 40.90  E-value: 7.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  490 IKHSLFQDYLLMdtVypAIAIAIVLLIMCVYTKSMFI----TLMTMFAIISSLIVSYFLY---RVVFNFE------FFPF 556
Cdd:COG2409    511 ISDALADDLPLV--I--PVVLGLIFLLLLLLFRSVVAplkaVLTNLLSLGAALGVLVLVFqhgWLLLGFTpgpldsFVPL 586

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070231  557 MnltALIILVGIGAD-DAFVLCDVW-NYTKfdkpRAETSEAVSVTLQH-------AALSMFVTsFttaAAFyanYVSNIT 627
Cdd:COG2409    587 L---LFVILFGLGMDyEVFLVSRIReEYDR----GGGTREAVIRGLARtgrvitsAALIMAAV-F---AAF---ATSPLV 652

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1907070231  628 AIRCFGVYAGTAILVNYVLMVTWL-PAVIVL 657
Cdd:COG2409    653 FLKQIGFGLAVGVLLDAFVVRMLLvPALMAL 683
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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