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Conserved domains on  [gi|1907182058|ref|XP_036009070|]
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zinc finger CCCH domain-containing protein 4 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 374-395 1.58e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


:

Pssm-ID: 465626  Cd Length: 22  Bit Score: 48.35  E-value: 1.58e-07
                           10        20
                   ....*....|....*....|..
gi 1907182058  374 VICKYFVEGRCTWGDHCNFSHD 395
Cdd:pfam18044    1 RLCRYFQKGGCRYGDNCRFSHD 22
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 974-1260 2.25e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 2.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  974 PLPIPKQDVPPV-PAALQSLPALDPRLHR----------STPPGPPNTRQRPGSTDPSTSGSNLPDFELLSRILKTVNVN 1042
Cdd:PHA03247  2560 PPAAPDRSVPPPrPAPRPSEPAVTSRARRpdappqsarpRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD 2639

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1043 TPGQSEKPSDPRVRKTPTDPRLQKPADPVAASRAAKPC--PTEASPPAASP-------SGDSSPPATAPYDPRVLAAGGL 1113
Cdd:PHA03247  2640 PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASspPQRPRRRAARPtvgsltsLADPPPPPPTPEPAPHALVSAT 2719

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1114 GQGSSSGQSSVLSGISLYDPRTPNAGGKTAEPASDTsAQPKGPEGNGKGSASKAKEPPFVRKSALEQPETGKASTDGATA 1193
Cdd:PHA03247  2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907182058 1194 TDRYNSYNRPRPKATAAPTAASSTPPPEGATPQPGVHNLPVPTLFGTVKPAPKTG----TGSPFAGNSPAR 1260
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvaPGGDVRRRPPSR 2869
ZnF_C3H1 smart00356
zinc finger;
401-425 1.23e-05

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.00  E-value: 1.23e-05
                            10        20
                    ....*....|....*....|....*
gi 1907182058   401 KRELCKFYITGFCARAENCPYMHGD 425
Cdd:smart00356    3 KTELCKFFKRGYCPRGDRCKFAHPL 27
OmdA pfam13376
Bacteriocin-protection, YdeI or OmpD-Associated; This is a family of archaeal and bacterial ...
 754-779 3.65e-03

Bacteriocin-protection, YdeI or OmpD-Associated; This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S). YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein.


:

Pssm-ID: 433158  Cd Length: 60  Bit Score: 37.05  E-value: 3.65e-03
                           10        20
                   ....*....|....*....|....*.
gi 1907182058  754 PSAQRALYLRIQQKQQEEERARRLAE 779
Cdd:pfam13376   27 PSYRREYLLWISSAKRPETRAKRIAK 52
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 713-1110 6.75e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 6.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  713 EELPGQPGEPLFPEHPLEP-DSFPEGGPPGRPKAGAGVPDFLPSAQRA----LYLRIQQKQQEEERARRLAESSKQDREN 787
Cdd:PHA03247  2586 ARRPDAPPQSARPRAPVDDrGDPRGPAPPSPLPPDTHAPDPPPPSPSPaanePDPHPPPTVPPPERPRDDPAPGRVSRPR 2665

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  788 EEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSS-RPQASVGEPSSsglgdprlqKGHPTGSRLSDPRLSRDPRLSRHAET 866
Cdd:PHA03247  2666 RARRLGRAAQASSPPQRPRRRAARPTVGSLTSLaDPPPPPPTPEP---------APHALVSATPLPPGPAAARQASPALP 2736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  867 SGGSGPGDSGPSDPRLARALPTSKAEGSLHSSPAGPSSSKGQPPAEEEEGerALREKAVNIPLDPLPGHPLRDPrsqlqq 946
Cdd:PHA03247  2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP--AVASLSESRESLPSPWDPADPP------ 2808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  947 fshikkdVTLSKPSFARTVLWNPEDLIPLPIPKQDVPPVPAALQSLPALdPRLHRSTPPGPPNTRQRPGSTDPSTSGSNL 1026
Cdd:PHA03247  2809 -------AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAAKPAAPAR 2880

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1027 PDFELLSR----------ILKTVNVNTPGQSEKPSDPRVRKTPTDPRLQKPADPVAASRAAKPCPTEASPPAASPSGDSS 1096
Cdd:PHA03247  2881 PPVRRLARpavsrstesfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960

                          410
                   ....*....|....
gi 1907182058 1097 PPATAPYDPRVLAA 1110
Cdd:PHA03247  2961 QPWLGALVPGRVAV 2974
 
Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 374-395 1.58e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 48.35  E-value: 1.58e-07
                           10        20
                   ....*....|....*....|..
gi 1907182058  374 VICKYFVEGRCTWGDHCNFSHD 395
Cdd:pfam18044    1 RLCRYFQKGGCRYGDNCRFSHD 22
PHA03247 PHA03247
large tegument protein UL36; Provisional
 974-1260 2.25e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 2.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  974 PLPIPKQDVPPV-PAALQSLPALDPRLHR----------STPPGPPNTRQRPGSTDPSTSGSNLPDFELLSRILKTVNVN 1042
Cdd:PHA03247  2560 PPAAPDRSVPPPrPAPRPSEPAVTSRARRpdappqsarpRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD 2639

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1043 TPGQSEKPSDPRVRKTPTDPRLQKPADPVAASRAAKPC--PTEASPPAASP-------SGDSSPPATAPYDPRVLAAGGL 1113
Cdd:PHA03247  2640 PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASspPQRPRRRAARPtvgsltsLADPPPPPPTPEPAPHALVSAT 2719

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1114 GQGSSSGQSSVLSGISLYDPRTPNAGGKTAEPASDTsAQPKGPEGNGKGSASKAKEPPFVRKSALEQPETGKASTDGATA 1193
Cdd:PHA03247  2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907182058 1194 TDRYNSYNRPRPKATAAPTAASSTPPPEGATPQPGVHNLPVPTLFGTVKPAPKTG----TGSPFAGNSPAR 1260
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvaPGGDVRRRPPSR 2869
ZnF_C3H1 smart00356
zinc finger;
401-425 1.23e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.00  E-value: 1.23e-05
                            10        20
                    ....*....|....*....|....*
gi 1907182058   401 KRELCKFYITGFCARAENCPYMHGD 425
Cdd:smart00356    3 KTELCKFFKRGYCPRGDRCKFAHPL 27
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 365-447 6.34e-05

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 46.40  E-value: 6.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  365 HQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKREL-CKFY-ITGFCARAENCPYMHGDfPCKLY--------HTT 434
Cdd:COG5084     96 HVNPVLSSSVVCKFFLRGLCKSGFSCEFLHEYDLRSSQGPpCRSFsLKGSCSSGPSCGYSHID-PDSFAgncdqysgATY 174

                           90
                   ....*....|...
gi 1907182058  435 GNCINGDDCMFSH 447
Cdd:COG5084    175 GFCPLGASCKFSH 187
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 405-423 1.78e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 39.71  E-value: 1.78e-04
                           10
                   ....*....|....*....
gi 1907182058  405 CKFYITGFCARAENCPYMH 423
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
ZnF_C3H1 smart00356
zinc finger;
374-395 1.34e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.22  E-value: 1.34e-03
                            10        20
                    ....*....|....*....|..
gi 1907182058   374 VICKYFVEGRCTWGDHCNFSHD 395
Cdd:smart00356    5 ELCKFFKRGYCPRGDRCKFAHP 26
OmdA pfam13376
Bacteriocin-protection, YdeI or OmpD-Associated; This is a family of archaeal and bacterial ...
 754-779 3.65e-03

Bacteriocin-protection, YdeI or OmpD-Associated; This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S). YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein.


Pssm-ID: 433158  Cd Length: 60  Bit Score: 37.05  E-value: 3.65e-03
                           10        20
                   ....*....|....*....|....*.
gi 1907182058  754 PSAQRALYLRIQQKQQEEERARRLAE 779
Cdd:pfam13376   27 PSYRREYLLWISSAKRPETRAKRIAK 52
PHA03247 PHA03247
large tegument protein UL36; Provisional
 713-1110 6.75e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 6.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  713 EELPGQPGEPLFPEHPLEP-DSFPEGGPPGRPKAGAGVPDFLPSAQRA----LYLRIQQKQQEEERARRLAESSKQDREN 787
Cdd:PHA03247  2586 ARRPDAPPQSARPRAPVDDrGDPRGPAPPSPLPPDTHAPDPPPPSPSPaanePDPHPPPTVPPPERPRDDPAPGRVSRPR 2665

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  788 EEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSS-RPQASVGEPSSsglgdprlqKGHPTGSRLSDPRLSRDPRLSRHAET 866
Cdd:PHA03247  2666 RARRLGRAAQASSPPQRPRRRAARPTVGSLTSLaDPPPPPPTPEP---------APHALVSATPLPPGPAAARQASPALP 2736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  867 SGGSGPGDSGPSDPRLARALPTSKAEGSLHSSPAGPSSSKGQPPAEEEEGerALREKAVNIPLDPLPGHPLRDPrsqlqq 946
Cdd:PHA03247  2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP--AVASLSESRESLPSPWDPADPP------ 2808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  947 fshikkdVTLSKPSFARTVLWNPEDLIPLPIPKQDVPPVPAALQSLPALdPRLHRSTPPGPPNTRQRPGSTDPSTSGSNL 1026
Cdd:PHA03247  2809 -------AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAAKPAAPAR 2880

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1027 PDFELLSR----------ILKTVNVNTPGQSEKPSDPRVRKTPTDPRLQKPADPVAASRAAKPCPTEASPPAASPSGDSS 1096
Cdd:PHA03247  2881 PPVRRLARpavsrstesfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960

                          410
                   ....*....|....
gi 1907182058 1097 PPATAPYDPRVLAA 1110
Cdd:PHA03247  2961 QPWLGALVPGRVAV 2974
 
Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 374-395 1.58e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 48.35  E-value: 1.58e-07
                           10        20
                   ....*....|....*....|..
gi 1907182058  374 VICKYFVEGRCTWGDHCNFSHD 395
Cdd:pfam18044    1 RLCRYFQKGGCRYGDNCRFSHD 22
PHA03247 PHA03247
large tegument protein UL36; Provisional
 974-1260 2.25e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 2.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  974 PLPIPKQDVPPV-PAALQSLPALDPRLHR----------STPPGPPNTRQRPGSTDPSTSGSNLPDFELLSRILKTVNVN 1042
Cdd:PHA03247  2560 PPAAPDRSVPPPrPAPRPSEPAVTSRARRpdappqsarpRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD 2639

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1043 TPGQSEKPSDPRVRKTPTDPRLQKPADPVAASRAAKPC--PTEASPPAASP-------SGDSSPPATAPYDPRVLAAGGL 1113
Cdd:PHA03247  2640 PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASspPQRPRRRAARPtvgsltsLADPPPPPPTPEPAPHALVSAT 2719

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1114 GQGSSSGQSSVLSGISLYDPRTPNAGGKTAEPASDTsAQPKGPEGNGKGSASKAKEPPFVRKSALEQPETGKASTDGATA 1193
Cdd:PHA03247  2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907182058 1194 TDRYNSYNRPRPKATAAPTAASSTPPPEGATPQPGVHNLPVPTLFGTVKPAPKTG----TGSPFAGNSPAR 1260
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvaPGGDVRRRPPSR 2869
PHA03247 PHA03247
large tegument protein UL36; Provisional
 887-1245 3.16e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  887 PTSKAEGSLHSSPAGPSSSKGQPPAEEEEgERALREKAVNIPLDPLPGHPLRDPRSQlqqfshikkdvTLSKPSFARTVL 966
Cdd:PHA03247  2604 DRGDPRGPAPPSPLPPDTHAPDPPPPSPS-PAANEPDPHPPPTVPPPERPRDDPAPG-----------RVSRPRRARRLG 2671

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  967 WNPEDLIPLPIPKQdvPPVPAALQSLPAL-DPrlhrstPPGPPNTRQRPGSTDPSTSGSNLPDFELLSRILKTVNVNTPG 1045
Cdd:PHA03247  2672 RAAQASSPPQRPRR--RAARPTVGSLTSLaDP------PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1046 QSEKPSDP-RVRKTPTDPRLQKPADPVAASRAAKPCPTEASPPAASPSGDSSPPATAPYDPRVLAAGGLGQGSSSGQSSV 1124
Cdd:PHA03247  2744 VPAGPATPgGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1125 lsgislydPRTPNAGGKTAEPASDTSAQPKGPEGNGKGsASKAKEPPFVRKSALEQPetgkASTDGATATDRYNSYNRPR 1204
Cdd:PHA03247  2824 --------PAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-GSVAPGGDVRRRPPSRSP----AAKPAAPARPPVRRLARPA 2890

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1907182058 1205 PKATAAPTAASSTPPPEGATPQPGVHNLPVPTLFGTVKPAP 1245
Cdd:PHA03247  2891 VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 376-394 4.45e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 44.33  E-value: 4.45e-06
                           10
                   ....*....|....*....
gi 1907182058  376 CKYFVEGRCTWGDHCNFSH 394
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
ZnF_C3H1 smart00356
zinc finger;
401-425 1.23e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.00  E-value: 1.23e-05
                            10        20
                    ....*....|....*....|....*
gi 1907182058   401 KRELCKFYITGFCARAENCPYMHGD 425
Cdd:smart00356    3 KTELCKFFKRGYCPRGDRCKFAHPL 27
PHA03378 PHA03378
EBNA-3B; Provisional
 997-1188 1.66e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.30  E-value: 1.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  997 PRLHRSTPPGPPNTRQR-PGSTDPSTSGSNLPDFELLSRILKTVNVNTPGQSEKPSDPRVRKTPTDPRLQK----PADPV 1071
Cdd:PHA03378   598 PVPHPSQTPEPPTTQSHiPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQighiPYQPS 677

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1072 ----AASRAAKPCPTEASPPAASPsGDSSPPATAPYDPRVLAAGGLGQGSSSGQSSVLSGISLYDPRTPNAGGKTAEPAS 1147
Cdd:PHA03378   678 ptgaNTMLPIQWAPGTMQPPPRAP-TPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARP 756

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1907182058 1148 DTSAQPKGPEGNGKGSASKAKEPPFVRKSALEQPETGKAST 1188
Cdd:PHA03378   757 PAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQ 797
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 365-447 6.34e-05

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 46.40  E-value: 6.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  365 HQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKREL-CKFY-ITGFCARAENCPYMHGDfPCKLY--------HTT 434
Cdd:COG5084     96 HVNPVLSSSVVCKFFLRGLCKSGFSCEFLHEYDLRSSQGPpCRSFsLKGSCSSGPSCGYSHID-PDSFAgncdqysgATY 174

                           90
                   ....*....|...
gi 1907182058  435 GNCINGDDCMFSH 447
Cdd:COG5084    175 GFCPLGASCKFSH 187
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 405-423 1.78e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 39.71  E-value: 1.78e-04
                           10
                   ....*....|....*....
gi 1907182058  405 CKFYITGFCARAENCPYMH 423
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 897-1258 1.90e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.93  E-value: 1.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  897 SSPAGPSSSKGQPPAEEEEGERALREKAVNIPLDPLPGHPLRDPRSQlqqfshikKDVTLSKPSFARTVLWNPEDLIPLP 976
Cdd:PHA03307   106 PTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASP--------PAAGASPAAVASDAASSRQAALPLS 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  977 IPKQDVPPVPAALQSLPALDPRLHRSTPPGPPNTRQRPGSTDPSTSGSNLPDFELLSrilKTVNVNTPGQSEKPSDPRVR 1056
Cdd:PHA03307   178 SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGA---SSSDSSSSESSGCGWGPENE 254

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1057 KTPTDPRLQKPADPVAASRAAKPCPTEASPPAASPSGDSSPPATAPYDPRVLAAgglgqgsssgqsSVLSGISLYDPRTP 1136
Cdd:PHA03307   255 CPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPA------------PSSPRASSSSSSSR 322

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1137 NAGGKTAEPASDTSAQPKGPEGNGKG-SASKAKEPPFVRKSALEQPETGKASTDGATATDRYNSYNRPRPKATAAPTAAS 1215
Cdd:PHA03307   323 ESSSSSTSSSSESSRGAAVSPGPSPSrSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRD 402

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1907182058 1216 STPPPEGATPQPGVHNLPVPTLFGTVKPAPKTGTGSPFAGNSP 1258
Cdd:PHA03307   403 ATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSGEPWPGSPP 445
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1044-1259 3.06e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 3.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1044 PGQSEKPSDPRVRKTPTD----PRLQKPADPVAASRAAKPCPTEASPPAASPSGDSSPPATAPYDPRVLAAGGLGQGSSS 1119
Cdd:PRK12323   365 PGQSGGGAGPATAAAAPVaqpaPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1120 GQSSVLSGISLYDP----RTPNAGgktAEPASDTSAQPKGPEGNGKGSASKAKEPPFVRKSALEQPETGKASTDGATATD 1195
Cdd:PRK12323   445 GGAPAPAPAPAAAPaaaaRPAAAG---PRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGW 521

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907182058 1196 RYNSYNRPRPKATAAPTAASSTPPPEGATPQPGVHNLPVPTlfGTVKPAPKTGTGSPFAGNSPA 1259
Cdd:PRK12323   522 VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVA--PRPPRASASGLPDMFDGDWPA 583
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
400-425 3.47e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 39.10  E-value: 3.47e-04
                           10        20
                   ....*....|....*....|....*..
gi 1907182058  400 KKRELCKFY-ITGFCARAENCPYMHGD 425
Cdd:pfam00642    1 YKTELCRFFlRTGYCKYGDRCKFAHGQ 27
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1044-1170 7.87e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 7.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1044 PGQSEKPSDPRVRKTPTDPRLQKPA-----DPVAASRAAKPCPTEASPPAASPSGDSSPPATAPydprVLAAGGLGQGSS 1118
Cdd:PRK14951   366 PAAAAEAAAPAEKKTPARPEAAAPAaapvaQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAP----AAAAPAAAPAAA 441

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907182058 1119 SGQSSVLSGISLYDPRTPNAGGKTAEPASDTSAQPKGPEGNGKGSASKAKEP 1170
Cdd:PRK14951   442 PAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
ZnF_C3H1 smart00356
zinc finger;
374-395 1.34e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.22  E-value: 1.34e-03
                            10        20
                    ....*....|....*....|..
gi 1907182058   374 VICKYFVEGRCTWGDHCNFSHD 395
Cdd:smart00356    5 ELCKFFKRGYCPRGDRCKFAHP 26
OmdA pfam13376
Bacteriocin-protection, YdeI or OmpD-Associated; This is a family of archaeal and bacterial ...
 754-779 3.65e-03

Bacteriocin-protection, YdeI or OmpD-Associated; This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S). YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein.


Pssm-ID: 433158  Cd Length: 60  Bit Score: 37.05  E-value: 3.65e-03
                           10        20
                   ....*....|....*....|....*.
gi 1907182058  754 PSAQRALYLRIQQKQQEEERARRLAE 779
Cdd:pfam13376   27 PSYRREYLLWISSAKRPETRAKRIAK 52
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
976-1268 4.86e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 4.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  976 PIPKQDVPPVPAALQSLPALDPRLHRSTPPGPPNTRQRPGSTDPSTSGSNLPdfellsrilkTVNVNTPGQSekpSDPRV 1055
Cdd:PRK07003   374 ARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEA----------PPAAPAPPAT---ADRGD 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1056 RKTPTDPRLQKPADpvAASRAAKPCPTEASPPAASPSGDSSPPATAPYDPRVLAAGGLGQGSSSGQssvlsgislydPRT 1135
Cdd:PRK07003   441 DAADGDAPVPAKAN--ARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATP-----------AAV 507

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1136 PNAGGKTAEPASDTSAQPKGPEGNGKGSASKAKEPPFVRKSAleqpetgKASTDGATATDRYNSYNRPRPKATAAPTAAS 1215
Cdd:PRK07003   508 PDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGA-------AAALDVLRNAGMRVSSDRGARAAAAAKPAAA 580

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907182058 1216 STPPPEGATPQPGVhnlPVPTLfgtvkPAPKTGTGSPFAGNSPAREGEQDAGS 1268
Cdd:PRK07003   581 PAAAPKPAAPRVAV---QVPTP-----RARAATGDAPPNGAARAEQAAESRGA 625
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 974-1100 5.00e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 41.25  E-value: 5.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  974 PLPIPKQDVPPVPAALQSLPALDPRLHRSTPPGPpntrqrpgSTDPSTSGSNLPDFELlsrilktvnVNTPGQSEKPsDP 1053
Cdd:PHA03269    23 NTNIPIPELHTSAATQKPDPAPAPHQAASRAPDP--------AVAPTSAASRKPDLAQ---------APTPAASEKF-DP 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1907182058 1054 RVRktPTDPRLQKPADPVAASRAAKPCPTEASPPAASPSGDSSPPAT 1100
Cdd:PHA03269    85 APA--PHQAASRAPDPAVAPQLAAAPKPDAAEAFTSAAQAHEAPADA 129
PHA03247 PHA03247
large tegument protein UL36; Provisional
 713-1110 6.75e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 6.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  713 EELPGQPGEPLFPEHPLEP-DSFPEGGPPGRPKAGAGVPDFLPSAQRA----LYLRIQQKQQEEERARRLAESSKQDREN 787
Cdd:PHA03247  2586 ARRPDAPPQSARPRAPVDDrGDPRGPAPPSPLPPDTHAPDPPPPSPSPaanePDPHPPPTVPPPERPRDDPAPGRVSRPR 2665

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  788 EEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSS-RPQASVGEPSSsglgdprlqKGHPTGSRLSDPRLSRDPRLSRHAET 866
Cdd:PHA03247  2666 RARRLGRAAQASSPPQRPRRRAARPTVGSLTSLaDPPPPPPTPEP---------APHALVSATPLPPGPAAARQASPALP 2736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  867 SGGSGPGDSGPSDPRLARALPTSKAEGSLHSSPAGPSSSKGQPPAEEEEGerALREKAVNIPLDPLPGHPLRDPrsqlqq 946
Cdd:PHA03247  2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP--AVASLSESRESLPSPWDPADPP------ 2808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058  947 fshikkdVTLSKPSFARTVLWNPEDLIPLPIPKQDVPPVPAALQSLPALdPRLHRSTPPGPPNTRQRPGSTDPSTSGSNL 1026
Cdd:PHA03247  2809 -------AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAAKPAAPAR 2880

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182058 1027 PDFELLSR----------ILKTVNVNTPGQSEKPSDPRVRKTPTDPRLQKPADPVAASRAAKPCPTEASPPAASPSGDSS 1096
Cdd:PHA03247  2881 PPVRRLARpavsrstesfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960

                          410
                   ....*....|....
gi 1907182058 1097 PPATAPYDPRVLAA 1110
Cdd:PHA03247  2961 QPWLGALVPGRVAV 2974
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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