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Conserved domains on  [gi|1907173228|ref|XP_036008139|]
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NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X5 [Mus musculus]

Protein Classification

NifU family protein( domain architecture ID 10002159)

NifU family protein proposed to provide a molecular scaffold for the assembly of [Fe-S] clusters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NifU COG0694
Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, ...
 37-176 2.71e-36

Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440458 [Multi-domain]  Cd Length: 176  Bit Score: 124.77  E-value: 2.71e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173228  37 FRIEGVKSVFFGPDFITVTKENEELDWNLLKPDIYATIMDFFASGLPLVTEETPPPPGEAGSSEEDDEVVAMIKELLDTR 116
Cdd:COG0694    37 EAPEVEEDDDVVVVAAVFVAVTDELSGPLLELAIIDAILAAAGGQLTLAAPDAAVAEVLSFHALTDAELEERIEEVLDEE 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173228 117 IRPTVQEDGGDVIYRGFEDGIVRLKLQGSCTSCPSSIITLKSGIQNMLQFYIPEVEGVEQ 176
Cdd:COG0694   117 IRPALASDGGDIELVDVEDGVVYVRLGGACSGCPSSTMTLKNGIERALKERVPEVKEVEA 176
 
Name Accession Description Interval E-value
NifU COG0694
Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, ...
 37-176 2.71e-36

Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440458 [Multi-domain]  Cd Length: 176  Bit Score: 124.77  E-value: 2.71e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173228  37 FRIEGVKSVFFGPDFITVTKENEELDWNLLKPDIYATIMDFFASGLPLVTEETPPPPGEAGSSEEDDEVVAMIKELLDTR 116
Cdd:COG0694    37 EAPEVEEDDDVVVVAAVFVAVTDELSGPLLELAIIDAILAAAGGQLTLAAPDAAVAEVLSFHALTDAELEERIEEVLDEE 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173228 117 IRPTVQEDGGDVIYRGFEDGIVRLKLQGSCTSCPSSIITLKSGIQNMLQFYIPEVEGVEQ 176
Cdd:COG0694   117 IRPALASDGGDIELVDVEDGVVYVRLGGACSGCPSSTMTLKNGIERALKERVPEVKEVEA 176
NifU pfam01106
NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common ...
 109-175 6.37e-32

NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.


Pssm-ID: 460066 [Multi-domain]  Cd Length: 67  Bit Score: 109.83  E-value: 6.37e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907173228 109 IKELLDTRIRPTVQEDGGDVIYRGFEDGIVRLKLQGSCTSCPSSIITLKSGIQNMLQFYIPEVEGVE 175
Cdd:pfam01106   1 IEEVLEEEIRPALQADGGDIELVDVDDGVVYVRLQGACSGCPSSTMTLKNGIEQALKEKVPEVKRVE 67
Nfu_N smart00932
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 34-81 7.79e-21

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 214919  Cd Length: 88  Bit Score: 82.19  E-value: 7.79e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907173228   34 RQLFRIEGVKSVFFGPDFITVTKeNEELDWNLLKPDIYATIMDFFASG 81
Cdd:smart00932  42 QKLFEIPGVKSVFFGPDFITVTK-YPDVDWEDLKPEVLSVIMEHFESG 88
 
Name Accession Description Interval E-value
NifU COG0694
Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, ...
 37-176 2.71e-36

Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440458 [Multi-domain]  Cd Length: 176  Bit Score: 124.77  E-value: 2.71e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173228  37 FRIEGVKSVFFGPDFITVTKENEELDWNLLKPDIYATIMDFFASGLPLVTEETPPPPGEAGSSEEDDEVVAMIKELLDTR 116
Cdd:COG0694    37 EAPEVEEDDDVVVVAAVFVAVTDELSGPLLELAIIDAILAAAGGQLTLAAPDAAVAEVLSFHALTDAELEERIEEVLDEE 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173228 117 IRPTVQEDGGDVIYRGFEDGIVRLKLQGSCTSCPSSIITLKSGIQNMLQFYIPEVEGVEQ 176
Cdd:COG0694   117 IRPALASDGGDIELVDVEDGVVYVRLGGACSGCPSSTMTLKNGIERALKERVPEVKEVEA 176
NifU pfam01106
NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common ...
 109-175 6.37e-32

NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.


Pssm-ID: 460066 [Multi-domain]  Cd Length: 67  Bit Score: 109.83  E-value: 6.37e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907173228 109 IKELLDTRIRPTVQEDGGDVIYRGFEDGIVRLKLQGSCTSCPSSIITLKSGIQNMLQFYIPEVEGVE 175
Cdd:pfam01106   1 IEEVLEEEIRPALQADGGDIELVDVDDGVVYVRLQGACSGCPSSTMTLKNGIEQALKEKVPEVKRVE 67
Nfu_N smart00932
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 34-81 7.79e-21

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 214919  Cd Length: 88  Bit Score: 82.19  E-value: 7.79e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907173228   34 RQLFRIEGVKSVFFGPDFITVTKeNEELDWNLLKPDIYATIMDFFASG 81
Cdd:smart00932  42 QKLFEIPGVKSVFFGPDFITVTK-YPDVDWEDLKPEVLSVIMEHFESG 88
Nfu_N pfam08712
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 34-74 3.62e-17

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 462574  Cd Length: 81  Bit Score: 72.50  E-value: 3.62e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907173228  34 RQLFRIEGVKSVFFGPDFITVTKeNEELDWNLLKPDIYATI 74
Cdd:pfam08712  42 QKLFAIPGVKSVFIGPDFITVTK-DDDVDWEDLKPEVRSVI 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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