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Conserved domains on  [gi|1889931417|ref|XP_035697321|]
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cation-dependent mannose-6-phosphate receptor-like [Branchiostoma floridae]

Protein Classification

cation-dependent mannose-6-phosphate receptor( domain architecture ID 1563581)

cation-dependent mannose 6-phosphate receptor (CD-MPR) is a key component of the lysosomal enzyme targeting system that binds newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and transports them to endosomal compartments

Gene Ontology:  GO:0015031
PubMed:  3156583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATG27 super family cl39051
Autophagy-related protein 27;
32-250 1.33e-78

Autophagy-related protein 27;


The actual alignment was detected with superfamily member pfam02157:

Pssm-ID: 476860  Cd Length: 254  Bit Score: 238.14  E-value: 1.33e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889931417  32 KEKKLLERLAPLtkANQLFKFR--DNPYNYEYKARICNPVESSKPDAGIIQVDRNGSAEHSLGMISKVNIKAGNNWMMLE 109
Cdd:pfam02157  21 KERALLKRLEPL--ANKSFEVTvgSGPETYTYNFRVCREVGKTASDAGLVQIDKKNGKETVIGRINETQVFNGSDWIMLI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889931417 110 YRGGDKYHSHCNGLERTSIIMILCDSSTVEGTMSIIEEHtRSNEEDCYYLFELYSNVVCSAKSSipgGLSVGSVLVLIFV 189
Cdd:pfam02157  99 YKGGDEYGSHCGKEKRKAIIMISCNRKVLADNFTIVIEE-REKEQDCFYLFELDSSLACPPEDS---HLSVGSILLIVFF 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1889931417 190 VVVGCYFLFGFLYQRFVVGAKGMEQIPHFSFWKDFGNLQADGCELVCRTQEAGPPRTYKGI 250
Cdd:pfam02157 175 SLVAVYIIGGFLYQRLVVGAKGMEQFPNYAFWQDLGNLVADGCDFVCRSKPRNAPAAYRGV 235
 
Name Accession Description Interval E-value
Man-6-P_recep pfam02157
Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation ...
 32-250 1.33e-78

Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation independent mannose-6-phosphate receptors.


Pssm-ID: 460468  Cd Length: 254  Bit Score: 238.14  E-value: 1.33e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889931417  32 KEKKLLERLAPLtkANQLFKFR--DNPYNYEYKARICNPVESSKPDAGIIQVDRNGSAEHSLGMISKVNIKAGNNWMMLE 109
Cdd:pfam02157  21 KERALLKRLEPL--ANKSFEVTvgSGPETYTYNFRVCREVGKTASDAGLVQIDKKNGKETVIGRINETQVFNGSDWIMLI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889931417 110 YRGGDKYHSHCNGLERTSIIMILCDSSTVEGTMSIIEEHtRSNEEDCYYLFELYSNVVCSAKSSipgGLSVGSVLVLIFV 189
Cdd:pfam02157  99 YKGGDEYGSHCGKEKRKAIIMISCNRKVLADNFTIVIEE-REKEQDCFYLFELDSSLACPPEDS---HLSVGSILLIVFF 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1889931417 190 VVVGCYFLFGFLYQRFVVGAKGMEQIPHFSFWKDFGNLQADGCELVCRTQEAGPPRTYKGI 250
Cdd:pfam02157 175 SLVAVYIIGGFLYQRLVVGAKGMEQFPNYAFWQDLGNLVADGCDFVCRSKPRNAPAAYRGV 235
 
Name Accession Description Interval E-value
Man-6-P_recep pfam02157
Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation ...
 32-250 1.33e-78

Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation independent mannose-6-phosphate receptors.


Pssm-ID: 460468  Cd Length: 254  Bit Score: 238.14  E-value: 1.33e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889931417  32 KEKKLLERLAPLtkANQLFKFR--DNPYNYEYKARICNPVESSKPDAGIIQVDRNGSAEHSLGMISKVNIKAGNNWMMLE 109
Cdd:pfam02157  21 KERALLKRLEPL--ANKSFEVTvgSGPETYTYNFRVCREVGKTASDAGLVQIDKKNGKETVIGRINETQVFNGSDWIMLI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1889931417 110 YRGGDKYHSHCNGLERTSIIMILCDSSTVEGTMSIIEEHtRSNEEDCYYLFELYSNVVCSAKSSipgGLSVGSVLVLIFV 189
Cdd:pfam02157  99 YKGGDEYGSHCGKEKRKAIIMISCNRKVLADNFTIVIEE-REKEQDCFYLFELDSSLACPPEDS---HLSVGSILLIVFF 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1889931417 190 VVVGCYFLFGFLYQRFVVGAKGMEQIPHFSFWKDFGNLQADGCELVCRTQEAGPPRTYKGI 250
Cdd:pfam02157 175 SLVAVYIIGGFLYQRLVVGAKGMEQFPNYAFWQDLGNLVADGCDFVCRSKPRNAPAAYRGV 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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