NCBI Conserved Domain Search

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...

454-550

2.16e-22

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

The actual alignment was detected with superfamily member cd05898:

Pssm-ID: 472250 Cd Length: 98 Bit Score: 91.94 E-value: 2.16e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 454 GPPRVRSPPVQYGVEGEVVKLECIISSVPPPTRILWSRNSQHVDIDNNDGYEIVTEPMADGVKNNLIIHNADEDDF-GQY 532
Cdd:cd05898     1 GPPIISSEQVQYAVRGERGKVKCFIGSTPPPDRIAWAWKENVLESGTLERYTVERTSTGSGVLSTLTINNIMEADFqTHY 80

                          90
                  ....*....|....*...
gi 1866093304 533 NCTVWNTFGQDSMIILLK 550
Cdd:cd05898    81 NCTAWNSFGSGTAIIQLE 98

Ig super family

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...

183-281

4.64e-16

The actual alignment was detected with superfamily member cd05759:

Pssm-ID: 472250 Cd Length: 98 Bit Score: 74.02 E-value: 4.64e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 183 PKIVQGDFLRTTAGMTVELTCESHAGKPPAELTWL-DGEgnvVSDGIEYTTQLLGDGKRANAALKWTLTPRREHDGKTFT 261
Cdd:cd05759     2 PVIEGGPVISLQAGVPYNLTCRARGAKPAAEIIWFrDGE---QLEGAVYSKELLKDGKRETTVSTLLITPSDLDTGRTFT 78

                          90       100
                  ....*....|....*....|
gi 1866093304 262 CRSENPALTQPLHARISLEV 281
Cdd:cd05759    79 CRARNEAIPNGKETSITLDV 98

Ig super family

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...

371-452

1.63e-11

The actual alignment was detected with superfamily member pfam07679:

Pssm-ID: 472250 [Multi-domain] Cd Length: 90 Bit Score: 60.73 E-value: 1.63e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 371 PVFRSTIENVAADIGSEVSLSCDVEGNPQPETMWTFEGSDavLSTESR-----------LVIPQLTIDRAGKYTCRATVa 439
Cdd:pfam07679   1 PKFTQKPKDVEVQEGESARFTCTVTGTPDPEVSWFKDGQP--LRSSDRfkvtyeggtytLTISNVQPDDSGKYTCVATN- 77

                          90
                  ....*....|...
gi 1866093304 440 GFAEISTDVLVFI 452
Cdd:pfam07679  78 SAGEAEASAELTV 90

IG_like

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

83-178

6.94e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 47.50 E-value: 6.94e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304   83 PADRTAIVGKAAVLPCRVL-NKVGTLQWTRDAFglgsdRELKGFPRYTmiGSDDEGDFSLQISRVTLEDDALFQCQVGAA 161
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASgSPPPEVTWYKQGG-----KLLAESGRFS--VSRSGSTSTLTISNVTPEDSGTYTCAATNS 73

                           90
                   ....*....|....*..
gi 1866093304  162 DGVKgirsrNAAFTVYV 178
Cdd:smart00410  74 SGSA-----SSGTTLTV 85

Ig super family

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...

285-367

8.07e-07

The actual alignment was detected with superfamily member pfam07679:

Pssm-ID: 472250 [Multi-domain] Cd Length: 90 Bit Score: 47.25 E-value: 8.07e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 285 PEITLKVSADKIMELDNVKFTCEAVANPaDVNIKWYRNDEVIPGDH---------STTYVISRVTRDyNKDTISCEVSNA 355
Cdd:pfam07679   1 PKFTQKPKDVEVQEGESARFTCTVTGTP-DPEVSWFKDGQPLRSSDrfkvtyeggTYTLTISNVQPD-DSGKYTCVATNS 78

                          90
                  ....*....|..
gi 1866093304 356 VGTTKSTHTLNV 367
Cdd:pfam07679  79 AGEAEASAELTV 90

Name

Accession

Description

Interval

E-value

IgI_5_KIRREL3

cd05898

Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; ...

454-550

2.16e-22

Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1). These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development. Neph1 and 2 may mediate axonal guidance and synapse formation in certain areas of the CNS. In the kidney they participate in the formation of the slit diaphragm.

Pssm-ID: 409479 Cd Length: 98 Bit Score: 91.94 E-value: 2.16e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 454 GPPRVRSPPVQYGVEGEVVKLECIISSVPPPTRILWSRNSQHVDIDNNDGYEIVTEPMADGVKNNLIIHNADEDDF-GQY 532
Cdd:cd05898     1 GPPIISSEQVQYAVRGERGKVKCFIGSTPPPDRIAWAWKENVLESGTLERYTVERTSTGSGVLSTLTINNIMEADFqTHY 80

                          90
                  ....*....|....*...
gi 1866093304 533 NCTVWNTFGQDSMIILLK 550
Cdd:cd05898    81 NCTAWNSFGSGTAIIQLE 98

IgI_2_KIRREL3-like

cd05759

Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...

183-281

4.64e-16

Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1), Kirrel2 (Neph3), and Drosophila RST (irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.

Pssm-ID: 409416 Cd Length: 98 Bit Score: 74.02 E-value: 4.64e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 183 PKIVQGDFLRTTAGMTVELTCESHAGKPPAELTWL-DGEgnvVSDGIEYTTQLLGDGKRANAALKWTLTPRREHDGKTFT 261
Cdd:cd05759     2 PVIEGGPVISLQAGVPYNLTCRARGAKPAAEIIWFrDGE---QLEGAVYSKELLKDGKRETTVSTLLITPSDLDTGRTFT 78

                          90       100
                  ....*....|....*....|
gi 1866093304 262 CRSENPALTQPLHARISLEV 281
Cdd:cd05759    79 CRARNEAIPNGKETSITLDV 98

IG_like

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

461-550

8.87e-13

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 64.06 E-value: 8.87e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304  461 PPVQYGVEGEVVKLECIISSVPPPTrILWSRNSQHVdIDNNDGYEIVTepmaDGVKNNLIIHNADEDDFGQYNCTVWNTF 540
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPE-VTWYKQGGKL-LAESGRFSVSR----SGSTSTLTISNVTPEDSGTYTCAATNSS 74

                           90
                   ....*....|
gi 1866093304  541 GQDSMIILLK 550
Cdd:smart00410  75 GSASSGTTLT 84

C2-set_2

pfam08205

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.

183-272

9.88e-12

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.

Pssm-ID: 400489 Cd Length: 89 Bit Score: 61.28 E-value: 9.88e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 183 PKIVQGDFLRTTAGMTVELTCESHAGKPPAELTWLDGEGNVVsdGIEYTTQLLGDGKRANAALKWTLTPRREHDGKTFTC 262
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLE--AAETSSEQDPESGLVTVTSELKLVPSRSDHGQSLTC 78

                          90
                  ....*....|
gi 1866093304 263 RSENPALTQP 272
Cdd:pfam08205  79 QVSYGALRGS 88

I-set

Immunoglobulin I-set domain;

371-452

1.63e-11

Immunoglobulin I-set domain;

Pssm-ID: 400151 [Multi-domain] Cd Length: 90 Bit Score: 60.73 E-value: 1.63e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 371 PVFRSTIENVAADIGSEVSLSCDVEGNPQPETMWTFEGSDavLSTESR-----------LVIPQLTIDRAGKYTCRATVa 439
Cdd:pfam07679   1 PKFTQKPKDVEVQEGESARFTCTVTGTPDPEVSWFKDGQP--LRSSDRfkvtyeggtytLTISNVQPDDSGKYTCVATN- 77

                          90
                  ....*....|...
gi 1866093304 440 GFAEISTDVLVFI 452
Cdd:pfam07679  78 SAGEAEASAELTV 90

Ig_3

Immunoglobulin domain; This family contains immunoglobulin-like domains.

455-538

5.69e-11

Immunoglobulin domain; This family contains immunoglobulin-like domains.

Pssm-ID: 464046 [Multi-domain] Cd Length: 78 Bit Score: 58.73 E-value: 5.69e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 455 PPRVRSPP-VQYGVEGEVVKLECIISSVPPPTrILWSRNSQhVDIDNNDGYEIVtepmaDGVKNNLIIHNADEDDFGQYN 533
Cdd:pfam13927   1 KPVITVSPsSVTVREGETVTLTCEATGSPPPT-ITWYKNGE-PISSGSTRSRSL-----SGSNSTLTISNVTRSDAGTYT 73


                  ....*
gi 1866093304 534 CTVWN 538
Cdd:pfam13927  74 CVASN 78

IG_like

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

378-450

5.58e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 50.58 E-value: 5.58e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304  378 ENVAADIGSEVSLSCDVEGNPQPETMWTFEGSDAVL----------STESRLVIPQLTIDRAGKYTCRATVA-GFAEIST 446
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAesgrfsvsrsGSTSTLTISNVTPEDSGTYTCAATNSsGSASSGT 81


                   ....
gi 1866093304  447 DVLV 450
Cdd:smart00410  82 TLTV 85

IgI_4_hemolin-like

cd20978

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...

371-450

2.34e-07

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.

Pssm-ID: 409570 [Multi-domain] Cd Length: 88 Bit Score: 48.93 E-value: 2.34e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 371 PVFRSTIE-NVAADIGSEVSLSCDVEGNPQPETMWTFEG------SDAVLSTESRLVIPQLTIDRAGKYTCRAT-VAGfa 442
Cdd:cd20978     1 PKFIQKPEkNVVVKGGQDVTLPCQVTGVPQPKITWLHNGkplqgpMERATVEDGTLTIINVQPEDTGYYGCVATnEIG-- 78


                  ....*...
gi 1866093304 443 EISTDVLV 450
Cdd:cd20978    79 DIYTETLL 86

IG_like

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

83-178

6.94e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 47.50 E-value: 6.94e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304   83 PADRTAIVGKAAVLPCRVL-NKVGTLQWTRDAFglgsdRELKGFPRYTmiGSDDEGDFSLQISRVTLEDDALFQCQVGAA 161
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASgSPPPEVTWYKQGG-----KLLAESGRFS--VSRSGSTSTLTISNVTPEDSGTYTCAATNS 73

                           90
                   ....*....|....*..
gi 1866093304  162 DGVKgirsrNAAFTVYV 178
Cdd:smart00410  74 SGSA-----SSGTTLTV 85

I-set

Immunoglobulin I-set domain;

285-367

8.07e-07

Immunoglobulin I-set domain;

Pssm-ID: 400151 [Multi-domain] Cd Length: 90 Bit Score: 47.25 E-value: 8.07e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 285 PEITLKVSADKIMELDNVKFTCEAVANPaDVNIKWYRNDEVIPGDH---------STTYVISRVTRDyNKDTISCEVSNA 355
Cdd:pfam07679   1 PKFTQKPKDVEVQEGESARFTCTVTGTP-DPEVSWFKDGQPLRSSDrfkvtyeggTYTLTISNVQPD-DSGKYTCVATNS 78

                          90
                  ....*....|..
gi 1866093304 356 VGTTKSTHTLNV 367
Cdd:pfam07679  79 AGEAEASAELTV 90

V-set

pfam07686

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...

81-162

1.72e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.

Pssm-ID: 462230 Cd Length: 109 Bit Score: 47.07 E-value: 1.72e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304  81 IEPADRTAIVGKAAVLPCRVL----NKVGTLQWTRDAFGLGSDRELKGF----------PRYTMIGSDDEGDFSLQISRV 146
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSssmsEASTSVYWYRQPPGKGPTFLIAYYsngseegvkkGRFSGRGDPSNGDGSLTIQNL 80

                          90
                  ....*....|....*.
gi 1866093304 147 TLEDDALFQCQVGAAD 162
Cdd:pfam07686  81 TLSDSGTYTCAVIPSG 96

IgV_SIRP

cd16097

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...

81-156

2.76e-06

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.

Pssm-ID: 409516 Cd Length: 111 Bit Score: 46.39 E-value: 2.76e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304  81 IEPADRTAI-VGKAAVLPCRV--LNKVGTLQWTRdafGLGSDREL----KG--FPRYTMIgSD----DEGDFSLQISRVT 147
Cdd:cd16097     3 IQPEKSVSVaAGESATLHCTVtsLIPVGPIQWFR---GAGPGRELiynqKEghFPRVTTV-SDltkrNNMDFSIRISNIT 78


                  ....*....
gi 1866093304 148 LEDDALFQC 156
Cdd:cd16097    79 PADAGTYYC 87

IG_like

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

300-367

6.97e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 44.80 E-value: 6.97e-06

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1866093304  300 DNVKFTCEAVANPaDVNIKWYRND----------EVIPGDHSTTYVISRVTRDYNkDTISCEVSNAVGTTKSTHTLNV 367
Cdd:smart00410  10 ESVTLSCEASGSP-PPEVTWYKQGgkllaesgrfSVSRSGSTSTLTISNVTPEDS-GTYTCAATNSSGSASSGTTLTV 85

IgI_titin_I1-like

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...

285-367

1.47e-05

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin domain I1 of the titin I-band and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig I1 domain of the titin I-band is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.

Pssm-ID: 409543 [Multi-domain] Cd Length: 94 Bit Score: 43.95 E-value: 1.47e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 285 PEITLKVSADKIMELDNVKFTCEAVANPaDVNIKWYRNDEVI-----PGDHS-------TTYVISRVTRDyNKDTISCEV 352
Cdd:cd20951     1 PEFIIRLQSHTVWEKSDAKLRVEVQGKP-DPEVKWYKNGVPIdpssiPGKYKieseygvHVLHIRRVTVE-DSAVYSAVA 78

                          90
                  ....*....|....*
gi 1866093304 353 SNAVGTTKSTHTLNV 367
Cdd:cd20951    79 KNIHGEASSSASVVV 93

Name

Accession

Description

Interval

E-value

IgI_5_KIRREL3

cd05898

Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; ...

454-550

2.16e-22

Pssm-ID: 409479 Cd Length: 98 Bit Score: 91.94 E-value: 2.16e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 454 GPPRVRSPPVQYGVEGEVVKLECIISSVPPPTRILWSRNSQHVDIDNNDGYEIVTEPMADGVKNNLIIHNADEDDF-GQY 532
Cdd:cd05898     1 GPPIISSEQVQYAVRGERGKVKCFIGSTPPPDRIAWAWKENVLESGTLERYTVERTSTGSGVLSTLTINNIMEADFqTHY 80

                          90
                  ....*....|....*...
gi 1866093304 533 NCTVWNTFGQDSMIILLK 550
Cdd:cd05898    81 NCTAWNSFGSGTAIIQLE 98

IgI_5_KIRREL3-like

cd05758

Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...

454-550

4.46e-17

Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (also known as Neph1), Kirrel2 (also known as Neph3), and Drosophila RST (also known as irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.

Pssm-ID: 319310 Cd Length: 98 Bit Score: 76.80 E-value: 4.46e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 454 GPPRVRSPPVQYGVEGEVVKLECIISSVPPPTRILWSRNSQHVDIDNNDGYEIVTEPMADGVKNNLIIHNADEDDFG-QY 532
Cdd:cd05758     1 GPPIITAEATQPAILGEKARLECLVFSSPPPDRIVWSWDEGFLESGSSGRFSVETFPTEPGVISVLHISGTQRSDFQtSF 80

                          90
                  ....*....|....*...
gi 1866093304 533 NCTVWNTFGQDSMIILLK 550
Cdd:cd05758    81 NCSAWNRFGEGTAIVSLG 98

IgI_2_KIRREL3-like

cd05759

Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...

183-281

4.64e-16

Pssm-ID: 409416 Cd Length: 98 Bit Score: 74.02 E-value: 4.64e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 183 PKIVQGDFLRTTAGMTVELTCESHAGKPPAELTWL-DGEgnvVSDGIEYTTQLLGDGKRANAALKWTLTPRREHDGKTFT 261
Cdd:cd05759     2 PVIEGGPVISLQAGVPYNLTCRARGAKPAAEIIWFrDGE---QLEGAVYSKELLKDGKRETTVSTLLITPSDLDTGRTFT 78

                          90       100
                  ....*....|....*....|
gi 1866093304 262 CRSENPALTQPLHARISLEV 281
Cdd:cd05759    79 CRARNEAIPNGKETSITLDV 98

IG_like

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

461-550

8.87e-13

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 64.06 E-value: 8.87e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304  461 PPVQYGVEGEVVKLECIISSVPPPTrILWSRNSQHVdIDNNDGYEIVTepmaDGVKNNLIIHNADEDDFGQYNCTVWNTF 540
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPE-VTWYKQGGKL-LAESGRFSVSR----SGSTSTLTISNVTPEDSGTYTCAATNSS 74

                           90
                   ....*....|
gi 1866093304  541 GQDSMIILLK 550
Cdd:smart00410  75 GSASSGTTLT 84

C2-set_2

pfam08205

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.

183-272

9.88e-12

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.

Pssm-ID: 400489 Cd Length: 89 Bit Score: 61.28 E-value: 9.88e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 183 PKIVQGDFLRTTAGMTVELTCESHAGKPPAELTWLDGEGNVVsdGIEYTTQLLGDGKRANAALKWTLTPRREHDGKTFTC 262
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLE--AAETSSEQDPESGLVTVTSELKLVPSRSDHGQSLTC 78

                          90
                  ....*....|
gi 1866093304 263 RSENPALTQP 272
Cdd:pfam08205  79 QVSYGALRGS 88

I-set

Immunoglobulin I-set domain;

371-452

1.63e-11

Immunoglobulin I-set domain;

Pssm-ID: 400151 [Multi-domain] Cd Length: 90 Bit Score: 60.73 E-value: 1.63e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 371 PVFRSTIENVAADIGSEVSLSCDVEGNPQPETMWTFEGSDavLSTESR-----------LVIPQLTIDRAGKYTCRATVa 439
Cdd:pfam07679   1 PKFTQKPKDVEVQEGESARFTCTVTGTPDPEVSWFKDGQP--LRSSDRfkvtyeggtytLTISNVQPDDSGKYTCVATN- 77

                          90
                  ....*....|...
gi 1866093304 440 GFAEISTDVLVFI 452
Cdd:pfam07679  78 SAGEAEASAELTV 90

Ig_3

Immunoglobulin domain; This family contains immunoglobulin-like domains.

371-437

1.82e-11

Immunoglobulin domain; This family contains immunoglobulin-like domains.

Pssm-ID: 464046 [Multi-domain] Cd Length: 78 Bit Score: 60.27 E-value: 1.82e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1866093304 371 PVFRSTIENVAADIGSEVSLSCDVEGNPQPETMWTFEG---------SDAVLSTESRLVIPQLTIDRAGKYTCRAT 437
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTCEATGSPPPTITWYKNGepissgstrSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77

Ig_3

Immunoglobulin domain; This family contains immunoglobulin-like domains.

455-538

5.69e-11

Immunoglobulin domain; This family contains immunoglobulin-like domains.

Pssm-ID: 464046 [Multi-domain] Cd Length: 78 Bit Score: 58.73 E-value: 5.69e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 455 PPRVRSPP-VQYGVEGEVVKLECIISSVPPPTrILWSRNSQhVDIDNNDGYEIVtepmaDGVKNNLIIHNADEDDFGQYN 533
Cdd:pfam13927   1 KPVITVSPsSVTVREGETVTLTCEATGSPPPT-ITWYKNGE-PISSGSTRSRSL-----SGSNSTLTISNVTRSDAGTYT 73


                  ....*
gi 1866093304 534 CTVWN 538
Cdd:pfam13927  74 CVASN 78

IgC1_2_PVR_like

cd05719

Second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and Necl-5), ...

180-281

5.41e-10

Second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and Necl-5), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (Necl-5)) and similar proteins. Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), these result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted, while CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" and has a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the second Ig-like domain of nectin-1, also known as poliovirus receptor related protein(PVRL)1 or CD111.

Pssm-ID: 409384 Cd Length: 96 Bit Score: 56.73 E-value: 5.41e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 180 PEPPKIVQGDFLRTTaGMTVELTCESHAGKPPAELTWldgEGNVvsDGIEYTTQLLGDGKRANAALKWTLTPRREHDGKT 259
Cdd:cd05719     1 PTNSLEGGPALLIGG-EPTLVATCISANGKPPASVTW---ETDL--KGEASTTQVRGSNGTVTVTSRYRLVPSREADGQP 74

                          90       100
                  ....*....|....*....|..
gi 1866093304 260 FTCRSENPALTQPLHARISLEV 281
Cdd:cd05719    75 LTCVVEHPSLEKDQRISVTLNV 96

I-set

Immunoglobulin I-set domain;

456-550

7.74e-10

Immunoglobulin I-set domain;

Pssm-ID: 400151 [Multi-domain] Cd Length: 90 Bit Score: 56.11 E-value: 7.74e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 456 PRVRSPPVQYGV-EGEVVKLECIISSVPPPTrILWSRN------SQHVDIDNNDGyeIVTepmadgvknnLIIHNADEDD 528
Cdd:pfam07679   1 PKFTQKPKDVEVqEGESARFTCTVTGTPDPE-VSWFKDgqplrsSDRFKVTYEGG--TYT----------LTISNVQPDD 67

                          90       100
                  ....*....|....*....|..
gi 1866093304 529 FGQYNCTVWNTFGQDSMIILLK 550
Cdd:pfam07679  68 SGKYTCVATNSAGEAEASAELT 89

IgC1_2_Nectin-3-4_like

cd07704

Second immunoglobulin (Ig) domain of nectin-3 and nectin-4 (poliovirus receptor related ...

175-271

3.89e-08

Second immunoglobulin (Ig) domain of nectin-3 and nectin-4 (poliovirus receptor related protein 4), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 or cluster of differentiation (CD) 113) and nectin-4 (poliovirus receptor related protein 4). Nectin-3 and nectin-4 belong to the nectin family comprised of four transmembrane glycoproteins (nectin-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. Nectin-3 has also been shown to form a heterophilic trans-interaction with nectin-1 in ciliary epithelia, establishing the apex-apex adhesion between the pigment and non-pigment cell layers. Nectin-4 has recently been identified in several types of breast carcinoma and can be used as a histological and serological marker for breast cancer.

Pssm-ID: 409501 Cd Length: 96 Bit Score: 51.36 E-value: 3.89e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 175 TVYVPPEPPKIVQGdflrttAGMTVELTCESHAGKPPAELTWldgEGNVvsDGIEyTTQLLGDGKRANAALKWTLTPRRE 254
Cdd:cd07704     2 LVSLNPGPALLIDG------GNETLAASCTAETGKPAASVTW---ETDL--GGME-SSRTFEHNRTATVTSEYHLVPTRF 69

                          90
                  ....*....|....*..
gi 1866093304 255 HDGKTFTCRSENPALTQ 271
Cdd:cd07704    70 ANGRPLTCVVSHPALQQ 86

IG_like

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

378-450

5.58e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 50.58 E-value: 5.58e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304  378 ENVAADIGSEVSLSCDVEGNPQPETMWTFEGSDAVL----------STESRLVIPQLTIDRAGKYTCRATVA-GFAEIST 446
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAesgrfsvsrsGSTSTLTISNVTPEDSGTYTCAATNSsGSASSGT 81


                   ....
gi 1866093304  447 DVLV 450
Cdd:smart00410  82 TLTV 85

IgI_2_Necl-1-4

cd05761

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...

178-281

1.23e-07

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.

Pssm-ID: 409418 Cd Length: 102 Bit Score: 50.12 E-value: 1.23e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 178 VPPEPPKI-------VQGDflrttagmTVELTCESHAGKPPAELTWLDGEGNV--VSDGIEYttqllGDGKRANAALKWT 248
Cdd:cd05761     2 GVPEKPVItgftspvVEGD--------EITLTCTTSGSKPAADIRWFKNDKELkgVKEVQES-----GAGKTFTVTSTLR 68

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1866093304 249 LTPRREHDGKTFTCRSENPALT-QPLHARISLEV 281
Cdd:cd05761    69 FRVDRDDDGVAVICRVDHESLTsTPKQTQQVLEV 102

Ig_2

pfam13895

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

383-452

2.21e-07

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

Pssm-ID: 464026 [Multi-domain] Cd Length: 79 Bit Score: 48.55 E-value: 2.21e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 383 DIGSEVSLSCDVEGNPQPETMWTFEGSdaVLSTESRLVIPQLTIDRAGKYTCRATVAGFAEISTDVLVFI 452
Cdd:pfam13895  12 TEGEPVTLTCSAPGNPPPSYTWYKDGS--AISSSPNFFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79

IgI_4_hemolin-like

cd20978

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...

371-450

2.34e-07

Pssm-ID: 409570 [Multi-domain] Cd Length: 88 Bit Score: 48.93 E-value: 2.34e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 371 PVFRSTIE-NVAADIGSEVSLSCDVEGNPQPETMWTFEG------SDAVLSTESRLVIPQLTIDRAGKYTCRAT-VAGfa 442
Cdd:cd20978     1 PKFIQKPEkNVVVKGGQDVTLPCQVTGVPQPKITWLHNGkplqgpMERATVEDGTLTIINVQPEDTGYYGCVATnEIG-- 78


                  ....*...
gi 1866093304 443 EISTDVLV 450
Cdd:cd20978    79 DIYTETLL 86

IgI_2_Titin_Z1z2-like

cd20972

Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and ...

455-544

2.56e-07

Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the titin Z1z2 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.

Pssm-ID: 409564 [Multi-domain] Cd Length: 91 Bit Score: 48.73 E-value: 2.56e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 455 PPR-VRSPPVQYGVEGEVVKLECIISSVPPPtRILWSRNSQhvDIDNNDGYEIVTEpmadGVKNNLIIHNADEDDFGQYN 533
Cdd:cd20972     1 PPQfIQKLRSQEVAEGSKVRLECRVTGNPTP-VVRWFCEGK--ELQNSPDIQIHQE----GDLHSLIIAEAFEEDTGRYS 73

                          90
                  ....*....|.
gi 1866093304 534 CTVWNTFGQDS 544
Cdd:cd20972    74 CLATNSVGSDT 84

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...

388-448

3.50e-07

Pssm-ID: 409353 [Multi-domain] Cd Length: 70 Bit Score: 47.71 E-value: 3.50e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 388 VSLSCDVEGNPQPETMWTFEGSDAVLSTE---------SRLVIPQLTIDRAGKYTCRATVAGFAEISTDV 448
Cdd:cd00096     1 VTLTCSASGNPPPTITWYKNGKPLPPSSRdsrrselgnGTLTISNVTLEDSGTYTCVASNSAGGSASASV 70

IG_like

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

83-178

6.94e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 47.50 E-value: 6.94e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304   83 PADRTAIVGKAAVLPCRVL-NKVGTLQWTRDAFglgsdRELKGFPRYTmiGSDDEGDFSLQISRVTLEDDALFQCQVGAA 161
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASgSPPPEVTWYKQGG-----KLLAESGRFS--VSRSGSTSTLTISNVTPEDSGTYTCAATNS 73

                           90
                   ....*....|....*..
gi 1866093304  162 DGVKgirsrNAAFTVYV 178
Cdd:smart00410  74 SGSA-----SSGTTLTV 85

I-set

Immunoglobulin I-set domain;

285-367

8.07e-07

Immunoglobulin I-set domain;

Pssm-ID: 400151 [Multi-domain] Cd Length: 90 Bit Score: 47.25 E-value: 8.07e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 285 PEITLKVSADKIMELDNVKFTCEAVANPaDVNIKWYRNDEVIPGDH---------STTYVISRVTRDyNKDTISCEVSNA 355
Cdd:pfam07679   1 PKFTQKPKDVEVQEGESARFTCTVTGTP-DPEVSWFKDGQPLRSSDrfkvtyeggTYTLTISNVQPD-DSGKYTCVATNS 78

                          90
                  ....*....|..
gi 1866093304 356 VGTTKSTHTLNV 367
Cdd:pfam07679  79 AGEAEASAELTV 90

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...

472-541

9.41e-07

Pssm-ID: 409353 [Multi-domain] Cd Length: 70 Bit Score: 46.55 E-value: 9.41e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 472 VKLECIISSVPPPTrILWSRNSQHVDIDNNDGYEIVTepmadgVKNNLIIHNADEDDFGQYNCTVWNTFG 541
Cdd:cd00096     1 VTLTCSASGNPPPT-ITWYKNGKPLPPSSRDSRRSEL------GNGTLTISNVTLEDSGTYTCVASNSAG 63

IgI_titin_I1-like

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...

468-544

1.20e-06

Pssm-ID: 409543 [Multi-domain] Cd Length: 94 Bit Score: 47.03 E-value: 1.20e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1866093304 468 EGEVVKLECIISSVPPPtRILWSRNSQHVDIDNNDG-YEIVTEpmaDGVkNNLIIHNADEDDFGQYNCTVWNTFGQDS 544
Cdd:cd20951    14 EKSDAKLRVEVQGKPDP-EVKWYKNGVPIDPSSIPGkYKIESE---YGV-HVLHIRRVTVEDSAVYSAVAKNIHGEAS 86

V-set

pfam07686

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...

81-162

1.72e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.

Pssm-ID: 462230 Cd Length: 109 Bit Score: 47.07 E-value: 1.72e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304  81 IEPADRTAIVGKAAVLPCRVL----NKVGTLQWTRDAFGLGSDRELKGF----------PRYTMIGSDDEGDFSLQISRV 146
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSssmsEASTSVYWYRQPPGKGPTFLIAYYsngseegvkkGRFSGRGDPSNGDGSLTIQNL 80

                          90
                  ....*....|....*.
gi 1866093304 147 TLEDDALFQCQVGAAD 162
Cdd:pfam07686  81 TLSDSGTYTCAVIPSG 96

IgI_1_Contactin-5

cd05848

First immunoglobulin (Ig) domain of contactin-5; member of the I-set of Ig superfamily domains; ...

450-541

2.61e-06

First immunoglobulin (Ig) domain of contactin-5; member of the I-set of Ig superfamily domains; The members here are composed of the first immunoglobulin (Ig) domain of the neural cell adhesion molecule contactin-5. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains, anchored to the membrane by glycosylphosphatidylinositol. The different contactins show different expression patterns in the central nervous system. In rats, a lack of contactin-5 (NB-2) results in an impairment of the neuronal activity in the auditory system. Contactin-5 is expressed specifically in the postnatal nervous system, peaking at about 3 weeks postnatal. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala; lower levels of expression have been detected in the corpus callosum, caudate nucleus, and spinal cord. This group belongs to the I-set of IgSF domains.

Pssm-ID: 409435 Cd Length: 96 Bit Score: 46.09 E-value: 2.61e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 450 VFIKGPPRVRSPpvqYGVEGEVVKLECIISSVPPPTrILWSRNSQHVDIDNNDGYEIVtepmaDGvknNLIIHNADE-DD 528
Cdd:cd05848     3 VFVQEPDDAIFP---TDSDEKKVILNCEARGNPVPT-YRWLRNGTEIDTESDYRYSLI-----DG---NLIISNPSEvKD 70

                          90
                  ....*....|...
gi 1866093304 529 FGQYNCTVWNTFG 541
Cdd:cd05848    71 SGRYQCLATNSIG 83

IgI_1_MuSK

cd20970

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...

378-437

2.71e-06

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin-like domains (Ig1) of the Muscle-specific kinase (MuSK). MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.

Pssm-ID: 409562 [Multi-domain] Cd Length: 92 Bit Score: 45.96 E-value: 2.71e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1866093304 378 ENVAADIGSEVSLSCDVEGNPQPETMWTFEGSDAVLSTE--------SRLVIPQLTIDRAGKYTCRAT 437
Cdd:cd20970    10 FTVTAREGENATFMCRAEGSPEPEISWTRNGNLIIEFNTryivrengTTLTIRNIRRSDMGIYLCIAS 77

IgI_Myotilin_C

cd05892

C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily ...

456-541

2.75e-06

C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the C-terminal immunoglobulin (Ig)-like domain of myotilin. Mytolin belongs to the palladin-myotilin-myopalladin family. Proteins belonging to the latter family contain multiple Ig-like domains and function as scaffolds, modulating the actin cytoskeleton. Myotilin is most abundant in skeletal and cardiac muscle and is involved in maintaining sarcomere integrity. It binds to alpha-actinin, filamin, and actin. Mutations in myotilin lead to muscle disorders. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

Pssm-ID: 409473 Cd Length: 92 Bit Score: 45.92 E-value: 2.75e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 456 PRVRSPPVQYGV-EGEVVKLECIISSVPPPtRILWSRNSQHVDIDNN------DGYEIVTepmadgvknnLIIHNADEDD 528
Cdd:cd05892     1 PMFIQKPQNKKVlEGDPVRLECQISAIPPP-QIFWKKNNEMLQYNTDrislyqDNCGRIC----------LLIQNANKKD 69

                          90
                  ....*....|...
gi 1866093304 529 FGQYNCTVWNTFG 541
Cdd:cd05892    70 AGWYTVSAVNEAG 82

IgV_SIRP

cd16097

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...

81-156

2.76e-06

Pssm-ID: 409516 Cd Length: 111 Bit Score: 46.39 E-value: 2.76e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304  81 IEPADRTAI-VGKAAVLPCRV--LNKVGTLQWTRdafGLGSDREL----KG--FPRYTMIgSD----DEGDFSLQISRVT 147
Cdd:cd16097     3 IQPEKSVSVaAGESATLHCTVtsLIPVGPIQWFR---GAGPGRELiynqKEghFPRVTTV-SDltkrNNMDFSIRISNIT 78


                  ....*....
gi 1866093304 148 LEDDALFQC 156
Cdd:cd16097    79 PADAGTYYC 87

Ig_2

pfam13895

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

285-367

3.43e-06

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

Pssm-ID: 464026 [Multi-domain] Cd Length: 79 Bit Score: 45.46 E-value: 3.43e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 285 PEITlkVSADKIMELDNVKFTCEAVANPaDVNIKWYRNDEVIPGdhSTTYVISRVTRDyNKDTISCEVSNAVGTTKS-TH 363
Cdd:pfam13895   2 PVLT--PSPTVVTEGEPVTLTCSAPGNP-PPSYTWYKDGSAISS--SPNFFTLSVSAE-DSGTYTCVARNGRGGKVSnPV 75


                  ....
gi 1866093304 364 TLNV 367
Cdd:pfam13895  76 ELTV 79

Ig_3

Immunoglobulin domain; This family contains immunoglobulin-like domains.

284-354

3.65e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.

Pssm-ID: 464046 [Multi-domain] Cd Length: 78 Bit Score: 45.25 E-value: 3.65e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 284 PPEITLKVSADKIMELDNVKFTCEAVANPAdVNIKWYRNDEVIPGDH---------STTYVISRVTRDYNkDTISCEVSN 354
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSPP-PTITWYKNGEPISSGStrsrslsgsNSTLTISNVTRSDA-GTYTCVASN 78

IgI_4_hemolin-like

cd20978

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...

451-541

4.70e-06

Pssm-ID: 409570 [Multi-domain] Cd Length: 88 Bit Score: 45.08 E-value: 4.70e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 451 FIKGPPRVRSppvqyGVEGEVVKLECIISSVPPPTrILWSRNSQHvdIDNNDGYEIVTepmadgvKNNLIIHNADEDDFG 530
Cdd:cd20978     3 FIQKPEKNVV-----VKGGQDVTLPCQVTGVPQPK-ITWLHNGKP--LQGPMERATVE-------DGTLTIINVQPEDTG 67

                          90
                  ....*....|.
gi 1866093304 531 QYNCTVWNTFG 541
Cdd:cd20978    68 YYGCVATNEIG 78

IgI_Myotilin_C_like

cd05744

Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of ...

455-544

5.09e-06

Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain in myotilin, palladin, and myopalladin. Myotilin, palladin, and myopalladin function as scaffolds that regulate actin organization. Myotilin and myopalladin are most abundant in skeletal and cardiac muscle; palladin is ubiquitously expressed in the organs of developing vertebrates and plays a key role in cellular morphogenesis. The three family members each interact with specific molecular partners with all three binding to alpha-actinin; In addition, palladin also binds to vasodilator-stimulated phosphoprotein (VASP) and ezrin, myotilin binds to filamin and actin, and myopalladin also binds to nebulin and cardiac ankyrin repeat protein (CARP). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

Pssm-ID: 409405 [Multi-domain] Cd Length: 91 Bit Score: 45.18 E-value: 5.09e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 455 PPRVRSPPVQYGVEGEVVKLECIISSVPPPtRILWSRNSQHVDIDNNDGYeIVTEpmadGVKNNLIIHNADEDDFGQYNC 534
Cdd:cd05744     1 PHFLQAPGDLEVQEGRLCRFDCKVSGLPTP-DLFWQLNGKPVRPDSAHKM-LVRE----NGRHSLIIEPVTKRDAGIYTC 74

                          90
                  ....*....|
gi 1866093304 535 TVWNTFGQDS 544
Cdd:cd05744    75 IARNRAGENS 84

IgI_3_NCAM-1

cd05730

Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of ...

374-453

5.88e-06

Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains; The members here are composed of the third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule (NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions) through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain.

Pssm-ID: 143207 [Multi-domain] Cd Length: 95 Bit Score: 45.31 E-value: 5.88e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 374 RSTIENVAADIGSEVSLSCDVEGNPQPETMWTFEGSDAVLSTE--------SRLVIPQLTIDRAGKYTCRA-TVAGFAEI 444
Cdd:cd05730     7 RQSEVNATANLGQSVTLACDADGFPEPTMTWTKDGEPIESGEEkysfnedgSEMTILDVDKLDEAEYTCIAeNKAGEQEA 86


                  ....*....
gi 1866093304 445 STDVLVFIK 453
Cdd:cd05730    87 EIHLKVFAK 95

IgI_telokin-like

cd20973

immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF ...

374-450

6.12e-06

immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig) domain in telokin, the C-terminal domain of myosin light chain kinase which is identical to telokin, and similar proteins. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the telokin Ig domain lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.

Pssm-ID: 409565 [Multi-domain] Cd Length: 88 Bit Score: 44.87 E-value: 6.12e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 374 RSTIENVAADIGSEVSLSCDVEGNPQPETMWTFEGSDAvlsTESR-------------LVIPQLTIDRAGKYTCRAT-VA 439
Cdd:cd20973     1 IQTLRDKEVVEGSAARFDCKVEGYPDPEVKWMKDDNPI---VESRrfqidqdedglcsLIISDVCGDDSGKYTCKAVnSL 77

                          90
                  ....*....|.
gi 1866093304 440 GFAEISTDVLV 450
Cdd:cd20973    78 GEATCSAELTV 88

IG_like

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

300-367

6.97e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 44.80 E-value: 6.97e-06

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1866093304  300 DNVKFTCEAVANPaDVNIKWYRND----------EVIPGDHSTTYVISRVTRDYNkDTISCEVSNAVGTTKSTHTLNV 367
Cdd:smart00410  10 ESVTLSCEASGSP-PPEVTWYKQGgkllaesgrfSVSRSGSTSTLTISNVTPEDS-GTYTCAATNSSGSASSGTTLTV 85

IgC2_CEACAM5-like

cd20948

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...

385-436

1.27e-05

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.

Pssm-ID: 409540 Cd Length: 76 Bit Score: 43.64 E-value: 1.27e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1866093304 385 GSEVSLSCDVEGNPQPETMWTFegSDAVLSTESRLVIPQLTIDRAGKYTCRA 436
Cdd:cd20948    10 GENLNLSCHAASNPPAQYSWTI--NGTFQTSSQELFLPAITENNEGTYTCSA 59

IgI_titin_I1-like

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...

285-367

1.47e-05

Pssm-ID: 409543 [Multi-domain] Cd Length: 94 Bit Score: 43.95 E-value: 1.47e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 285 PEITLKVSADKIMELDNVKFTCEAVANPaDVNIKWYRNDEVI-----PGDHS-------TTYVISRVTRDyNKDTISCEV 352
Cdd:cd20951     1 PEFIIRLQSHTVWEKSDAKLRVEVQGKP-DPEVKWYKNGVPIdpssiPGKYKieseygvHVLHIRRVTVE-DSAVYSAVA 78

                          90
                  ....*....|....*
gi 1866093304 353 SNAVGTTKSTHTLNV 367
Cdd:cd20951    79 KNIHGEASSSASVVV 93

IgI_1_Titin_Z1z2-like

cd20974

First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and ...

371-450

1.58e-05

First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin (Ig)-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the titin Z1z2 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.

Pssm-ID: 409566 [Multi-domain] Cd Length: 93 Bit Score: 43.88 E-value: 1.58e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 371 PVFRSTIENVAADIGSEVSLSCDVEGNPQPETMWTFEGSDAVLST-----------ESRLVIPQLTIDRAGKYTCRAT-V 438
Cdd:cd20974     1 PVFTQPLQSVVVLEGSTATFEAHVSGKPVPEVSWFRDGQVISTSTlpgvqisfsdgRAKLSIPAVTKANSGRYSLTATnG 80

                          90
                  ....*....|..
gi 1866093304 439 AGFAEISTDVLV 450
Cdd:cd20974    81 SGQATSTAELLV 92

IgI_2_Robo

cd05724

Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...

469-541

1.62e-05

Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of the Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit-2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

Pssm-ID: 409389 [Multi-domain] Cd Length: 87 Bit Score: 43.54 E-value: 1.62e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1866093304 469 GEVVKLECiissVPP-----PTrILWSRNSQHVDIDNNdGYEIVTepmaDGvknNLIIHNADEDDFGQYNCTVWNTFG 541
Cdd:cd05724    12 GEMAVLEC----SPPrghpePT-VSWRKDGQPLNLDNE-RVRIVD----DG---NLLIAEARKSDEGTYKCVATNMVG 76

IgC1_2_Nectin-2_Necl-5_like

cd07703

Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; ...

170-272

1.83e-05

Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; member of the C1-set of the Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.

Pssm-ID: 409500 Cd Length: 97 Bit Score: 43.93 E-value: 1.83e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 170 RNAAFTVyvppeppKIVQGDFLRTTAgmtvelTCESHAGKPPAELTW---LDGEGNvvsdgieyTTQLLG-DGKRANAAL 245
Cdd:cd07703     2 KNSAEAQ-------EVQAGGIPVPVA------RCVSANGRPPARISWsstLNGNAN--------TTQVPGpDSGTVTVTS 60

                          90       100
                  ....*....|....*....|....*..
gi 1866093304 246 KWTLTPRREHDGKTFTCRSENPALTQP 272
Cdd:cd07703    61 EYSLVPTPEANGKEVTCKVEHETLEEP 87

IGv

smart00406

Immunoglobulin V-Type;

94-158

2.06e-05

Immunoglobulin V-Type;

Pssm-ID: 214650 Cd Length: 81 Bit Score: 43.14 E-value: 2.06e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304   94 AVLPCRVLNK---VGTLQWTRDAFG-----LGSDR---------ELKGfpRYTMIGSDDEGDFSLQISRVTLEDDALFQC 156
Cdd:smart00406   2 VTLSCKFSGStfsSYYVSWVRQPPGkglewLGYIGsngssyyqeSYKG--RFTISKDTSKNDVSLTISNLRVEDTGTYYC 79


                   ..
gi 1866093304  157 QV 158
Cdd:smart00406  80 AV 81

IgI_4_Robo

cd05726

Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...

385-449

2.48e-05

Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; Members here are composed the fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1, Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

Pssm-ID: 409391 [Multi-domain] Cd Length: 98 Bit Score: 43.41 E-value: 2.48e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 385 GSEVSLSCDVEGNPQPETMWTFEGSDAVL--------------STESRLVIPQLTIDRAGKYTCRA-TVAG------FAE 443
Cdd:cd05726    14 GRTVTFQCETKGNPQPAIFWQKEGSQNLLfpyqppqpssrfsvSPTGDLTITNVQRSDVGYYICQAlNVAGsilakaQLE 93


                  ....*.
gi 1866093304 444 IsTDVL 449
Cdd:cd05726    94 V-TDVL 98

IgI_1_MuSK

cd20970

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...

468-538

2.51e-05

Pssm-ID: 409562 [Multi-domain] Cd Length: 92 Bit Score: 43.27 E-value: 2.51e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1866093304 468 EGEVVKLECIISSVPPPTrILWSRNSQHVdIDNNDGYEIvtepMADGvkNNLIIHNADEDDFGQYNCTVWN 538
Cdd:cd20970    16 EGENATFMCRAEGSPEPE-ISWTRNGNLI-IEFNTRYIV----RENG--TTLTIRNIRRSDMGIYLCIASN 78

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...

302-364

2.80e-05

Pssm-ID: 409353 [Multi-domain] Cd Length: 70 Bit Score: 42.32 E-value: 2.80e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1866093304 302 VKFTCEAVANPaDVNIKWYRNDEVIPGDHSTTY---------VISRVTRDYNKdTISCEVSNAVGTTKSTHT 364
Cdd:cd00096     1 VTLTCSASGNP-PPTITWYKNGKPLPPSSRDSRrselgngtlTISNVTLEDSG-TYTCVASNSAGGSASASV 70

IgI_2_Titin_Z1z2-like

cd20972

Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and ...

385-450

2.89e-05

Pssm-ID: 409564 [Multi-domain] Cd Length: 91 Bit Score: 42.96 E-value: 2.89e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1866093304 385 GSEVSLSCDVEGNPQPETMWTFEGS------DAVLSTES---RLVIPQLTIDRAGKYTCRAT-VAGFAEISTDVLV 450
Cdd:cd20972    16 GSKVRLECRVTGNPTPVVRWFCEGKelqnspDIQIHQEGdlhSLIIAEAFEEDTGRYSCLATnSVGSDTTSAEIFV 91

Ig_Titin_like

cd05748

Immunoglobulin (Ig)-like domain of titin and similar proteins; The members here are composed ...

468-550

3.05e-05

Immunoglobulin (Ig)-like domain of titin and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain found in titin-like proteins and similar proteins. Titin (also called connectin) is a fibrous sarcomeric protein specifically found in vertebrate striated muscle. Titin is a giant protein; depending on isoform composition, it ranges from 2970 to 3700 kDa, and is of a length that spans half a sarcomere. Titin largely consists of multiple repeats of Ig-like and fibronectin type 3 (FN-III)-like domains. Titin connects the ends of myosin thick filaments to Z disks and extends along the thick filament to the H zone. It appears to function similarly to an elastic band, keeping the myosin filaments centered in the sarcomere during muscle contraction or stretching. Within the sarcomere, titin is also attached to or is associated with myosin binding protein C (MyBP-C). MyBP-C appears to contribute to the generation of passive tension by titin and like titin has repeated Ig-like and FN-III domains. Also included in this group are worm twitchin and insect projectin, thick filament proteins of invertebrate muscle which also have repeated Ig-like and FN-III domains.

Pssm-ID: 409406 [Multi-domain] Cd Length: 82 Bit Score: 42.58 E-value: 3.05e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 468 EGEVVKLECIISSVPPPTrILWSRN------SQHVDIDNNDGYEIvtepmadgvknnLIIHNADEDDFGQYNCTVWNTFG 541
Cdd:cd05748     6 AGESLRLDIPIKGRPTPT-VTWSKDgqplkeTGRVQIETTASSTS------------LVIKNAKRSDSGKYTLTLKNSAG 72


                  ....*....
gi 1866093304 542 QDSMIILLK 550
Cdd:cd05748    73 EKSATINVK 81

Ig4_Contactin-2-like

cd05728

Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains; The ...

376-444

3.65e-05

Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains; The members here are composed of the fourth Ig domain of the neural cell adhesion molecule contactin-2. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-2 (also called TAG-1, axonin-1) facilitates cell adhesion by homophilic binding between molecules in apposed membranes. The first four Ig domains form the intermolecular binding fragment which arranges as a compact U-shaped module by contacts between Ig domains 1 and 4, and domains 2 and 3. It has been proposed that a linear zipper-like array forms, from contactin-2 molecules alternatively provided by the two apposed membranes.

Pssm-ID: 143205 [Multi-domain] Cd Length: 85 Bit Score: 42.59 E-value: 3.65e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 376 TIENVAADIGSEVSLSCDVEGNPQPETMWTFEGSdaVLSTESR-------LVIPQLTIDRAGKYTCRA-----TVAGFAE 443
Cdd:cd05728     5 VISDTEADIGSSLRWECKASGNPRPAYRWLKNGQ--PLASENRieveagdLRITKLSLSDSGMYQCVAenkhgTIYASAE 82


                  .
gi 1866093304 444 I 444
Cdd:cd05728    83 L 83

I-set

Immunoglobulin I-set domain;

78-158

4.09e-05

Immunoglobulin I-set domain;

Pssm-ID: 400151 [Multi-domain] Cd Length: 90 Bit Score: 42.63 E-value: 4.09e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304  78 EFAIEPADRTAIVGKAAVLPCRVL-NKVGTLQWTRDafglgsDRELKGFPRYTMigSDDEGDFSLQISRVTLEDDALFQC 156
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTVTgTPDPEVSWFKD------GQPLRSSDRFKV--TYEGGTYTLTISNVQPDDSGKYTC 73


                  ..
gi 1866093304 157 QV 158
Cdd:pfam07679  74 VA 75

IgI_2_Follistatin_like

cd05736

Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; ...

371-436

1.05e-04

Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain found in human Follistatin-related protein 5 (FSTL5) and a follistatin-like molecule encoded by the CNS-related Mahya gene. Mahya genes have been retained in certain Bilaterian branches during evolution. They are conserved in Hymenoptera and Deuterostomes, but are absent from other metazoan species such as fruit fly and nematode. Mahya proteins are secretory, with a follistatin-like domain (Kazal-type serine/threonine protease inhibitor domain and EF-hand calcium-binding domain), two Ig-like domains, and a novel C-terminal domain. Mahya may be involved in learning and memory and in processing of sensory information in Hymenoptera and vertebrates. Follistatin is a secreted, multidomain protein that binds activins with high affinity and antagonizes their signaling.

Pssm-ID: 409399 [Multi-domain] Cd Length: 93 Bit Score: 41.48 E-value: 1.05e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1866093304 371 PVFRSTIENVAADIGSEVSLSCDVEGNPQPETMWTFEGSD---------AVLSTESRLVIPQLTIDRAGKYTCRA 436
Cdd:cd05736     1 PVIRVYPEFQAKEPGVEASLRCHAEGIPLPRVQWLKNGMDinpklskqlTLIANGSELHISNVRYEDTGAYTCIA 75

IgI_2_FGFRL1-like

cd05856

Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1 ...

380-435

1.35e-04

Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor like-1(FGFRL1). FGFRL1 is comprised of a signal peptide, three extracellular Ig-like modules, a transmembrane segment, and a short intracellular domain. FGFRL1 is expressed preferentially in skeletal tissues. Similar to FGF receptors, the expressed protein interacts specifically with heparin and with FGF2. FGFRL1 does not have a protein tyrosine kinase domain at its C-terminus; neither does its cytoplasmic domain appear to interact with a signaling partner. It has been suggested that FGFRL1 may not have any direct signaling function, but instead acts as a decoy receptor trapping FGFs and preventing them from binding other receptors.

Pssm-ID: 409442 Cd Length: 92 Bit Score: 41.00 E-value: 1.35e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1866093304 380 VAADIGSEVSLSCDVEGNPQPETMWTFEGSDAVLSTESR-------LVIPQLTIDRAGKYTCR 435
Cdd:cd05856    14 IARPVGSSVRLKCVASGNPRPDITWLKDNKPLTPPEIGEnkkkkwtLSLKNLKPEDSGKYTCH 76

pfam00047

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...

460-545

1.37e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.

Pssm-ID: 395002 Cd Length: 86 Bit Score: 41.03 E-value: 1.37e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 460 SPPVQYGV-EGEVVKLECIISSVPPPTRILWSRN------SQHVDIDNNDGYeivtepmadgvKNNLIIHNADEDDFGQY 532
Cdd:pfam00047   1 SAPPTVTVlEGDSATLTCSASTGSPGPDVTWSKEggtlieSLKVKHDNGRTT-----------QSSLLISNVTKEDAGTY 69

                          90
                  ....*....|...
gi 1866093304 533 NCTVWNTFGQDSM 545
Cdd:pfam00047  70 TCVVNNPGGSATL 82

Ig0_BSG1

cd20940

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...

384-437

1.73e-04

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.

Pssm-ID: 409534 Cd Length: 116 Bit Score: 41.49 E-value: 1.73e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1866093304 384 IGSEVSLSCDVEGNPQPETMWTFEGS---------------DAV-------LSTESRLVIPQLTIDRAGKYTCRAT 437
Cdd:cd20940    14 VGDSVELHCEAVGSPIPEIQWWFEGQepneicsqlwdgarlDRVhinatyhQHATSTISIDNLTEEDTGTYECRAS 89

Ig5_Contactin

cd04969

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth ...

370-445

1.85e-04

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.

Pssm-ID: 409358 [Multi-domain] Cd Length: 89 Bit Score: 40.52 E-value: 1.85e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 370 GPVFRSTIenvaADIGSEVSLSCDVEGNPQPETMWTF------EGSDAVLSTESRLVIPQLTIDRAGKYTCRAT-VAGFA 442
Cdd:cd04969     6 NPVKKKIL----AAKGGDVIIECKPKASPKPTISWSKgtelltNSSRICILPDGSLKIKNVTKSDEGKYTCFAVnFFGKA 81


                  ...
gi 1866093304 443 EIS 445
Cdd:cd04969    82 NST 84

IgI_2_Necl-4

cd05885

Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the ...

178-269

2.01e-04

Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4; also known as cell adhesion molecule 4 (CADM4)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1-Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Ig domains are likely to participate in ligand binding and recognition. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. In injured peripheral nerve cells, the mRNA signal for both Necl-4 and Necl-5 was observed to be elevated. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.

Pssm-ID: 409468 Cd Length: 100 Bit Score: 41.10 E-value: 2.01e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 178 VPPEPPKIVqgdfLRTTA--GMTVELTCESHAGKPPAELTWLDGEGNV--VSDGIEyttqllgDGKRANAALKWTLTPRR 253
Cdd:cd05885     2 VAPENPVVE----VREQAveGGEVELSCLVPRSRPAATLRWYRDRKELkgVSSGQE-------NGKVWSVASTVRFRVDR 70

                          90
                  ....*....|....*.
gi 1866093304 254 EHDGKTFTCRSENPAL 269
Cdd:cd05885    71 KDDGGIVICEAQNQAL 86

IgI_Myotilin_C_like

cd05744

Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of ...

385-450

2.51e-04

Pssm-ID: 409405 [Multi-domain] Cd Length: 91 Bit Score: 40.56 E-value: 2.51e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1866093304 385 GSEVSLSCDVEGNPQPETMW-------TFEGSDAVLSTES---RLVIPQLTIDRAGKYTCRAT-VAGFAEISTDVLV 450
Cdd:cd05744    15 GRLCRFDCKVSGLPTPDLFWqlngkpvRPDSAHKMLVRENgrhSLIIEPVTKRDAGIYTCIARnRAGENSFNAELVV 91

IgI_1_Contactin-1

cd05849

First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains; ...

468-541

2.68e-04

First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains; The members here are composed of the first immunoglobulin (Ig) domain of the neural cell adhesion molecule contactin-1. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma. This group belongs to the I-set of IgSF domains.

Pssm-ID: 409436 [Multi-domain] Cd Length: 95 Bit Score: 40.32 E-value: 2.68e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1866093304 468 EGEVvKLECIISSVPPPTrILWSRNSQHVDIdNNDGYEIVtepmadgvKNNLIIHNADED-DFGQYNCTVWNTFG 541
Cdd:cd05849    19 EGKV-SVNCRARANPFPI-YKWRKNNLDIDL-TNDRYSMV--------GGNLVINNPDKYkDAGRYVCIVSNIYG 82

Ig_C5_MyBP-C

cd05894

C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C); The members here ...

467-550

3.06e-04

C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C); The members here are composed of the C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C). MyBP-C consists of repeated domains, Ig and fibronectin type 3, and various linkers. Three isoforms of MYBP-C exist: slow-skeletal (ssMyBP-C), fast-skeletal (fsMyBP-C), and cardiac (cMyBP-C). cMYBP-C has insertions between and inside domains and an additional cardiac-specific Ig domain at the N-terminus. For cMYBP_C an interaction has been demonstrated between this C5 domain and the Ig C8 domain.

Pssm-ID: 409475 Cd Length: 86 Bit Score: 39.82 E-value: 3.06e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 467 VEGEVVKLECIISSVPPPTrILWSRNSQhvDIDNNDGyEIVTEPMADgvKNNLIIHNADEDDFGQYNCTVWNTFGQDSMI 546
Cdd:cd05894     8 VAGNKLRLDVPISGEPAPT-VTWSRGDK--AFTATEG-RVRVESYKD--LSSFVIEGAEREDEGVYTITVTNPVGEDHAS 81


                  ....
gi 1866093304 547 ILLK 550
Cdd:cd05894    82 LFVK 85

IgI_1_Contactin-5

cd05848

First immunoglobulin (Ig) domain of contactin-5; member of the I-set of Ig superfamily domains; ...

370-437

3.20e-04

Pssm-ID: 409435 Cd Length: 96 Bit Score: 40.31 E-value: 3.20e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 370 GPVFRSTIENVAADIGSE---VSLSCDVEGNPQPETMWTFEGSDAVLSTESR-------LVI--PQLTIDrAGKYTCRAT 437
Cdd:cd05848     1 GPVFVQEPDDAIFPTDSDekkVILNCEARGNPVPTYRWLRNGTEIDTESDYRyslidgnLIIsnPSEVKD-SGRYQCLAT 79

IgI_4_Dscam

cd20956

Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...

371-437

3.95e-04

Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.

Pssm-ID: 409548 [Multi-domain] Cd Length: 96 Bit Score: 39.85 E-value: 3.95e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 371 PVFRSTIENVAADIGSEVSLSCDVEGNPQPETMWTFEG-----------SDAVlsTESRLVIPQLTIDRA-----GKYTC 434
Cdd:cd20956     2 PVLLETFSEQTLQPGPSVSLKCVASGNPLPQITWTLDGfpipesprfrvGDYV--TSDGDVVSYVNISSVrvedgGEYTC 79


                  ...
gi 1866093304 435 RAT 437
Cdd:cd20956    80 TAT 82

IgI_4_MYLK-like

cd20976

Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a ...

455-542

4.49e-04

Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain from smooth muscle myosin light chain kinase (MYLK) and similar domains. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of this group shows that the fourth Ig-like domain from myosin light chain kinase lacks this strand and thus belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.

Pssm-ID: 409568 [Multi-domain] Cd Length: 90 Bit Score: 39.54 E-value: 4.49e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 455 PPRVRS-PPVQYGVEGEVVKLECIISSVPPPtRILWSRNSQHVdidNNDGYEIVTEPMAdgvkNNLIIHNADEDDFGQYN 533
Cdd:cd20976     1 APSFSSvPKDLEAVEGQDFVAQCSARGKPVP-RITWIRNAQPL---QYAADRSTCEAGV----GELHIQDVLPEDHGTYT 72


                  ....*....
gi 1866093304 534 CTVWNTFGQ 542
Cdd:cd20976    73 CLAKNAAGQ 81

Ig_DSCAM

cd05734

Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM); The members ...

455-543

4.65e-04

Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM); The members here are composed of the immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM). DSCAM is a cell adhesion molecule expressed largely in the developing nervous system. The gene encoding DSCAM is located at human chromosome 21q22, the locus associated with the intellectual disability phenotype of Down Syndrome. DSCAM is predicted to be the largest member of the IG superfamily. It has been demonstrated that DSCAM can mediate cation-independent homophilic intercellular adhesion.

Pssm-ID: 409397 [Multi-domain] Cd Length: 97 Bit Score: 39.78 E-value: 4.65e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 455 PPR-VRSPPVQYGVEGEVVKLECIISSVPPPTrILW-----SRNSQHVDIDNNDGYEIVtepMADGvknNLIIHNADEDD 528
Cdd:cd05734     1 PPRfVVQPNDQDGIYGKAVVLNCSADGYPPPT-IVWkhskgSGVPQFQHIVPLNGRIQL---LSNG---SLLIKHVLEED 73

                          90
                  ....*....|....*
gi 1866093304 529 FGQYNCTVWNTFGQD 543
Cdd:cd05734    74 SGYYLCKVSNDVGAD 88

IgI_1_Contactin

cd04967

First immunoglobulin (Ig) domain of contactin; member of the I-set of (Ig) superfamily domains; ...

370-437

4.98e-04

First immunoglobulin (Ig) domain of contactin; member of the I-set of (Ig) superfamily domains; The members here are composed of the first immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma. This group belongs to the I-set of IgSF domains.

Pssm-ID: 409356 [Multi-domain] Cd Length: 96 Bit Score: 39.53 E-value: 4.98e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1866093304 370 GPVFRSTIENVAADIGS---EVSLSCDVEGNPQPETMWTFEGSDAVLSTESR--LVIPQLTIDR------AGKYTCRAT 437
Cdd:cd04967     1 GPVFEEQPDDTIFPEDSdekKVALNCRARANPVPSYRWLMNGTEIDLESDYRysLVDGTLVISNpskakdAGHYQCLAT 79

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...

199-271

5.33e-04

Pssm-ID: 409353 [Multi-domain] Cd Length: 70 Bit Score: 38.85 E-value: 5.33e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1866093304 199 VELTCEShAGKPPAELTWLDGEGNVVSDGIEYTTQLLGDGKranaalkWTLTPRREHDGKTFTCRSENPALTQ 271
Cdd:cd00096     1 VTLTCSA-SGNPPPTITWYKNGKPLPPSSRDSRRSELGNGT-------LTISNVTLEDSGTYTCVASNSAGGS 65

IgI_titin_I1-like

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...

371-450

5.34e-04

Pssm-ID: 409543 [Multi-domain] Cd Length: 94 Bit Score: 39.71 E-value: 5.34e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 371 PVFRSTIENVAADIGSEVSLSCDVEGNPQPETMWTFEG-------SDAVLSTESR-----LVIPQLTIDRAGKYTCRAT- 437
Cdd:cd20951     1 PEFIIRLQSHTVWEKSDAKLRVEVQGKPDPEVKWYKNGvpidpssIPGKYKIESEygvhvLHIRRVTVEDSAVYSAVAKn 80

                          90
                  ....*....|...
gi 1866093304 438 VAGFAEISTDVLV 450
Cdd:cd20951    81 IHGEASSSASVVV 93

IgI_3_WFIKKN-like

cd05765

Third immunoglobulin-like domain of the human WFIKKN (WAP, follistatin, immunoglobulin, Kunitz ...

381-440

5.40e-04

Third immunoglobulin-like domain of the human WFIKKN (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein), and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin-like domain of the human WFIKKN (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein) and similar proteins. WFIKKN is a secreted protein that consists of multiple types of protease inhibitory modules, including two tandem Kunitz-type protease inhibitor-domains. The Ig superfamily is a heterogenous group of proteins built on a common fold comprised of a sandwich of two beta sheets. Members of the Ig superfamily are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

Pssm-ID: 409422 [Multi-domain] Cd Length: 95 Bit Score: 39.45 E-value: 5.40e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1866093304 381 AADIGSEVSLSCDVEGNPQPETMWT--FEGSDAVLSTESRLV-------IPQLTI-----DRAGKYTCRATVAG 440
Cdd:cd05765    11 TVKVGETASFHCDVTGRPQPEITWEkqVPGKENLIMRPNHVRgnvvvtnIGQLVIynaqpQDAGLYTCTARNSG 84

IgI_3_Robo

cd05725

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...

82-176

8.02e-04

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

Pssm-ID: 409390 [Multi-domain] Cd Length: 83 Bit Score: 38.53 E-value: 8.02e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304  82 EPADRTAIVGKAAVLPCRVL-NKVGTLQWTRDafglgsDREL-KGfpRYTMIgsddeGDFSLQISRVTLEDDALFQCQvg 159
Cdd:cd05725     3 RPQNQVVLVDDSAEFQCEVGgDPVPTVRWRKE------DGELpKG--RYEIL-----DDHSLKIRKVTAGDMGSYTCV-- 67

                          90
                  ....*....|....*..
gi 1866093304 160 aADGVKGIRSRNAAFTV 176
Cdd:cd05725    68 -AENMVGKIEASATLTV 83

IgI_Lingo-1

cd20969

Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing ...

457-550

8.63e-04

Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1); The members here are composed of the immunoglobulin I-set (IgI) domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1). Human Lingo-1 is a central nervous system-specific transmembrane glycoprotein also known as LERN-1, which functions as a negative regulator of neuronal survival, axonal regeneration, and oligodendrocyte differentiation and myelination. Lingo-1 is a key component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. The ligand-binding ectodomain of human Lingo-1 contains a bimodular, kinked structure composed of leucine-rich repeat (LRR) and immunoglobulin (Ig)-like modules. Diseases associated with Lingo-1 include mental retardation, autosomal recessive 64 and essential tremor. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the Lingo-1 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.

Pssm-ID: 409561 Cd Length: 92 Bit Score: 38.91 E-value: 8.63e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 457 RVRSPPVQYGVEGEVVKLECIISSVPPPTrILW-SRNSQHVDIDNNDGYEIVTepmaDGvknNLIIHNADEDDFGQYNCT 535
Cdd:cd20969     5 RDRKAQQVFVDEGHTVQFVCRADGDPPPA-ILWlSPRKHLVSAKSNGRLTVFP----DG---TLEVRYAQVQDNGTYLCI 76

                          90
                  ....*....|....*
gi 1866093304 536 VWNTFGQDSMIILLK 550
Cdd:cd20969    77 AANAGGNDSMPAHLH 91

IgI_NCAM-1_like

cd05732

Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1) and similar ...

377-436

9.89e-04

Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1) and similar proteins; The members here are composed of the fourth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule (NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain. Also included in this group is NCAM-2 (also known as OCAM/mamFas II and RNCAM) NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE). One of the unique features of I-set domains is the lack of a C" strand. The structures of this group show that the Ig domain lacks this strand and thus is a member of the I-set of Ig domains.

Pssm-ID: 409395 [Multi-domain] Cd Length: 96 Bit Score: 38.66 E-value: 9.89e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1866093304 377 IENVAADIGSEVSLSCDVEGNPQPETMWTFeGSDAVLSTE---------------SRLVIPQLTIDRAGKYTCRA 436
Cdd:cd05732     8 LENQTAVELEQITLTCEAEGDPIPEITWRR-ATRGISFEEgdldgrivvrgharvSSLTLKDVQLTDAGRYDCEA 81

Ig_Semaphorin_C

cd04979

Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are ...

385-441

1.01e-03

Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are composed of the immunoglobulin (Ig)-like domain in semaphorins. Semaphorins are transmembrane protein that have important roles in a variety of tissues. Functionally, semaphorins were initially characterized for their importance in the development of the nervous system and in axonal guidance. Later they have been found to be important for the formation and functioning of the cardiovascular, endocrine, gastrointestinal, hepatic, immune, musculoskeletal, renal, reproductive, and respiratory systems. Semaphorins function through binding to their receptors and transmembrane semaphorins also serves as receptors themselves. Although molecular mechanism of semaphorins is poorly understood, the Ig-like domains may be involved in ligand binding or dimerization.

Pssm-ID: 409368 Cd Length: 88 Bit Score: 38.59 E-value: 1.01e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1866093304 385 GSEVSLSCDVEGNPQPETmWTFEGSDA--------VLSTESRLVIPQLTIDRAGKYTCRATVAGF 441
Cdd:cd04979    11 GDTVILSCSVKSNNAPVT-WIHNGKKVpryrsprlVLKTERGLLIRSAQEADAGVYECHSGERVL 74

Ig5_Contactin

cd04969

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth ...

451-541

1.02e-03

Pssm-ID: 409358 [Multi-domain] Cd Length: 89 Bit Score: 38.60 E-value: 1.02e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 451 FIKGPPRvRSPPVQYGveGEVVkLECIISSVPPPTrILWSRNSqhvdidnndgyEIVTEP-----MADGvknNLIIHNAD 525
Cdd:cd04969     3 FELNPVK-KKILAAKG--GDVI-IECKPKASPKPT-ISWSKGT-----------ELLTNSsriciLPDG---SLKIKNVT 63

                          90
                  ....*....|....*.
gi 1866093304 526 EDDFGQYNCTVWNTFG 541
Cdd:cd04969    64 KSDEGKYTCFAVNFFG 79

IgI_2_Follistatin_like

cd05736

Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; ...

456-554

1.07e-03

Pssm-ID: 409399 [Multi-domain] Cd Length: 93 Bit Score: 38.78 E-value: 1.07e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 456 PRVR-SPPVQYGVEGEVVKLECIISSVPPPtRILWSRNSQHVDIDNNDGYEIVtepmADGVKnnLIIHNADEDDFGQYNC 534
Cdd:cd05736     1 PVIRvYPEFQAKEPGVEASLRCHAEGIPLP-RVQWLKNGMDINPKLSKQLTLI----ANGSE--LHISNVRYEDTGAYTC 73

                          90       100
                  ....*....|....*....|
gi 1866093304 535 TVWNTFGQDSMIILLKKQKS 554
Cdd:cd05736    74 IAKNEGGVDEDISSLFVEDS 93

IgI_Titin_M1-like

cd20927

Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains; The members ...

466-544

1.26e-03

Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains; The members here are composed of the Immunoglobulin-like M1 I-set domain from Titin and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the titin-M1 domain lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.

Pssm-ID: 409521 Cd Length: 90 Bit Score: 38.48 E-value: 1.26e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1866093304 466 GVEGEVVKLECIISSVPPPTRILWSRNSQHvdIDNNDGYEIVTEpmaDGVKNnLIIHNADEDDFGQYNCTVWNTFGQDS 544
Cdd:cd20927    11 GEEGGHVKYVCKIENYDQSTQVTWYFGVRQ--LENSEKYEITYE---DGVAI-LYVKDITKFDDGTYRCKVVNDYGEDS 83

IgI_Twitchin_like

cd20949

C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin, ...

385-436

1.37e-03

C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin, and similar domains; member of the I-set IgSF domains; The members here are composed of the C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin and similar proteins, including Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. In humans these proteins are called Titin. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig-like domain of the Twitchin is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins (titin, telokin, and twitchin), the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D.

Pssm-ID: 409541 [Multi-domain] Cd Length: 89 Bit Score: 38.08 E-value: 1.37e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1866093304 385 GSEVSLSCDVEGNPQPETMWTFEGSDAVLSTE--SR-------LVIPQLTIDRAGKYTCRA 436
Cdd:cd20949    14 GQSATILCEVKGEPQPNVTWHFNGQPISASVAdmSKyriladgLLINKVTQDDTGEYTCRA 74

IgC2_CD22_d3

cd20937

Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 ...

285-369

1.54e-03

Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 (C2)-set of IgSF domains; The members here are composed of the third immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.

Pssm-ID: 409531 Cd Length: 88 Bit Score: 38.24 E-value: 1.54e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 285 PEITLKVS-ADKIM-ELDNVKFTCE-AVANPADVNIKWYRNDEVIPGDHSTTYVISRVTRDyNKDTISCEVSNAVGTTKS 361
Cdd:cd20937     1 PKLEIKVTpSDAIVrEGDSVTMTCEvSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKD-QSGKYCCQVSNDVGPGRS 79


                  ....*....
gi 1866093304 362 THT-LNVLY 369
Cdd:cd20937    80 EEVfLQVQY 88

IgC2_3_Dscam

cd20957

Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...

76-159

1.55e-03

Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the Constant 2 (C2)-set of IgSF domains; The members here are composed of the third immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C, and C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.

Pssm-ID: 409549 [Multi-domain] Cd Length: 88 Bit Score: 37.90 E-value: 1.55e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304  76 PQEFAIEPADRTAIVGKAAVLPCRVL-NKVGTLQWTRDAFGLGSDRELKgfprytmIGSDDegdfSLQISRVTLEDDALF 154
Cdd:cd20957     1 PLSATIDPPVQTVDFGRTAVFNCSVTgNPIHTVLWMKDGKPLGHSSRVQ-------ILSED----VLVIPSVKREDKGMY 69


                  ....*
gi 1866093304 155 QCQVG 159
Cdd:cd20957    70 QCFVR 74

IgI_2_Necl-1-4

cd05761

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...

285-368

1.57e-03

Pssm-ID: 409418 Cd Length: 102 Bit Score: 38.56 E-value: 1.57e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 285 PEITLKVSAdkIMELDNVKFTCEAVANPADVNIKWYRNDEVIPG-------DHSTTYVIS-----RVTRDYNKDTISCEV 352
Cdd:cd05761     7 PVITGFTSP--VVEGDEITLTCTTSGSKPAADIRWFKNDKELKGvkevqesGAGKTFTVTstlrfRVDRDDDGVAVICRV 84

                          90
                  ....*....|....*.
gi 1866093304 353 SNAVGTTKSTHTLNVL 368
Cdd:cd05761    85 DHESLTSTPKQTQQVL 100

Ig_Perlecan_like

cd05743

Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan ...

469-541

1.83e-03

Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar proteins. Perlecan consists of five domains: domain I has three putative heparan sulfate attachment sites, domain II has four LDL receptor-like repeats, and one Ig-like repeat, domain III resembles the short arm of laminin chains, domain IV has multiple Ig-like repeats (21 repeats in human perlecan), and domain V resembles the globular G domain of the laminin A chain and internal repeats of EGF. Perlecan may participate in a variety of biological functions including cell binding, LDL-metabolism, basement membrane assembly and selective permeability, calcium binding, and growth- and neurite-promoting activities.

Pssm-ID: 143220 Cd Length: 78 Bit Score: 37.47 E-value: 1.83e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1866093304 469 GEVVKLECIISSVPPPTrILWSRNSQHVDidNNDGYEIVTEpmadGVKNNLIIHNADEDDFGQYNCTVWNTFG 541
Cdd:cd05743     1 GETVEFTCVATGVPTPI-INWRLNWGHVP--DSARVSITSE----GGYGTLTIRDVKESDQGAYTCEAINTRG 66

IgI_2_Necl-2

cd05883

Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (Necl-2); member of the I-set ...

178-281

2.13e-03

Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (Necl-2); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (Necl-2; also known as cell adhesion molecule 1 (CADM1)). Nectin-like molecules (Necls) have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Necl-2 has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Ig domains are likely to participate in ligand binding and recognition.

Pssm-ID: 409466 Cd Length: 99 Bit Score: 37.98 E-value: 2.13e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 178 VPPEPPKI-VQGDFlrTTAGMTVELTCESHAGKPPAELTWLDGEGNVV---------SDGIEYTTQLLgdgkranaalkw 247
Cdd:cd05883     2 VPPRNLVIdIQKDT--AVEGEEIELNCTAMASKPAATIRWFKGNKELTgkseveewySRMFTVTSQLM------------ 67

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1866093304 248 tLTPRREHDGKTFTCRSENPALTQpLHARISLEV 281
Cdd:cd05883    68 -LKVTKEDDGVPVICLVDHPAVKD-LQTQRYLEV 99

IgI_2_Necl-3

cd05884

Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set ...

180-281

2.17e-03

Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3; also known as cell adhesion molecule 2 (CADM2)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Ig domains are likely to participate in ligand binding and recognition.

Pssm-ID: 409467 Cd Length: 104 Bit Score: 37.99 E-value: 2.17e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 180 PEPPKIvQGDFLRTTAGMTVELTCESHAGKPPAELTWLDGEGNVvsDGIEYTTQLLGDGKRANAALKWTLTPRREHDGKT 259
Cdd:cd05884     5 PEKPQI-SGFTSPVMEGDHIQLTCKTSGSKPAADIRWFKNDKEV--KDVKYLKAEDANRKTFTVSSSLDFHVDRDDDGVA 81

                          90       100
                  ....*....|....*....|...
gi 1866093304 260 FTCRSENPALTQ-PLHARISLEV 281
Cdd:cd05884    82 ITCRVDHESLTAtPQIAMQVLEI 104

IgC2_3_Dscam

cd20957

Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...

460-538

2.18e-03

Pssm-ID: 409549 [Multi-domain] Cd Length: 88 Bit Score: 37.51 E-value: 2.18e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1866093304 460 SPPVQYGVEGEVVKLECIISSVPPPTrILWSRNSQHvdIDNNDGYEIVTEPMadgvknnLIIHNADEDDFGQYNCTVWN 538
Cdd:cd20957     7 DPPVQTVDFGRTAVFNCSVTGNPIHT-VLWMKDGKP--LGHSSRVQILSEDV-------LVIPSVKREDKGMYQCFVRN 75

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...

94-158

2.35e-03

Pssm-ID: 409353 [Multi-domain] Cd Length: 70 Bit Score: 36.92 E-value: 2.35e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1866093304  94 AVLPCRVL-NKVGTLQWTRDAFGLGSDRELKGFprytmigsDDEGDFSLQISRVTLEDDALFQCQV 158
Cdd:cd00096     1 VTLTCSASgNPPPTITWYKNGKPLPPSSRDSRR--------SELGNGTLTISNVTLEDSGTYTCVA 58

Ig_DSCAM

cd05735

Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM); The members here ...

461-552

2.85e-03

Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM); The members here are composed of the immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM). DSCAM is a cell adhesion molecule expressed largely in the developing nervous system. The gene encoding DSCAM is located at human chromosome 21q22, the locus associated with the intellectual disability phenotype of Down Syndrome. DSCAM is predicted to be the largest member of the IG superfamily. It has been demonstrated that DSCAM can mediate cation-independent homophilic intercellular adhesion.

Pssm-ID: 409398 Cd Length: 101 Bit Score: 37.47 E-value: 2.85e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 461 PPVQYGVEGEVVKLECIISSvPPPTRILWSRNSQHVDIDNNDGYEIVTEPMADGVKNNLIIHNADEDDFGQYNCTVWNTF 540
Cdd:cd05735    10 PNTTLATKGQKKEMSCTAHG-EKPIIVRWEKEDTIINPSEMSRYLVTTKEVGDEVISTLQILPTVREDSGFFSCHAINSY 88

                          90
                  ....*....|..
gi 1866093304 541 GQDSMIILLKKQ 552
Cdd:cd05735    89 GEDRGIIQLTVQ 100

IgI_5_Robo

cd20952

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...

372-437

3.36e-03

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors

Pssm-ID: 409544 [Multi-domain] Cd Length: 87 Bit Score: 37.09 E-value: 3.36e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1866093304 372 VFRSTIENVAADIGSEVSLSCDVEGNPQPETMWTFEGSdAVLSTESR--------LVIPQLTIDRAGKYTCRAT 437
Cdd:cd20952     1 IILQGPQNQTVAVGGTVVLNCQATGEPVPTISWLKDGV-PLLGKDERittlengsLQIKGAEKSDTGEYTCVAL 73

Ig_2

pfam13895

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

456-539

4.39e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

Pssm-ID: 464026 [Multi-domain] Cd Length: 79 Bit Score: 36.60 E-value: 4.39e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1866093304 456 PRVRSPPVQYgVEGEVVKLECIISSVPPPTrILWSRNSQHVdidnNDGYeivtepmadgvknNLIIHNADEDDFGQYNCT 535
Cdd:pfam13895   2 PVLTPSPTVV-TEGEPVTLTCSAPGNPPPS-YTWYKDGSAI----SSSP-------------NFFTLSVSAEDSGTYTCV 62


                  ....
gi 1866093304 536 VWNT 539
Cdd:pfam13895  63 ARNG 66

IgI_NCAM-2

cd05870

Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 2 (NCAM-2); The members ...

377-436

5.20e-03

Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 2 (NCAM-2); The members here are composed of the fourth Ig domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM). NCAM-2 is organized similarly to NCAM, including five N-terminal Ig-like domains and two fibronectin type III domains. NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE), and may function like NCAM, as an adhesion molecule. One of the unique features of I-set domains is the lack of a C" strand. The structures of this group show that the Ig domain lacks this strand and thus is a member of the I-set of Ig domains.

Pssm-ID: 143278 [Multi-domain] Cd Length: 98 Bit Score: 36.88 E-value: 5.20e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1866093304 377 IENVAADIGSEVSLSCDVEGNPQPETMW-------TFEGSDAVLS---------TESRLVIPQLTIDRAGKYTCRA 436
Cdd:cd05870     8 LKNETTVENGAATLSCKAEGEPIPEITWkrasdghTFSEGDKSPDgrievkgqhGESSLHIKDVKLSDSGRYDCEA 83

Ig_3