|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
107-372 |
1.30e-22 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 100.78 E-value: 1.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 107 QLEKIYPEELSRLHRLETLNLQNNRLTSrgLPEkAFEHLINLNYLYLANNKLTLAPRFLPNAlisvdfaanyltkiyglt 186
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPE-ELANLTNLKELDLSNNQLTDLPEPLGNL------------------ 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 187 fgqkPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVPKHL--PPALYKLHLKNNKLEKIPPgAFSELSSL 264
Cdd:COG4886 159 ----TNLKSLDLSNNQLTD--LPEELGN-LTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 265 RELYLQNNYLTdeglDNETFWKLSSLEYLDLSSNNLSRVPAGLP-RSLVLLHLEKNAIRSVDADVLTPIRSLEYLLLHSN 343
Cdd:COG4886 231 ETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
|
250 260
....*....|....*....|....*....
gi 1864505195 344 QLRAQGIHPLAFQGLKRLHTVHLYNNALE 372
Cdd:COG4886 307 LLNLLELLILLLLLTTLLLLLLLLKGLLV 335
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
70-308 |
1.12e-20 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 96.69 E-value: 1.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 70 RDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIyPEELSRlhRLETLNLQNNRLTSrgLPEKAFEhliNLN 149
Cdd:PRK15370 173 RDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG--NIKTLYANSNQLTS--IPATLPD---TIQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 150 YLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGlTFGQKPNLRSVYLHNNKLADAGLPD-----NMFNGS-------- 216
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPE-NLPEELRYLSVYDNSIRTLPAHLPSgithlNVQSNSltalpetl 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 217 -SNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKL----EKIPPgafselsSLRELYLQNNYLTD--EGLDnetfwklSS 289
Cdd:PRK15370 324 pPGLKTLEAGENALTSLPASLPPELQVLDVSKNQItvlpETLPP-------TITTLDVSRNALTNlpENLP-------AA 389
|
250
....*....|....*....
gi 1864505195 290 LEYLDLSSNNLSRVPAGLP 308
Cdd:PRK15370 390 LQIMQASRNNLVRLPESLP 408
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
238-300 |
7.93e-13 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 63.31 E-value: 7.93e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505195 238 PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNL 300
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
247-582 |
5.59e-12 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.04 E-value: 5.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 247 NNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 326
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 327 DVLTPIRSLEYLLLHSNQLRAQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR--RVRTLMILHNQITGIGrEDFATTY 404
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 405 FLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlhtLPPGLprnvhvlkvkrnelaalargalAGMAQLRELYLTS 484
Cdd:COG4886 160 NLKSLDLSNNQLTD--------------------------LPEEL----------------------GNLTNLKELDLSN 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 485 NRLRSralGPRAWVDLAGLQLLDIAGNQLTEIPQGLPE--SLEYLYLQNNKINAVPanAFDSTPNLKGIFLRFNKLAVGs 562
Cdd:COG4886 192 NQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL- 265
|
330 340
....*....|....*....|
gi 1864505195 563 vvdSAFRRLKHLQVLDIEGN 582
Cdd:COG4886 266 ---PPLANLTNLKTLDLSNN 282
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
222-424 |
2.55e-11 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 63.65 E-value: 2.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 222 LILSSNFLRHVPK-HLPPALYKLHLKNNKLEKIPpgAFSELSSLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNN 299
Cdd:cd21340 7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 300 LSRVpAGL--PRSLVLLHLEKNAIRS-----VDADVLTPI-RSLEYLLLHSNQLRAqgIHPLAfqGLKRLhtvhlynnal 371
Cdd:cd21340 80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNIDS--LEPLA--PLRNL---------- 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1864505195 372 ervpsglprrvRTLMILHNQITGIGR--EDFATTYFLEELNLSYNRITSPQMHRD 424
Cdd:cd21340 145 -----------EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRD 188
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
229-521 |
3.14e-11 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 66.26 E-value: 3.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 229 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSelsSLRELYLQNNYLTD--EGLDNetfwklsSLEYLDLSSNNLSRVPAG 306
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSipATLPD-------TIQEMELSINRITELPER 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 307 LPRSLVLLHLEKNAIRSVdADVLTpiRSLEYLLLHSNQLRAQGIH-PLAFQGLkrlhtvHLYNNALERVPSGLPRRVRTL 385
Cdd:PRK15370 260 LPSALQSLDLFHNKISCL-PENLP--EELRYLSVYDNSIRTLPAHlPSGITHL------NVQSNSLTALPETLPPGLKTL 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 386 MILHNQITGIGRedfATTYFLEELNLSYNRITspqmhrdafrklrllrsldlsgnrlhTLPPGLPRNVHVLKVKRNelaa 465
Cdd:PRK15370 331 EAGENALTSLPA---SLPPELQVLDVSKNQIT--------------------------VLPETLPPTITTLDVSRN---- 377
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1864505195 466 largalaGMAQLRElyltsnrlrsralgprawvDL-AGLQLLDIAGNQLTEIPQGLP 521
Cdd:PRK15370 378 -------ALTNLPE-------------------NLpAALQIMQASRNNLVRLPESLP 408
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
523-582 |
4.16e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.44 E-value: 4.16e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 523 SLEYLYLQNNKINAVPANAFDSTPNLKGIFLRFNKLavGSVVDSAFRRLKHLQVLDIEGN 582
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGN 59
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
68-98 |
4.35e-04 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 38.07 E-value: 4.35e-04
10 20 30
....*....|....*....|....*....|.
gi 1864505195 68 CPRDCACSqEGVVDCGGIDLREFPGDLPEHT 98
Cdd:smart00013 2 CPAPCNCS-GTAVDCSGRGLTEVPLDLPPDT 31
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
314-556 |
1.72e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.15 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 314 LHLEKNAIRSVDAdvLTPIRSLEYLLLHSNQLRAqgIHPLAFqgLKRLHTVHLYNNALERVP--SGLPRrvrtlmilhnq 391
Cdd:cd21340 7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITK--IENLEF--LTNLTHLYLQNNQIEKIEnlENLVN----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 392 itgigredfattyfLEELNLSYNRITspqmhrdafrklrllrslDLSGnrLHTLPpglprnvhvlkvkrnelaalargal 471
Cdd:cd21340 70 --------------LKKLYLGGNRIS------------------VVEG--LENLT------------------------- 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 472 agmaQLRELYLTSNRLRSR---ALGPRAWVDLAG-LQLLDIAGNQLTEIpQGLP--ESLEYLYLQNNKINAVP--ANAFD 543
Cdd:cd21340 91 ----NLEELHIENQRLPPGeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAplRNLEQLDASNNQISDLEelLDLLS 165
|
250
....*....|...
gi 1864505195 544 STPNLKGIFLRFN 556
Cdd:cd21340 166 SWPSLRELDLTGN 178
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
107-372 |
1.30e-22 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 100.78 E-value: 1.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 107 QLEKIYPEELSRLHRLETLNLQNNRLTSrgLPEkAFEHLINLNYLYLANNKLTLAPRFLPNAlisvdfaanyltkiyglt 186
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPE-ELANLTNLKELDLSNNQLTDLPEPLGNL------------------ 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 187 fgqkPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVPKHL--PPALYKLHLKNNKLEKIPPgAFSELSSL 264
Cdd:COG4886 159 ----TNLKSLDLSNNQLTD--LPEELGN-LTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 265 RELYLQNNYLTdeglDNETFWKLSSLEYLDLSSNNLSRVPAGLP-RSLVLLHLEKNAIRSVDADVLTPIRSLEYLLLHSN 343
Cdd:COG4886 231 ETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
|
250 260
....*....|....*....|....*....
gi 1864505195 344 QLRAQGIHPLAFQGLKRLHTVHLYNNALE 372
Cdd:COG4886 307 LLNLLELLILLLLLTTLLLLLLLLKGLLV 335
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
101-375 |
4.31e-22 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 99.24 E-value: 4.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 101 LSLQNNQLEKIyPEELSRLHRLETLNLQNNRLTSrgLPEkAFEHLINLNYLYLANNKLTLAPRFLPN--ALISVDFAANY 178
Cdd:COG4886 118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTD--LPE-PLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQ 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 179 LTKIyGLTFGQKPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVP--KHLpPALYKLHLKNNKLEKIPPG 256
Cdd:COG4886 194 ITDL-PEPLGNLTNLEELDLSGNQLTD--LPEPLAN-LTNLETLDLSNNQLTDLPelGNL-TNLEELDLSNNQLTDLPPL 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 257 AfsELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDADVLTPIRSLE 336
Cdd:COG4886 269 A--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346
|
250 260 270
....*....|....*....|....*....|....*....
gi 1864505195 337 YLLLHSNQLRAQGIHPLAFQGLKRLHTVHLYNNALERVP 375
Cdd:COG4886 347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
98-372 |
9.68e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 95.00 E-value: 9.68e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 98 TNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLINLNYLYLANNKLTLAPRFLPNALISVDFAAN 177
Cdd:COG4886 20 LLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 178 YLTKIYGLTFGQKPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVPKHLP--PALYKLHLKNNKLEKIPP 255
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPEELAN-LTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 256 gAFSELSSLRELYLQNNYLTDEGldnETFWKLSSLEYLDLSSNNLSRVPAGLPR--SLVLLHLEKNAIRSVDAdvLTPIR 333
Cdd:COG4886 177 -ELGNLTNLKELDLSNNQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLT 250
|
250 260 270
....*....|....*....|....*....|....*....
gi 1864505195 334 SLEYLLLHSNQLRaqGIHPLAfqGLKRLHTVHLYNNALE 372
Cdd:COG4886 251 NLEELDLSNNQLT--DLPPLA--NLTNLKTLDLSNNQLT 285
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
70-308 |
1.12e-20 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 96.69 E-value: 1.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 70 RDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIyPEELSRlhRLETLNLQNNRLTSrgLPEKAFEhliNLN 149
Cdd:PRK15370 173 RDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG--NIKTLYANSNQLTS--IPATLPD---TIQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 150 YLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGlTFGQKPNLRSVYLHNNKLADAGLPD-----NMFNGS-------- 216
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPE-NLPEELRYLSVYDNSIRTLPAHLPSgithlNVQSNSltalpetl 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 217 -SNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKL----EKIPPgafselsSLRELYLQNNYLTD--EGLDnetfwklSS 289
Cdd:PRK15370 324 pPGLKTLEAGENALTSLPASLPPELQVLDVSKNQItvlpETLPP-------TITTLDVSRNALTNlpENLP-------AA 389
|
250
....*....|....*....
gi 1864505195 290 LEYLDLSSNNLSRVPAGLP 308
Cdd:PRK15370 390 LQIMQASRNNLVRLPESLP 408
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
106-417 |
1.97e-18 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 89.52 E-value: 1.97e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 106 NQLEKIYPEELSRLHRLETLNLQNNRLTsrGLPEKAFEHLINLNYLYLANNKLT--LAPR-FLPNALISVDFAANYLTKI 182
Cdd:PLN00113 222 NNLSGEIPYEIGGLTSLNHLDLVYNNLT--GPIPSSLGNLKNLQYLFLYQNKLSgpIPPSiFSLQKLISLDLSDNSLSGE 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 183 YGLTFGQKPNLRSVYLHNNKL------ADAGLP--------DNMFNGS--------SNVEVLILSSNFLR-HVPKHLPPA 239
Cdd:PLN00113 300 IPELVIQLQNLEILHLFSNNFtgkipvALTSLPrlqvlqlwSNKFSGEipknlgkhNNLTVLDLSTNNLTgEIPEGLCSS 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 240 --LYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEgLDNEtFWKLSSLEYLDLSSNNLS-RVPAG---LPrSLVL 313
Cdd:PLN00113 380 gnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGE-LPSE-FTKLPLVYFLDISNNNLQgRINSRkwdMP-SLQM 456
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 314 LHLEKNAIRSVDADVLTPIRsLEYLLLHSNQLraQGIHPLAFQGLKRLHTVHLYNNALE-RVPSGLP--RRVRTLMILHN 390
Cdd:PLN00113 457 LSLARNKFFGGLPDSFGSKR-LENLDLSRNQF--SGAVPRKLGSLSELMQLKLSENKLSgEIPDELSscKKLVSLDLSHN 533
|
330 340
....*....|....*....|....*..
gi 1864505195 391 QITGIGREDFATTYFLEELNLSYNRIT 417
Cdd:PLN00113 534 QLSGQIPASFSEMPVLSQLDLSQNQLS 560
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
118-582 |
1.37e-17 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 86.83 E-value: 1.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 118 RLHRLETLNLQNNRLtSRGLPEKAFEHLINLNYLYLANNKLTLA-PR-FLPNaLISVDFAANYLT-KIYgLTFGQKPNLR 194
Cdd:PLN00113 91 RLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTGSiPRgSIPN-LETLDLSNNMLSgEIP-NDIGSFSSLK 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 195 SVYLHNNKLAdAGLPDNMFNGSSnVEVLILSSN-FLRHVPKHLPP--ALYKLHLKNNKLEKIPPGAFSELSSLRELYLQN 271
Cdd:PLN00113 168 VLDLGGNVLV-GKIPNSLTNLTS-LEFLTLASNqLVGQIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVY 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 272 NYLTdeGLDNETFWKLSSLEYLDLSSNNLS-RVPAGL--PRSLVLLHLEKNAIRSVDADVLTPIRSLEYLLLHSNQLraQ 348
Cdd:PLN00113 246 NNLT--GPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIfsLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF--T 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 349 GIHPLAFQGLKRLHTVHLYNNALE-RVPSGLPRR--VRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSpqmhrda 425
Cdd:PLN00113 322 GKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHnnLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEG------- 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 426 frklrllrsldlsgnrlhTLPPGLP--RNVHVLKVKRNELAALARGALAGMAQLRELYLTSNRLRSRaLGPRAWvDLAGL 503
Cdd:PLN00113 395 ------------------EIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGR-INSRKW-DMPSL 454
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 504 QLLDIAGNQLTeipQGLPES-----LEYLYLQNNKINAVPANAFDSTPNLKGIFLRFNKLAvgSVVDSAFRRLKHLQVLD 578
Cdd:PLN00113 455 QMLSLARNKFF---GGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS--GEIPDELSSCKKLVSLD 529
|
....
gi 1864505195 579 IEGN 582
Cdd:PLN00113 530 LSHN 533
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
101-560 |
1.42e-16 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 83.74 E-value: 1.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 101 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSrGLPEKaFEHLINLNYLYLANNKLTLAPRFLPNALIS---VDFAAN 177
Cdd:PLN00113 169 LDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVG-QIPRE-LGQMKSLKWIYLGYNNLSGEIPYEIGGLTSlnhLDLVYN 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 178 YLTKIYGLTFGQKPNLRSVYLHNNKLADAgLPDNMFnGSSNVEVLILSSNFLR-HVPKHLP--PALYKLHLKNNKLEKIP 254
Cdd:PLN00113 247 NLTGPIPSSLGNLKNLQYLFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSgEIPELVIqlQNLEILHLFSNNFTGKI 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 255 PGAFSELSSLRELYLQNNYLTDEGLDNetFWKLSSLEYLDLSSNNLS-RVPAGLPRS--LVLLHLEKNAIRSVDADVLTP 331
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNKFSGEIPKN--LGKHNNLTVLDLSTNNLTgEIPEGLCSSgnLFKLILFSNSLEGEIPKSLGA 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 332 IRSLEYLLLHSNQLraQGIHPLAFQGLKRLHTVHLYNNALE-RVPSG---LPrRVRTLMILHNQITGiGREDFATTYFLE 407
Cdd:PLN00113 403 CRSLRRVRLQDNSF--SGELPSEFTKLPLVYFLDISNNNLQgRINSRkwdMP-SLQMLSLARNKFFG-GLPDSFGSKRLE 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 408 ELNLSYNRITSpqmhrdafrklrllrsldLSGNRLHTLPpglprNVHVLKVKRNELAALARGALAGMAQLRELYLTSNRL 487
Cdd:PLN00113 479 NLDLSRNQFSG------------------AVPRKLGSLS-----ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864505195 488 RSRAlgPRAWVDLAGLQLLDIAGNQLT-EIPQGLP--ESLEYLYLQNNKINAvpanafdSTPNlKGIFLRFNKLAV 560
Cdd:PLN00113 536 SGQI--PASFSEMPVLSQLDLSQNQLSgEIPKNLGnvESLVQVNISHNHLHG-------SLPS-TGAFLAINASAV 601
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
200-418 |
3.97e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 74.58 E-value: 3.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 200 NNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNyltdegl 279
Cdd:COG4886 34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 280 dnETFWKLSSLEYLDLSSNNLSRVPAGLPR--SLVLLHLEKNAIRSVDADvLTPIRSLEYLLLHSNQLraQGIhPLAFQG 357
Cdd:COG4886 107 --EELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL--TDL-PEELGN 180
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505195 358 LKRLHTVHLYNNALERVPSGL--PRRVRTLMILHNQITGIGrEDFATTYFLEELNLSYNRITS 418
Cdd:COG4886 181 LTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTD 242
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
147-416 |
1.31e-13 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 73.96 E-value: 1.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 147 NLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKiygLTFGQKPNLRSVYLHNNKLAD--AGLPDNmfngssnVEVLIL 224
Cdd:PRK15370 179 NKTELRLKILGLTTIPACIPEQITTLILDNNELKS---LPENLQGNIKTLYANSNQLTSipATLPDT-------IQEMEL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 225 SSNFLRHVPKHLPPALYKLHLKNNKLEKIPpgafselsslrelylqnNYLTDEgldnetfwklssLEYLDLSSNNLSRVP 304
Cdd:PRK15370 249 SINRITELPERLPSALQSLDLFHNKISCLP-----------------ENLPEE------------LRYLSVYDNSIRTLP 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 305 AGLPRSLVLLHLEKNAIRSVDAdVLTPirSLEYLLLHSNQLRA--QGIHPlafqglkRLHTVHLYNNALERVPSGLPRRV 382
Cdd:PRK15370 300 AHLPSGITHLNVQSNSLTALPE-TLPP--GLKTLEAGENALTSlpASLPP-------ELQVLDVSKNQITVLPETLPPTI 369
|
250 260 270
....*....|....*....|....*....|....
gi 1864505195 383 RTLMILHNQITGIGREDFATTYFLEElnlSYNRI 416
Cdd:PRK15370 370 TTLDVSRNALTNLPENLPAALQIMQA---SRNNL 400
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
238-300 |
7.93e-13 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 63.31 E-value: 7.93e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505195 238 PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNL 300
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
247-582 |
5.59e-12 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.04 E-value: 5.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 247 NNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 326
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 327 DVLTPIRSLEYLLLHSNQLRAQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR--RVRTLMILHNQITGIGrEDFATTY 404
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 405 FLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlhtLPPGLprnvhvlkvkrnelaalargalAGMAQLRELYLTS 484
Cdd:COG4886 160 NLKSLDLSNNQLTD--------------------------LPEEL----------------------GNLTNLKELDLSN 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 485 NRLRSralGPRAWVDLAGLQLLDIAGNQLTEIPQGLPE--SLEYLYLQNNKINAVPanAFDSTPNLKGIFLRFNKLAVGs 562
Cdd:COG4886 192 NQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL- 265
|
330 340
....*....|....*....|
gi 1864505195 563 vvdSAFRRLKHLQVLDIEGN 582
Cdd:COG4886 266 ---PPLANLTNLKTLDLSNN 282
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
222-424 |
2.55e-11 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 63.65 E-value: 2.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 222 LILSSNFLRHVPK-HLPPALYKLHLKNNKLEKIPpgAFSELSSLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNN 299
Cdd:cd21340 7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 300 LSRVpAGL--PRSLVLLHLEKNAIRS-----VDADVLTPI-RSLEYLLLHSNQLRAqgIHPLAfqGLKRLhtvhlynnal 371
Cdd:cd21340 80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNIDS--LEPLA--PLRNL---------- 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1864505195 372 ervpsglprrvRTLMILHNQITGIGR--EDFATTYFLEELNLSYNRITSPQMHRD 424
Cdd:cd21340 145 -----------EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRD 188
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
229-521 |
3.14e-11 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 66.26 E-value: 3.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 229 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSelsSLRELYLQNNYLTD--EGLDNetfwklsSLEYLDLSSNNLSRVPAG 306
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSipATLPD-------TIQEMELSINRITELPER 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 307 LPRSLVLLHLEKNAIRSVdADVLTpiRSLEYLLLHSNQLRAQGIH-PLAFQGLkrlhtvHLYNNALERVPSGLPRRVRTL 385
Cdd:PRK15370 260 LPSALQSLDLFHNKISCL-PENLP--EELRYLSVYDNSIRTLPAHlPSGITHL------NVQSNSLTALPETLPPGLKTL 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 386 MILHNQITGIGRedfATTYFLEELNLSYNRITspqmhrdafrklrllrsldlsgnrlhTLPPGLPRNVHVLKVKRNelaa 465
Cdd:PRK15370 331 EAGENALTSLPA---SLPPELQVLDVSKNQIT--------------------------VLPETLPPTITTLDVSRN---- 377
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1864505195 466 largalaGMAQLRElyltsnrlrsralgprawvDL-AGLQLLDIAGNQLTEIPQGLP 521
Cdd:PRK15370 378 -------ALTNLPE-------------------NLpAALQIMQASRNNLVRLPESLP 408
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
55-385 |
1.04e-10 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 64.80 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 55 SPEEPVPG-PAVVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKI--YPEElsrlhrLETLNLQNNR 131
Cdd:PRK15387 180 APAEESRGrAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLpaLPPE------LRTLEVSGNQ 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 132 LTSRG-LPEKAFEhlinlnyLYLANNKLTLAPRfLPNALISVDFAANYLTKIYGLtfgqKPNLRSVYLHNNKLAD-AGLP 209
Cdd:PRK15387 254 LTSLPvLPPGLLE-------LSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSLPVL----PPGLQELSVSDNQLASlPALP 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 210 DNM-----FNGS--------SNVEVLILSSNFLRHVPKhLPPALYKLHLKNNKLEKIPpgafSELSSLRELYLQNNYLTD 276
Cdd:PRK15387 322 SELcklwaYNNQltslptlpSGLQELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLTS 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 277 EGLdnetfwKLSSLEYLDLSSNNLSRVPAgLPRSLVLLHLEKNAIRSVdADVLTPIRSLEYLLLHSNQLRAQgihplAFQ 356
Cdd:PRK15387 397 LPV------LPSELKELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPLSER-----TLQ 463
|
330 340 350
....*....|....*....|....*....|..
gi 1864505195 357 GLKRLHTVHLYNNAL---ERVPSGLPRRVRTL 385
Cdd:PRK15387 464 ALREITSAPGYSGPIirfDMAGASAPRETRAL 495
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
300-540 |
2.04e-10 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 63.95 E-value: 2.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 300 LSRVPAGLPRSLVLLHLEKNAIRSVDADvltpirsleyllLHSNqlraqgihplafqglkrLHTVHLYNNALERVPSGLP 379
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPEN------------LQGN-----------------IKTLYANSNQLTSIPATLP 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 380 RRVRTLMILHNQITGIgREDFATTyfLEELNLSYNRITS-PQMHRDAFRKLRLLRsldlsgNRLHTLPPGLPRNVHVLKV 458
Cdd:PRK15370 241 DTIQEMELSINRITEL-PERLPSA--LQSLDLFHNKISClPENLPEELRYLSVYD------NSIRTLPAHLPSGITHLNV 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 459 KRNELAALARGALAgmaQLRELYLTSNRLRS--RALGPRawvdlagLQLLDIAGNQLTEIPQGLPESLEYLYLQNNKINA 536
Cdd:PRK15370 312 QSNSLTALPETLPP---GLKTLEAGENALTSlpASLPPE-------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTN 381
|
....
gi 1864505195 537 VPAN 540
Cdd:PRK15370 382 LPEN 385
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
100-303 |
2.05e-09 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 57.87 E-value: 2.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 100 HLSLQNNQLEKIypEELSRLHRLETLNLQNNRLTS-RGLpekafEHLINLNYLYLANNKLTlaprflpnalisvdfaany 178
Cdd:cd21340 6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKiENL-----EFLTNLTHLYLQNNQIE------------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 179 ltKIYGLtfGQKPNLRSVYLHNNKLadaglpdnmfngsSNVEVLilssnflrhvpkHLPPALYKLHLKNNKLekiPPG-- 256
Cdd:cd21340 60 --KIENL--ENLVNLKKLYLGGNRI-------------SVVEGL------------ENLTNLEELHIENQRL---PPGek 107
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1864505195 257 -AFSELS------SLRELYLQNNYLTDegLDNetFWKLSSLEYLDLSSNNLSRV 303
Cdd:cd21340 108 lTFDPRSlaalsnSLRVLNISGNNIDS--LEP--LAPLRNLEQLDASNNQISDL 157
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
234-417 |
4.66e-09 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 58.14 E-value: 4.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 234 KHLPPALYKLHLKNNKLEKIPPG------AFSELSSLRELYLQNNYLTDEGLDN-ETFWKLSSLEYLDLSSNNLS----- 301
Cdd:cd00116 47 LRPQPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVlESLLRSSSLQELKLNNNGLGdrglr 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 302 ---RVPAGLPRSLVLLHLEKNAIRSVD----ADVLTPIRSLEYLLLHSNQLRAQGIHPLAfQGLK---RLHTVHLYNNAL 371
Cdd:cd00116 127 llaKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRALA-EGLKancNLEVLDLNNNGL 205
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864505195 372 ERVPSGL-------PRRVRTLMILHNQITGIGREDFATTYF-----LEELNLSYNRIT 417
Cdd:cd00116 206 TDEGASAlaetlasLKSLEVLNLGDNNLTDAGAAALASALLspnisLLTLSLSCNDIT 263
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
101-349 |
6.50e-09 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 57.75 E-value: 6.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 101 LSLQNNQLEKIYPEELSRLHR-LETLNLQNNRLTSRGLP--EKAFEHLINLNYLYLANNKLTLAPRFLpnalisvDFAAN 177
Cdd:cd00116 3 LSLKGELLKTERATELLPKLLcLQVLRLEGNTLGEEAAKalASALRPQPSLKELCLSLNETGRIPRGL-------QSLLQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 178 YLTKIYGLT-------------------FGQKPNLRSVYLHNNKLADAGLP---DNMFNGSSNVEVLILSSNFLRHVP-- 233
Cdd:cd00116 76 GLTKGCGLQeldlsdnalgpdgcgvlesLLRSSSLQELKLNNNGLGDRGLRllaKGLKDLPPALEKLVLGRNRLEGASce 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 234 ---KHLP--PALYKLHLKNNKLEkiPPG------AFSELSSLRELYLQNNYLTDEG--LDNETFWKLSSLEYLDLSSNNL 300
Cdd:cd00116 156 alaKALRanRDLKELNLANNGIG--DAGiralaeGLKANCNLEVLDLNNNGLTDEGasALAETLASLKSLEVLNLGDNNL 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864505195 301 SRVPA--------GLPRSLVLLHLEKNAIRSVDA-DVLTPIR---SLEYLLLHSNQLRAQG 349
Cdd:cd00116 234 TDAGAaalasallSPNISLLTLSLSCNDITDDGAkDLAEVLAekeSLLELDLRGNKFGEEG 294
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
293-538 |
3.13e-08 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 56.71 E-value: 3.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 293 LDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDAdvLTP-IRSLEyllLHSNQLRAQGIHPlafQGLKRLHtvhLYNNAL 371
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPA--LPPeLRTLE---VSGNQLTSLPVLP---PGLLELS---IFSNPL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 372 ERVPSgLPRRVRTLMILHNQITGIGredfATTYFLEELNLSYNRITS-PQMHRDAFRklrllrsLDLSGNRLHTLPPgLP 450
Cdd:PRK15387 275 THLPA-LPSGLCKLWIFGNQLTSLP----VLPPGLQELSVSDNQLASlPALPSELCK-------LWAYNNQLTSLPT-LP 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 451 RNVHVLKVKRNELAALARGAlagmAQLRELYLTSNRLRSRALGPrawvdlAGLQLLDIAGNQLTEIPQgLPESLEYLYLQ 530
Cdd:PRK15387 342 SGLQELSVSDNQLASLPTLP----SELYKLWAYNNRLTSLPALP------SGLKELIVSGNRLTSLPV-LPSELKELMVS 410
|
....*...
gi 1864505195 531 NNKINAVP 538
Cdd:PRK15387 411 GNRLTSLP 418
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
191-274 |
2.01e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.90 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 191 PNLRSVYLHNNKLADagLPDNMFNGSSNVEVLILSsnflrhvpkhlppalyklhlkNNKLEKIPPGAFSELSSLRELYLQ 270
Cdd:pfam13855 1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLS---------------------NNLLTTLSPGAFSGLPSLRYLDLS 57
|
....
gi 1864505195 271 NNYL 274
Cdd:pfam13855 58 GNRL 61
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
75-417 |
5.97e-07 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 52.10 E-value: 5.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 75 SQEGVVDCGGIDLREFPGDLPEHTNHLS---LQNNQLEKIYPEELSRL--HRLETLNLQNNRLTSRGLPekafehlinln 149
Cdd:COG5238 64 RFEGQGDPGLNPVALEKAAEAFPTQLLVvdwEGAEEVSPVALAETATAvaTPPPDLRRIMAKTLEDSLI----------- 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 150 yLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLT-------FGQKPNLRSVYLHNNKLADAGLPD--NMFNGSSNVE 220
Cdd:COG5238 133 -LYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLaaismakALQNNSVETVYLGCNQIGDEGIEElaEALTQNTTVT 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 221 VLILSSNflrHVPKHLPPALYKlHLKNNKlekippgafselsSLRELYLQNNYLTDEGLDN--ETFWKLSSLEYLDLSSN 298
Cdd:COG5238 212 TLWLKRN---PIGDEGAEILAE-ALKGNK-------------SLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGN 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 299 NLS-----RVPAGLPRSLVL--LHLEKNAIRSVDADVLTP----IRSLEYLLLHSNQLRAQGIHPL--AFQGLKRLHTVH 365
Cdd:COG5238 275 QIGaegaiALAKALQGNTTLtsLDLSVNRIGDEGAIALAEglqgNKTLHTLNLAYNGIGAQGAIALakALQENTTLHSLD 354
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1864505195 366 LYNN------------ALERVPSglprrVRTLMILHNQITGIGREDFA---TTYFLEELNLSYNRIT 417
Cdd:COG5238 355 LSDNqigdegaialakYLEGNTT-----LRELNLGKNNIGKQGAEALIdalQTNRLHTLILDGNLIG 416
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
290-556 |
7.32e-07 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 52.47 E-value: 7.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 290 LEYLDLSSNNLSRVPAgLPRSLVLLHLEKNAIRSVDAdvlTPiRSLEYLLLHSNQLRAQGIHPLAFQGLKrlhtvhLYNN 369
Cdd:PRK15387 244 LRTLEVSGNQLTSLPV-LPPGLLELSIFSNPLTHLPA---LP-SGLCKLWIFGNQLTSLPVLPPGLQELS------VSDN 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 370 ALERVPSgLPRRVRTLMILHNQITGIGredfATTYFLEELNLSYNRITS-PQMHRDAFRklrllrsLDLSGNRLHTLPpG 448
Cdd:PRK15387 313 QLASLPA-LPSELCKLWAYNNQLTSLP----TLPSGLQELSVSDNQLASlPTLPSELYK-------LWAYNNRLTSLP-A 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 449 LPRNVHVLKVKRNELAALARGAlagmAQLRELYLTSNRLRSRALGPrawvdlAGLQLLDIAGNQLTEIPQGLPE--SLEY 526
Cdd:PRK15387 380 LPSGLKELIVSGNRLTSLPVLP----SELKELMVSGNRLTSLPMLP------SGLLSLSVYRNQLTRLPESLIHlsSETT 449
|
250 260 270
....*....|....*....|....*....|...
gi 1864505195 527 LYLQNNKINAVPANAF---DSTPNLKGIFLRFN 556
Cdd:PRK15387 450 VNLEGNPLSERTLQALreiTSAPGYSGPIIRFD 482
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
262-345 |
7.47e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 46.36 E-value: 7.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 262 SSLRELYLQNNYLTDegLDNETFWKLSSLEYLDLSSNNLSrvpaglprslvllhleknairSVDADVLTPIRSLEYLLLH 341
Cdd:pfam13855 1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLT---------------------TLSPGAFSGLPSLRYLDLS 57
|
....
gi 1864505195 342 SNQL 345
Cdd:pfam13855 58 GNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
101-158 |
9.93e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.98 E-value: 9.93e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864505195 101 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSrgLPEKAFEHLINLNYLYLANNKL 158
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
359-582 |
1.12e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 51.62 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 359 KRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIgREDFATTyfLEELNLSYNRITSpqmhrdafrklrllrsldls 438
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPDT--IQEMELSINRITE-------------------- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 439 gnrlhtLPPGLPrnvhvlkvkrnelaalargalagmAQLRELYLTSNRLRSRalgPRAWVDlaGLQLLDIAGNQLTEIPQ 518
Cdd:PRK15370 256 ------LPERLP------------------------SALQSLDLFHNKISCL---PENLPE--ELRYLSVYDNSIRTLPA 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1864505195 519 GLPESLEYLYLQNNKINAVPANAfdsTPNLKgiFLRFNKLAVGSVVDSAfrrLKHLQVLDIEGN 582
Cdd:PRK15370 301 HLPSGITHLNVQSNSLTALPETL---PPGLK--TLEAGENALTSLPASL---PPELQVLDVSKN 356
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
243-440 |
1.16e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 49.78 E-value: 1.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 243 LHLKNNKLEKIppGAFSELSSLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNNLSRVP--AGLPRsLVLLHLEKN 319
Cdd:cd21340 7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKiENLEF-----LTNLTHLYLQNNQIEKIEnlENLVN-LKKLYLGGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 320 AIRSVDAdvLTPIRSLEYLLLhSNQLRAQGiHPLAFQglkrlhtvhlynnalERVPSGLPRRVRTLMILHNQITGIgrED 399
Cdd:cd21340 79 RISVVEG--LENLTNLEELHI-ENQRLPPG-EKLTFD---------------PRSLAALSNSLRVLNISGNNIDSL--EP 137
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1864505195 400 FATTYFLEELNLSYNRITSPQMHRDAFRKLRLLRSLDLSGN 440
Cdd:cd21340 138 LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
414-540 |
2.15e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 50.85 E-value: 2.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 414 NRITSPQMHRDAFRKLRLLRSLDLSGnrLHTLPPGLPRNVHVLKVKRNELAALARGALagmAQLRELYLTSNRLRS---- 489
Cdd:PRK15370 164 NREEAVQRMRDCLKNNKTELRLKILG--LTTIPACIPEQITTLILDNNELKSLPENLQ---GNIKTLYANSNQLTSipat 238
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505195 490 -------RALGPRAWVDL-----AGLQLLDIAGNQLTEIPQGLPESLEYLYLQNNKINAVPAN 540
Cdd:PRK15370 239 lpdtiqeMELSINRITELperlpSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAH 301
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
523-582 |
4.16e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.44 E-value: 4.16e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 523 SLEYLYLQNNKINAVPANAFDSTPNLKGIFLRFNKLavGSVVDSAFRRLKHLQVLDIEGN 582
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGN 59
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
476-534 |
4.59e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.44 E-value: 4.59e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505195 476 QLRELYLTSNRLRSraLGPRAWVDLAGLQLLDIAGNQLTEIP----QGLPeSLEYLYLQNNKI 534
Cdd:pfam13855 2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSpgafSGLP-SLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
100-254 |
7.59e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 47.47 E-value: 7.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 100 HLSLQNNQLEKIypEELSRLHRLETLNLQNNRLTS-RGLpekafEHLINLNYLYLANNKLTLAPRFL--PNALISVdfaa 176
Cdd:cd21340 50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVvEGL-----ENLTNLEELHIENQRLPPGEKLTfdPRSLAAL---- 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 177 nyltkiygltfgqKPNLRSVYLHNNKLADaglpDNMFNGSSNVEVLILSSNFLRHVPKHLP-----PALYKLHLKNNKLE 251
Cdd:cd21340 119 -------------SNSLRVLNISGNNIDS----LEPLAPLRNLEQLDASNNQISDLEELLDllsswPSLRELDLTGNPVC 181
|
...
gi 1864505195 252 KIP 254
Cdd:cd21340 182 KKP 184
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
208-462 |
9.36e-06 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 48.62 E-value: 9.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 208 LPDNMfngSSNVEVLILSSNFLRHVPKhLPPALYKLHLKNNKLEKIP---PGafselssLRELYLQNNYLTD-EGLDnet 283
Cdd:PRK15387 216 LPDCL---PAHITTLVIPDNNLTSLPA-LPPELRTLEVSGNQLTSLPvlpPG-------LLELSIFSNPLTHlPALP--- 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 284 fwklSSLEYLDLSSNNLSRVPAgLPRSLVLLHLEKNAIRSVDAdvlTPiRSLEYLLLHSNQLRAQGIHPLAFQGLKrlht 363
Cdd:PRK15387 282 ----SGLCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLASLPA---LP-SELCKLWAYNNQLTSLPTLPSGLQELS---- 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 364 vhLYNNALERVPSgLPRRVRTLMILHNQITGIGredfATTYFLEELNLSYNRITSPQMHRDAFRKLRLLrsldlsGNRLH 443
Cdd:PRK15387 349 --VSDNQLASLPT-LPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLTSLPVLPSELKELMVS------GNRLT 415
|
250
....*....|....*....
gi 1864505195 444 TLPPgLPRNVHVLKVKRNE 462
Cdd:PRK15387 416 SLPM-LPSGLLSLSVYRNQ 433
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
121-203 |
1.66e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.51 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 121 RLETLNLQNNRLTSrgLPEKAFEHLINLNYLYLANNKLTlapRFLPNALisvdfaanyltkiYGLtfgqkPNLRSVYLHN 200
Cdd:pfam13855 2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLT---TLSPGAF-------------SGL-----PSLRYLDLSG 58
|
...
gi 1864505195 201 NKL 203
Cdd:pfam13855 59 NRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
502-558 |
3.68e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.74 E-value: 3.68e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 502 GLQLLDIAGNQLTEIPQGL---PESLEYLYLQNNKINAVPANAFDSTPNLKGIFLRFNKL 558
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
363-571 |
3.69e-05 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 46.69 E-value: 3.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 363 TVHLYNNALERVPSgLPRRVRTLMILHNQITGIGredfattyFLEELNLSYNRITSPQMHRDAFrkLRLLRSLDLSGNRL 442
Cdd:PRK15387 226 TLVIPDNNLTSLPA-LPPELRTLEVSGNQLTSLP--------VLPPGLLELSIFSNPLTHLPAL--PSGLCKLWIFGNQL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 443 HTLPPgLPRNVHVLKVKRNELAALARGAlagmAQLRELYLTSNRLRSRALGPrawvdlAGLQLLDIAGNQLTEIPQgLPE 522
Cdd:PRK15387 295 TSLPV-LPPGLQELSVSDNQLASLPALP----SELCKLWAYNNQLTSLPTLP------SGLQELSVSDNQLASLPT-LPS 362
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1864505195 523 SLEYLYLQNNKINAVPAnafdSTPNLKGIFLRFNKLAVGSVVDSAFRRL 571
Cdd:PRK15387 363 ELYKLWAYNNRLTSLPA----LPSGLKELIVSGNRLTSLPVLPSELKEL 407
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
75-298 |
2.65e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 43.50 E-value: 2.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 75 SQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLE----KIYPEELSRLHRLETLNLQNNRLTSRGLPE--KAFEHLINL 148
Cdd:cd00116 116 NNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEgascEALAKALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNL 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 149 NYLYLANNKLTLAPrflpnaliSVDFAAnyltkiyglTFGQKPNLRSVYLHNNKLADAGLPDnmfngssnvevlILSSNf 228
Cdd:cd00116 196 EVLDLNNNGLTDEG--------ASALAE---------TLASLKSLEVLNLGDNNLTDAGAAA------------LASAL- 245
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1864505195 229 lrhvpKHLPPALYKLHLKNNKLEKIPPGAFSEL----SSLRELYLQNNYLTDEG---LDNETFWKLSSLEYLDLSSN 298
Cdd:cd00116 246 -----LSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGEEGaqlLAESLLEPGNELESLWVKDD 317
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
68-98 |
4.35e-04 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 38.07 E-value: 4.35e-04
10 20 30
....*....|....*....|....*....|.
gi 1864505195 68 CPRDCACSqEGVVDCGGIDLREFPGDLPEHT 98
Cdd:smart00013 2 CPAPCNCS-GTAVDCSGRGLTEVPLDLPPDT 31
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
314-556 |
1.72e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.15 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 314 LHLEKNAIRSVDAdvLTPIRSLEYLLLHSNQLRAqgIHPLAFqgLKRLHTVHLYNNALERVP--SGLPRrvrtlmilhnq 391
Cdd:cd21340 7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITK--IENLEF--LTNLTHLYLQNNQIEKIEnlENLVN----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 392 itgigredfattyfLEELNLSYNRITspqmhrdafrklrllrslDLSGnrLHTLPpglprnvhvlkvkrnelaalargal 471
Cdd:cd21340 70 --------------LKKLYLGGNRIS------------------VVEG--LENLT------------------------- 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505195 472 agmaQLRELYLTSNRLRSR---ALGPRAWVDLAG-LQLLDIAGNQLTEIpQGLP--ESLEYLYLQNNKINAVP--ANAFD 543
Cdd:cd21340 91 ----NLEELHIENQRLPPGeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAplRNLEQLDASNNQISDLEelLDLLS 165
|
250
....*....|...
gi 1864505195 544 STPNLKGIFLRFN 556
Cdd:cd21340 166 SWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
309-371 |
1.95e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 36.73 E-value: 1.95e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505195 309 RSLVLLHLEKNAIRSVDADVLTPIRSLEYLLLHSNQLraQGIHPLAFQGLKRLHTVHLYNNAL 371
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
96-132 |
3.14e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 36.35 E-value: 3.14e-03
10 20 30
....*....|....*....|....*....|....*..
gi 1864505195 96 EHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRL 132
Cdd:pfam13855 25 SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
240-307 |
3.63e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 40.18 E-value: 3.63e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864505195 240 LYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNLS-RVPAGL 307
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN--GSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
263-300 |
4.77e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.30 E-value: 4.77e-03
10 20 30
....*....|....*....|....*....|....*...
gi 1864505195 263 SLRELYLQNNYLTDEGLdnetFWKLSSLEYLDLSSNNL 300
Cdd:pfam12799 2 NLEVLDLSNNQITDIPP----LAKLPNLETLDLSGNNK 35
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
474-513 |
9.93e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 34.81 E-value: 9.93e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1864505195 474 MAQLRELYLTSNRLRSraLGPRAWVDLAGLQLLDIAGNQL 513
Cdd:pfam13855 24 LSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| |
