|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
130-395 |
8.72e-24 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 104.25 E-value: 8.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 130 QLEKIYPEELSRLHRLETLNLQNNRLTSrgLPEkAFEHLINLNYLYLANNKLTLAPRFLPNAlisvdfaanyltkiyglt 209
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPE-ELANLTNLKELDLSNNQLTDLPEPLGNL------------------ 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 210 fgqkPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVPKHL--PPALYKLHLKNNKLEKIPPgAFSELSSL 287
Cdd:COG4886 159 ----TNLKSLDLSNNQLTD--LPEELGN-LTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 288 RELYLQNNYLTdeglDNETFWKLSSLEYLDLSSNNLSRVPAGLP-RSLVLLHLEKNAIRSVDADVLTPIRSLEYLLLHSN 366
Cdd:COG4886 231 ETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
|
250 260
....*....|....*....|....*....
gi 1864505193 367 QLRAQGIHPLAFQGLKRLHTVHLYNNALE 395
Cdd:COG4886 307 LLNLLELLILLLLLTTLLLLLLLLKGLLV 335
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
93-331 |
1.23e-20 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 96.69 E-value: 1.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 93 RDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIyPEELSRlhRLETLNLQNNRLTSrgLPEKAFEhliNLN 172
Cdd:PRK15370 173 RDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG--NIKTLYANSNQLTS--IPATLPD---TIQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 173 YLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGlTFGQKPNLRSVYLHNNKLADAGLPD-----NMFNGS-------- 239
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPE-NLPEELRYLSVYDNSIRTLPAHLPSgithlNVQSNSltalpetl 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 240 -SNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKL----EKIPPgafselsSLRELYLQNNYLTD--EGLDnetfwklSS 312
Cdd:PRK15370 324 pPGLKTLEAGENALTSLPASLPPELQVLDVSKNQItvlpETLPP-------TITTLDVSRNALTNlpENLP-------AA 389
|
250
....*....|....*....
gi 1864505193 313 LEYLDLSSNNLSRVPAGLP 331
Cdd:PRK15370 390 LQIMQASRNNLVRLPESLP 408
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
261-323 |
3.59e-13 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 64.47 E-value: 3.59e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505193 261 PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNL 323
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
270-605 |
6.69e-13 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 71.12 E-value: 6.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 270 NNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 349
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 350 DVLTPIRSLEYLLLHSNQLRAQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR--RVRTLMILHNQITGIGrEDFATTY 427
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 428 FLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlhtLPPGLprnvhvlkvkrnelaalargalAGMAQLRELYLTS 507
Cdd:COG4886 160 NLKSLDLSNNQLTD--------------------------LPEEL----------------------GNLTNLKELDLSN 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 508 NRLRSralGPRAWVDLAGLQLLDIAGNQLTEIPQGLPE--SLEYLYLQNNKINAVPanAFDSTPNLKGIFLRFNKLAVGs 585
Cdd:COG4886 192 NQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL- 265
|
330 340
....*....|....*....|
gi 1864505193 586 vvdSAFRRLKHLQVLDIEGN 605
Cdd:COG4886 266 ---PPLANLTNLKTLDLSNN 282
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
245-447 |
8.38e-12 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 65.19 E-value: 8.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 245 LILSSNFLRHVPK-HLPPALYKLHLKNNKLEKIPpgAFSELSSLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNN 322
Cdd:cd21340 7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 323 LSRVpAGL--PRSLVLLHLEKNAIRS-----VDADVLTPI-RSLEYLLLHSNQLRAqgIHPLAfqGLKRLhtvhlynnal 394
Cdd:cd21340 80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNIDS--LEPLA--PLRNL---------- 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1864505193 395 ervpsglprrvRTLMILHNQITGIGR--EDFATTYFLEELNLSYNRITSPQMHRD 447
Cdd:cd21340 145 -----------EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRD 188
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
252-544 |
3.38e-11 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 66.26 E-value: 3.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 252 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSelsSLRELYLQNNYLTD--EGLDNetfwklsSLEYLDLSSNNLSRVPAG 329
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSipATLPD-------TIQEMELSINRITELPER 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 330 LPRSLVLLHLEKNAIRSVdADVLTpiRSLEYLLLHSNQLRAQGIH-PLAFQGLkrlhtvHLYNNALERVPSGLPRRVRTL 408
Cdd:PRK15370 260 LPSALQSLDLFHNKISCL-PENLP--EELRYLSVYDNSIRTLPAHlPSGITHL------NVQSNSLTALPETLPPGLKTL 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 409 MILHNQITGIGRedfATTYFLEELNLSYNRITspqmhrdafrklrllrsldlsgnrlhTLPPGLPRNVHVLKVKRNelaa 488
Cdd:PRK15370 331 EAGENALTSLPA---SLPPELQVLDVSKNQIT--------------------------VLPETLPPTITTLDVSRN---- 377
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1864505193 489 largalaGMAQLRElyltsnrlrsralgprawvDL-AGLQLLDIAGNQLTEIPQGLP 544
Cdd:PRK15370 378 -------ALTNLPE-------------------NLpAALQIMQASRNNLVRLPESLP 408
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
499-557 |
2.33e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.21 E-value: 2.33e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505193 499 QLRELYLTSNRLRSraLGPRAWVDLAGLQLLDIAGNQLTEIP----QGLPeSLEYLYLQNNKI 557
Cdd:pfam13855 2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSpgafSGLP-SLRYLDLSGNRL 61
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
91-121 |
4.51e-04 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 38.07 E-value: 4.51e-04
10 20 30
....*....|....*....|....*....|.
gi 1864505193 91 CPRDCACSqEGVVDCGGIDLREFPGDLPEHT 121
Cdd:smart00013 2 CPAPCNCS-GTAVDCSGRGLTEVPLDLPPDT 31
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
337-579 |
5.91e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 41.70 E-value: 5.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 337 LHLEKNAIRSVDAdvLTPIRSLEYLLLHSNQLRAqgIHPLAFqgLKRLHTVHLYNNALERVP--SGLPRrvrtlmilhnq 414
Cdd:cd21340 7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITK--IENLEF--LTNLTHLYLQNNQIEKIEnlENLVN----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 415 itgigredfattyfLEELNLSYNRITspqmhrdafrklrllrslDLSGnrLHTLPpglprnvhvlkvkrnelaalargal 494
Cdd:cd21340 70 --------------LKKLYLGGNRIS------------------VVEG--LENLT------------------------- 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 495 agmaQLRELYLTSNRLRSR---ALGPRAWVDLAG-LQLLDIAGNQLTEIpQGLP--ESLEYLYLQNNKINAVP--ANAFD 566
Cdd:cd21340 91 ----NLEELHIENQRLPPGeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAplRNLEQLDASNNQISDLEelLDLLS 165
|
250
....*....|...
gi 1864505193 567 STPNLKGIFLRFN 579
Cdd:cd21340 166 SWPSLRELDLTGN 178
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
130-395 |
8.72e-24 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 104.25 E-value: 8.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 130 QLEKIYPEELSRLHRLETLNLQNNRLTSrgLPEkAFEHLINLNYLYLANNKLTLAPRFLPNAlisvdfaanyltkiyglt 209
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPE-ELANLTNLKELDLSNNQLTDLPEPLGNL------------------ 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 210 fgqkPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVPKHL--PPALYKLHLKNNKLEKIPPgAFSELSSL 287
Cdd:COG4886 159 ----TNLKSLDLSNNQLTD--LPEELGN-LTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 288 RELYLQNNYLTdeglDNETFWKLSSLEYLDLSSNNLSRVPAGLP-RSLVLLHLEKNAIRSVDADVLTPIRSLEYLLLHSN 366
Cdd:COG4886 231 ETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
|
250 260
....*....|....*....|....*....
gi 1864505193 367 QLRAQGIHPLAFQGLKRLHTVHLYNNALE 395
Cdd:COG4886 307 LLNLLELLILLLLLTTLLLLLLLLKGLLV 335
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
124-398 |
3.31e-23 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 102.70 E-value: 3.31e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 124 LSLQNNQLEKIyPEELSRLHRLETLNLQNNRLTSrgLPEkAFEHLINLNYLYLANNKLTLAPRFLPN--ALISVDFAANY 201
Cdd:COG4886 118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTD--LPE-PLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQ 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 202 LTKIyGLTFGQKPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVP--KHLpPALYKLHLKNNKLEKIPPG 279
Cdd:COG4886 194 ITDL-PEPLGNLTNLEELDLSGNQLTD--LPEPLAN-LTNLETLDLSNNQLTDLPelGNL-TNLEELDLSNNQLTDLPPL 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 280 AfsELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDADVLTPIRSLE 359
Cdd:COG4886 269 A--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346
|
250 260 270
....*....|....*....|....*....|....*....
gi 1864505193 360 YLLLHSNQLRAQGIHPLAFQGLKRLHTVHLYNNALERVP 398
Cdd:COG4886 347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
121-395 |
8.84e-22 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 98.08 E-value: 8.84e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 121 TNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLINLNYLYLANNKLTLAPRFLPNALISVDFAAN 200
Cdd:COG4886 20 LLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 201 YLTKIYGLTFGQKPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVPKHLP--PALYKLHLKNNKLEKIPP 278
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPEELAN-LTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 279 gAFSELSSLRELYLQNNYLTDEGldnETFWKLSSLEYLDLSSNNLSRVPAGLPR--SLVLLHLEKNAIRSVDAdvLTPIR 356
Cdd:COG4886 177 -ELGNLTNLKELDLSNNQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLT 250
|
250 260 270
....*....|....*....|....*....|....*....
gi 1864505193 357 SLEYLLLHSNQLRaqGIHPLAfqGLKRLHTVHLYNNALE 395
Cdd:COG4886 251 NLEELDLSNNQLT--DLPPLA--NLTNLKTLDLSNNQLT 285
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
93-331 |
1.23e-20 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 96.69 E-value: 1.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 93 RDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIyPEELSRlhRLETLNLQNNRLTSrgLPEKAFEhliNLN 172
Cdd:PRK15370 173 RDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG--NIKTLYANSNQLTS--IPATLPD---TIQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 173 YLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGlTFGQKPNLRSVYLHNNKLADAGLPD-----NMFNGS-------- 239
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPE-NLPEELRYLSVYDNSIRTLPAHLPSgithlNVQSNSltalpetl 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 240 -SNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKL----EKIPPgafselsSLRELYLQNNYLTD--EGLDnetfwklSS 312
Cdd:PRK15370 324 pPGLKTLEAGENALTSLPASLPPELQVLDVSKNQItvlpETLPP-------TITTLDVSRNALTNlpENLP-------AA 389
|
250
....*....|....*....
gi 1864505193 313 LEYLDLSSNNLSRVPAGLP 331
Cdd:PRK15370 390 LQIMQASRNNLVRLPESLP 408
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
129-440 |
1.55e-18 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 90.29 E-value: 1.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 129 NQLEKIYPEELSRLHRLETLNLQNNRLTsrGLPEKAFEHLINLNYLYLANNKLT--LAPR-FLPNALISVDFAANYLTKI 205
Cdd:PLN00113 222 NNLSGEIPYEIGGLTSLNHLDLVYNNLT--GPIPSSLGNLKNLQYLFLYQNKLSgpIPPSiFSLQKLISLDLSDNSLSGE 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 206 YGLTFGQKPNLRSVYLHNNKL------ADAGLP--------DNMFNGS--------SNVEVLILSSNFLR-HVPKHLPPA 262
Cdd:PLN00113 300 IPELVIQLQNLEILHLFSNNFtgkipvALTSLPrlqvlqlwSNKFSGEipknlgkhNNLTVLDLSTNNLTgEIPEGLCSS 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 263 --LYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEgLDNEtFWKLSSLEYLDLSSNNLS-RVPAG---LPrSLVL 336
Cdd:PLN00113 380 gnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGE-LPSE-FTKLPLVYFLDISNNNLQgRINSRkwdMP-SLQM 456
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 337 LHLEKNAIRSVDADVLTPIRsLEYLLLHSNQLraQGIHPLAFQGLKRLHTVHLYNNALE-RVPSGLP--RRVRTLMILHN 413
Cdd:PLN00113 457 LSLARNKFFGGLPDSFGSKR-LENLDLSRNQF--SGAVPRKLGSLSELMQLKLSENKLSgEIPDELSscKKLVSLDLSHN 533
|
330 340
....*....|....*....|....*..
gi 1864505193 414 QITGIGREDFATTYFLEELNLSYNRIT 440
Cdd:PLN00113 534 QLSGQIPASFSEMPVLSQLDLSQNQLS 560
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
141-605 |
1.06e-17 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 87.60 E-value: 1.06e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 141 RLHRLETLNLQNNRLtSRGLPEKAFEHLINLNYLYLANNKLTLA-PR-FLPNaLISVDFAANYLT-KIYgLTFGQKPNLR 217
Cdd:PLN00113 91 RLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTGSiPRgSIPN-LETLDLSNNMLSgEIP-NDIGSFSSLK 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 218 SVYLHNNKLAdAGLPDNMFNGSSnVEVLILSSN-FLRHVPKHLPP--ALYKLHLKNNKLEKIPPGAFSELSSLRELYLQN 294
Cdd:PLN00113 168 VLDLGGNVLV-GKIPNSLTNLTS-LEFLTLASNqLVGQIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVY 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 295 NYLTdeGLDNETFWKLSSLEYLDLSSNNLS-RVPAGL--PRSLVLLHLEKNAIRSVDADVLTPIRSLEYLLLHSNQLraQ 371
Cdd:PLN00113 246 NNLT--GPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIfsLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF--T 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 372 GIHPLAFQGLKRLHTVHLYNNALE-RVPSGLPRR--VRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSpqmhrda 448
Cdd:PLN00113 322 GKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHnnLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEG------- 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 449 frklrllrsldlsgnrlhTLPPGLP--RNVHVLKVKRNELAALARGALAGMAQLRELYLTSNRLRSRaLGPRAWvDLAGL 526
Cdd:PLN00113 395 ------------------EIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGR-INSRKW-DMPSL 454
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 527 QLLDIAGNQLTeipQGLPES-----LEYLYLQNNKINAVPANAFDSTPNLKGIFLRFNKLAvgSVVDSAFRRLKHLQVLD 601
Cdd:PLN00113 455 QMLSLARNKFF---GGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS--GEIPDELSSCKKLVSLD 529
|
....
gi 1864505193 602 IEGN 605
Cdd:PLN00113 530 LSHN 533
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
124-583 |
1.20e-16 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 84.13 E-value: 1.20e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 124 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSrGLPEKaFEHLINLNYLYLANNKLTLAPRFLPNALIS---VDFAAN 200
Cdd:PLN00113 169 LDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVG-QIPRE-LGQMKSLKWIYLGYNNLSGEIPYEIGGLTSlnhLDLVYN 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 201 YLTKIYGLTFGQKPNLRSVYLHNNKLADAgLPDNMFnGSSNVEVLILSSNFLR-HVPKHLP--PALYKLHLKNNKLEKIP 277
Cdd:PLN00113 247 NLTGPIPSSLGNLKNLQYLFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSgEIPELVIqlQNLEILHLFSNNFTGKI 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 278 PGAFSELSSLRELYLQNNYLTDEGLDNetFWKLSSLEYLDLSSNNLS-RVPAGLPRS--LVLLHLEKNAIRSVDADVLTP 354
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNKFSGEIPKN--LGKHNNLTVLDLSTNNLTgEIPEGLCSSgnLFKLILFSNSLEGEIPKSLGA 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 355 IRSLEYLLLHSNQLraQGIHPLAFQGLKRLHTVHLYNNALE-RVPSG---LPrRVRTLMILHNQITGiGREDFATTYFLE 430
Cdd:PLN00113 403 CRSLRRVRLQDNSF--SGELPSEFTKLPLVYFLDISNNNLQgRINSRkwdMP-SLQMLSLARNKFFG-GLPDSFGSKRLE 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 431 ELNLSYNRITSpqmhrdafrklrllrsldLSGNRLHTLPpglprNVHVLKVKRNELAALARGALAGMAQLRELYLTSNRL 510
Cdd:PLN00113 479 NLDLSRNQFSG------------------AVPRKLGSLS-----ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864505193 511 RSRAlgPRAWVDLAGLQLLDIAGNQLT-EIPQGLP--ESLEYLYLQNNKINAvpanafdSTPNlKGIFLRFNKLAV 583
Cdd:PLN00113 536 SGQI--PASFSEMPVLSQLDLSQNQLSgEIPKNLGnvESLVQVNISHNHLHG-------SLPS-TGAFLAINASAV 601
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
223-557 |
4.22e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 77.67 E-value: 4.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 223 NNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNyltdegl 302
Cdd:COG4886 34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 303 dnETFWKLSSLEYLDLSSNNLSRVPAGLPR--SLVLLHLEKNAIRSVDADvLTPIRSLEYLLLHSNQLraQGIhPLAFQG 380
Cdd:COG4886 107 --EELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL--TDL-PEELGN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 381 LKRLHTVHLYNNALERVPSGLPRRVRtlmilhnqitgigredfattyfLEELNLSYNRITSpqmhrdafrklrllrsldl 460
Cdd:COG4886 181 LTNLKELDLSNNQITDLPEPLGNLTN----------------------LEELDLSGNQLTD------------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 461 sgnrlhtLPPGLPRnvhvlkvkrnelaalargalagMAQLRELYLTSNRLRS-RALGprawvDLAGLQLLDIAGNQLTEI 539
Cdd:COG4886 220 -------LPEPLAN----------------------LTNLETLDLSNNQLTDlPELG-----NLTNLEELDLSNNQLTDL 265
|
330
....*....|....*....
gi 1864505193 540 PQGLP-ESLEYLYLQNNKI 557
Cdd:COG4886 266 PPLANlTNLKTLDLSNNQL 284
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
170-439 |
1.41e-13 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 73.96 E-value: 1.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 170 NLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKiygLTFGQKPNLRSVYLHNNKLAD--AGLPDNmfngssnVEVLIL 247
Cdd:PRK15370 179 NKTELRLKILGLTTIPACIPEQITTLILDNNELKS---LPENLQGNIKTLYANSNQLTSipATLPDT-------IQEMEL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 248 SSNFLRHVPKHLPPALYKLHLKNNKLEKIPpgafselsslrelylqnNYLTDEgldnetfwklssLEYLDLSSNNLSRVP 327
Cdd:PRK15370 249 SINRITELPERLPSALQSLDLFHNKISCLP-----------------ENLPEE------------LRYLSVYDNSIRTLP 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 328 AGLPRSLVLLHLEKNAIRSVDAdVLTPirSLEYLLLHSNQLRA--QGIHPlafqglkRLHTVHLYNNALERVPSGLPRRV 405
Cdd:PRK15370 300 AHLPSGITHLNVQSNSLTALPE-TLPP--GLKTLEAGENALTSlpASLPP-------ELQVLDVSKNQITVLPETLPPTI 369
|
250 260 270
....*....|....*....|....*....|....
gi 1864505193 406 RTLMILHNQITGIGREDFATTYFLEElnlSYNRI 439
Cdd:PRK15370 370 TTLDVSRNALTNLPENLPAALQIMQA---SRNNL 400
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
261-323 |
3.59e-13 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 64.47 E-value: 3.59e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505193 261 PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNL 323
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
270-605 |
6.69e-13 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 71.12 E-value: 6.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 270 NNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 349
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 350 DVLTPIRSLEYLLLHSNQLRAQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR--RVRTLMILHNQITGIGrEDFATTY 427
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 428 FLEELNLSYNRITSpqmhrdafrklrllrsldlsgnrlhtLPPGLprnvhvlkvkrnelaalargalAGMAQLRELYLTS 507
Cdd:COG4886 160 NLKSLDLSNNQLTD--------------------------LPEEL----------------------GNLTNLKELDLSN 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 508 NRLRSralGPRAWVDLAGLQLLDIAGNQLTEIPQGLPE--SLEYLYLQNNKINAVPanAFDSTPNLKGIFLRFNKLAVGs 585
Cdd:COG4886 192 NQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL- 265
|
330 340
....*....|....*....|
gi 1864505193 586 vvdSAFRRLKHLQVLDIEGN 605
Cdd:COG4886 266 ---PPLANLTNLKTLDLSNN 282
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
245-447 |
8.38e-12 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 65.19 E-value: 8.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 245 LILSSNFLRHVPK-HLPPALYKLHLKNNKLEKIPpgAFSELSSLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNN 322
Cdd:cd21340 7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 323 LSRVpAGL--PRSLVLLHLEKNAIRS-----VDADVLTPI-RSLEYLLLHSNQLRAqgIHPLAfqGLKRLhtvhlynnal 394
Cdd:cd21340 80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNIDS--LEPLA--PLRNL---------- 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1864505193 395 ervpsglprrvRTLMILHNQITGIGR--EDFATTYFLEELNLSYNRITSPQMHRD 447
Cdd:cd21340 145 -----------EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRD 188
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
252-544 |
3.38e-11 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 66.26 E-value: 3.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 252 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSelsSLRELYLQNNYLTD--EGLDNetfwklsSLEYLDLSSNNLSRVPAG 329
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSipATLPD-------TIQEMELSINRITELPER 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 330 LPRSLVLLHLEKNAIRSVdADVLTpiRSLEYLLLHSNQLRAQGIH-PLAFQGLkrlhtvHLYNNALERVPSGLPRRVRTL 408
Cdd:PRK15370 260 LPSALQSLDLFHNKISCL-PENLP--EELRYLSVYDNSIRTLPAHlPSGITHL------NVQSNSLTALPETLPPGLKTL 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 409 MILHNQITGIGRedfATTYFLEELNLSYNRITspqmhrdafrklrllrsldlsgnrlhTLPPGLPRNVHVLKVKRNelaa 488
Cdd:PRK15370 331 EAGENALTSLPA---SLPPELQVLDVSKNQIT--------------------------VLPETLPPTITTLDVSRN---- 377
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1864505193 489 largalaGMAQLRElyltsnrlrsralgprawvDL-AGLQLLDIAGNQLTEIPQGLP 544
Cdd:PRK15370 378 -------ALTNLPE-------------------NLpAALQIMQASRNNLVRLPESLP 408
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
80-408 |
1.29e-10 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 64.41 E-value: 1.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 80 EEPVPGPAVVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKI--YPEElsrlhrLETLNLQNNRLTS 157
Cdd:PRK15387 183 EESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLpaLPPE------LRTLEVSGNQLTS 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 158 RG-LPEKAFEhlinlnyLYLANNKLTLAPRfLPNALISVDFAANYLTKIYGLtfgqKPNLRSVYLHNNKLAD-AGLPDNM 235
Cdd:PRK15387 257 LPvLPPGLLE-------LSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSLPVL----PPGLQELSVSDNQLASlPALPSEL 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 236 -----FNGS--------SNVEVLILSSNFLRHVPKhLPPALYKLHLKNNKLEKIPpgafSELSSLRELYLQNNYLTDEGL 302
Cdd:PRK15387 325 cklwaYNNQltslptlpSGLQELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLTSLPV 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 303 dnetfwKLSSLEYLDLSSNNLSRVPAgLPRSLVLLHLEKNAIRSVdADVLTPIRSLEYLLLHSNQLRAQgihplAFQGLK 382
Cdd:PRK15387 400 ------LPSELKELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPLSER-----TLQALR 466
|
330 340
....*....|....*....|....*....
gi 1864505193 383 RLHTVHLYNNAL---ERVPSGLPRRVRTL 408
Cdd:PRK15387 467 EITSAPGYSGPIirfDMAGASAPRETRAL 495
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
323-563 |
2.23e-10 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 63.95 E-value: 2.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 323 LSRVPAGLPRSLVLLHLEKNAIRSVDADvltpirsleyllLHSNqlraqgihplafqglkrLHTVHLYNNALERVPSGLP 402
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPEN------------LQGN-----------------IKTLYANSNQLTSIPATLP 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 403 RRVRTLMILHNQITGIgREDFATTyfLEELNLSYNRITS-PQMHRDAFRKLRLLRsldlsgNRLHTLPPGLPRNVHVLKV 481
Cdd:PRK15370 241 DTIQEMELSINRITEL-PERLPSA--LQSLDLFHNKISClPENLPEELRYLSVYD------NSIRTLPAHLPSGITHLNV 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 482 KRNELAALARGALAgmaQLRELYLTSNRLRS--RALGPRawvdlagLQLLDIAGNQLTEIPQGLPESLEYLYLQNNKINA 559
Cdd:PRK15370 312 QSNSLTALPETLPP---GLKTLEAGENALTSlpASLPPE-------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTN 381
|
....
gi 1864505193 560 VPAN 563
Cdd:PRK15370 382 LPEN 385
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
123-326 |
6.47e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 59.41 E-value: 6.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 123 HLSLQNNQLEKIypEELSRLHRLETLNLQNNRLTS-RGLpekafEHLINLNYLYLANNKLTlaprflpnalisvdfaany 201
Cdd:cd21340 6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKiENL-----EFLTNLTHLYLQNNQIE------------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 202 ltKIYGLtfGQKPNLRSVYLHNNKLadaglpdnmfngsSNVEVLilssnflrhvpkHLPPALYKLHLKNNKLekiPPG-- 279
Cdd:cd21340 60 --KIENL--ENLVNLKKLYLGGNRI-------------SVVEGL------------ENLTNLEELHIENQRL---PPGek 107
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1864505193 280 -AFSELS------SLRELYLQNNYLTDegLDNetFWKLSSLEYLDLSSNNLSRV 326
Cdd:cd21340 108 lTFDPRSlaalsnSLRVLNISGNNIDS--LEP--LAPLRNLEQLDASNNQISDL 157
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
257-440 |
2.39e-09 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 59.29 E-value: 2.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 257 KHLPPALYKLHLKNNKLEKIPPG------AFSELSSLRELYLQNNYLTDEGLDN-ETFWKLSSLEYLDLSSNNLS----- 324
Cdd:cd00116 47 LRPQPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVlESLLRSSSLQELKLNNNGLGdrglr 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 325 ---RVPAGLPRSLVLLHLEKNAIRSVD----ADVLTPIRSLEYLLLHSNQLRAQGIHPLAfQGLK---RLHTVHLYNNAL 394
Cdd:cd00116 127 llaKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRALA-EGLKancNLEVLDLNNNGL 205
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864505193 395 ERVPSGL-------PRRVRTLMILHNQITGIGREDFATTYF-----LEELNLSYNRIT 440
Cdd:cd00116 206 TDEGASAlaetlasLKSLEVLNLGDNNLTDAGAAALASALLspnisLLTLSLSCNDIT 263
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
124-372 |
2.66e-09 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 58.91 E-value: 2.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 124 LSLQNNQLEKIYPEELSRLHR-LETLNLQNNRLTSRGLP--EKAFEHLINLNYLYLANNKLTLAPRFLpnalisvDFAAN 200
Cdd:cd00116 3 LSLKGELLKTERATELLPKLLcLQVLRLEGNTLGEEAAKalASALRPQPSLKELCLSLNETGRIPRGL-------QSLLQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 201 YLTKIYGLT-------------------FGQKPNLRSVYLHNNKLADAGLP---DNMFNGSSNVEVLILSSNFLRHVP-- 256
Cdd:cd00116 76 GLTKGCGLQeldlsdnalgpdgcgvlesLLRSSSLQELKLNNNGLGDRGLRllaKGLKDLPPALEKLVLGRNRLEGASce 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 257 ---KHLP--PALYKLHLKNNKLEkiPPG------AFSELSSLRELYLQNNYLTDEG--LDNETFWKLSSLEYLDLSSNNL 323
Cdd:cd00116 156 alaKALRanRDLKELNLANNGIG--DAGiralaeGLKANCNLEVLDLNNNGLTDEGasALAETLASLKSLEVLNLGDNNL 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864505193 324 SRVPA--------GLPRSLVLLHLEKNAIRSVDA-DVLTPIR---SLEYLLLHSNQLRAQG 372
Cdd:cd00116 234 TDAGAaalasallSPNISLLTLSLSCNDITDDGAkDLAEVLAekeSLLELDLRGNKFGEEG 294
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
316-561 |
3.94e-08 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 56.71 E-value: 3.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 316 LDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDAdvLTP-IRSLEyllLHSNQLRAQGIHPlafQGLKRLHtvhLYNNAL 394
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPA--LPPeLRTLE---VSGNQLTSLPVLP---PGLLELS---IFSNPL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 395 ERVPSgLPRRVRTLMILHNQITGIGredfATTYFLEELNLSYNRITS-PQMHRDAFRklrllrsLDLSGNRLHTLPPgLP 473
Cdd:PRK15387 275 THLPA-LPSGLCKLWIFGNQLTSLP----VLPPGLQELSVSDNQLASlPALPSELCK-------LWAYNNQLTSLPT-LP 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 474 RNVHVLKVKRNELAALARGAlagmAQLRELYLTSNRLRSRALGPrawvdlAGLQLLDIAGNQLTEIPQgLPESLEYLYLQ 553
Cdd:PRK15387 342 SGLQELSVSDNQLASLPTLP----SELYKLWAYNNRLTSLPALP------SGLKELIVSGNRLTSLPV-LPSELKELMVS 410
|
....*...
gi 1864505193 554 NNKINAVP 561
Cdd:PRK15387 411 GNRLTSLP 418
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
214-297 |
9.34e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 9.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 214 PNLRSVYLHNNKLADagLPDNMFNGSSNVEVLILSsnflrhvpkhlppalyklhlkNNKLEKIPPGAFSELSSLRELYLQ 293
Cdd:pfam13855 1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLS---------------------NNLLTTLSPGAFSGLPSLRYLDLS 57
|
....
gi 1864505193 294 NNYL 297
Cdd:pfam13855 58 GNRL 61
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
98-440 |
2.03e-07 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 53.64 E-value: 2.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 98 SQEGVVDCGGIDLREFPGDLPEHTNHLS---LQNNQLEKIYPEELSRL--HRLETLNLQNNRLTSRGLPekafehlinln 172
Cdd:COG5238 64 RFEGQGDPGLNPVALEKAAEAFPTQLLVvdwEGAEEVSPVALAETATAvaTPPPDLRRIMAKTLEDSLI----------- 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 173 yLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLT-------FGQKPNLRSVYLHNNKLADAGLPD--NMFNGSSNVE 243
Cdd:COG5238 133 -LYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLaaismakALQNNSVETVYLGCNQIGDEGIEElaEALTQNTTVT 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 244 VLILSSNflrHVPKHLPPALYKlHLKNNKlekippgafselsSLRELYLQNNYLTDEGLDN--ETFWKLSSLEYLDLSSN 321
Cdd:COG5238 212 TLWLKRN---PIGDEGAEILAE-ALKGNK-------------SLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGN 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 322 NLS-----RVPAGLPRSLVL--LHLEKNAIRSVDADVLTP----IRSLEYLLLHSNQLRAQGIHPL--AFQGLKRLHTVH 388
Cdd:COG5238 275 QIGaegaiALAKALQGNTTLtsLDLSVNRIGDEGAIALAEglqgNKTLHTLNLAYNGIGAQGAIALakALQENTTLHSLD 354
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1864505193 389 LYNN------------ALERVPSglprrVRTLMILHNQITGIGREDFA---TTYFLEELNLSYNRIT 440
Cdd:COG5238 355 LSDNqigdegaialakYLEGNTT-----LRELNLGKNNIGKQGAEALIdalQTNRLHTLILDGNLIG 416
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
285-368 |
3.65e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.52 E-value: 3.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 285 SSLRELYLQNNYLTDegLDNETFWKLSSLEYLDLSSNNLSrvpaglprslvllhleknairSVDADVLTPIRSLEYLLLH 364
Cdd:pfam13855 1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLT---------------------TLSPGAFSGLPSLRYLDLS 57
|
....
gi 1864505193 365 SNQL 368
Cdd:pfam13855 58 GNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
266-463 |
5.27e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 50.94 E-value: 5.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 266 LHLKNNKLEKIppGAFSELSSLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNNLSRVP--AGLPRsLVLLHLEKN 342
Cdd:cd21340 7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKiENLEF-----LTNLTHLYLQNNQIEKIEnlENLVN-LKKLYLGGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 343 AIRSVDAdvLTPIRSLEYLLLhSNQLRAQGiHPLAFQglkrlhtvhlynnalERVPSGLPRRVRTLMILHNQITGIgrED 422
Cdd:cd21340 79 RISVVEG--LENLTNLEELHI-ENQRLPPG-EKLTFD---------------PRSLAALSNSLRVLNISGNNIDSL--EP 137
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1864505193 423 FATTYFLEELNLSYNRITSPQMHRDAFRKLRLLRSLDLSGN 463
Cdd:cd21340 138 LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
124-181 |
5.67e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 46.75 E-value: 5.67e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864505193 124 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSrgLPEKAFEHLINLNYLYLANNKL 181
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
313-579 |
9.66e-07 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 52.09 E-value: 9.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 313 LEYLDLSSNNLSRVPAgLPRSLVLLHLEKNAIRSVDAdvlTPiRSLEYLLLHSNQLRAQGIHPLAFQGLKrlhtvhLYNN 392
Cdd:PRK15387 244 LRTLEVSGNQLTSLPV-LPPGLLELSIFSNPLTHLPA---LP-SGLCKLWIFGNQLTSLPVLPPGLQELS------VSDN 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 393 ALERVPSgLPRRVRTLMILHNQITGIGredfATTYFLEELNLSYNRITS-PQMHRDAFRklrllrsLDLSGNRLHTLPpG 471
Cdd:PRK15387 313 QLASLPA-LPSELCKLWAYNNQLTSLP----TLPSGLQELSVSDNQLASlPTLPSELYK-------LWAYNNRLTSLP-A 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 472 LPRNVHVLKVKRNELAALARGAlagmAQLRELYLTSNRLRSRALGPrawvdlAGLQLLDIAGNQLTEIPQGLPE--SLEY 549
Cdd:PRK15387 380 LPSGLKELIVSGNRLTSLPVLP----SELKELMVSGNRLTSLPMLP------SGLLSLSVYRNQLTRLPESLIHlsSETT 449
|
250 260 270
....*....|....*....|....*....|...
gi 1864505193 550 LYLQNNKINAVPANAF---DSTPNLKGIFLRFN 579
Cdd:PRK15387 450 VNLEGNPLSERTLQALreiTSAPGYSGPIIRFD 482
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
382-605 |
1.18e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 51.62 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 382 KRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIgREDFATTyfLEELNLSYNRITSpqmhrdafrklrllrsldls 461
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPDT--IQEMELSINRITE-------------------- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 462 gnrlhtLPPGLPrnvhvlkvkrnelaalargalagmAQLRELYLTSNRLRSRalgPRAWVDlaGLQLLDIAGNQLTEIPQ 541
Cdd:PRK15370 256 ------LPERLP------------------------SALQSLDLFHNKISCL---PENLPE--ELRYLSVYDNSIRTLPA 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1864505193 542 GLPESLEYLYLQNNKINAVPANAfdsTPNLKgiFLRFNKLAVGSVVDSAfrrLKHLQVLDIEGN 605
Cdd:PRK15370 301 HLPSGITHLNVQSNSLTALPETL---PPGLK--TLEAGENALTSLPASL---PPELQVLDVSKN 356
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
499-557 |
2.33e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.21 E-value: 2.33e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505193 499 QLRELYLTSNRLRSraLGPRAWVDLAGLQLLDIAGNQLTEIP----QGLPeSLEYLYLQNNKI 557
Cdd:pfam13855 2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSpgafSGLP-SLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
437-563 |
2.33e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 50.85 E-value: 2.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 437 NRITSPQMHRDAFRKLRLLRSLDLSGnrLHTLPPGLPRNVHVLKVKRNELAALARGALagmAQLRELYLTSNRLRS---- 512
Cdd:PRK15370 164 NREEAVQRMRDCLKNNKTELRLKILG--LTTIPACIPEQITTLILDNNELKSLPENLQ---GNIKTLYANSNQLTSipat 238
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505193 513 -------RALGPRAWVDL-----AGLQLLDIAGNQLTEIPQGLPESLEYLYLQNNKINAVPAN 563
Cdd:PRK15370 239 lpdtiqeMELSINRITELperlpSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAH 301
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
546-605 |
2.37e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.21 E-value: 2.37e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 546 SLEYLYLQNNKINAVPANAFDSTPNLKGIFLRFNKLavGSVVDSAFRRLKHLQVLDIEGN 605
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
123-295 |
3.53e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 48.24 E-value: 3.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 123 HLSLQNNQLEKIypEELSRLHRLETLNLQNNRLtSR--GLpekafEHLINLNYLYLANNKLTLAPRFL--PNALISVdfa 198
Cdd:cd21340 50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI-SVveGL-----ENLTNLEELHIENQRLPPGEKLTfdPRSLAAL--- 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 199 anyltkiygltfgqKPNLRSVYLHNNKLADaglpDNMFNGSSNVEVLILSSNFLRHVpkhlppalyklhlknNKLEkipp 278
Cdd:cd21340 119 --------------SNSLRVLNISGNNIDS----LEPLAPLRNLEQLDASNNQISDL---------------EELL---- 161
|
170
....*....|....*..
gi 1864505193 279 GAFSELSSLRELYLQNN 295
Cdd:cd21340 162 DLLSSWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
144-226 |
7.19e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.67 E-value: 7.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 144 RLETLNLQNNRLTSrgLPEKAFEHLINLNYLYLANNKLTlapRFLPNALisvdfaanyltkiYGLtfgqkPNLRSVYLHN 223
Cdd:pfam13855 2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLT---TLSPGAF-------------SGL-----PSLRYLDLSG 58
|
...
gi 1864505193 224 NKL 226
Cdd:pfam13855 59 NRL 61
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
231-485 |
1.21e-05 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 48.62 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 231 LPDNMfngSSNVEVLILSSNFLRHVPKhLPPALYKLHLKNNKLEKIP---PGafselssLRELYLQNNYLTD-EGLDnet 306
Cdd:PRK15387 216 LPDCL---PAHITTLVIPDNNLTSLPA-LPPELRTLEVSGNQLTSLPvlpPG-------LLELSIFSNPLTHlPALP--- 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 307 fwklSSLEYLDLSSNNLSRVPAgLPRSLVLLHLEKNAIRSVDAdvlTPiRSLEYLLLHSNQLRAQGIHPLAFQGLKrlht 386
Cdd:PRK15387 282 ----SGLCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLASLPA---LP-SELCKLWAYNNQLTSLPTLPSGLQELS---- 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 387 vhLYNNALERVPSgLPRRVRTLMILHNQITGIGredfATTYFLEELNLSYNRITSPQMHRDAFRKLRLLrsldlsGNRLH 466
Cdd:PRK15387 349 --VSDNQLASLPT-LPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLTSLPVLPSELKELMVS------GNRLT 415
|
250
....*....|....*....
gi 1864505193 467 TLPPgLPRNVHVLKVKRNE 485
Cdd:PRK15387 416 SLPM-LPSGLLSLSVYRNQ 433
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
525-581 |
2.25e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.51 E-value: 2.25e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 525 GLQLLDIAGNQLTEIPQGL---PESLEYLYLQNNKINAVPANAFDSTPNLKGIFLRFNKL 581
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
386-594 |
4.46e-05 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 46.69 E-value: 4.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 386 TVHLYNNALERVPSgLPRRVRTLMILHNQITGIGredfattyFLEELNLSYNRITSPQMHRDAFrkLRLLRSLDLSGNRL 465
Cdd:PRK15387 226 TLVIPDNNLTSLPA-LPPELRTLEVSGNQLTSLP--------VLPPGLLELSIFSNPLTHLPAL--PSGLCKLWIFGNQL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 466 HTLPPgLPRNVHVLKVKRNELAALARGAlagmAQLRELYLTSNRLRSRALGPrawvdlAGLQLLDIAGNQLTEIPQgLPE 545
Cdd:PRK15387 295 TSLPV-LPPGLQELSVSDNQLASLPALP----SELCKLWAYNNQLTSLPTLP------SGLQELSVSDNQLASLPT-LPS 362
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1864505193 546 SLEYLYLQNNKINAVPAnafdSTPNLKGIFLRFNKLAVGSVVDSAFRRL 594
Cdd:PRK15387 363 ELYKLWAYNNRLTSLPA----LPSGLKELIVSGNRLTSLPVLPSELKEL 407
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
98-321 |
1.28e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 44.65 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 98 SQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLE----KIYPEELSRLHRLETLNLQNNRLTSRGLPE--KAFEHLINL 171
Cdd:cd00116 116 NNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEgascEALAKALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNL 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 172 NYLYLANNKLTLAPrflpnaliSVDFAAnyltkiyglTFGQKPNLRSVYLHNNKLADAGLPDnmfngssnvevlILSSNf 251
Cdd:cd00116 196 EVLDLNNNGLTDEG--------ASALAE---------TLASLKSLEVLNLGDNNLTDAGAAA------------LASAL- 245
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1864505193 252 lrhvpKHLPPALYKLHLKNNKLEKIPPGAFSEL----SSLRELYLQNNYLTDEG---LDNETFWKLSSLEYLDLSSN 321
Cdd:cd00116 246 -----LSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGEEGaqlLAESLLEPGNELESLWVKDD 317
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
91-121 |
4.51e-04 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 38.07 E-value: 4.51e-04
10 20 30
....*....|....*....|....*....|.
gi 1864505193 91 CPRDCACSqEGVVDCGGIDLREFPGDLPEHT 121
Cdd:smart00013 2 CPAPCNCS-GTAVDCSGRGLTEVPLDLPPDT 31
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
337-579 |
5.91e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 41.70 E-value: 5.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 337 LHLEKNAIRSVDAdvLTPIRSLEYLLLHSNQLRAqgIHPLAFqgLKRLHTVHLYNNALERVP--SGLPRrvrtlmilhnq 414
Cdd:cd21340 7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITK--IENLEF--LTNLTHLYLQNNQIEKIEnlENLVN----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 415 itgigredfattyfLEELNLSYNRITspqmhrdafrklrllrslDLSGnrLHTLPpglprnvhvlkvkrnelaalargal 494
Cdd:cd21340 70 --------------LKKLYLGGNRIS------------------VVEG--LENLT------------------------- 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 495 agmaQLRELYLTSNRLRSR---ALGPRAWVDLAG-LQLLDIAGNQLTEIpQGLP--ESLEYLYLQNNKINAVP--ANAFD 566
Cdd:cd21340 91 ----NLEELHIENQRLPPGeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAplRNLEQLDASNNQISDLEelLDLLS 165
|
250
....*....|...
gi 1864505193 567 STPNLKGIFLRFN 579
Cdd:cd21340 166 SWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
332-394 |
1.23e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.50 E-value: 1.23e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864505193 332 RSLVLLHLEKNAIRSVDADVLTPIRSLEYLLLHSNQLraQGIHPLAFQGLKRLHTVHLYNNAL 394
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
119-155 |
2.11e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 36.73 E-value: 2.11e-03
10 20 30
....*....|....*....|....*....|....*..
gi 1864505193 119 EHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRL 155
Cdd:pfam13855 25 SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
286-323 |
2.85e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.07 E-value: 2.85e-03
10 20 30
....*....|....*....|....*....|....*...
gi 1864505193 286 SLRELYLQNNYLTDEGLdnetFWKLSSLEYLDLSSNNL 323
Cdd:pfam12799 2 NLEVLDLSNNQITDIPP----LAKLPNLETLDLSGNNK 35
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
263-330 |
4.01e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 40.18 E-value: 4.01e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864505193 263 LYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNLS-RVPAGL 330
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN--GSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
497-536 |
6.30e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.58 E-value: 6.30e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1864505193 497 MAQLRELYLTSNRLRSraLGPRAWVDLAGLQLLDIAGNQL 536
Cdd:pfam13855 24 LSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
289-610 |
6.91e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 38.88 E-value: 6.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 289 ELYLQNNYLTDEGLDnETFWKLSSLEYLDLSSNNLSRVPAglprslvllhleknairSVDADVLTPIRSLEYLLLHSNQL 368
Cdd:cd00116 2 QLSLKGELLKTERAT-ELLPKLLCLQVLRLEGNTLGEEAA-----------------KALASALRPQPSLKELCLSLNET 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 369 ----RAQGIHPLAFQGLKRLHTVHLYNNAL-----ERVPSGLPRRVRTLMILHNQITGIGREDFATTYF------LEELN 433
Cdd:cd00116 64 gripRGLQSLLQGLTKGCGLQELDLSDNALgpdgcGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLkdlppaLEKLV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 434 LSYNRITSPQMHR--DAFRKLRLLRSLDLSGNRLHtlPPGLPRNVHVLKVKRNelaalargalagmaqLRELYLTSNRLR 511
Cdd:cd00116 144 LGRNRLEGASCEAlaKALRANRDLKELNLANNGIG--DAGIRALAEGLKANCN---------------LEVLDLNNNGLT 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864505193 512 sralgprawvdlaglqllDIAGNQLTEIPQGLPeSLEYLYLQNNKINAVPANAFDS-----TPNLKGIFLRFNKLAVGSV 586
Cdd:cd00116 207 ------------------DEGASALAETLASLK-SLEVLNLGDNNLTDAGAAALASallspNISLLTLSLSCNDITDDGA 267
|
330 340
....*....|....*....|....*.
gi 1864505193 587 VDSA--FRRLKHLQVLDIEGNfEFGD 610
Cdd:cd00116 268 KDLAevLAEKESLLELDLRGN-KFGE 292
|
|
| |
