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Conserved domains on  [gi|1860490560|ref|XP_034942950|]
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histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2 [Chelonus insularis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DOT1 pfam08123
Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating ...
 115-317 2.96e-98

Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating histone H3. H3 methylation by DOT1 has been shown to be required for the DNA damage checkpoint in yeast.


:

Pssm-ID: 149273  Cd Length: 205  Bit Score: 312.31  E-value: 2.96e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  115 YNQAVV-EPDKLNQYEPFSPEVYGETSYELVCQMIDQIDVTEDDIFIDLGSGVGQVVLQMAASTFCKISVGVEKAEVPSR 193
Cdd:pfam08123    1 YSRSVSpDANKLNHYKAFSNEVYGELLPEFLSDVLDKCNLGPQDVFVDLGSGVGNCVLQAALEFGCKLSFGCEIMDNASN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  194 YAQSMEINFRKWLNWYGKRCGEYRLVKGDFLADENRESI-TSATIVFVNNFAFGPTVDHQLKERFADLRDGARIVSSKSF 272
Cdd:pfam08123   81 LAELQDEEFKKRCKLFGKKLGKIEFIRGSFLDNERVEEIiPEADVILVNNFAFDPELNLQLKEMLQDLKDGCKIISLKSF 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1860490560  273 CPLNFRITDRNLSDIGTIMHVSEMTPLKGSVSWTGKPVSYYLHVI 317
Cdd:pfam08123  161 VPLNYRINFRNLSDIFNILKVEELKLPEGSVSWTSRGVEYYISTV 205
CC_DOT1L cd20902
coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; ...
 507-570 2.93e-17

coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; This family contains DOT1L (disruptor of telomeric-silencing 1-like), a non-SET domain histone lysine methyltransferase (HKMT) that catalyzes monomethylation, dimethylation, and trimethylation of nucleosomal H3K79. DOT1L is recruited to the homeobox A by AF10 (ALL1-Fused gene from chromosome 10 protein), one of the mixed-lineage leukemia 1 (MLL1)-fusion partners that function in acute myeloid leukemia (ALL). Aberration of the MLL gene is implicated in acute leukemia; chromosomal translocations of MLL1 generate oncogenic chimeric proteins, containing the non-catalytic N-terminal portion of MLL1 fused with many partners such as AF10. The aberrant recruitment of DOT1L by MLL fusions and the resulting H3K79 methylation are thought to affect gene expression by altering chromatin accessibility. AF10 and DOT1L interact through their coiled coil domains.


:

Pssm-ID: 411016 [Multi-domain]  Cd Length: 65  Bit Score: 76.96  E-value: 2.93e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1860490560  507 LQILLDLYRDQFMLMLEAIKTPAYKVSVNTDLAKERERNSKLQSRAAQLEKQIKVLIDDSVALL 570
Cdd:cd20902      2 LQKLLESFKIQYLQFLAYMKTPQYKASLQQQIEQEKEKNKQLTGKAQQLEKQIQALQKEGVRLL 65
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 537-690 1.13e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.85  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  537 DLAKERERNSKLQSRAAQLEKQIKVLIDDsVALLKARMTELGInasspcDLLAKAKEIVLRHKQLQAKASKLQAQVSSME 616
Cdd:COG1196    303 DIARLEERRRELEERLEELEEELAELEEE-LEELEEELEELEE------ELEEAEEELEEAEAELAEAEEALLEAEAELA 375

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1860490560  617 TEQSRLAALRHQELQEKFNAHGSTNNISNppQALTQEYILKEISATLSQRKKLHSQVSKLEHELNLLERATSEK 690
Cdd:COG1196    376 EAEEELEELAEELLEALRAAAELAAQLEE--LEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEA 447
 
Name Accession Description Interval E-value
DOT1 pfam08123
Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating ...
 115-317 2.96e-98

Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating histone H3. H3 methylation by DOT1 has been shown to be required for the DNA damage checkpoint in yeast.


Pssm-ID: 149273  Cd Length: 205  Bit Score: 312.31  E-value: 2.96e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  115 YNQAVV-EPDKLNQYEPFSPEVYGETSYELVCQMIDQIDVTEDDIFIDLGSGVGQVVLQMAASTFCKISVGVEKAEVPSR 193
Cdd:pfam08123    1 YSRSVSpDANKLNHYKAFSNEVYGELLPEFLSDVLDKCNLGPQDVFVDLGSGVGNCVLQAALEFGCKLSFGCEIMDNASN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  194 YAQSMEINFRKWLNWYGKRCGEYRLVKGDFLADENRESI-TSATIVFVNNFAFGPTVDHQLKERFADLRDGARIVSSKSF 272
Cdd:pfam08123   81 LAELQDEEFKKRCKLFGKKLGKIEFIRGSFLDNERVEEIiPEADVILVNNFAFDPELNLQLKEMLQDLKDGCKIISLKSF 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1860490560  273 CPLNFRITDRNLSDIGTIMHVSEMTPLKGSVSWTGKPVSYYLHVI 317
Cdd:pfam08123  161 VPLNYRINFRNLSDIFNILKVEELKLPEGSVSWTSRGVEYYISTV 205
CC_DOT1L cd20902
coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; ...
 507-570 2.93e-17

coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; This family contains DOT1L (disruptor of telomeric-silencing 1-like), a non-SET domain histone lysine methyltransferase (HKMT) that catalyzes monomethylation, dimethylation, and trimethylation of nucleosomal H3K79. DOT1L is recruited to the homeobox A by AF10 (ALL1-Fused gene from chromosome 10 protein), one of the mixed-lineage leukemia 1 (MLL1)-fusion partners that function in acute myeloid leukemia (ALL). Aberration of the MLL gene is implicated in acute leukemia; chromosomal translocations of MLL1 generate oncogenic chimeric proteins, containing the non-catalytic N-terminal portion of MLL1 fused with many partners such as AF10. The aberrant recruitment of DOT1L by MLL fusions and the resulting H3K79 methylation are thought to affect gene expression by altering chromatin accessibility. AF10 and DOT1L interact through their coiled coil domains.


Pssm-ID: 411016 [Multi-domain]  Cd Length: 65  Bit Score: 76.96  E-value: 2.93e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1860490560  507 LQILLDLYRDQFMLMLEAIKTPAYKVSVNTDLAKERERNSKLQSRAAQLEKQIKVLIDDSVALL 570
Cdd:cd20902      2 LQKLLESFKIQYLQFLAYMKTPQYKASLQQQIEQEKEKNKQLTGKAQQLEKQIQALQKEGVRLL 65
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 537-690 1.13e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.85  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  537 DLAKERERNSKLQSRAAQLEKQIKVLIDDsVALLKARMTELGInasspcDLLAKAKEIVLRHKQLQAKASKLQAQVSSME 616
Cdd:COG1196    303 DIARLEERRRELEERLEELEEELAELEEE-LEELEEELEELEE------ELEEAEEELEEAEAELAEAEEALLEAEAELA 375

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1860490560  617 TEQSRLAALRHQELQEKFNAHGSTNNISNppQALTQEYILKEISATLSQRKKLHSQVSKLEHELNLLERATSEK 690
Cdd:COG1196    376 EAEEELEELAEELLEALRAAAELAAQLEE--LEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEA 447
Leu_zip pfam15294
Leucine zipper; This family includes Leucine zipper transcription factor-like protein 1 ...
 535-665 2.87e-03

Leucine zipper; This family includes Leucine zipper transcription factor-like protein 1 (LZTFL1) and Leucine zipper protein 2 (LUZP2).


Pssm-ID: 464620 [Multi-domain]  Cd Length: 276  Bit Score: 41.23  E-value: 2.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  535 NTDLAKERERNSKLQSRAAQLEKQIKVLIDDSVALLKA------RMTELGINASSP---CDLLAKAKEIVLRHKQLQAKA 605
Cdd:pfam15294  132 HMEIERLKEENEKLKERLKTLESQATQALDEKSKLEKAlkdlqkEQGAKKDVKSNLkeiSDLEEKMAALKSDLEKTLNAS 211

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1860490560  606 SKLQAQVssmeteQSRLAALRHQ-------------ELQEKFNAHGSTNNISnppQALTQ--EYIlKEISATLSQ 665
Cdd:pfam15294  212 TALQKSL------EEDLASTKHEllkvqeqlemaekELEKKFQQTAAYRNMK---EMLTKknEQI-KELRKRLSK 276
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 159-267 7.65e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 37.41  E-value: 7.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  159 FIDLGSGVGQVVLQMAASTFCKIsVGVEKAEVPSRYAQSmeinfrkwlNWYGKRCGEYRLVKGDFLADENREsITSATIV 238
Cdd:cd02440      2 VLDLGCGTGALALALASGPGARV-TGVDISPVALELARK---------AAAALLADNVEVLKGDAEELPPEA-DESFDVI 70

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1860490560  239 FVNN-FAFGPTVDHQLKERFAD-LRDGARIV 267
Cdd:cd02440     71 ISDPpLHHLVEDLARFLEEARRlLKPGGVLV 101
 
Name Accession Description Interval E-value
DOT1 pfam08123
Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating ...
 115-317 2.96e-98

Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating histone H3. H3 methylation by DOT1 has been shown to be required for the DNA damage checkpoint in yeast.


Pssm-ID: 149273  Cd Length: 205  Bit Score: 312.31  E-value: 2.96e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  115 YNQAVV-EPDKLNQYEPFSPEVYGETSYELVCQMIDQIDVTEDDIFIDLGSGVGQVVLQMAASTFCKISVGVEKAEVPSR 193
Cdd:pfam08123    1 YSRSVSpDANKLNHYKAFSNEVYGELLPEFLSDVLDKCNLGPQDVFVDLGSGVGNCVLQAALEFGCKLSFGCEIMDNASN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  194 YAQSMEINFRKWLNWYGKRCGEYRLVKGDFLADENRESI-TSATIVFVNNFAFGPTVDHQLKERFADLRDGARIVSSKSF 272
Cdd:pfam08123   81 LAELQDEEFKKRCKLFGKKLGKIEFIRGSFLDNERVEEIiPEADVILVNNFAFDPELNLQLKEMLQDLKDGCKIISLKSF 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1860490560  273 CPLNFRITDRNLSDIGTIMHVSEMTPLKGSVSWTGKPVSYYLHVI 317
Cdd:pfam08123  161 VPLNYRINFRNLSDIFNILKVEELKLPEGSVSWTSRGVEYYISTV 205
CC_DOT1L cd20902
coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; ...
 507-570 2.93e-17

coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; This family contains DOT1L (disruptor of telomeric-silencing 1-like), a non-SET domain histone lysine methyltransferase (HKMT) that catalyzes monomethylation, dimethylation, and trimethylation of nucleosomal H3K79. DOT1L is recruited to the homeobox A by AF10 (ALL1-Fused gene from chromosome 10 protein), one of the mixed-lineage leukemia 1 (MLL1)-fusion partners that function in acute myeloid leukemia (ALL). Aberration of the MLL gene is implicated in acute leukemia; chromosomal translocations of MLL1 generate oncogenic chimeric proteins, containing the non-catalytic N-terminal portion of MLL1 fused with many partners such as AF10. The aberrant recruitment of DOT1L by MLL fusions and the resulting H3K79 methylation are thought to affect gene expression by altering chromatin accessibility. AF10 and DOT1L interact through their coiled coil domains.


Pssm-ID: 411016 [Multi-domain]  Cd Length: 65  Bit Score: 76.96  E-value: 2.93e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1860490560  507 LQILLDLYRDQFMLMLEAIKTPAYKVSVNTDLAKERERNSKLQSRAAQLEKQIKVLIDDSVALL 570
Cdd:cd20902      2 LQKLLESFKIQYLQFLAYMKTPQYKASLQQQIEQEKEKNKQLTGKAQQLEKQIQALQKEGVRLL 65
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 537-690 1.13e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.85  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  537 DLAKERERNSKLQSRAAQLEKQIKVLIDDsVALLKARMTELGInasspcDLLAKAKEIVLRHKQLQAKASKLQAQVSSME 616
Cdd:COG1196    303 DIARLEERRRELEERLEELEEELAELEEE-LEELEEELEELEE------ELEEAEEELEEAEAELAEAEEALLEAEAELA 375

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1860490560  617 TEQSRLAALRHQELQEKFNAHGSTNNISNppQALTQEYILKEISATLSQRKKLHSQVSKLEHELNLLERATSEK 690
Cdd:COG1196    376 EAEEELEELAEELLEALRAAAELAAQLEE--LEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEA 447
Leu_zip pfam15294
Leucine zipper; This family includes Leucine zipper transcription factor-like protein 1 ...
 535-665 2.87e-03

Leucine zipper; This family includes Leucine zipper transcription factor-like protein 1 (LZTFL1) and Leucine zipper protein 2 (LUZP2).


Pssm-ID: 464620 [Multi-domain]  Cd Length: 276  Bit Score: 41.23  E-value: 2.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  535 NTDLAKERERNSKLQSRAAQLEKQIKVLIDDSVALLKA------RMTELGINASSP---CDLLAKAKEIVLRHKQLQAKA 605
Cdd:pfam15294  132 HMEIERLKEENEKLKERLKTLESQATQALDEKSKLEKAlkdlqkEQGAKKDVKSNLkeiSDLEEKMAALKSDLEKTLNAS 211

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1860490560  606 SKLQAQVssmeteQSRLAALRHQ-------------ELQEKFNAHGSTNNISnppQALTQ--EYIlKEISATLSQ 665
Cdd:pfam15294  212 TALQKSL------EEDLASTKHEllkvqeqlemaekELEKKFQQTAAYRNMK---EMLTKknEQI-KELRKRLSK 276
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 159-267 7.65e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 37.41  E-value: 7.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860490560  159 FIDLGSGVGQVVLQMAASTFCKIsVGVEKAEVPSRYAQSmeinfrkwlNWYGKRCGEYRLVKGDFLADENREsITSATIV 238
Cdd:cd02440      2 VLDLGCGTGALALALASGPGARV-TGVDISPVALELARK---------AAAALLADNVEVLKGDAEELPPEA-DESFDVI 70

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1860490560  239 FVNN-FAFGPTVDHQLKERFAD-LRDGARIV 267
Cdd:cd02440     71 ISDPpLHHLVEDLARFLEEARRlLKPGGVLV 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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