NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1848734806|ref|XP_034750690|]
View 

kelch-like protein 11 [Etheostoma cragini]

Protein Classification

kelch-like protein 11( domain architecture ID 13605368)

kelch-like protein 11 (KLHL11) is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation

Gene Symbol:  klhl11
Gene Ontology:  GO:0005515
PubMed:  23349464|23676014|17120193|15544948|10603472

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 40-180 3.95e-84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18241:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 135  Bit Score: 260.94  E-value: 3.95e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  40 FTSSSHCSELSRRQNEQRKQGLFCDVTLAFSSGAASgsvqscEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWS 119
Cdd:cd18241     1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGAGGR------EFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1848734806 120 SELGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNC 180
Cdd:cd18241    75 SEPGPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 175-262 5.17e-58

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


:

Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 190.56  E-value: 5.17e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                  ....*...
gi 1848734806 255 ERSRYFEE 262
Cdd:cd18451    81 ERERYFEE 88
PHA03098 super family cl33709
kelch-like protein; Provisional
 58-551 6.79e-37

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 145.30  E-value: 6.79e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  58 KQGLFCDVTLAFSSGaaSGSVQscefsAHRSVLAAATDYFTPLLGGQFSE---SLSGRVEMkewsselgpepdtVESVIQ 134
Cdd:PHA03098    5 ELQKFCDESIIIVNG--GGIIK-----VHKIILSSSSEYFKKMFKNNFKEneiNLNIDYDS-------------FNEVIK 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 135 YMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDD 214
Cdd:PHA03098   65 YIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDP 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 215 EFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSRYFEELFRLLRLPQIKPTYLTR------------VVK 282
Cdd:PHA03098  145 DFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKlkrwklrikkkkIVF 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 283 TEQLVSANEAC-------LRLVSEAVEGHAIRFENLKSTDM---------EFWSSHMASFQPRFGQNM--DVIMVVGGVS 344
Cdd:PHA03098  225 NKRCIKIIYSKkynlnkiLPRSSTFGSIIYIHITMSIFTYNyitnysplsEINTIIDIHYVYCFGSVVlnNVIYFIGGMN 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 345 EGGDYLSECVGYFIYEDRWVNLPHIHNHLDGHAIAATESHVYVAGSMEPGFA-KTVERYNPNRNTWEQVSNLTTRKHSFG 423
Cdd:PHA03098  305 KNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPC 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 424 LTCIKDILYSIGGHGNFSPGFKDVSIYEPEQDKWHNLESAPKILRDVKAVSvEDRYVYVTARTPVdTDNDDGLKTVtTRY 503
Cdd:PHA03098  385 VVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISY-IDNIKVYNIV-ESY 461

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 504 DTESRQWQDVDSLplidNYCIFQMAVASTN--FYHTASCCPKSYTERDEV 551
Cdd:PHA03098  462 NPVTNKWTELSSL----NFPRINASLCIFNnkIYVVGGDKYEYYINEIEV 507
Kelch smart00612
Kelch domain;
587-633 3.63e-05

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 3.63e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1848734806  587 VFIIGGWKNSddvdkQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 633
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
 
Name Accession Description Interval E-value
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-180 3.95e-84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 260.94  E-value: 3.95e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  40 FTSSSHCSELSRRQNEQRKQGLFCDVTLAFSSGAASgsvqscEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWS 119
Cdd:cd18241     1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGAGGR------EFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1848734806 120 SELGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNC 180
Cdd:cd18241    75 SEPGPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 175-262 5.17e-58

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 190.56  E-value: 5.17e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                  ....*...
gi 1848734806 255 ERSRYFEE 262
Cdd:cd18451    81 ERERYFEE 88
PHA03098 PHA03098
kelch-like protein; Provisional
 58-551 6.79e-37

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 145.30  E-value: 6.79e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  58 KQGLFCDVTLAFSSGaaSGSVQscefsAHRSVLAAATDYFTPLLGGQFSE---SLSGRVEMkewsselgpepdtVESVIQ 134
Cdd:PHA03098    5 ELQKFCDESIIIVNG--GGIIK-----VHKIILSSSSEYFKKMFKNNFKEneiNLNIDYDS-------------FNEVIK 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 135 YMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDD 214
Cdd:PHA03098   65 YIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDP 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 215 EFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSRYFEELFRLLRLPQIKPTYLTR------------VVK 282
Cdd:PHA03098  145 DFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKlkrwklrikkkkIVF 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 283 TEQLVSANEAC-------LRLVSEAVEGHAIRFENLKSTDM---------EFWSSHMASFQPRFGQNM--DVIMVVGGVS 344
Cdd:PHA03098  225 NKRCIKIIYSKkynlnkiLPRSSTFGSIIYIHITMSIFTYNyitnysplsEINTIIDIHYVYCFGSVVlnNVIYFIGGMN 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 345 EGGDYLSECVGYFIYEDRWVNLPHIHNHLDGHAIAATESHVYVAGSMEPGFA-KTVERYNPNRNTWEQVSNLTTRKHSFG 423
Cdd:PHA03098  305 KNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPC 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 424 LTCIKDILYSIGGHGNFSPGFKDVSIYEPEQDKWHNLESAPKILRDVKAVSvEDRYVYVTARTPVdTDNDDGLKTVtTRY 503
Cdd:PHA03098  385 VVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISY-IDNIKVYNIV-ESY 461

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 504 DTESRQWQDVDSLplidNYCIFQMAVASTN--FYHTASCCPKSYTERDEV 551
Cdd:PHA03098  462 NPVTNKWTELSSL----NFPRINASLCIFNnkIYVVGGDKYEYYINEIEV 507
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 180-282 1.40e-31

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 118.42  E-value: 1.40e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 180 CVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSRY 259
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 1848734806 260 FEELFRLLRLPQIKPTYLTRVVK 282
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 180-280 7.56e-28

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 107.81  E-value: 7.56e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  180 CVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSRY 259
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1848734806  260 FEELFRLLRLPQIKPTYLTRV 280
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 54-175 1.35e-23

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 95.79  E-value: 1.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEwsselgPEPDTVESVI 133
Cdd:pfam00651   2 NELREQGELCDVTLV---------VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD------VSPEDFEALL 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1848734806 134 QYMYTGEIrVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:pfam00651  67 EFMYTGKL-ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 64-175 2.40e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 77.73  E-value: 2.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806   64 DVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSselgpePDTVESVIQYMYTGEIRV 143
Cdd:smart00225   1 DVTLV---------VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVS------PEDFRALLNFLYTGKLDL 65

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1848734806  144 STCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:smart00225  66 PEENVEELLELADYLQIPGLVELCEEFLLKLL 97
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
335-633 1.66e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 71.34  E-value: 1.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 335 DVIMVVGGVSeGGDYLSECVGYFIYEDRWVNLPHIHNHLDGHAIAAT-ESHVYVAG-----SMEPGFAKTVERYNPNRNT 408
Cdd:COG3055    23 GKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGgftgaNPSSTPLNDVYVYDPATNT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 409 WEQVSNLTTRKHSFGLTCIKDILYSIGGHGNfSPGFKDVSIYEPEQDKWHNLESAPKILRDVKAVSVEDRYVYVtartpV 488
Cdd:COG3055   102 WTKLAPMPTPRGGATALLLDGKIYVVGGWDD-GGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDGKILV-----I 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 489 DTDNDDGlktvttrydtESRQWQDVDSLPlidnycifqmavastnfyhtasccpksyTERDEVAKLKISGRIsdeilesl 568
Cdd:COG3055   176 GGRNGSG----------FSNTWTTLAPLP----------------------------TARAGHAAAVLGGKI-------- 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1848734806 569 ppevtsiegaaichfdedvFIIGGwknsddvDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 633
Cdd:COG3055   210 -------------------LVFGG-------ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248
Kelch smart00612
Kelch domain;
587-633 3.63e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 3.63e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1848734806  587 VFIIGGWKNSddvdkQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 633
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
Kelch smart00612
Kelch domain;
384-425 9.42e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 40.23  E-value: 9.42e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1848734806  384 HVYVAGSMEPG-FAKTVERYNPNRNTWEQVSNLTTRKHSFGLT 425
Cdd:smart00612   1 KIYVVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 375-416 3.34e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 3.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1848734806 375 GHAIAATESHVYVA-GSMEPGFAKTVERYNPNRNTWEQVSNLT 416
Cdd:pfam01344   4 GAGVVVVGGKIYVIgGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 577-624 2.09e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 2.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1848734806 577 GAAICHFDEDVFIIGGWKNSDDVDKqyrkeAYRYCAERKRWMLLPPMP 624
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNS-----VEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-180 3.95e-84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 260.94  E-value: 3.95e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  40 FTSSSHCSELSRRQNEQRKQGLFCDVTLAFSSGAASgsvqscEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWS 119
Cdd:cd18241     1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGAGGR------EFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1848734806 120 SELGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNC 180
Cdd:cd18241    75 SEPGPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 175-262 5.17e-58

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 190.56  E-value: 5.17e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                  ....*...
gi 1848734806 255 ERSRYFEE 262
Cdd:cd18451    81 ERERYFEE 88
PHA03098 PHA03098
kelch-like protein; Provisional
 58-551 6.79e-37

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 145.30  E-value: 6.79e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  58 KQGLFCDVTLAFSSGaaSGSVQscefsAHRSVLAAATDYFTPLLGGQFSE---SLSGRVEMkewsselgpepdtVESVIQ 134
Cdd:PHA03098    5 ELQKFCDESIIIVNG--GGIIK-----VHKIILSSSSEYFKKMFKNNFKEneiNLNIDYDS-------------FNEVIK 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 135 YMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDD 214
Cdd:PHA03098   65 YIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDP 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 215 EFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSRYFEELFRLLRLPQIKPTYLTR------------VVK 282
Cdd:PHA03098  145 DFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKlkrwklrikkkkIVF 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 283 TEQLVSANEAC-------LRLVSEAVEGHAIRFENLKSTDM---------EFWSSHMASFQPRFGQNM--DVIMVVGGVS 344
Cdd:PHA03098  225 NKRCIKIIYSKkynlnkiLPRSSTFGSIIYIHITMSIFTYNyitnysplsEINTIIDIHYVYCFGSVVlnNVIYFIGGMN 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 345 EGGDYLSECVGYFIYEDRWVNLPHIHNHLDGHAIAATESHVYVAGSMEPGFA-KTVERYNPNRNTWEQVSNLTTRKHSFG 423
Cdd:PHA03098  305 KNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPC 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 424 LTCIKDILYSIGGHGNFSPGFKDVSIYEPEQDKWHNLESAPKILRDVKAVSvEDRYVYVTARTPVdTDNDDGLKTVtTRY 503
Cdd:PHA03098  385 VVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISY-IDNIKVYNIV-ESY 461

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 504 DTESRQWQDVDSLplidNYCIFQMAVASTN--FYHTASCCPKSYTERDEV 551
Cdd:PHA03098  462 NPVTNKWTELSSL----NFPRINASLCIFNnkIYVVGGDKYEYYINEIEV 507
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 180-282 1.40e-31

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 118.42  E-value: 1.40e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 180 CVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSRY 259
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 1848734806 260 FEELFRLLRLPQIKPTYLTRVVK 282
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 180-280 7.56e-28

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 107.81  E-value: 7.56e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  180 CVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSRY 259
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1848734806  260 FEELFRLLRLPQIKPTYLTRV 280
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-181 8.62e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 102.95  E-value: 8.62e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  43 SSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEwssel 122
Cdd:cd18237     2 AKLLADFMGVMNNMRKQKTLCDVILI---------VEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKD----- 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1848734806 123 gPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18237    68 -AEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 175-304 8.91e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 97.47  E-value: 8.91e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18452     1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 255 ERSRYFEELFRLLRLPQIKPTYLTRVVKTEQLVSANEACLRLVSEAVEGH 304
Cdd:cd18452    81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFH 130
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 54-175 1.35e-23

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 95.79  E-value: 1.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEwsselgPEPDTVESVI 133
Cdd:pfam00651   2 NELREQGELCDVTLV---------VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD------VSPEDFEALL 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1848734806 134 QYMYTGEIrVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:pfam00651  67 EFMYTGKL-ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-180 4.45e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 94.82  E-value: 4.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  42 SSSHCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSse 121
Cdd:cd18242     1 TNSHAKSILNTMNSLRKSNTLCDVTL---------RVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLT-- 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1848734806 122 lgpePDTVESVIQYMYTGEIRVSTCNVHEVLELAdrfLLLQL---KDFCGEFLKKKLSLTNC 180
Cdd:cd18242    70 ----ASTMEILLDFVYTETVHVTVENVQELLPAA---CLLQLkgvKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-180 1.56e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 93.16  E-value: 1.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESlsgrvemKEWSSEL-GPEPDTVESV 132
Cdd:cd18240     9 NELRLEGKLCDVVI---------RVNGVEFPAHRNILCACSPYFRALFTNGWNET-------EKKVYKIpGVSPEMMELI 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1848734806 133 IQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNC 180
Cdd:cd18240    73 IEYAYTRTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-174 2.82e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 92.34  E-value: 2.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKewsselGPEPDTVESVI 133
Cdd:cd18247    11 EEIRRQGKLCDVTL---------KVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQ------GIEPSALEALI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1848734806 134 QYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKK 174
Cdd:cd18247    76 NFAYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-181 6.91e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 91.70  E-value: 6.91e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMkewsseLGP 124
Cdd:cd18256     3 HASLILAQLNKLRGQHEFCDVQL---------QVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQI------HGV 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1848734806 125 EPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18256    68 EPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-158 9.31e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 89.54  E-value: 9.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  62 FCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSselgpePDTVESVIQYMYTGEI 141
Cdd:cd18186     1 LCDVTL---------VVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVS------PEAFEALLDYIYTGEL 65

                          90
                  ....*....|....*..
gi 1848734806 142 RVSTCNVHEVLELADRF 158
Cdd:cd18186    66 ELSEENVEELLAAADKL 82
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-183 1.39e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 85.00  E-value: 1.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLlggqFSESLSGRVEMKewsSEL-GPEPDTVESV 132
Cdd:cd18306    10 NALRKNRQFCDVIL---------QVGGHEIPAHRAVLACASPYLFEL----FSSDSDGESILT---VKLdGLDPDAVEVL 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1848734806 133 IQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18306    74 VNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-180 2.50e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 84.05  E-value: 2.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  44 SHCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSselg 123
Cdd:cd18250     3 AHALHLLRGLSELRAERKFFDVTL---------CAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVS---- 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1848734806 124 pePDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNC 180
Cdd:cd18250    70 --AEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 178-281 2.68e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 83.51  E-value: 2.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 178 TNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERS 257
Cdd:cd18457     4 NNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENRE 83

                          90       100
                  ....*....|....*....|....
gi 1848734806 258 RYFEELFRLLRLPQIKPTYLTRVV 281
Cdd:cd18457    84 EYLPELLSKVRLPLLRPQFLTDRV 107
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-183 2.93e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 84.49  E-value: 2.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  35 EEAEDftsSSHCSELSRRQNEQRKQGLFCDVTLAFSSGAASGSVQSCeFSAHRSVLAAATDYFTPLLGGQFSESLSGRVE 114
Cdd:cd18273     2 EELED---AAHARALLAQLKSFYDARLLTDVTIEVNGPGSGPGSGRL-FPCNRNVLAAASPYFKSMFTGGLYESKQETVT 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1848734806 115 MKewsselGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18273    78 IH------DVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-175 3.34e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 83.63  E-value: 3.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEwsselgPEPDTVESVI 133
Cdd:cd18235    13 NELRKQNLLCDVIL---------VADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQD------VDGKALLLLI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1848734806 134 QYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:cd18235    78 DYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQL 119
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 175-304 1.44e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 82.42  E-value: 1.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18513     1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 255 ERSRYFEELFRLLRLPQIKPTYLTRVVKTEQLVSANEACLRLVSEAVEGH 304
Cdd:cd18513    81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 175-304 3.33e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 81.23  E-value: 3.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18512     1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 255 ERSRYFEELFRLLRLPQIKPTYLTRVVKTEQLVSANEACLRLVSEAVEGH 304
Cdd:cd18512    81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-180 3.70e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 80.65  E-value: 3.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKewsselGP 124
Cdd:cd18253     1 HSESILQVFNEFRDSRLFTDVII---------CVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEIN------GI 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1848734806 125 EPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNC 180
Cdd:cd18253    66 LAEAMDCFLQYVYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-182 4.59e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 80.59  E-value: 4.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  43 SSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSEl 122
Cdd:cd18265     4 PCHAERILQVLNAYRRSGTFTDVVLL---------VDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAA- 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 123 gpepdTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVA 182
Cdd:cd18265    74 -----AMEVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-181 6.94e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 80.64  E-value: 6.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  39 DFTSSSHCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEw 118
Cdd:cd18259     9 DFCLPSHPQSILDGLQTLRSNPKLSDVTL---------LVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKD- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1848734806 119 sselgPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18259    79 -----VDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-175 7.52e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 80.12  E-value: 7.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKE---Wsse 121
Cdd:cd18338     4 HMKKAFKVMNELRSQNLLCDVTIV---------AEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEvdgW--- 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1848734806 122 lgpepdTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:cd18338    72 ------TLKMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 178-288 1.21e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 79.20  E-value: 1.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 178 TNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERS 257
Cdd:cd18445     4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRK 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1848734806 258 RYFEELFRLLRLPQIKPTYLTRVVKTEQLVS 288
Cdd:cd18445    84 EHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-183 1.23e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 79.44  E-value: 1.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  47 SELSRRQNEQRKQGLFCDVTLAFSSgaasgsvqsCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKewsselGPEP 126
Cdd:cd18268     8 SELLRQLNSLRQERILTDVILCTGD---------KEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLK------GIDS 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1848734806 127 DTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18268    73 DVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 64-175 2.40e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 77.73  E-value: 2.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806   64 DVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSselgpePDTVESVIQYMYTGEIRV 143
Cdd:smart00225   1 DVTLV---------VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVS------PEDFRALLNFLYTGKLDL 65

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1848734806  144 STCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:smart00225  66 PEENVEELLELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-175 6.98e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 77.07  E-value: 6.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  44 SHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSElg 123
Cdd:cd18339     3 AHMKKAFKVMNELRSKQLLCDVTIV---------AEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ-- 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1848734806 124 pepdTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:cd18339    72 ----TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-172 7.09e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 76.61  E-value: 7.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  49 LSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESlSGRVEMKEwssELGPEPDT 128
Cdd:cd18245     1 LLRALNSFREEPHLCDATLV---------VGGEEIPVQKNVLAAASPYFRAKLNYNPPKD-DGSTYKIE---LEGISVEV 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1848734806 129 VESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLK 172
Cdd:cd18245    68 MEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-182 1.04e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 76.56  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWsselgpEPDTVESVI 133
Cdd:cd18238     7 HQFYENGELCDVTL---------KVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDI------DEEAVELLV 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1848734806 134 QYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVA 182
Cdd:cd18238    72 DFAYTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 175-270 1.82e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 75.04  E-value: 1.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPF-HLVRdWLSDAEITVDSEEVLFEAVVKWVQKNP 253
Cdd:cd18448     2 LHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAqHLEK-LISSSDLNVESESQVYEAVMKWVKHDP 80

                          90
                  ....*....|....*..
gi 1848734806 254 EERSRYFEELFRLLRLP 270
Cdd:cd18448    81 QHRKRHLDDLLSQVRLP 97
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-171 1.87e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 76.14  E-value: 1.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  40 FTSSSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSgrVEMKEWS 119
Cdd:cd18278     9 YESTVHCTNILLCLNDQRKQDILCDVTLI---------VEGKEFRAHRAVLAACSEYFLQALVGQTENDLV--VSLPEEV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1848734806 120 SELGPEPdtvesVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFL 171
Cdd:cd18278    78 TARGFGP-----LLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-181 5.91e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 73.94  E-value: 5.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  63 CDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKewsselGPEPDTVESVIQYMYTGEIR 142
Cdd:cd18234     2 CDVIL---------IAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLK------DVDPDALWTLVQYCYTGRLE 66

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1848734806 143 VSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18234    67 LKEDNVESLLATACLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-187 1.18e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 74.16  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMkewsseLGP 124
Cdd:cd18266     8 HSNLVLQGLNEQRQRGLFCDVVLV---------ADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVEL------VGA 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1848734806 125 EPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAVHSLA 187
Cdd:cd18266    73 SYIGLKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-183 3.44e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 72.68  E-value: 3.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  34 AEEAEDFTSSSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRV 113
Cdd:cd18244     2 AGDVEVYNSSIHDTSVSAGFRALYEEGLLLDVTLV---------IEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKI 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 114 EMKewsselGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18244    73 HLK------GLTATGFSHVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-183 3.46e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 73.10  E-value: 3.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  40 FTSSSHCSELSRRQNEQRKQGLFCDVTLafSSGAASgsvqsceFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEws 119
Cdd:cd18267    18 FHKSSYADSVLTHLNLLRQQRLFTDVLL--HAGNRS-------FPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHD-- 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1848734806 120 selGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18267    87 ---SIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-172 6.35e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 71.80  E-value: 6.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSELG- 123
Cdd:cd18327     8 HSSELLSCLNEQRRAGLLCDLTI---------KTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAGGGQDVCELDf 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 124 PEPDTVESVIQYMYTGEIRVSTCNVHEVLElADRFLLLQ-LKDFCGEFLK 172
Cdd:cd18327    79 VGPEALGALLEFAYTATLTISSSNMREVLR-AARLLEIPcVADACADILQ 127
PHA02713 PHA02713
hypothetical protein; Provisional
 61-516 7.72e-15

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 77.74  E-value: 7.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  61 LFCDVTLAFSSGAasgsvqscEFSAHRSVLAAATDYF-----TPLLggqfSESLSGRVEMKEWsselgpEPDTVESVIQY 135
Cdd:PHA02713   24 ILCDVIITIGDGE--------EIKAHKTILAAGSKYFrtlftTPMI----IRDLVTRVNLQMF------DKDAVKNIVQY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 136 MYTGEIrvSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAV-HSLAHMYTLdQLALRAADMIRRNFHKVIQDD 214
Cdd:PHA02713   86 LYNRHI--SSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMyHRLYEMSHI-PIVKYIKRMLMSNIPTLITTD 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 215 EFYTLPFHLVRDWLSdaeiTVDSEEVLFEA-----VVKWVQKNpeersrYFEELFRLLRLPQIKPTYLTRvvKTEQLVSA 289
Cdd:PHA02713  163 AFKKTVFEILFDIIS----TNDNVYLYREGykvtiLLKWLEYN------YITEEQLLCILSCIDIQNLDK--KSRLLLYS 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 290 NEAClrlvseaveghairfeNLKSTDMEFWSSHMasfqprfgQNMDVI-MVVGGVSEGGDY--LSECV-GYFIYEDRWVN 365
Cdd:PHA02713  231 NKTI----------------NMYPSCIQFLLDNK--------QNRNIIpRQLCLVCHDTKYnvCNPCIlVYNINTMEYSV 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 366 LPHIHNHLDGHAIAATESHVYVAGSM---EPGFAKtVERYNPNRNTWEQVSNLTTRKHSFGLTCIKDILYSIGGHgNFSP 442
Cdd:PHA02713  287 ISTIPNHIINYASAIVDNEIIIAGGYnfnNPSLNK-VYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQ-NGTN 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 443 GFKDVSIYEPEQDKWHNLESAPKILRDVkAVSVEDRYVY-------------VTARTPVDTDNDDGLKTVTTRYDTESRQ 509
Cdd:PHA02713  365 VERTIECYTMGDDKWKMLPDMPIALSSY-GMCVLDQYIYiiggrtehidytsVHHMNSIDMEEDTHSSNKVIRYDTVNNI 443


                  ....*..
gi 1848734806 510 WQDVDSL 516
Cdd:PHA02713  444 WETLPNF 450
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-175 8.27e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 71.43  E-value: 8.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  44 SHCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSEL- 122
Cdd:cd18228     1 SHSQELLGKLNSLRNEGHFCDVTI---------RVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSPAGKCVLDLh 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1848734806 123 -----GPEPdtvesVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:cd18228    72 hvtvtGFAP-----LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 180-277 8.44e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 70.82  E-value: 8.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 180 CVAVHSLAHMYTLDqlalraadmirrNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSRY 259
Cdd:cd18444    19 CTDLLKVAHNYTME------------HFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERKKH 86

                          90
                  ....*....|....*...
gi 1848734806 260 FEELFRLLRLPQIKPTYL 277
Cdd:cd18444    87 LAKLLALIRLPLLTPQFL 104
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-180 9.41e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 71.37  E-value: 9.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  40 FTSSSHCSELSRRQNEQRKQGLFCDVTLAFSSGAASgsvqsceFSAHRSVLAAATDYFTPLLGGQFSESlsgrvEMKEWS 119
Cdd:cd18239     1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDET-------FPVHRAMMASASDYFKAMFTGGMKEQ-----ELMCIK 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1848734806 120 SElGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNC 180
Cdd:cd18239    69 LH-GVSKIGLKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-180 1.19e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 70.89  E-value: 1.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaASGSVqsceFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSElgp 124
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLI-----ADGQR----FQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAK--- 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1848734806 125 epdTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNC 180
Cdd:cd18255    69 ---GLKHILDFAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-175 1.44e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 70.49  E-value: 1.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  43 SSHCSELSRRQNEQRKQGLFCDVTLAFSSGAasgsvQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKewssel 122
Cdd:cd18248     2 EDHTKEAFQIMNELRLSQQLCDVTLKVKYQD-----PKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIE------ 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1848734806 123 GPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:cd18248    71 GVHPCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-183 1.58e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 71.02  E-value: 1.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  78 VQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEwsselgPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADR 157
Cdd:cd18340    34 IKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLED------VDPDVMGKILHYIYTSEIEITEQNVQDIFAAANM 107

                          90       100
                  ....*....|....*....|....*.
gi 1848734806 158 FLLLQLKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18340   108 FQIPSIFTVCVSFLQKRLCLSNCLAI 133
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-183 2.36e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 70.13  E-value: 2.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  82 EFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEwsselgPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLL 161
Cdd:cd18269    38 EFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLED------VDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIP 111

                          90       100
                  ....*....|....*....|..
gi 1848734806 162 QLKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18269   112 SIFTVCVSYLQKRLSLSNCLAI 133
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 176-252 6.34e-14

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 67.05  E-value: 6.34e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1848734806 176 SLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKN 252
Cdd:cd18508     1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-181 8.82e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 68.31  E-value: 8.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  43 SSHCSELSRRQNEQRKQGLFCDVTLAFSSGAAsgsvqsceFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKewssel 122
Cdd:cd18252     2 SSHPADFLDAFRTFYLDGLFTDITLQCASGQI--------FHCHKAALAACSSYFKVMFTADMKEKSNNVIKLS------ 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1848734806 123 GPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18252    68 GIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-171 1.10e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 68.03  E-value: 1.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSElgp 124
Cdd:cd18287     5 HVHFLSEDIGALFLNEEYSDVTFV---------VEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAE--- 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 125 epdTVESVIQYMYTGEIRVSTC---NVHEVLELADRFLLLQLKDFCGEFL 171
Cdd:cd18287    73 ---AFKALLKYIYTGRLTLTDLkedVLLDVLGLAHQYGFEELEAAISDYL 119
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 175-253 1.21e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 66.48  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQD-DEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNP 253
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHDP 80
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
335-633 1.66e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 71.34  E-value: 1.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 335 DVIMVVGGVSeGGDYLSECVGYFIYEDRWVNLPHIHNHLDGHAIAAT-ESHVYVAG-----SMEPGFAKTVERYNPNRNT 408
Cdd:COG3055    23 GKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGgftgaNPSSTPLNDVYVYDPATNT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 409 WEQVSNLTTRKHSFGLTCIKDILYSIGGHGNfSPGFKDVSIYEPEQDKWHNLESAPKILRDVKAVSVEDRYVYVtartpV 488
Cdd:COG3055   102 WTKLAPMPTPRGGATALLLDGKIYVVGGWDD-GGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDGKILV-----I 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 489 DTDNDDGlktvttrydtESRQWQDVDSLPlidnycifqmavastnfyhtasccpksyTERDEVAKLKISGRIsdeilesl 568
Cdd:COG3055   176 GGRNGSG----------FSNTWTTLAPLP----------------------------TARAGHAAAVLGGKI-------- 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1848734806 569 ppevtsiegaaichfdedvFIIGGwknsddvDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 633
Cdd:COG3055   210 -------------------LVFGG-------ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 179-277 1.81e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 66.67  E-value: 1.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 179 NCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSR 258
Cdd:cd18468     4 NCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRKQ 83

                          90
                  ....*....|....*....
gi 1848734806 259 YFEELFRLLRLPQIKPTYL 277
Cdd:cd18468    84 HIAELLAVVRLPFIHPSYL 102
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 175-274 2.12e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 66.30  E-value: 2.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEItVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18476     1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                          90       100
                  ....*....|....*....|
gi 1848734806 255 ERSRYFEELFRLLRLPQIKP 274
Cdd:cd18476    80 ARKGYIHDLFKKVRLQYVHP 99
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-181 2.52e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 67.18  E-value: 2.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  78 VQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKewsselGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADR 157
Cdd:cd18236    31 VDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIK------GVDAETMQILLDYTYTSKVLITKQNVQRVLEAASL 104

                          90       100
                  ....*....|....*....|....
gi 1848734806 158 FLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18236   105 FQFLRMVDACASFLTEALHPENCV 128
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-181 3.03e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 66.96  E-value: 3.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  44 SHCSELSRRQNEQRKQGLFCDVTLAfsSGAASgsvqsceFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEwsselG 123
Cdd:cd18254     4 SHPDCVLTHLNTLRKQCMFTDVTLW--AGNRS-------FPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHD-----S 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1848734806 124 PEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18254    70 LHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 175-268 3.48e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 65.95  E-value: 3.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18517     1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                          90
                  ....*....|....
gi 1848734806 255 ERSRYFEELFRLLR 268
Cdd:cd18517    81 NRVKSLGEIFDCIR 94
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 175-269 3.91e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 65.55  E-value: 3.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTL-PFHLVRDWLSDAeITVDSEEVLFEAVVKWVQKNP 253
Cdd:cd18516     1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLsPDELIAIISSDS-LNVEKEEDVFEAVMKWVGKDQ 79

                          90
                  ....*....|....*.
gi 1848734806 254 EERSRYFEELFRLLRL 269
Cdd:cd18516    80 EERTKALPVLLESIRF 95
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 175-256 3.97e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 65.04  E-value: 3.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18480     1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                  ..
gi 1848734806 255 ER 256
Cdd:cd18480    81 AR 82
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-171 4.83e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 66.24  E-value: 4.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  40 FTSSSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSgrVEMKEWS 119
Cdd:cd18277     5 YESSVHSTNVLLSLNDQRKKDVLCDVTIL---------VEGQRFRAHRSVLAACSSYFHSRIVGQADAELN--ITLPEEV 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1848734806 120 SELGPEPdtvesVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFL 171
Cdd:cd18277    74 TVKGFEP-----LIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-180 1.29e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 65.59  E-value: 1.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  42 SSSHCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSe 121
Cdd:cd18264     8 SKSHGEAVLSQYQSLRAEGFLCDVVL---------EAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSA- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1848734806 122 LGpepdtVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNC 180
Cdd:cd18264    78 AG-----LQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 179-282 1.56e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 64.41  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 179 NCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSR 258
Cdd:cd18446     5 NCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERLP 84

                          90       100
                  ....*....|....*....|....
gi 1848734806 259 YFEELFRLLRLPQIKPTYLTRVVK 282
Cdd:cd18446    85 LLPRVLENVRLPLLDPWYFVETVE 108
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-181 1.57e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 64.78  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  40 FTSSSHCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWs 119
Cdd:cd18249     1 YTSDKHPRQTLEAINLLRKHRELCDVVL---------VVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDI- 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1848734806 120 selgpEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18249    71 -----DERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 175-270 1.74e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 63.81  E-value: 1.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                          90
                  ....*....|....*.
gi 1848734806 255 ERSRYFEELFRLLRLP 270
Cdd:cd18467    81 ERQKYLAQLLHCVRLP 96
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 82-167 3.33e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 63.13  E-value: 3.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  82 EFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWsselgpEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLL 161
Cdd:cd18314    17 KFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDV------EPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVP 90


                  ....*.
gi 1848734806 162 QLKDFC 167
Cdd:cd18314    91 DLEKLC 96
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-179 4.35e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 63.83  E-value: 4.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  42 SSSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSe 121
Cdd:cd18261     8 SKSHKDAVLAALNQQRNDGILCDITLV---------AEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTS- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1848734806 122 LGpepdtVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTN 179
Cdd:cd18261    78 LG-----LKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 175-273 5.13e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 62.51  E-value: 5.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90
                  ....*....|....*....
gi 1848734806 255 ERSRYFEELFRLLRLPQIK 273
Cdd:cd18460    81 HRQHFWPELLQHVRLPFVR 99
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-171 5.32e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 63.03  E-value: 5.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLggqfsesLSGRVEMKEWSSELG- 123
Cdd:cd18326     8 HSSDILSSLNEQRTQGLLCDVVIL---------VEGREFPTHRSVLAACSQYFKKLF-------TSGAVVDQQNVYEIDf 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1848734806 124 PEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFL 171
Cdd:cd18326    72 VSAEALTALLDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-172 8.15e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 62.58  E-value: 8.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLggqfsesLSGRVEMKEWSSELG- 123
Cdd:cd18198     8 HSSEILSGLNEQRTQGLLCDVVIL---------VQGREYRTHRSVLAACSQYFKKLF-------TSGAVVDQQNVYEIDf 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 124 PEPDTVESVIQYMYTGEIRVSTCNVHEVLELAdRFLLLQ-LKDFCGEFLK 172
Cdd:cd18198    72 VSPEALTALLEFAYTATLTVSTANVGDILSAA-RLLEIPcVSHVCAEILD 120
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-183 9.77e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 62.76  E-value: 9.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  44 SHCSELSRRQNEQRKQGLFCDVTLAfssgaaSGSVQsceFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKewsselG 123
Cdd:cd18336     1 NHAEQTFRKMENYLQHKQLCDVLLI------AGNLK---IPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKME------G 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 124 PEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18336    66 VDPDALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 178-263 1.33e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 61.16  E-value: 1.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 178 TNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTL-PFHLVrDWLSDAEITVDSEEVLFEAVVKWVQKNPEER 256
Cdd:cd18458     5 SNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLsPCQLV-ALISRDELNVRCESEVYNAVIRWVKYDEENR 83


                  ....*..
gi 1848734806 257 SRYFEEL 263
Cdd:cd18458    84 RQYLEAL 90
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 83-183 1.42e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 62.17  E-value: 1.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  83 FSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEwsselgPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQ 162
Cdd:cd18341    39 LPCHRLILAACSPYFREYFLSEESEEKKKEVVLDN------VDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPS 112

                          90       100
                  ....*....|....*....|.
gi 1848734806 163 LKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18341   113 VFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-173 1.48e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 62.29  E-value: 1.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  43 SSHCSELSRRQNEQRKQG-LFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGR-VEMKEWSS 120
Cdd:cd18207     7 SQHSADMLHNLNQQRKSGgRFCDVLL---------RVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPReLEMHTISS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1848734806 121 ELgpepdtVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKK 173
Cdd:cd18207    78 KV------FGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQ 124
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 176-263 1.63e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 61.18  E-value: 1.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 176 SLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEE 255
Cdd:cd18455     1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80


                  ....*...
gi 1848734806 256 RSRYFEEL 263
Cdd:cd18455    81 RKVHLKDL 88
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-170 1.76e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 60.97  E-value: 1.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  62 FCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGG---QFSESLSGRVEMKEWSselgpePDTVESVIQYMYT 138
Cdd:cd18307     1 FCDVVI---------SVDNHSFAAHRNVLAAVSPFVKSLISSndmKATDELSITIDCDYLS------PETVEQLLDYFYT 65

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1848734806 139 GEIRVSTCNVHEVLELADRFLLLQLKDFCGEF 170
Cdd:cd18307    66 GKIVISEKNVEDLLKGAKYFNIPRLKDHCVDF 97
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 83-183 2.49e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 61.54  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  83 FSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMkewsseLGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQ 162
Cdd:cd18274    35 FSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI------VGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQIPS 108

                          90       100
                  ....*....|....*....|.
gi 1848734806 163 LKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18274   109 LQDQCAQFMISRLDPQNSIGV 129
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 175-268 2.52e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 60.63  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                          90
                  ....*....|....
gi 1848734806 255 ERSRYFEELFRLLR 268
Cdd:cd18477    81 NRQKALPTVFESIR 94
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 180-277 2.94e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 60.46  E-value: 2.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 180 CVAVHSLAHMYTLDqlalraadmirrNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSRY 259
Cdd:cd18511    19 CTDLHKVAHNYTME------------HFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVEQRRKD 86

                          90
                  ....*....|....*...
gi 1848734806 260 FEELFRLLRLPQIKPTYL 277
Cdd:cd18511    87 LSKLLAYIRLPLLAPQFL 104
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 179-269 3.36e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 60.07  E-value: 3.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 179 NCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSR 258
Cdd:cd18479     5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQ 84

                          90
                  ....*....|.
gi 1848734806 259 YFEELFRLLRL 269
Cdd:cd18479    85 YLSSVLSQIRI 95
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 175-253 3.42e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 59.44  E-value: 3.42e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNP 253
Cdd:cd18474     1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 178-276 3.81e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 60.15  E-value: 3.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 178 TNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERS 257
Cdd:cd18469     6 TNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQARA 85

                          90
                  ....*....|....*....
gi 1848734806 258 RYFEELFRLLRLPQIKPTY 276
Cdd:cd18469    86 AHLPELLSLVHLSLLTDQY 104
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-156 4.11e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 60.54  E-value: 4.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFtpllgGQFSESLSGRVEMkewsseLGP 124
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTI---------VIGQFQFKAHRNVLAAFSEYF-----GAQYKDTEDNIVF------LDQ 60

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1848734806 125 E---PDTVESVIQYMYTGEIRVSTCNVHEVLELAD 156
Cdd:cd18217    61 SqvsADGFQKLLEFIYTGNLNLDSWNVAEIHQAAS 95
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
335-450 4.47e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 64.02  E-value: 4.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 335 DVIMVVGGVSEGGdylsecvgyfiYEDRWVNLPHIHNHLDGHAIAATESHVYVAGSmEPGFAKTVERYNPNRNTWEQVSN 414
Cdd:COG3055   170 GKILVIGGRNGSG-----------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGG-ESGFSDEVEAYDPATNTWTALGE 237

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1848734806 415 LTTRKHSFGLTCIKDILYSIGGH---GNFSPGFKDVSIY 450
Cdd:COG3055   238 LPTPRHGHAAVLTDGKVYVIGGEtkpGVRTPLVTSAEVY 276
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 179-251 5.32e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 58.94  E-value: 5.32e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1848734806 179 NCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQK 251
Cdd:cd18463     6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-175 5.92e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 60.25  E-value: 5.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKewsselGP 124
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVL---------RVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQ------CI 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1848734806 125 EPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:cd18257    66 DETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQL 116
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-171 6.74e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 59.84  E-value: 6.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  42 SSSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSe 121
Cdd:cd18329     1 ISSHQSRLLQQLDEQRKQELFCDCSIL---------VEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFS- 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1848734806 122 lgpePDTVESVIQYMYTGEIRVSTCNVHEVLELADrflLLQLKD---FCGEFL 171
Cdd:cd18329    71 ----PDTFTIILDFVYSGKLSLTSQNVIEVMSAAS---YLQMTDvisVCKTFI 116
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-169 7.62e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 59.80  E-value: 7.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  48 ELSRRQNEqrkqGLFCDVTLAfssgAASGSVqscefSAHRSVLAAATDYFTPLLGGQFSESLSGRV-EMKEWSSElgpep 126
Cdd:cd18293     5 QLHRQQNS----GVFCDVLLQ----AEGESV-----PAHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAH----- 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1848734806 127 dTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGE 169
Cdd:cd18293    67 -TLLKLVDFLYTSELEVSSEEAQDVLAAARRLQISELESLCLE 108
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 62-158 7.82e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 58.72  E-value: 7.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  62 FCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSgRVEMKEWSSElgpepdTVESVIQYMYTGEI 141
Cdd:cd18315     1 LVDVTLA---------CEGGSLKAHKLVLAAASPYFAALLKETPPDEHP-VIILPDVPYS------ELKALLDFIYTGEV 64

                          90
                  ....*....|....*..
gi 1848734806 142 RVSTCNVHEVLELADRF 158
Cdd:cd18315    65 NVSQEQLESLLKLAELL 81
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 175-249 8.04e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 58.17  E-value: 8.04e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWV 249
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-175 8.63e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 60.43  E-value: 8.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWsselgpEPDTVESVI 133
Cdd:cd18246    31 NRMRQRGLLCDIVL---------HVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDI------DPQALEQLV 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1848734806 134 QYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:cd18246    96 QYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 137
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-181 9.04e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 59.99  E-value: 9.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  48 ELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRvEMKEWSSELgpEPD 127
Cdd:cd18258     3 EMLKELNQQRRAKEFTDLKII---------VEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGE-KLELTMSNI--NAD 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1848734806 128 TVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18258    71 VLELLLEFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-155 1.11e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 59.51  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  44 SHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGgqfSESLSGRVEMKEWSSelg 123
Cdd:cd18328     7 NHSSEVLCSLNEQRHDGLLCDVVLI---------VQDQEYRTHRSVLAACSKYFKKLFT---AGTLADQPYVYEIDF--- 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1848734806 124 PEPDTVESVIQYMYTGEIRVSTCNVHEVLELA 155
Cdd:cd18328    72 VTPEALSAILEFAYTSTLTITTSNVKHILNAA 103
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 174-270 1.19e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 58.59  E-value: 1.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 174 KLSLTNCVAVHSLAHMYTLDQLaLRAAD-MIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKN 252
Cdd:cd18459     1 QLDPSNCLGIRAFADTHACREL-LRIADkFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYN 79

                          90
                  ....*....|....*...
gi 1848734806 253 PEERSRYFEELFRLLRLP 270
Cdd:cd18459    80 IQERRPHLPQVLQHVRLP 97
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-171 1.21e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 58.80  E-value: 1.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  61 LFCDVTLAFssgaasGSVQScEFSAHRSVLAAATDYFTPLLGGQF-SESLSGRVEMKEwsselgPEPDTVESVIQYMYTG 139
Cdd:cd18294    13 EFSDVKFLV------GPERQ-EIFAHKCILAARCEVFRAMFLTGPqKESTQSPLVLSD------IEPEVFRAVLEFIYTN 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1848734806 140 EIRVSTCNVHEVLELADRFLLLQLKDFCGEFL 171
Cdd:cd18294    80 CVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-181 1.63e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 59.25  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  58 KQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEwsselgPEPDTVESVIQYMY 137
Cdd:cd18270    22 EQQLLTDIVLI---------VEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRN------VDAATLQIIITYAY 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1848734806 138 TGEIRVSTCNVHEVLELAdrfLLLQLKDF---CGEFLKKKLSLTNCV 181
Cdd:cd18270    87 TGNLAINDSTVEQLYETA---CFLQVEDVlqrCREYLIKKINAENCV 130
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-166 1.66e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 58.89  E-value: 1.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLlggqFSESLSGRVEMKEwsselGPEPDTVESVI 133
Cdd:cd18290    19 NEQRLQGLYCDVSVV---------VKGHAFKAHRAVLAASSSYFRDL----FNSSRSAVVELPA-----AVQPQSFQQIL 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1848734806 134 QYMYTGeiRVStcnvhevLELADRFLLLQLKDF 166
Cdd:cd18290    81 SFCYTG--RLS-------MNVGDQFLLMYTAGF 104
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 78-175 1.90e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 58.85  E-value: 1.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  78 VQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWS-SELgpEPDTVESVIQYMYTGEIRVSTCNVHEVLELAD 156
Cdd:cd18296    24 VEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENNGSIPVVTlHDV--SPEVFAIVLYYIYTDDTDLPPENAYDVLYVAD 101

                          90
                  ....*....|....*....
gi 1848734806 157 RFLLLQLKDFCGEFLKKKL 175
Cdd:cd18296   102 MYLLPGLKRLCGTVLAQSL 120
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-104 2.04e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 58.75  E-value: 2.04e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQ 104
Cdd:cd18195     1 HAGALLLQLNEQRLRGLFCDVTLI---------AGDTKFRAHRSVLAASSPYFRELLSSP 51
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 179-270 3.98e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 57.18  E-value: 3.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 179 NCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFytlpFHLVRDWL-----SDaEITVDSEEVLFEAVVKWVQKNP 253
Cdd:cd18483     5 NSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEF----LHLTKDQLisilnSD-DLNVEKEEHVYESIIHWFEHEQ 79

                          90
                  ....*....|....*...
gi 1848734806 254 EERSRYFEELF-RLLRLP 270
Cdd:cd18483    80 SKREMHLPEIFaKCIRMP 97
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-170 6.19e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 56.91  E-value: 6.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  59 QGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLL-GGQFSESLSGRVEMKEwsselgpEPDTV---ESVIQ 134
Cdd:cd18292    14 NEELSDIVL---------RVGGKVFHAHRLILAKSSDVFRVMLsNDWWSESKQSEIELVE-------DPECAavfEKFLR 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1848734806 135 YMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEF 170
Cdd:cd18292    78 YLYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 180-277 9.30e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 56.18  E-value: 9.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 180 CVAVHSLAHMYTLDqlalraadmirrNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSRY 259
Cdd:cd18509    19 CIELMKVAHSYTME------------NIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSD 86

                          90
                  ....*....|....*...
gi 1848734806 260 FEELFRLLRLPQIKPTYL 277
Cdd:cd18509    87 LSMLLAYIRLPLLPPQLL 104
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 176-230 1.09e-09

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 54.59  E-value: 1.09e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1848734806 176 SLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSD 230
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 174-277 1.15e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 56.08  E-value: 1.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 174 KLSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNP 253
Cdd:cd18510     1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                          90       100
                  ....*....|....*....|....
gi 1848734806 254 EERSRYFEELFRLLRLPQIKPTYL 277
Cdd:cd18510    81 QNRQKDLGMLLSYIRLPLLPPQLL 104
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-176 1.77e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 56.12  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  43 SSHCSELSRRQNEQRKQGLFCDVTLafssgAASGSVqsceFSAHRSVLAAATDYFTPLLGGQFSESlsgrvemkewssel 122
Cdd:cd18201     2 NSYCYQLLQELNEQRKKGILCDVNI-----VVSGKV----FRAHKNILVAGSRFFKTLYCFTNKES-------------- 58

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1848734806 123 gPEPDTVE----------SVI-QYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLS 176
Cdd:cd18201    59 -CDQTTVThldvvavqgfSVIlDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-179 1.87e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 56.00  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  61 LFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWsselgpEPDTVESVIQYMYTGE 140
Cdd:cd18279    17 RFTDCCL---------CVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDV------DPEVFKEMMRFIYTGK 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1848734806 141 IRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTN 179
Cdd:cd18279    82 APNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-159 1.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 55.96  E-value: 1.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  55 EQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQfsESLSGRVEMKEwsselGPEPDTVESVIQ 134
Cdd:cd18212    16 EQRKKDFLCDITLI---------VENVQFRAHKALLAASSEYFSMMFADE--GEVGQSIYMLE-----GMVAETFGALLE 79

                          90       100
                  ....*....|....*....|....*
gi 1848734806 135 YMYTGEIRVSTCNVHEVLELAdRFL 159
Cdd:cd18212    80 FIYTGCLQVGEKSLEQILATA-QFL 103
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-183 2.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 56.44  E-value: 2.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  40 FTSSSHCSELSRR-QNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEW 118
Cdd:cd18272     9 FTDRSHSSRVAQSiMDLCLEDGLFADVTI---------SVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1848734806 119 SSELgpepdtVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18272    80 SESV------FQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 59-175 2.63e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 54.94  E-value: 2.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  59 QGLFCDVTLAFSSGAasgsvqsceFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSElgpepdTVESVIQYMYT 138
Cdd:cd18300     6 KGLFSDVTFIVEDGT---------IPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKE------TFLALLEYLYT 70

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1848734806 139 GEIRVSTCN-VHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:cd18300    71 DQAPILEDGdCVGLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-183 2.70e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 55.84  E-value: 2.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  40 FTSSSHCSELSRRQNEQRKQGLFCDVTLAFSSGaasgsvqscEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKews 119
Cdd:cd18337     1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDR---------RIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKME--- 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1848734806 120 selGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18337    69 ---GVEPNALWALVQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
319-484 3.43e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 58.24  E-value: 3.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 319 WSSHMASFQPRFGQNMDV----IMVVGGVSEGGDYLSECVgYFIYEDRWV---NLPHIHNHLdgHAIAATESHVYVAGsm 391
Cdd:COG3055   102 WTKLAPMPTPRGGATALLldgkIYVVGGWDDGGNVAWVEV-YDPATGTWTqlaPLPTPRDHL--AAAVLPDGKILVIG-- 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 392 epGFAKTVerynpNRNTWEQVSNLTTRKHSFGLTCIKDILYSIGGHGNFspgFKDVSIYEPEQDKWHNLESAPKILRDVK 471
Cdd:COG3055   177 --GRNGSG-----FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHA 246

                         170
                  ....*....|...
gi 1848734806 472 AVSVEDRyVYVTA 484
Cdd:COG3055   247 AVLTDGK-VYVIG 258
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 175-277 3.67e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 54.35  E-value: 3.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18462     1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                          90       100
                  ....*....|....*....|...
gi 1848734806 255 ERSRYFEELFRLLRLpQIKPTYL 277
Cdd:cd18462    81 KRIECAYDLLSSIKL-DLDEIYL 102
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-183 3.96e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 55.05  E-value: 3.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKewsselGP 124
Cdd:cd18335     2 HAEQTFRKMESYLKQQQLCDVILI---------AGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKME------GI 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1848734806 125 EPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVAV 183
Cdd:cd18335    67 DPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-171 4.05e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 54.01  E-value: 4.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  63 CDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSgrVEMKEWSSELGPEPdtvesVIQYMYTGEIR 142
Cdd:cd18955     2 CDVTIV---------VEDQRFRAHRAVLAACSDYFLSRVVGQTDGDLV--ITLPEEVTVKGFEP-----LLQFAYTAKLL 65

                          90       100
                  ....*....|....*....|....*....
gi 1848734806 143 VSTCNVHEVLELADRFLLLQLKDFCGEFL 171
Cdd:cd18955    66 LSKENVLEVCRCAEFLGVHNIEKACFDFL 94
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 178-269 4.30e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 54.08  E-value: 4.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 178 TNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERS 257
Cdd:cd18514     4 SNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRK 83

                          90
                  ....*....|..
gi 1848734806 258 RYFEELFRLLRL 269
Cdd:cd18514    84 DYLPELLRNVRL 95
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-170 4.90e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 54.38  E-value: 4.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGqfseSLSGRVEMKEWSSElgp 124
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATL---------DVGGRVFKAHWSVLACCSHFFQSLYGD----GTSGSVVLPESFAE--- 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1848734806 125 epdTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEF 170
Cdd:cd18232    65 ---VFGLLLDFFYTGELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-178 5.27e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 54.68  E-value: 5.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  43 SSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSEL 122
Cdd:cd18230     2 TSHYRHLLRELNEQRQHGILCDVCII---------VEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQ 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1848734806 123 GpepdtVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLT 178
Cdd:cd18230    73 G-----FKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 174-270 5.32e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 53.90  E-value: 5.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 174 KLSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNP 253
Cdd:cd18447     1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                          90
                  ....*....|....*..
gi 1848734806 254 EERSRYFEELFRLLRLP 270
Cdd:cd18447    81 PNRQPYMVDILAKVRFP 97
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 62-179 5.45e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 54.29  E-value: 5.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  62 FCDVTLAfssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSE-SLSGRVEMkewsselgPEP-DTVESVIQYMYTG 139
Cdd:cd18302     5 LYDVTIV--------SEDGKEFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTM--------PIPsDILEIILDYLYTD 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1848734806 140 EIRVST--------CNvheVLELADRFLLLQLKDFCGEFLKKKLSLTN 179
Cdd:cd18302    69 EASAVKesqnveflCN---VLVIADQLLITRLKEICEVALVELLSLKN 113
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-181 6.04e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 54.84  E-value: 6.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  57 RKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSselgpePDTVESVIQYM 136
Cdd:cd18271    19 REQNAFFDFNII---------VKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLS------PKAVKAFLDYA 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1848734806 137 YTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18271    84 YTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-167 1.09e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 53.70  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLlggqFSEslSGRVEMKEWSSEL-G 123
Cdd:cd18202     2 HGQTVLDQLNQQRLNNQFCDVTLL---------IEGEEYKAHKSVLAANSEYFREL----FIE--KGAVSSHEAVVDLsG 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1848734806 124 PEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFC 167
Cdd:cd18202    67 FCKSSFLPLLEFAYTSELTFDFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-171 1.15e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 53.31  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  47 SELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYF--TPLLGGQFSESLSGRVemkewsselgp 124
Cdd:cd18210     6 SSLLESLNQQRMEGKLCDISI---------HVQGRVFRAHRAVLAASSPYFhdQVLLKNMSSISLPGVM----------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1848734806 125 EPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFL 171
Cdd:cd18210    66 DPGAFESVLASAYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-173 1.21e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 53.32  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTP--LLGGQFSESLSGRVemkewssel 122
Cdd:cd18200     1 YSSALLETLNKHRLEGKFCDLSV---------HVQGRVFRAHKAVLAASSPYFHDklLLNDTNCLVLPSVI--------- 62

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1848734806 123 gpEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKK 173
Cdd:cd18200    63 --EAAAFENLLQLIYSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELLKE 111
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-179 1.46e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 53.47  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  78 VQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEwsselgPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADR 157
Cdd:cd18343    28 VGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEIND------VDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADK 101

                          90       100
                  ....*....|....*....|..
gi 1848734806 158 FLLLQLKDFCGEFLKKKLSLTN 179
Cdd:cd18343   102 YALERLKVMCEEALCNNLSVEN 123
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-154 1.54e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 52.95  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSgrVEMKEWSselgp 124
Cdd:cd18209     1 HAISLLSALNEERLKGQLCDVLLI---------VGDQKFRAHKNVLAASSEYFQSLFTEKENESQS--VFQLDFC----- 64

                          90       100       110
                  ....*....|....*....|....*....|
gi 1848734806 125 EPDTVESVIQYMYTGEIRVSTCNVHEVLEL 154
Cdd:cd18209    65 EPDAFENVLNYIYSSSLFVEKSSLAAVQEL 94
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-172 2.18e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 52.59  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLggQFSESLSGRVEMKEWSSELGp 124
Cdd:cd18233     1 HSCHLLQQLHEQRIQGLLCDCMLV---------VKGVCFKAHKNVLAAFSQYFRSLF--QNSSSQKNDVFHLDIKNVGG- 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1848734806 125 epdtVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLK 172
Cdd:cd18233    69 ----IGQILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 78-190 2.18e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 53.03  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  78 VQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSselgpePDTVESVIQYMYTGEIRV-STCNVHEVLELAD 156
Cdd:cd18286    24 VDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVS------HAAVSFVLLFIYGGVLDLpDDVNLGELLSLAD 97

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1848734806 157 RFLLLQLKDfcgeflkkklsltncVAVHSLAHMY 190
Cdd:cd18286    98 MYGLDGLKD---------------VVAYTLRRDY 116
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-172 2.51e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 52.63  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  36 EAEDFTSSshcseLSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFtpllggqfseslSGRVEM 115
Cdd:cd18227     4 EFPDFSST-----ILQKLNQQRQQGQLCDISV---------VVQGHLFRAHKAVLAASSPYF------------CDQVLL 57

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 116 KEWSSELGPE---PDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLK 172
Cdd:cd18227    58 KNSRRIVLPDvmnPRVFENILLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-143 2.60e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 52.48  E-value: 2.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSElgpepdTVESVI 133
Cdd:cd18223    10 NEQRIQGILCDVTIV---------VEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAE------VFAEIL 74

                          90
                  ....*....|
gi 1848734806 134 QYMYTGEIRV 143
Cdd:cd18223    75 NFIYSSKVVV 84
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-179 3.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 52.80  E-value: 3.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  82 EFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEwsselgPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLL 161
Cdd:cd18342    33 EFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND------VEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALE 106

                          90
                  ....*....|....*...
gi 1848734806 162 QLKDFCGEFLKKKLSLTN 179
Cdd:cd18342   107 RLKVMCEDALCSNLSVEN 124
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-162 3.84e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 51.85  E-value: 3.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQfseslsGRVEMKEWSSELGp 124
Cdd:cd18206     5 HSQHVLEQLNQQRQLGLLCDCTFV---------VDGVDFKAHKAVLAACSEYFRMLFVDQ------KDVVHLDISNAAG- 68

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1848734806 125 epdtVESVIQYMYTGEIRVSTCNVHEVLELADrFLLLQ 162
Cdd:cd18206    69 ----LGQVLEFMYTAKLSLSPENVDDVLAVAT-FLQMQ 101
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 178-269 4.38e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 51.51  E-value: 4.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 178 TNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERS 257
Cdd:cd18515     3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                          90
                  ....*....|..
gi 1848734806 258 RYFEELFRLLRL 269
Cdd:cd18515    83 CYLSELLQTVRL 94
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 175-273 4.75e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 51.54  E-value: 4.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                          90
                  ....*....|....*....
gi 1848734806 255 ERSRYFEELFRLLRLPQIK 273
Cdd:cd18456    81 GRRQHVPRLMKCVRLPLLS 99
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 187-249 5.25e-08

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 50.27  E-value: 5.25e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1848734806 187 AHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWV 249
Cdd:cd18493    12 AKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-181 7.84e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 51.35  E-value: 7.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESlsgRVEMKEWSselgpePDTVESVI 133
Cdd:cd18260    10 NRMRQERFLCDLTIA---------TKTKSFDVHKVVMASCSEYFRNILKKDPSLQ---RVELNDIS------PLGLATVI 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1848734806 134 QYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18260    72 TYAYTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 178-269 8.93e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 50.57  E-value: 8.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 178 TNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERS 257
Cdd:cd18464     3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRH 82

                          90
                  ....*....|..
gi 1848734806 258 RYFEELFRLLRL 269
Cdd:cd18464    83 EVLPELLRSVRL 94
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-171 9.17e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 50.88  E-value: 9.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSelgp 124
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSII---------VEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVFS---- 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 125 ePDTVESVIQYMYTGEIRVSTCNVHEVLELADrflLLQLKD---FCGEFL 171
Cdd:cd18199    68 -SDAFSIILDFVYSGKLSLTSQNVIEVMSAAS---YLQMTDvinVCKTFI 113
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 83-179 9.20e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 51.12  E-value: 9.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  83 FSAHRSVLAAATDYFTPLLGGQFSESLSGRVE---MKEwsselgpepDTVESVIQYMYTG---EIRVSTCNVHEVLELAD 156
Cdd:cd18297    24 FYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEipdIRY---------DIFQLMMQYLYTGgveSLDVAQDDALELLRAAS 94

                          90       100
                  ....*....|....*....|...
gi 1848734806 157 RFLLLQLKDFCGEFLKKKLSLTN 179
Cdd:cd18297    95 FFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-181 1.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 50.78  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  58 KQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESlsgrvemkEWSselGPEPDTVESVIQYMY 137
Cdd:cd18303    14 DKELYSDITI---------KLADKSIPAHKFVLAARSEKWSNENLASTNEL--------DLS---DISYEVVLALLRWLY 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1848734806 138 TGEIRVSTCNVH--EVLELADRFLLLQLKDFCGEFLKKKLSLTNCV 181
Cdd:cd18303    74 TDELDLTLDDEFllELMKAAKRFQLTDLVERCERALMSSVNVDNCI 119
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-172 1.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 50.63  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQfseslsGRVEMKEWSSELGP 124
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLL---------VGGTPLRAHKAVLIACSGFFYSIFSGR------VGEGVSVLTLPSGL 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1848734806 125 EPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLK 172
Cdd:cd18332    67 EARGFQLLLDFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 178-274 1.81e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 49.73  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 178 TNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERS 257
Cdd:cd18485     4 SNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRV 83

                          90
                  ....*....|....*..
gi 1848734806 258 RYFEELFRLLRLPQIKP 274
Cdd:cd18485    84 QHLVELLKQVRLELVSP 100
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-159 2.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 50.04  E-value: 2.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESlSGRVEMKEWSSelgpepDTVESVI 133
Cdd:cd18204    10 NEQRLEGEFCDIAIV---------VEDVKFRAHRCVLAACSTYFKKLFKKLEVDS-SSVIEIDFLRS------DIFEEVL 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 1848734806 134 QYMYTGEIRVSTCNVHEVLE----LADRFL 159
Cdd:cd18204    74 NYMYTAKISVKKEDVNLMMSsgqiLGIRFL 103
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-171 2.07e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 49.92  E-value: 2.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  52 RQNEQRK-QGLFCDVTLAFSSgaasgsvQSCEFSAHRSVLAAATDYFTPLlggqFSESLS-GRVEMkewsSELGPEPDTV 129
Cdd:cd18231     3 RLNEQRLfQPDLCDVDIVLVR-------QRSTFPAHKGVLAAYSQFFHSL----FTQNKQlQRVEL----SLEALTSQGL 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1848734806 130 ESVIQYMYTGEIRVSTCNVHEVLELADrflLLQLKDF---CGEFL 171
Cdd:cd18231    68 QQILNFIYTSKLLVNSCNVQDVLNAAA---VLQMNDIaasCQELI 109
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 175-272 2.53e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 49.10  E-value: 2.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNpE 254
Cdd:cd18470     1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-Q 79

                          90
                  ....*....|....*...
gi 1848734806 255 ERSRYFEELFRLLRLPQI 272
Cdd:cd18470    80 KRVKYAADLLSNIRFGTI 97
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 51-156 2.81e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 49.51  E-value: 2.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  51 RRQNEQRKQGLFCDVTLAFSSGAasgsvqscEFSAHRSVLAAATDYFTPLLGGQfsESLSGRVEMkewSSELgpEPDTVE 130
Cdd:cd18311     3 QRLQNLFNKTEYCDLTLQFRDNE--------QLKVHRLVLSACTDYFNVLEQTC--EIVDDTLIM---PNEL--QADAVV 67

                          90       100
                  ....*....|....*....|....*.
gi 1848734806 131 SVIQYMYTGEIRVSTCNVHEVLELAD 156
Cdd:cd18311    68 PVINFMYTGQLEFEEKSYGKLLRTAK 93
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-179 2.92e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 49.85  E-value: 2.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  62 FCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSELGPEpdtvesVIQYMYTGEI 141
Cdd:cd18345    18 FSDVTL---------CVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMRE------MLRFIYTGKA 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1848734806 142 RVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTN 179
Cdd:cd18345    83 PNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-174 3.24e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 49.65  E-value: 3.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLlggqFSESLSGRvEMKEWSSELGP 124
Cdd:cd18325     6 HSRQLLQCLSQQRHQGFLCDCTVL---------VGEAQFRAHRAVLASCSMYFHLF----YRDQLDKR-DIVHLNSDIVT 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 125 EPdTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKK 174
Cdd:cd18325    72 AP-AFSLLLEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKDK 120
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 175-252 6.23e-07

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 47.34  E-value: 6.23e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKN 252
Cdd:cd18503     1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-161 7.10e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 48.28  E-value: 7.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  42 SSSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQfsESLSGRVEMkewsSE 121
Cdd:cd18192     1 RPSHSSYVLQQLNNQREWGFLCDCCIA---------IDDIYFQAHKAVLAACSSYFRMMFINH--QHTTAQLNL----SN 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1848734806 122 LGPEPDTVESVIQYMYTGEIRVSTCNVHEvLELADRFLLL 161
Cdd:cd18192    66 MKISAECFDLILQFMYLGKIMTAPSDFEQ-LKVAMNYLQL 104
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-173 8.79e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 48.30  E-value: 8.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  43 SSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLggqFSESLsgrvemkewsseL 122
Cdd:cd18216     1 PSHATQLLLQLNNQRTKGFLCDVIIV---------VENSLFRAHKNVLAASSGYFKSLV---LHDNL------------I 56

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1848734806 123 GPEPDTVES-----VIQYMYTGEIRVST---CNVHEVLELADRFLLLQLKDFCGEFLKK 173
Cdd:cd18216    57 HLDQDMVSPtvfqqILDFIYTGKLLDSLfeePNLSEVLAAANYLQLPDLAALCRSKLKR 115
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-179 1.08e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 48.41  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  82 EFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWsselgpEPDTVESVIQYMYTGeiRVSTCNVH----EVLELADR 157
Cdd:cd18344    34 EFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDL------DPQVFKEMMGFIYTG--KAPHLHSHsmacDVLAAADK 105

                          90       100
                  ....*....|....*....|..
gi 1848734806 158 FLLLQLKDFCGEFLKKKLSLTN 179
Cdd:cd18344   106 YGLEGLKVLCEDALCRNLSVEN 127
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-167 1.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 47.90  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  42 SSSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGqfSESLSGRVEMKEWSSe 121
Cdd:cd18224     6 SSDHPNNLLKELNKCRLSETMCDVTIV---------VGNRSFAAHKAVLACAAGYFQKLFLS--TELDVARTYVVDFIT- 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1848734806 122 lgpePDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFC 167
Cdd:cd18224    74 ----PANFEKVLSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 78-179 1.23e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 47.86  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  78 VQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSELgpepdtVESVIQYMYTGEIRVSTCNVHEVLELADR 157
Cdd:cd18352    20 VEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEV------FELMMRFIYTGSVDITNDIAKDLLRAADQ 93

                          90       100
                  ....*....|....*....|..
gi 1848734806 158 FLLLQLKDFCGEFLKKKLSLTN 179
Cdd:cd18352    94 YLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-153 1.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 47.52  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  43 SSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLggqfseSLSGRVemkewsSEL 122
Cdd:cd18219     2 TQYSGSLLKSLNEQRGHGLFCDVTVI---------VEDRKFRAHKNILSASSTYFHQLF------SVAGQV------VEL 60

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1848734806 123 G-PEPDTVESVIQYMYTGEI-RVSTCNVHEVLE 153
Cdd:cd18219    61 NfIRADIFAEILNYIYSSKIvRVRSDLLEELIK 93
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-171 1.30e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 47.61  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSEslSGRvemKEWSSELGPEPDTVESVI 133
Cdd:cd18330    10 NEQRKRDFFCDCSII---------VEGRIFKAHRNILFANSGYFRALLIHYIQD--SGR---HSTASLDIVTSEAFSIIL 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1848734806 134 QYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFL 171
Cdd:cd18330    76 DFLYSGKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-176 1.38e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 48.50  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLlggqFSESLSGRvEMKEWSSELGP 124
Cdd:cd18324     6 HSRHLLQCLSEQRHQGFLCDCTVL---------VGDAQFRAHRAVLASCSMYFHLF----YKDQLDKR-DIVHLNSDIVT 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1848734806 125 EPdTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLS 176
Cdd:cd18324    72 AP-AFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKAT 122
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 58-172 1.76e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 46.82  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  58 KQGLFCDVTLAFSSGaasgsvqsCEFSAHRSVLAAATDYFTPLLGGQFSeslsgrVEMKEWSSelgpePDTVESVIQYMY 137
Cdd:cd18299     8 HSPSCADVVFILQGG--------VRIFAHRIVLAAASSVFADLFLMMTV------VTLDSDIT-----PEAFRRVLEFLY 68

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1848734806 138 TGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLK 172
Cdd:cd18299    69 TGVLDENEDDLKELKDAAELLELFDLVMMCTNVLN 103
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-159 2.66e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 47.20  E-value: 2.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  42 SSSHCSELSRRQNEQRKQGLFCDVTLAFssgaasGSVQsceFSAHRSVLAAATDYFTPLLGGQFSESLsgrvemKEWSSE 121
Cdd:cd18213     1 VSSHSLVLLQQLNMQREFGFLCDCTVAI------GDVY---FKAHRAVLAAFSNYFKMIFIHQSSECI------KIQPTD 65

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1848734806 122 LgpEPDTVESVIQYMYTGEIRVSTCNvHEVLELADRFL 159
Cdd:cd18213    66 I--QPDIFSYLLHIMYTGKGPKQSVD-HSRLEEGIRFL 100
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-175 2.94e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 47.12  E-value: 2.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTpllggQFSESLSGRVEMKEWSSELGP 124
Cdd:cd18194     6 HSRQLLQCLREQRSQGFLCDCTVL---------VGSAQFPAHRAVLASCSMYFH-----LFYRDRLDKRDLVRLNSDIVT 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1848734806 125 EPdTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:cd18194    72 AP-AFGLLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKA 121
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-164 3.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 46.39  E-value: 3.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLggqfsesLSGRVEMkewssELGP--EPDTVES 131
Cdd:cd18229    10 NAQRLGGHFCDVTV---------RIHDASLRAHRCVLAAGSPFFHDKL-------LLGHSEI-----EVPPvvPAQTVRQ 68

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1848734806 132 VIQYMYTGEIRVSTCNVHEVLELADrflLLQLK 164
Cdd:cd18229    69 LVEFMYSGSLVVAQSEALQILTAAS---ILQIK 98
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-144 3.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 46.95  E-value: 3.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSES--LSGRVemkewsselgpEPDTVES 131
Cdd:cd18289    21 NEQRLMGLYCDVSIV---------VKGQAFKAHRAVLAASSLYFRDLFSGNSKSAfeLPATV-----------PPACFQQ 80

                          90
                  ....*....|...
gi 1848734806 132 VIQYMYTGEIRVS 144
Cdd:cd18289    81 ILSFCYTGKLTMA 93
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-175 3.83e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 46.77  E-value: 3.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  42 SSSHCSELSRRQNEQRKQGLFCDVTLAFSSgaaSGSVQscEFSAHRSVLAAATDYFTPL-LGGQFSESLSGRVEMKEWSS 120
Cdd:cd18211     5 SKSAPSNLLNEMHKLRLLGHLCDVTVQVEH---QGSKE--EFSAHKAVLAASSKYFKEVfLNEKISDGKNTNVMLNEIYT 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1848734806 121 ElgpepdTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKL 175
Cdd:cd18211    80 A------DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 175-270 6.02e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 45.11  E-value: 6.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVqKNPE 254
Cdd:cd18449     1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWL-RHED 79

                          90
                  ....*....|....*.
gi 1848734806 255 ERSRYFEELFRLLRLP 270
Cdd:cd18449    80 DRMQFAAKLMENIRFP 95
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 82-158 6.40e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 44.81  E-value: 6.40e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1848734806  82 EFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMkewsSELGPEPDTVESVIQYMYTGE-IRVSTCNVHEVLELADRF 158
Cdd:cd18190    10 KFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDF----EENGISIEAMRAVIDFSVTGRlDLFSVENVHEVLELASKF 83
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-170 7.29e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 45.63  E-value: 7.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSgrvemkEWSSELGP 124
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLV---------VGREQFRAHKTVLMACSGLFYSIFTDQLKNNVS------VINLDPEI 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1848734806 125 EPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEF 170
Cdd:cd18215    67 EPEGFRILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-169 7.67e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 45.44  E-value: 7.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  54 NEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSEslsgrVEMKEWSSelgpePDTVESVI 133
Cdd:cd18208    17 NEQRNRGHFCDVTV---------RIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD-----IEIPSVVS-----VQSVQKLI 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1848734806 134 QYMYTGEIRVSTCNVHEVLELADrflLLQLKDFCGE 169
Cdd:cd18208    78 DFMYSGVLRVSQSEALQILTAAS---ILQIKTVIDE 110
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-172 8.35e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 45.42  E-value: 8.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  36 EAEDFTSS--SHCSELsrrqneqRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLggqfseSLSgrv 113
Cdd:cd18222     4 EIPDFSNSvlSHLNQL-------RMQGRLCDIVV---------NVQGQSFRAHKVVLAASSPYFRDHM------SLN--- 58

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1848734806 114 EMKEWSSELGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLK 172
Cdd:cd18222    59 EMSTVSISVIKNPTVFEQLLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILE 117
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 50-163 9.48e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 45.34  E-value: 9.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  50 SRRQNEQRKQGLFCDVTLAFSSGAasgsvqsceFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSElgpepdTV 129
Cdd:cd18358     8 ANRIKECLSKGTFSDVTFKLDDGT---------INAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKV------SM 72

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1848734806 130 ESVIQYMYTGEIR-VSTCNVHEVLELADRFLLLQL 163
Cdd:cd18358    73 QAVLDYLYTKQLSpTADLDPLELIALANRFCLPHL 107
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 55-156 9.56e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 44.89  E-value: 9.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  55 EQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFtpllggqfSESLSGRvemKEWSSELGPEPDTV--ESV 132
Cdd:cd18262    11 RLREQRLLLDETV---------SVGGRSYGVHSVILAAVSSLF--------RERLLGS---NGPLPPLSLEVTPVgwEAV 70

                          90       100
                  ....*....|....*....|....
gi 1848734806 133 IQYMYTGEIRVSTCNVHEVLELAD 156
Cdd:cd18262    71 LTFAYTGVLGRNPATVGDILVAAE 94
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-173 9.81e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 45.28  E-value: 9.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  44 SHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLggqfseslsgrveMKEWSSELG 123
Cdd:cd18333     3 SHSRQLLLQLNTQRTKGFLCDVIIV---------VQNALFRAHKNILAASSVYLKSLV-------------VHDNLINLD 60

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1848734806 124 PE---PDTVESVIQYMYTGeiRVSTC------NVHEVLELADRFLLLQLKDFCGEFLKK 173
Cdd:cd18333    61 HEmvsPGIFRLILDYIYTG--RLSEGdpgseqNLGAVLAAASYLQIPDLVALCKKKLKR 117
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-179 1.41e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 45.03  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  57 RKQgLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLggqfseSLSGRVEMkewsselGPEPDTVESVIQYM 136
Cdd:cd18243    28 RKQ-LFCDVTL---------TAQGQQFHCHKAVLASCSQYFRSLF------SINNLVLQ-------GCSSIGLRLVLEYL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1848734806 137 YTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTN 179
Cdd:cd18243    85 YTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 175-272 1.43e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 44.14  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFytlpFHLVRDWLSDAeITVDS----EEVLFEAVVKWVQ 250
Cdd:cd14822     1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGF----LTLSKSALKEL-LSRDSfcapEVDIFNAVRRWCE 75

                          90       100
                  ....*....|....*....|..
gi 1848734806 251 KNPEERSRyFEELFRLLRLPQI 272
Cdd:cd14822    76 HNPDSKED-AKEILEAVRLPLM 96
PHA02790 PHA02790
Kelch-like protein; Provisional
 128-458 1.55e-05

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 48.12  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 128 TVESVIQYMYTGEIRVSTCNVHEVLeladRFLLLQLKDF----CGEFLKKKLSLTNCVAVHSLAHMYTLDQLALRAADMI 203
Cdd:PHA02790   73 SLTSIVIYSYTGKVYIDSHNVVNLL----RASILTSVEFiiytCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFI 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 204 RRNFHKVIQD--DEFYTLPFHLVrdwLSDAEITVDSEEVLFEAVVKWVQKNPEERSRYFEELFRLLRLPQIKPTYLTRV- 280
Cdd:PHA02790  149 AKHFLELEDDiiDNFDYLSMKLI---LESDELNVPDEDYVVDFVIKWYMKRRNRLGNLLLLIKNVIRSNYLSPRGINNVk 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 281 --VKTEQLVSANEACLRLVSEAVEGHAIRFENLKSTDMEFWSSHMAsfqprfgqnmDVIMVVGGVSEgGDYLSECVGYFI 358
Cdd:PHA02790  226 wiLDCTKIFHCDKQPRKSYKYPFIEYPMNMDQIIDIFHMCTSTHVG----------EVVYLIGGWMN-NEIHNNAIAVNY 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 359 YEDRWVNLPHIHN-HLDGHAIAATESHVYVAGSMEPgfaKTVERYNPNRNTWEQVSNLTTRKHSFGLTCIKDILYSIGGH 437
Cdd:PHA02790  295 ISNNWIPIPPMNSpRLYASGVPANNKLYVVGGLPNP---TSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGH 371

                         330       340
                  ....*....|....*....|.
gi 1848734806 438 gnfSPGFKDVSIYEPEQDKWH 458
Cdd:PHA02790  372 ---SETDTTTEYLLPNHDQWQ 389
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-173 1.58e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 44.57  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  44 SHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLggQFSESLSGRVEMKewsselg 123
Cdd:cd18334     3 NHAKQLLLQLNQQRAKGFLCDVIIV---------VENALFRAHKNILAASSMYFKSLV--LHDNLINLDTDMV------- 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1848734806 124 pEPDTVESVIQYMYTGEI----RVSTCNVHEVLELADRFLLLQLKDFCGEFLKK 173
Cdd:cd18334    65 -NPTVFRQILDFIYTGKLltsdQPGEQNFNALLTAASYLQLHDLAALCRKKLKR 117
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 58-182 1.75e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 44.42  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  58 KQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSselgpePDTVESVIQYMY 137
Cdd:cd18263     9 EKGVGCDVQL---------EADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIP------AKDLRLLISFAY 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1848734806 138 TGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTNCVA 182
Cdd:cd18263    74 SGILHLSWENLFEATCTALQLQISGALALCLDFLQREISPARCLD 118
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-179 1.86e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 44.66  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  61 LFCDVTLAFSSGAASGSV-QSCEFSAHRSVLAAATDYFTPLLGGQFSESlSGRVEMKEwsselgPEPDTVESVIQYMYTG 139
Cdd:cd18346    21 LLSDVRFVVGKGRPRGPGpGAQRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIELPD------VEPAAFLALLRFLYSD 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1848734806 140 EIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTN 179
Cdd:cd18346    94 EVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 51-163 2.30e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 44.22  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  51 RRQNEQRK---QGLFCDVTLAFSSGAasgsvqsceFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSElgpepd 127
Cdd:cd18359     6 RRTNRVKEclaKGTFSDVTFMLDDGT---------ISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRS------ 70

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1848734806 128 TVESVIQYMYTGEIRVST-CNVHEVLELADRFLLLQL 163
Cdd:cd18359    71 SMRAVLEYLYTGQFSSSPdLDDMKLIILANRLCLPHL 107
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 175-268 3.52e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 43.26  E-value: 3.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHK-VIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNP 253
Cdd:cd18482     1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                          90
                  ....*....|....*
gi 1848734806 254 EERSRYFEELFRLLR 268
Cdd:cd18482    81 KERAASAAEVLKCVR 95
PLN02193 PLN02193
nitrile-specifier protein
 376-516 3.54e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.87  E-value: 3.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 376 HAIAATESHVYVAGSMEP-GFAKTVERYNPNRNTWEQVSN----LTTRKHSfGLTCIKDILYSIGGHGNFSpgFKDVSIY 450
Cdd:PLN02193  272 HSMAADEENVYVFGGVSAtARLKTLDSYNIVDKKWFHCSTpgdsFSIRGGA-GLEVVQGKVWVVYGFNGCE--VDDVHYY 348

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1848734806 451 EPEQDKWHNLES--APKILRDVKAVSVEDRYVYV----TARTPVDTDNDDGLKTVTTRYDTESRQWQDVDSL 516
Cdd:PLN02193  349 DPVQDKWTQVETfgVRPSERSVFASAAVGKHIVIfggeIAMDPLAHVGPGQLTDGTFALDTETLQWERLDKF 420
Kelch smart00612
Kelch domain;
587-633 3.63e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 3.63e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1848734806  587 VFIIGGWKNSddvdkQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 633
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 62-168 3.92e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 42.71  E-value: 3.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  62 FC-DVTLAFssgaasgsvQSCEFSAHRSVLAAATDYFTPLLggqfSESLSGRVEMkewSSELGPEPDTVE---SVIQYMY 137
Cdd:cd18283     1 YCtDVDLVF---------QGTCFPVHRAILSARCPFFRDLL----SSSPGYGAEI---PVDLPTAGIDVPmfsALLRYLY 64

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1848734806 138 TGEIRVSTCNvhevleLADRFLLLQLKDFCG 168
Cdd:cd18283    65 TGEFGSEDSR------SQNLDVLIQLSEEFG 89
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-165 4.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 43.28  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  57 RKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVemkewsselgPEPDTVESVIQYM 136
Cdd:cd18225    18 RKEQQFCDCTI---------FIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASV----------VSPEEFALLLEMV 78

                          90       100
                  ....*....|....*....|....*....
gi 1848734806 137 YTGEIRVSTCNVHEVLELADRfllLQLKD 165
Cdd:cd18225    79 YTGKLPPGKHNFTKIISVADS---LQMFD 104
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-171 9.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 42.50  E-value: 9.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  40 FTSSSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGqfseslsGRVEMKEWS 119
Cdd:cd18251     1 YRSVAHSQALLDGLVALRDSGILFDVVLV---------VEGKPIEAHRILLAASCDYFRGMFAG-------GLREMQQTE 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1848734806 120 SEL-GPEPDTVESVIQYMYTGEIRVSTCNVHEVLELAdrfLLLQLKD---FCGEFL 171
Cdd:cd18251    65 VLIhGVSYNAMCKILDFIYTSELELSLDNVQETLTAA---CQLQIPEvigFCCDFL 117
Kelch smart00612
Kelch domain;
384-425 9.42e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 40.23  E-value: 9.42e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1848734806  384 HVYVAGSMEPG-FAKTVERYNPNRNTWEQVSNLTTRKHSFGLT 425
Cdd:smart00612   1 KIYVVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-179 1.48e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 41.98  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  61 LFCDVTLAFSSGAASGSVqscefSAHRSVLAAATDYFTPLLGGQFSESlSGRVEMKEwsselgPEPDTVESVIQYMYTGE 140
Cdd:cd18347    21 VLSDVHFLVGKGLGSQRI-----PAHRFVLAVGSAVFDAMFNGGMATT-STEIELPD------VEPAAFLALLKFLYSDE 88

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1848734806 141 IRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKKLSLTN 179
Cdd:cd18347    89 VQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 375-416 3.34e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 3.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1848734806 375 GHAIAATESHVYVA-GSMEPGFAKTVERYNPNRNTWEQVSNLT 416
Cdd:pfam01344   4 GAGVVVVGGKIYVIgGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 179-268 3.47e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 40.27  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 179 NCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQD--DEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPeeR 256
Cdd:cd18471     5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHNC--R 82

                          90
                  ....*....|..
gi 1848734806 257 SRYFEELFRLLR 268
Cdd:cd18471    83 YQYMDELLQYVR 94
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-141 3.65e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 40.75  E-value: 3.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  43 SSHCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLsgrvemkewssEL 122
Cdd:cd18193     2 ANHGLILLQQLNAQREFGFLCDCTVA---------IGDVYFKAHKSVLASFSNYFKMLFVHQTSECV-----------RL 61

                          90       100
                  ....*....|....*....|..
gi 1848734806 123 GP---EPDTVESVIQYMYTGEI 141
Cdd:cd18193    62 KPtdiQPDIFSYLLHLMYTGKM 83
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-174 4.84e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 40.42  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLggQFSESlSGRVEMKEWSSELgP 124
Cdd:cd18196     4 HFEQIFQQLNYQRLHGQLCDCVIV---------VGNRHFKAHRSVLAACSTHFRALF--TVAEG-DQTMNMIQLDSEV-V 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1848734806 125 EPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLKKK 174
Cdd:cd18196    71 TAEAFAALIDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTR 120
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-183 5.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 39.78  E-value: 5.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  85 AHRSVLAAATDYFTPLLGGQFseslsgrVEMKewsselGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELAdRFLLLQLK 164
Cdd:cd18275    18 AHKSVLAAKSDYFRARLSRDI-------LKVK------GLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGA-RFLQMPCA 83

                          90       100
                  ....*....|....*....|
gi 1848734806 165 DFCG-EFLKKKLSLTNCVAV 183
Cdd:cd18275    84 AQCAvDAVRAQLCLGNCYEV 103
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-173 6.58e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 39.54  E-value: 6.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  85 AHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSelgpepDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLK 164
Cdd:cd18298    26 VHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSY------PVYYAFLRYLYTDQVDLPPEDAIGLLDLANSYCEERLK 99


                  ....*....
gi 1848734806 165 DFCGEFLKK 173
Cdd:cd18298   100 KLCEDIIKQ 108
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 83-183 6.74e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 40.17  E-value: 6.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  83 FSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSElgpepdTVESVIQYMYTGEIRVSTCNVHEVLELAdrfLLLQ 162
Cdd:cd18276    33 FPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAE------SVSIILNYMYSSDLHLTNSNVQGVATAA---FFLQ 103

                          90       100
                  ....*....|....*....|....
gi 1848734806 163 LKDF---CGEFLKKKLSLTNCVAV 183
Cdd:cd18276   104 MEDIfsvCQKYMMDHMDASNCLGI 127
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 82-158 7.22e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 38.80  E-value: 7.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1848734806  82 EFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSSElgpepdTVESVIQYMYTGEIRVSTCNVHEVLELADRF 158
Cdd:cd01165     9 KFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPE------DFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-172 8.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 39.62  E-value: 8.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  39 DFTSSSHCSELSRRQNEQRKQGLFCDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFtpllggqfsESLSGRVEMKEW 118
Cdd:cd18220     2 QFDVPEYSNTVLSQLNELRLQGKLCDIIV---------HIQGQPFRAHKAVLAASSPYF---------RDHSALSTMSGL 63

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1848734806 119 SSELGPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLKDFCGEFLK 172
Cdd:cd18220    64 SISVIKNPNVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 179-277 8.39e-04

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 39.38  E-value: 8.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 179 NCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPEERSR 258
Cdd:cd18466     5 NCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRKK 84

                          90
                  ....*....|....*....
gi 1848734806 259 YFEELFRLLRLPQIKPTYL 277
Cdd:cd18466    85 HVVEVLEPVRFPLLPPQRL 103
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 59-165 1.17e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 39.15  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  59 QGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKEWSselgpePDTVESVIQYMYT 138
Cdd:cd18295    16 QGSYSDVTFN---------VHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVN------PDAFRALLQYLYT 80

                          90       100
                  ....*....|....*....|....*..
gi 1848734806 139 GEIRVSTCNVHEVLELADRFLLLQLKD 165
Cdd:cd18295    81 GRLEIHVDDVEDCKRLAKQCRLEELIE 107
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 179-263 1.33e-03

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 38.76  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 179 NCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPfHLVRDWL--SDAEITVDSEEVLFEAVVKWVQKNPEER 256
Cdd:cd18502     5 NCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLP-RLQIEVIleSNQELESINERKLCQLVLEWVQRSIEEG 83


                  ....*..
gi 1848734806 257 SRYFEEL 263
Cdd:cd18502    84 GLDLDDL 90
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 175-258 1.35e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 38.74  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 175 LSLTNCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVVKWVQKNPE 254
Cdd:cd18465     1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80


                  ....
gi 1848734806 255 ERSR 258
Cdd:cd18465    81 RRAS 84
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 179-265 1.47e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 38.33  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806 179 NCVAVHSLAHMYTLDQLALRAADMIRRNFHKVIQDDEFYTLPFHLVRDWLSDAeitVDSEEVLFEAVVKWVQKNPEERSr 258
Cdd:cd18481     5 NCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKDG---VPCSQNPTAAIEAWINHNKEERE- 80


                  ....*..
gi 1848734806 259 YFEELFR 265
Cdd:cd18481    81 GFSETLT 87
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-155 1.89e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 39.04  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  45 HCSELSRRQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYFTPLlggqFSESLSGRvEMKEWSSELGP 124
Cdd:cd18323     6 HSRHLLQSLREQRHQGFLCDCTVL---------VGSTQFLAHRAVLASCSPFFHMF----YKEQLDKR-DLVCINNEIVT 71

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1848734806 125 EPdTVESVIQYMYTGEIRVSTCNVHEVLELA 155
Cdd:cd18323    72 AP-AFSLLLEFMYEGRLSFNDTPVEDVLAAA 101
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 577-624 2.09e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 2.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1848734806 577 GAAICHFDEDVFIIGGWKNSDDVDKqyrkeAYRYCAERKRWMLLPPMP 624
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNS-----VEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
375-418 2.24e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 2.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1848734806 375 GHAIAATESHVYVAGSMEPGFA--KTVERYNPNRNTWEQVSNLTTR 418
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGYTNASPalNKLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-97 2.34e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 38.44  E-value: 2.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1848734806  52 RQNEQRKQGLFCDVTLAfssgaasgsVQSCEFSAHRSVLAAATDYF 97
Cdd:cd18221     8 RLNEQRELDQFTDITLI---------VDGHQFKAHKAVLAACSQFF 44
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-167 3.76e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 37.69  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  63 CDVTLafssgaasgSVQSCEFSAHRSVLAAATDYFTPLLGGQFSESLSGRVEMKewsselGPEPDTVESVIQYMYTGEI- 141
Cdd:cd18280    15 ADVTF---------NVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIE------DVEPPVFKALLHFIYKDELp 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1848734806 142 -----------RVSTCNVHEVLELADRFLLLQLKDFC 167
Cdd:cd18280    80 ddvepagsdssSLDTTMAQHLLAAADRYALERLRLLC 116
Kelch_6 pfam13964
Kelch motif;
577-627 5.61e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.39  E-value: 5.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1848734806 577 GAAICHFDEDVFIIGGWKNsddvDKQYRKEAYRYCAERKRWMLLPPMPQPR 627
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGYTN----ASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-175 6.88e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 36.60  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  85 AHRSVLAAATDYFTPLLGGQFSESLSgRVEMKEwsselgPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLK 164
Cdd:cd18282    25 AHKYVLATGSSVFYAMFYGGLAENKN-EIEIPD------VEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLA 97

                          90
                  ....*....|.
gi 1848734806 165 DFCGEFLKKKL 175
Cdd:cd18282    98 RACVQFLETSL 108
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-179 7.12e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 37.03  E-value: 7.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848734806  85 AHRSVLAAATDYFTPLLGGQFSESlSGRVEMKEwsselgPEPDTVESVIQYMYTGEIRVSTCNVHEVLELADRFLLLQLK 164
Cdd:cd18281    40 AHKFVLSIGSAVFDAMFNGGMATT-SAEIELPD------VEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 112

                          90
                  ....*....|....*
gi 1848734806 165 DFCGEFLKKKLSLTN 179
Cdd:cd18281   113 SACVEFLKKNLSSDN 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH