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Conserved domains on  [gi|1841885211|ref|XP_034269455|]
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GPI mannosyltransferase 2 isoform X2 [Pantherophis guttatus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 13-516 4.89e-115

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam04188:

Pssm-ID: 473917  Cd Length: 439  Bit Score: 346.90  E-value: 4.89e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211  13 EVVCFAVFCRIVTLLLQALF-NLLIPDHAADAFSPPRLSDPGFLDRLLEWLLGGLSRWDAEHFLFIAEHGYIYEHNCAFF 91
Cdd:pfam04188   3 ELTLYAVLFRSLQLLLVFLTpIRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAFS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211  92 PLFPLTLKAAANIIFWPFQGFLCFRSCLLLSAALLNAVFSVLASWTLYELSCAVLQCRRRAFLSSILFCLTPANIFMAAA 171
Cdd:pfam04188  83 PLWPFFVRLFIKSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTSI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 172 YSESMFAFLVFAALWSLEKGHRWLSLLLFSLATGVRSNGLINAGFLIYSQTKlfafRFRASENVLRKKGPFLKLAAALGL 251
Cdd:pfam04188 163 YSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLG----IYFIDLIELTKNRKFVKAICFPFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 252 MSASVALPFAMFQYYAYFKFCHPdiglggavpkpllqlaeskgyrvaASEGGMPPWCSWNFPVLYTYIQDTYWNVGFLRY 331
Cdd:pfam04188 239 SGSLMFLPFLYFQYYLYKTFCPQ------------------------RSAGNEPPWCKSQLPLLYSYIQSHYWGVGFLKY 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 332 FEVKQIPNFLLASPVIVLGSWAIWWYVTANPWHCLTLGLVRRKSAATqghdSHKPAEGFGSPGLLVYVVHAAALLVFGTF 411
Cdd:pfam04188 295 WTPKQIPNFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKK----AEKPDLGFLSPQVFVLVVHTRALVVIVCF 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 412 FMHVQVLTRFLgSSSPVLYWFCAHLLydnepllqdgGSPSKHRESlaekpsvdnyfstcSRHENPVLMLLSKWKqsrilt 491
Cdd:pfam04188 371 FMHVQVLTRFL-SFLPLHYWFLADLL----------VSDKKKMWN--------------PLGDDKIVKFYIYWL------ 419

                         490       500
                  ....*....|....*....|....*
gi 1841885211 492 kcilgYVLSYWLLGLVLHCNFFPWT 516
Cdd:pfam04188 420 -----ACSFYILLGTLLFANFLPPT 439
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 13-516 4.89e-115

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 346.90  E-value: 4.89e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211  13 EVVCFAVFCRIVTLLLQALF-NLLIPDHAADAFSPPRLSDPGFLDRLLEWLLGGLSRWDAEHFLFIAEHGYIYEHNCAFF 91
Cdd:pfam04188   3 ELTLYAVLFRSLQLLLVFLTpIRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAFS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211  92 PLFPLTLKAAANIIFWPFQGFLCFRSCLLLSAALLNAVFSVLASWTLYELSCAVLQCRRRAFLSSILFCLTPANIFMAAA 171
Cdd:pfam04188  83 PLWPFFVRLFIKSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTSI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 172 YSESMFAFLVFAALWSLEKGHRWLSLLLFSLATGVRSNGLINAGFLIYSQTKlfafRFRASENVLRKKGPFLKLAAALGL 251
Cdd:pfam04188 163 YSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLG----IYFIDLIELTKNRKFVKAICFPFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 252 MSASVALPFAMFQYYAYFKFCHPdiglggavpkpllqlaeskgyrvaASEGGMPPWCSWNFPVLYTYIQDTYWNVGFLRY 331
Cdd:pfam04188 239 SGSLMFLPFLYFQYYLYKTFCPQ------------------------RSAGNEPPWCKSQLPLLYSYIQSHYWGVGFLKY 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 332 FEVKQIPNFLLASPVIVLGSWAIWWYVTANPWHCLTLGLVRRKSAATqghdSHKPAEGFGSPGLLVYVVHAAALLVFGTF 411
Cdd:pfam04188 295 WTPKQIPNFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKK----AEKPDLGFLSPQVFVLVVHTRALVVIVCF 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 412 FMHVQVLTRFLgSSSPVLYWFCAHLLydnepllqdgGSPSKHRESlaekpsvdnyfstcSRHENPVLMLLSKWKqsrilt 491
Cdd:pfam04188 371 FMHVQVLTRFL-SFLPLHYWFLADLL----------VSDKKKMWN--------------PLGDDKIVKFYIYWL------ 419

                         490       500
                  ....*....|....*....|....*
gi 1841885211 492 kcilgYVLSYWLLGLVLHCNFFPWT 516
Cdd:pfam04188 420 -----ACSFYILLGTLLFANFLPPT 439
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
69-219 1.19e-09

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 58.04  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211  69 WDAEHFLFIAEHGYIY---EHNCAFFPLFPLTLKAAANIIFwPFQGFLCFRSClllsaallnaVFSVLASWTLYELsCAV 145
Cdd:COG5542     4 FLSPWYRAIATSGYFAalgKQFGDYFPLYPYLLRLVMYLGL-PFLLAGKLVSI----------LADLVAAYLLYRW-VKK 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1841885211 146 LQCRRRAFLSSILFCLTPANIFMAAAY--SESMFAFLVFAALWSLEKGHRWLSLLLFSLATGVRSNGLINAGFLIY 219
Cdd:COG5542    72 YYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFKPQAVFLLPALLI 147
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 13-516 4.89e-115

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 346.90  E-value: 4.89e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211  13 EVVCFAVFCRIVTLLLQALF-NLLIPDHAADAFSPPRLSDPGFLDRLLEWLLGGLSRWDAEHFLFIAEHGYIYEHNCAFF 91
Cdd:pfam04188   3 ELTLYAVLFRSLQLLLVFLTpIRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAFS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211  92 PLFPLTLKAAANIIFWPFQGFLCFRSCLLLSAALLNAVFSVLASWTLYELSCAVLQCRRRAFLSSILFCLTPANIFMAAA 171
Cdd:pfam04188  83 PLWPFFVRLFIKSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTSI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 172 YSESMFAFLVFAALWSLEKGHRWLSLLLFSLATGVRSNGLINAGFLIYSQTKlfafRFRASENVLRKKGPFLKLAAALGL 251
Cdd:pfam04188 163 YSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLG----IYFIDLIELTKNRKFVKAICFPFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 252 MSASVALPFAMFQYYAYFKFCHPdiglggavpkpllqlaeskgyrvaASEGGMPPWCSWNFPVLYTYIQDTYWNVGFLRY 331
Cdd:pfam04188 239 SGSLMFLPFLYFQYYLYKTFCPQ------------------------RSAGNEPPWCKSQLPLLYSYIQSHYWGVGFLKY 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 332 FEVKQIPNFLLASPVIVLGSWAIWWYVTANPWHCLTLGLVRRKSAATqghdSHKPAEGFGSPGLLVYVVHAAALLVFGTF 411
Cdd:pfam04188 295 WTPKQIPNFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKK----AEKPDLGFLSPQVFVLVVHTRALVVIVCF 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211 412 FMHVQVLTRFLgSSSPVLYWFCAHLLydnepllqdgGSPSKHRESlaekpsvdnyfstcSRHENPVLMLLSKWKqsrilt 491
Cdd:pfam04188 371 FMHVQVLTRFL-SFLPLHYWFLADLL----------VSDKKKMWN--------------PLGDDKIVKFYIYWL------ 419

                         490       500
                  ....*....|....*....|....*
gi 1841885211 492 kcilgYVLSYWLLGLVLHCNFFPWT 516
Cdd:pfam04188 420 -----ACSFYILLGTLLFANFLPPT 439
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
69-219 1.19e-09

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 58.04  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1841885211  69 WDAEHFLFIAEHGYIY---EHNCAFFPLFPLTLKAAANIIFwPFQGFLCFRSClllsaallnaVFSVLASWTLYELsCAV 145
Cdd:COG5542     4 FLSPWYRAIATSGYFAalgKQFGDYFPLYPYLLRLVMYLGL-PFLLAGKLVSI----------LADLVAAYLLYRW-VKK 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1841885211 146 LQCRRRAFLSSILFCLTPANIFMAAAY--SESMFAFLVFAALWSLEKGHRWLSLLLFSLATGVRSNGLINAGFLIY 219
Cdd:COG5542    72 YYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFKPQAVFLLPALLI 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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