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Conserved domains on  [gi|1836601684|ref|XP_033859303|]
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serum response factor-like isoform X2 [Acipenser ruthenus]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 13416758)

MADS (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor)-box domain-containing protein functions as a transcription factor and may be involved in various important aspects of development and differentiation; such as serum response factor that binds to the serum response element (SRE), and controls expression of genes that regulate the cytoskeleton during development, morphogenesis and cell migration

CATH:  3.40.1810.10
Gene Ontology:  GO:0003700|GO:0046983
PubMed:  8875863|29802068|12949148
SCOP:  4001594

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 185-266 4.78e-27

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


:

Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 104.65  E-value: 4.78e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 185 GRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRK-LQPMITSETGKALIQTCLN 263
Cdd:cd00266     1 GRKKIKIKRIENKKKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSeVEGVISRFEVLSALERKKK 80


                  ...
gi 1836601684 264 SPD 266
Cdd:cd00266    81 AVD 83
ARG80 super family cl34888
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 183-418 1.11e-20

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


The actual alignment was detected with superfamily member COG5068:

Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 94.70  E-value: 1.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 183 TRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQT-C 261
Cdd:COG5068    80 SVTGRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFTTPKLESVVKSLEGKSLIQSpC 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 262 LNSPDSPPRSdpttdqrmsatgfeetdltyqVSESDSSGETKDTLKPAFTvASLPGTSTCNPTAPTTTTMQVSSGASFPI 341
Cdd:COG5068   160 SNAPSDSSEE---------------------PSSSASFSVDPNDNNPMGS-FQHNGSPQTNFIPLQNPQTQQYQQHSSRK 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 342 TNYLAPISASGNANSITSANGTVLKTAATSGgvmQLPSGFTFMSGTPLPPGTPTIP----ISQLQSHSLaiQGQPGQTIT 417
Cdd:COG5068   218 DHPTVPHSNTNNGRPPAKFMIPELHSSHSTL---DLPSDFISDSGFPNQSSTSIFPldsaIIQITPPHL--PNNPPQENR 292


                  .
gi 1836601684 418 G 418
Cdd:COG5068   293 H 293
 
Name Accession Description Interval E-value
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 185-266 4.78e-27

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 104.65  E-value: 4.78e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 185 GRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRK-LQPMITSETGKALIQTCLN 263
Cdd:cd00266     1 GRKKIKIKRIENKKKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSeVEGVISRFEVLSALERKKK 80


                  ...
gi 1836601684 264 SPD 266
Cdd:cd00266    81 AVD 83
MADS smart00432
MADS domain;
185-243 1.75e-24

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 96.47  E-value: 1.75e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1836601684  185 GRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATR 243
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFASP 59
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 183-418 1.11e-20

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 94.70  E-value: 1.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 183 TRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQT-C 261
Cdd:COG5068    80 SVTGRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFTTPKLESVVKSLEGKSLIQSpC 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 262 LNSPDSPPRSdpttdqrmsatgfeetdltyqVSESDSSGETKDTLKPAFTvASLPGTSTCNPTAPTTTTMQVSSGASFPI 341
Cdd:COG5068   160 SNAPSDSSEE---------------------PSSSASFSVDPNDNNPMGS-FQHNGSPQTNFIPLQNPQTQQYQQHSSRK 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 342 TNYLAPISASGNANSITSANGTVLKTAATSGgvmQLPSGFTFMSGTPLPPGTPTIP----ISQLQSHSLaiQGQPGQTIT 417
Cdd:COG5068   218 DHPTVPHSNTNNGRPPAKFMIPELHSSHSTL---DLPSDFISDSGFPNQSSTSIFPldsaIIQITPPHL--PNNPPQENR 292


                  .
gi 1836601684 418 G 418
Cdd:COG5068   293 H 293
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
193-240 1.13e-20

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 85.17  E-value: 1.13e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1836601684 193 FIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTF 240
Cdd:pfam00319   1 RIENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
 
Name Accession Description Interval E-value
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 185-266 4.78e-27

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 104.65  E-value: 4.78e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 185 GRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRK-LQPMITSETGKALIQTCLN 263
Cdd:cd00266     1 GRKKIKIKRIENKKKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSeVEGVISRFEVLSALERKKK 80


                  ...
gi 1836601684 264 SPD 266
Cdd:cd00266    81 AVD 83
MADS smart00432
MADS domain;
185-243 1.75e-24

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 96.47  E-value: 1.75e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1836601684  185 GRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATR 243
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFASP 59
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 185-242 2.40e-23

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 93.35  E-value: 2.40e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1836601684 185 GRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFAT 242
Cdd:cd00120     1 GRGKIEIKRIENKTSRQVTFSKRRNGLFKKASELSVLCDAEVAVIVFSPSGKLYEFWS 58
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 183-418 1.11e-20

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 94.70  E-value: 1.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 183 TRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQT-C 261
Cdd:COG5068    80 SVTGRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFTTPKLESVVKSLEGKSLIQSpC 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 262 LNSPDSPPRSdpttdqrmsatgfeetdltyqVSESDSSGETKDTLKPAFTvASLPGTSTCNPTAPTTTTMQVSSGASFPI 341
Cdd:COG5068   160 SNAPSDSSEE---------------------PSSSASFSVDPNDNNPMGS-FQHNGSPQTNFIPLQNPQTQQYQQHSSRK 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836601684 342 TNYLAPISASGNANSITSANGTVLKTAATSGgvmQLPSGFTFMSGTPLPPGTPTIP----ISQLQSHSLaiQGQPGQTIT 417
Cdd:COG5068   218 DHPTVPHSNTNNGRPPAKFMIPELHSSHSTL---DLPSDFISDSGFPNQSSTSIFPldsaIIQITPPHL--PNNPPQENR 292


                  .
gi 1836601684 418 G 418
Cdd:COG5068   293 H 293
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
193-240 1.13e-20

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 85.17  E-value: 1.13e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1836601684 193 FIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTF 240
Cdd:pfam00319   1 RIENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 185-249 5.31e-18

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 78.75  E-value: 5.31e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1836601684 185 GRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMI 249
Cdd:cd00265     1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKII 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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