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Conserved domains on  [gi|1849975277|ref|XP_033856990|]
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telethonin [Acipenser ruthenus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Telethonin super family cl09707
Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle ...
 26-163 3.95e-43

Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle protein, titin. The very N-terminus of titin, composed of two immunoglobulin-like (Ig) domains, referred to as Z1 and Z2, interacts with the N-terminal region (residues 1-53) of telethonin, mediating the antiparallel assembly of two Z1Z2 domains. The C-terminus of the telethonin appears to induce dimerization of this 2:1 titin/telethonin structure which thus forms a complex necessary for myofibril assembly and maintenance of the intact Z-disk of skeletal and cardiac muscles.


The actual alignment was detected with superfamily member pfam09470:

Pssm-ID: 462811  Cd Length: 150  Bit Score: 141.08  E-value: 3.95e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849975277  26 DKELYHSSWQDLVMETRPWEKTTLSENNTQKKETYEKKHLDTFLVQRSPDQKMKIGRLGERMTEYQLPYRNVLPVPIFMP 105
Cdd:pfam09470   1 RRESYTADWQSVSLKTQPEDRQSLHMVDDSRRETLSRQWQARPLVQRCPSGVMRMGTLGRGVREYQLPYRNTLPLPIFKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1849975277 106 NKvLSVAKDSArapTPAELKAIMEFEKAlsSGVSVGRREISEITKEMPKLIQPIRMDF 163
Cdd:pfam09470  81 AE-LGTRLGRG---TPHTLEDLMPFETA--DGVCPDKREVSEITRDLPPVVQPTRMEF 132
 
Name Accession Description Interval E-value
Telethonin pfam09470
Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle ...
 26-163 3.95e-43

Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle protein, titin. The very N-terminus of titin, composed of two immunoglobulin-like (Ig) domains, referred to as Z1 and Z2, interacts with the N-terminal region (residues 1-53) of telethonin, mediating the antiparallel assembly of two Z1Z2 domains. The C-terminus of the telethonin appears to induce dimerization of this 2:1 titin/telethonin structure which thus forms a complex necessary for myofibril assembly and maintenance of the intact Z-disk of skeletal and cardiac muscles.


Pssm-ID: 462811  Cd Length: 150  Bit Score: 141.08  E-value: 3.95e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849975277  26 DKELYHSSWQDLVMETRPWEKTTLSENNTQKKETYEKKHLDTFLVQRSPDQKMKIGRLGERMTEYQLPYRNVLPVPIFMP 105
Cdd:pfam09470   1 RRESYTADWQSVSLKTQPEDRQSLHMVDDSRRETLSRQWQARPLVQRCPSGVMRMGTLGRGVREYQLPYRNTLPLPIFKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1849975277 106 NKvLSVAKDSArapTPAELKAIMEFEKAlsSGVSVGRREISEITKEMPKLIQPIRMDF 163
Cdd:pfam09470  81 AE-LGTRLGRG---TPHTLEDLMPFETA--DGVCPDKREVSEITRDLPPVVQPTRMEF 132
 
Name Accession Description Interval E-value
Telethonin pfam09470
Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle ...
 26-163 3.95e-43

Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle protein, titin. The very N-terminus of titin, composed of two immunoglobulin-like (Ig) domains, referred to as Z1 and Z2, interacts with the N-terminal region (residues 1-53) of telethonin, mediating the antiparallel assembly of two Z1Z2 domains. The C-terminus of the telethonin appears to induce dimerization of this 2:1 titin/telethonin structure which thus forms a complex necessary for myofibril assembly and maintenance of the intact Z-disk of skeletal and cardiac muscles.


Pssm-ID: 462811  Cd Length: 150  Bit Score: 141.08  E-value: 3.95e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849975277  26 DKELYHSSWQDLVMETRPWEKTTLSENNTQKKETYEKKHLDTFLVQRSPDQKMKIGRLGERMTEYQLPYRNVLPVPIFMP 105
Cdd:pfam09470   1 RRESYTADWQSVSLKTQPEDRQSLHMVDDSRRETLSRQWQARPLVQRCPSGVMRMGTLGRGVREYQLPYRNTLPLPIFKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1849975277 106 NKvLSVAKDSArapTPAELKAIMEFEKAlsSGVSVGRREISEITKEMPKLIQPIRMDF 163
Cdd:pfam09470  81 AE-LGTRLGRG---TPHTLEDLMPFETA--DGVCPDKREVSEITRDLPPVVQPTRMEF 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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