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Conserved domains on  [gi|1835591817|ref|XP_033812647|]
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reticulon-4 receptor [Geotrypetes seraphini]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-258 2.23e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 2.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  90 ISLIESLAFYGLHKLEELDIGDNiNLKSInPITFQGLTRLHTLHINRCGLLELPKGIFQgLFSLQFLYIQNNNLQSLhDD 169
Cdd:COG4886   101 LDLSGNEELSNLTNLESLDLSGN-QLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDL-PE 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 170 TFLDLANLTYLFLHDNKIKSLSEnVFRGLISLDRLLLHQNRVNQIhSQAFHDLGKVMTLYLFNNNLTELqgDCLTPLINL 249
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNL 252


                  ....*....
gi 1835591817 250 QYLRLNGNE 258
Cdd:COG4886   253 EELDLSNNQ 261
LRR_8 pfam13855
Leucine rich repeat;
57-112 1.55e-04

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835591817  57 QRIFLHNNKIIQVKDKSLSLCHNMTILRIHSNNISLIESLAFYGLHKLEELDIGDN 112
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRRNT smart00013
Leucine rich repeat N-terminal domain;
23-53 4.46e-04

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 4.46e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1835591817   23 ACPMACLCssePKITVNCQQQKLTEIPSEIP 53
Cdd:smart00013   1 ACPAPCNC---SGTAVDCSGRGLTEVPLDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-258 2.23e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 2.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  90 ISLIESLAFYGLHKLEELDIGDNiNLKSInPITFQGLTRLHTLHINRCGLLELPKGIFQgLFSLQFLYIQNNNLQSLhDD 169
Cdd:COG4886   101 LDLSGNEELSNLTNLESLDLSGN-QLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDL-PE 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 170 TFLDLANLTYLFLHDNKIKSLSEnVFRGLISLDRLLLHQNRVNQIhSQAFHDLGKVMTLYLFNNNLTELqgDCLTPLINL 249
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNL 252


                  ....*....
gi 1835591817 250 QYLRLNGNE 258
Cdd:COG4886   253 EELDLSNNQ 261
LRR_8 pfam13855
Leucine rich repeat;
152-211 2.24e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 2.24e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 152 SLQFLYIQNNNLQSLHDDTFLDLANLTYLFLHDNKIKSLSENVFRGLISLDRLLLHQNRV 211
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 59-215 7.52e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 7.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  59 IFLHNNKIiqVKDKSLSLCHNMTILRIHSNNISLIESLAFygLHKLEELDIGDNiNLKSINPitFQGLTRLHTLHINR-- 136
Cdd:cd21340     7 LYLNDKNI--TKIDNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNN-QIEKIEN--LENLVNLKKLYLGGnr 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 137 ---------CGLLE--------LPKGifQGLF-----------SLQFLYIQNNNLQSLHDdtFLDLANLTYLFLHDNKIK 188
Cdd:cd21340    80 isvveglenLTNLEelhienqrLPPG--EKLTfdprslaalsnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                         170       180
                  ....*....|....*....|....*....
gi 1835591817 189 SLSE--NVFRGLISLDRLLLHQNRVNQIH 215
Cdd:cd21340   156 DLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-201 5.77e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 5.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  28 CLCSSEPKITVNcqQQKLTEIPSEIPIQSQRIFLHNNKIIQVKDkslSLCHNMTILRIHSNNI-SLIESLAfyglHKLEE 106
Cdd:PRK15370  175 CLKNNKTELRLK--ILGLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLtSIPATLP----DTIQE 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 107 LDIGDN--INLKSINPITFQGLTRLHTlhinrcGLLELPKGIFQGlfsLQFLYIQNNNLQSLHDDTfldLANLTYLFLHD 184
Cdd:PRK15370  246 MELSINriTELPERLPSALQSLDLFHN------KISCLPENLPEE---LRYLSVYDNSIRTLPAHL---PSGITHLNVQS 313

                         170
                  ....*....|....*..
gi 1835591817 185 NKIKSLSENVFRGLISL 201
Cdd:PRK15370  314 NSLTALPETLPPGLKTL 330
LRR_8 pfam13855
Leucine rich repeat;
57-112 1.55e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835591817  57 QRIFLHNNKIIQVKDKSLSLCHNMTILRIHSNNISLIESLAFYGLHKLEELDIGDN 112
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRRNT smart00013
Leucine rich repeat N-terminal domain;
23-53 4.46e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 4.46e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1835591817   23 ACPMACLCssePKITVNCQQQKLTEIPSEIP 53
Cdd:smart00013   1 ACPAPCNC---SGTAVDCSGRGLTEVPLDLP 28
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 23-53 1.20e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1835591817  23 ACPMACLCSsepKITVNCQQQKLTEIPSEIP 53
Cdd:pfam01462   1 ACPVPCHCS---ATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-258 2.23e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 2.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  90 ISLIESLAFYGLHKLEELDIGDNiNLKSInPITFQGLTRLHTLHINRCGLLELPKGIFQgLFSLQFLYIQNNNLQSLhDD 169
Cdd:COG4886   101 LDLSGNEELSNLTNLESLDLSGN-QLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDL-PE 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 170 TFLDLANLTYLFLHDNKIKSLSEnVFRGLISLDRLLLHQNRVNQIhSQAFHDLGKVMTLYLFNNNLTELqgDCLTPLINL 249
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNL 252


                  ....*....
gi 1835591817 250 QYLRLNGNE 258
Cdd:COG4886   253 EELDLSNNQ 261
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-255 7.50e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 7.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  37 TVNCQQQKLTEIPSEIP--IQSQRIFLHNNKIIQVkDKSLSLCHNMTILRIHSNNISLIESlAFYGLHKLEELDIGDNiN 114
Cdd:COG4886   117 SLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN-Q 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 115 LKSInPITFQGLTRLHTLHINRCGLLELPKGIfQGLFSLQFLYIQNNNLQSLhdDTFLDLANLTYLFLHDNKIKSLSENV 194
Cdd:COG4886   194 ITDL-PEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA 269

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835591817 195 frGLISLDRLLLHQNRVNQIHSQAFHDLGKVMTLYLFNNNLTELQGDCLTPLINLQYLRLN 255
Cdd:COG4886   270 --NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
LRR_8 pfam13855
Leucine rich repeat;
152-211 2.24e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 2.24e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 152 SLQFLYIQNNNLQSLHDDTFLDLANLTYLFLHDNKIKSLSENVFRGLISLDRLLLHQNRV 211
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
127-187 2.37e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 2.37e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835591817 127 TRLHTLHINRCGLLELPKGIFQGLFSLQFLYIQNNNLQSLHDDTFLDLANLTYLFLHDNKI 187
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 59-215 7.52e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 7.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  59 IFLHNNKIiqVKDKSLSLCHNMTILRIHSNNISLIESLAFygLHKLEELDIGDNiNLKSINPitFQGLTRLHTLHINR-- 136
Cdd:cd21340     7 LYLNDKNI--TKIDNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNN-QIEKIEN--LENLVNLKKLYLGGnr 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 137 ---------CGLLE--------LPKGifQGLF-----------SLQFLYIQNNNLQSLHDdtFLDLANLTYLFLHDNKIK 188
Cdd:cd21340    80 isvveglenLTNLEelhienqrLPPG--EKLTfdprslaalsnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                         170       180
                  ....*....|....*....|....*....
gi 1835591817 189 SLSE--NVFRGLISLDRLLLHQNRVNQIH 215
Cdd:cd21340   156 DLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-258 2.27e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 2.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  37 TVNCQQQKLTEIPSEI-PIQS-QRIFLHNNKIIQVKDkSLSLCHNMTILRIHSNNISLIeSLAFYGLHKLEELDIGDNiN 114
Cdd:COG4886   163 SLDLSNNQLTDLPEELgNLTNlKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN-Q 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 115 LKSINPITfqGLTRLHTLHINRCGLLELPKgiFQGLFSLQFLYIQNNNLQSLHDDTFLDLANLTYLFLHDNKIKSLSENV 194
Cdd:COG4886   240 LTDLPELG--NLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835591817 195 FRGLISLDRLLLHQNRVNQIHSQAFHDLGKVMTLYLFNNNLTELQGDCLTPLINLQYLRLNGNE 258
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379
LRR_8 pfam13855
Leucine rich repeat;
176-235 1.69e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.69e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 176 NLTYLFLHDNKIKSLSENVFRGLISLDRLLLHQNRVNQIHSQAFHDLGKVMTLYLFNNNL 235
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
79-163 3.04e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  79 NMTILRIHSNNISLIESLAFYGLHKLEELDIGDNiNLKSINPITFQGLTrlhtlhinrcgllelpkgifqglfSLQFLYI 158
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLP------------------------SLRYLDL 56


                  ....*
gi 1835591817 159 QNNNL 163
Cdd:pfam13855  57 SGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
200-257 7.28e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 7.28e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1835591817 200 SLDRLLLHQNRVNQIHSQAFHDLGKVMTLYLFNNNLTELQGDCLTPLINLQYLRLNGN 257
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-258 2.38e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 2.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 104 LEELDIGDNINLKSINPITFQGLTRLHTLHINRCGLLELPKGIFQGLFSLQFLYIQNNNlqslhddTFLDLANLTYLFLH 183
Cdd:COG4886    49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLS 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835591817 184 DNKIKSLSENvFRGLISLDRLLLHQNRVNQIHSqAFHDLGKVMTLYLFNNNLTELqGDCLTPLINLQYLRLNGNE 258
Cdd:COG4886   122 GNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-201 5.77e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 5.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  28 CLCSSEPKITVNcqQQKLTEIPSEIPIQSQRIFLHNNKIIQVKDkslSLCHNMTILRIHSNNI-SLIESLAfyglHKLEE 106
Cdd:PRK15370  175 CLKNNKTELRLK--ILGLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLtSIPATLP----DTIQE 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 107 LDIGDN--INLKSINPITFQGLTRLHTlhinrcGLLELPKGIFQGlfsLQFLYIQNNNLQSLHDDTfldLANLTYLFLHD 184
Cdd:PRK15370  246 MELSINriTELPERLPSALQSLDLFHN------KISCLPENLPEE---LRYLSVYDNSIRTLPAHL---PSGITHLNVQS 313

                         170
                  ....*....|....*..
gi 1835591817 185 NKIKSLSENVFRGLISL 201
Cdd:PRK15370  314 NSLTALPETLPPGLKTL 330
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 141-257 9.10e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 9.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 141 ELPKGIfQGLFSLQFLYIQNNNLQSLHDDTFLDLANLTYLFLHDNKIK-SLSENVF--RGLISLDrllLHQNRVNQIHSQ 217
Cdd:PLN00113  227 EIPYEI-GGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFslQKLISLD---LSDNSLSGEIPE 302

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1835591817 218 AFHDLGKVMTLYLFNNNLTELQGDCLTPLINLQYLRLNGN 257
Cdd:PLN00113  303 LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN 342
LRR_8 pfam13855
Leucine rich repeat;
57-112 1.55e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835591817  57 QRIFLHNNKIIQVKDKSLSLCHNMTILRIHSNNISLIESLAFYGLHKLEELDIGDN 112
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 174-258 2.14e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 2.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 174 LANLTYLFLHDNKIKSLSEnvFRGLISLDRLLLHQNRVNQIhsQAFHDLGKVMTLYLFNNNLTELQGdcLTPLINLQYLR 253
Cdd:cd21340     1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74


                  ....*
gi 1835591817 254 LNGNE 258
Cdd:cd21340    75 LGGNR 79
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 87-201 3.67e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 40.22  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  87 SNNISLIESLAFYGLHKLEELDIGDniNLKSINPITFQGlTRLHTLHINrCGLLELPKGIFQGLFSLQFLYIqNNNLQSL 166
Cdd:pfam13306  19 PSSLTSIGEYAFSNCTSLKSITLPS--SLTSIGSYAFYN-CSLTSITIP-SSLTSIGEYAFSNCSNLKSITL-PSNLTSI 93

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1835591817 167 HDDTFLDlANLTYLFLHDNkIKSLSENVFRGLISL 201
Cdd:pfam13306  94 GSYAFSN-CSLKSITIPSS-VTTIGSYAFSNCSNL 126
LRRNT smart00013
Leucine rich repeat N-terminal domain;
23-53 4.46e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 4.46e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1835591817   23 ACPMACLCssePKITVNCQQQKLTEIPSEIP 53
Cdd:smart00013   1 ACPAPCNC---SGTAVDCSGRGLTEVPLDLP 28
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 23-53 1.20e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1835591817  23 ACPMACLCSsepKITVNCQQQKLTEIPSEIP 53
Cdd:pfam01462   1 ACPVPCHCS---ATVVNCSDRGLTAVPRDLP 28
LRR_9 pfam14580
Leucine-rich repeat;
83-187 2.99e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.59  E-value: 2.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  83 LRIHSNNISLIESLAfYGLHKLEELDIGDNINLKSINpitFQGLTRLHTLHINRCGLLELPKGIFQGLFSLQFLYIQNNN 162
Cdd:pfam14580  24 LDLRGYKIPIIENLG-ATLDQFDTIDFSDNEIRKLDG---FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNN 99

                          90       100
                  ....*....|....*....|....*.
gi 1835591817 163 LQSLHD-DTFLDLANLTYLFLHDNKI 187
Cdd:pfam14580 100 LQELGDlDPLASLKKLTFLSLLRNPV 125
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-258 8.22e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 8.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817  72 KSLSLCHNMTILRIHSNNIS--LIESLAFYGlhKLEELDIGDNiNLKSINPITFQGLTRLHTLHINRCGLL-ELPKGiFQ 148
Cdd:PLN00113  350 KNLGKHNNLTVLDLSTNNLTgeIPEGLCSSG--NLFKLILFSN-SLEGEIPKSLGACRSLRRVRLQDNSFSgELPSE-FT 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835591817 149 GLFSLQFLYIQNNNLQSLHDDTFLDLANLTYLFLHDNKIKSLSENVFRGlISLDRLLLHQNRVNQIHSQAFHDLGKVMTL 228
Cdd:PLN00113  426 KLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQL 504

                         170       180       190
                  ....*....|....*....|....*....|
gi 1835591817 229 YLFNNNLTELQGDCLTPLINLQYLRLNGNE 258
Cdd:PLN00113  505 KLSENKLSGEIPDELSSCKKLVSLDLSHNQ 534
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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