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Conserved domains on  [gi|1835668675|ref|XP_033805117|]
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interferon gamma receptor 2 [Geotrypetes seraphini]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414172)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tissue_fac super family cl47630
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 24-116 2.91e-17

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


The actual alignment was detected with superfamily member pfam01108:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 75.88  E-value: 2.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675  24 LADSLPNLPAPQNVRICSYNLIQVLYWDPvsVENGIGKVTYEVEFQAYGTKDWY-KMKCSKITETQCNFTNAFPN-TWRI 101
Cdd:pfam01108  15 SAAGGPSLPAPQNVTFQSTNFKNILTWEP--GPNSPPDVVYTVQYKIYGSGDWKnVPNCTNITRTECDLTDETSDlTETY 92

                          90
                  ....*....|....*
gi 1835668675 102 FLRVRTVNNQLESEW 116
Cdd:pfam01108  93 YARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 128-219 1.25e-16

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


:

Pssm-ID: 462746  Cd Length: 103  Bit Score: 73.92  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675 128 TTVGPPtSVKVTSDFGLLIVAFSPPFDKISE----------LNYYVYYWKN--NAEKKVKATRSTSVKLNDLDPWTEYCL 195
Cdd:pfam09294   1 TIIGPP-EVELEVEGGSLNVTVKDPETREGKnlslrdlygsLQYRVSYWKNssNGEKKNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|....
gi 1835668675 196 QVFAEYTTGEKNGTLSEPVCNRTT 219
Cdd:pfam09294  80 SVQAFSPLDNKSSQRSPPQCIRTT 103
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 24-116 2.91e-17

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 75.88  E-value: 2.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675  24 LADSLPNLPAPQNVRICSYNLIQVLYWDPvsVENGIGKVTYEVEFQAYGTKDWY-KMKCSKITETQCNFTNAFPN-TWRI 101
Cdd:pfam01108  15 SAAGGPSLPAPQNVTFQSTNFKNILTWEP--GPNSPPDVVYTVQYKIYGSGDWKnVPNCTNITRTECDLTDETSDlTETY 92

                          90
                  ....*....|....*
gi 1835668675 102 FLRVRTVNNQLESEW 116
Cdd:pfam01108  93 YARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 128-219 1.25e-16

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 73.92  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675 128 TTVGPPtSVKVTSDFGLLIVAFSPPFDKISE----------LNYYVYYWKN--NAEKKVKATRSTSVKLNDLDPWTEYCL 195
Cdd:pfam09294   1 TIIGPP-EVELEVEGGSLNVTVKDPETREGKnlslrdlygsLQYRVSYWKNssNGEKKNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|....
gi 1835668675 196 QVFAEYTTGEKNGTLSEPVCNRTT 219
Cdd:pfam09294  80 SVQAFSPLDNKSSQRSPPQCIRTT 103
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 131-218 7.85e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 7.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675 131 GPPTSVKVTS-DFGLLIVAFSPPFDKISE-LNYYVYYWKNNAEK----KVKATRSTSVKLNDLDPWTEYCLQVFAEYTTG 204
Cdd:cd00063     2 SPPTNLRVTDvTSTSVTLSWTPPEDDGGPiTGYVVEYREKGSGDwkevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|....
gi 1835668675 205 EknGTLSEPVCNRT 218
Cdd:cd00063    82 E--SPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 131-205 9.48e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 9.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675  131 GPPTSVKV---TSDFglLIVAFSPPFDKISElNYYVYYWKNNAEKKVKATR------STSVKLNDLDPWTEYCLQVFAEY 201
Cdd:smart00060   2 SPPSNLRVtdvTSTS--VTLSWEPPPDDGIT-GYIVGYRVEYREEGSEWKEvnvtpsSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....
gi 1835668675  202 TTGE 205
Cdd:smart00060  79 GAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 32-123 4.70e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675  32 PAPQNVRICSYNLIQV-LYWDPVSVENGIGkVTYEVEFQAYGTKDWYKMKCSKITETQCNFTNAFPNTwRIFLRVRTVNN 110
Cdd:cd00063     2 SPPTNLRVTDVTSTSVtLSWTPPEDDGGPI-TGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGT-EYEFRVRAVNG 79

                          90
                  ....*....|...
gi 1835668675 111 QLESEWVNTTDFQ 123
Cdd:cd00063    80 GGESPPSESVTVT 92
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 24-116 2.91e-17

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 75.88  E-value: 2.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675  24 LADSLPNLPAPQNVRICSYNLIQVLYWDPvsVENGIGKVTYEVEFQAYGTKDWY-KMKCSKITETQCNFTNAFPN-TWRI 101
Cdd:pfam01108  15 SAAGGPSLPAPQNVTFQSTNFKNILTWEP--GPNSPPDVVYTVQYKIYGSGDWKnVPNCTNITRTECDLTDETSDlTETY 92

                          90
                  ....*....|....*
gi 1835668675 102 FLRVRTVNNQLESEW 116
Cdd:pfam01108  93 YARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 128-219 1.25e-16

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 73.92  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675 128 TTVGPPtSVKVTSDFGLLIVAFSPPFDKISE----------LNYYVYYWKN--NAEKKVKATRSTSVKLNDLDPWTEYCL 195
Cdd:pfam09294   1 TIIGPP-EVELEVEGGSLNVTVKDPETREGKnlslrdlygsLQYRVSYWKNssNGEKKNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|....
gi 1835668675 196 QVFAEYTTGEKNGTLSEPVCNRTT 219
Cdd:pfam09294  80 SVQAFSPLDNKSSQRSPPQCIRTT 103
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 131-218 7.85e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 7.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675 131 GPPTSVKVTS-DFGLLIVAFSPPFDKISE-LNYYVYYWKNNAEK----KVKATRSTSVKLNDLDPWTEYCLQVFAEYTTG 204
Cdd:cd00063     2 SPPTNLRVTDvTSTSVTLSWTPPEDDGGPiTGYVVEYREKGSGDwkevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|....
gi 1835668675 205 EknGTLSEPVCNRT 218
Cdd:cd00063    82 E--SPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
131-205 9.45e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 9.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675 131 GPPTSVKV---TSDFglLIVAFSPPFDKISELNYY-VYYWK---NNAEKKVKATRST-SVKLNDLDPWTEYCLQVFAEYT 202
Cdd:pfam00041   1 SAPSNLTVtdvTSTS--LTVSWTPPPDGNGPITGYeVEYRPknsGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNG 78


                  ...
gi 1835668675 203 TGE 205
Cdd:pfam00041  79 GGE 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 131-205 9.48e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 9.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675  131 GPPTSVKV---TSDFglLIVAFSPPFDKISElNYYVYYWKNNAEKKVKATR------STSVKLNDLDPWTEYCLQVFAEY 201
Cdd:smart00060   2 SPPSNLRVtdvTSTS--VTLSWEPPPDDGIT-GYIVGYRVEYREEGSEWKEvnvtpsSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....
gi 1835668675  202 TTGE 205
Cdd:smart00060  79 GAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 32-123 4.70e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835668675  32 PAPQNVRICSYNLIQV-LYWDPVSVENGIGkVTYEVEFQAYGTKDWYKMKCSKITETQCNFTNAFPNTwRIFLRVRTVNN 110
Cdd:cd00063     2 SPPTNLRVTDVTSTSVtLSWTPPEDDGGPI-TGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGT-EYEFRVRAVNG 79

                          90
                  ....*....|...
gi 1835668675 111 QLESEWVNTTDFQ 123
Cdd:cd00063    80 GGESPPSESVTVT 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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