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Conserved domains on  [gi|1818147686|ref|XP_032578843|]
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protein groucho isoform X3 [Drosophila sechellia]

Protein Classification

WD40 domain-containing protein( domain architecture ID 10511324)

WD40 domain-containing protein similar to Drosophila melanogaster protein groucho and Homo sapiens transducin-like enhancer proteins; also contains a Groucho/TLE N-terminal Q-rich domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 20-132 2.76e-79

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


:

Pssm-ID: 461094  Cd Length: 117  Bit Score: 248.49  E-value: 2.76e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686  20 IKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVMYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQ 99
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1818147686 100 ADHQQQVLQAVERAKQVTMQELNLIIG----IHAQQV 132
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGqqqqLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
430-715 2.81e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.71  E-value: 2.81e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 430 HGEVVCAVTISNPTKYVYTGGK-GCVKVWDISQPgnknpvsqlDCLQR----DNYIRSVKLLPDGRTLIVGGEASNLSIW 504
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATG---------KLLRTltghSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 505 DLASPTPRikAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLD 584
Cdd:COG2319   190 DLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 585 NTVRSWDLREGRQLQQ-HDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDK-YQLHLHESCVLSLRFAACGKWFVS 662
Cdd:COG2319   268 GTVRLWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLAS 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1818147686 663 TGKDNLLNAWRTPYGASIFQSKE-TSSVLSCDISTDDKYIVTGSGDKKATVYEV 715
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 20-132 2.76e-79

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 248.49  E-value: 2.76e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686  20 IKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVMYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQ 99
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1818147686 100 ADHQQQVLQAVERAKQVTMQELNLIIG----IHAQQV 132
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGqqqqLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
430-715 2.81e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.71  E-value: 2.81e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 430 HGEVVCAVTISNPTKYVYTGGK-GCVKVWDISQPgnknpvsqlDCLQR----DNYIRSVKLLPDGRTLIVGGEASNLSIW 504
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATG---------KLLRTltghSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 505 DLASPTPRikAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLD 584
Cdd:COG2319   190 DLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 585 NTVRSWDLREGRQLQQ-HDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDK-YQLHLHESCVLSLRFAACGKWFVS 662
Cdd:COG2319   268 GTVRLWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLAS 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1818147686 663 TGKDNLLNAWRTPYGASIFQSKE-TSSVLSCDISTDDKYIVTGSGDKKATVYEV 715
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 429-714 1.62e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 1.62e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 429 SHGEVVCAVTISNPTKYVYTGGK-GCVKVWDIsqpgNKNPVSQLDCLQRDNyIRSVKLLPDGRTLIVGGEASNLSIWDLa 507
Cdd:cd00200     7 GHTGGVTCVAFSPDGKLLATGSGdGTIKVWDL----ETGELLRTLKGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 508 sPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTV 587
Cdd:cd00200    81 -ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 588 RSWDLREGR---QLQQHDfsSQIFSLGYCPTGDWLAVGMENSHVEV--LHASKPdKYQLHLHESCVLSLRFAACGKWFVS 662
Cdd:cd00200   160 KLWDLRTGKcvaTLTGHT--GEVNSVAFSPDGEKLLSSSSDGTIKLwdLSTGKC-LGTLRGHENGVNSVAFSPDGYLLAS 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1818147686 663 TGKDNLLNAWRTPYGASIFQ-SKETSSVLSCDISTDDKYIVTGSGDKKATVYE 714
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 555-591 1.69e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.69e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1818147686  555 LVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWD 591
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
555-591 1.45e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.45e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1818147686 555 LVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWD 591
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 451-713 9.27e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 9.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 451 KGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPtprIKAELTSAAPACYALAIS 530
Cdd:PLN00181  457 EGLCKYLSFSKLRVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESI---IKDGRDIHYPVVELASRS 533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 531 PDSKVCF---------SCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDI-SPDGSRLWTGGLDNTVRSWDLREGRQLQQ 600
Cdd:PLN00181  534 KLSGICWnsyiksqvaSSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGT 613

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 601 HDFSSQIFSLGY-CPTGDWLAVGMENSHVEVLHASKPdkyQLHL-----HESCVLSLRFAACGKwFVSTGKDNLLNAWRT 674
Cdd:PLN00181  614 IKTKANICCVQFpSESGRSLAFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDL 689

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1818147686 675 PYGASIFQSKETSSVLS-------CDISTDDKYIVTGSGDKKATVY 713
Cdd:PLN00181  690 SMSISGINETPLHSFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 20-132 2.76e-79

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 248.49  E-value: 2.76e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686  20 IKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVMYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQ 99
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1818147686 100 ADHQQQVLQAVERAKQVTMQELNLIIG----IHAQQV 132
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGqqqqLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
430-715 2.81e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.71  E-value: 2.81e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 430 HGEVVCAVTISNPTKYVYTGGK-GCVKVWDISQPgnknpvsqlDCLQR----DNYIRSVKLLPDGRTLIVGGEASNLSIW 504
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATG---------KLLRTltghSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 505 DLASPTPRikAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLD 584
Cdd:COG2319   190 DLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 585 NTVRSWDLREGRQLQQ-HDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDK-YQLHLHESCVLSLRFAACGKWFVS 662
Cdd:COG2319   268 GTVRLWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLAS 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1818147686 663 TGKDNLLNAWRTPYGASIFQSKE-TSSVLSCDISTDDKYIVTGSGDKKATVYEV 715
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 429-714 1.62e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 1.62e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 429 SHGEVVCAVTISNPTKYVYTGGK-GCVKVWDIsqpgNKNPVSQLDCLQRDNyIRSVKLLPDGRTLIVGGEASNLSIWDLa 507
Cdd:cd00200     7 GHTGGVTCVAFSPDGKLLATGSGdGTIKVWDL----ETGELLRTLKGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 508 sPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTV 587
Cdd:cd00200    81 -ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 588 RSWDLREGR---QLQQHDfsSQIFSLGYCPTGDWLAVGMENSHVEV--LHASKPdKYQLHLHESCVLSLRFAACGKWFVS 662
Cdd:cd00200   160 KLWDLRTGKcvaTLTGHT--GEVNSVAFSPDGEKLLSSSSDGTIKLwdLSTGKC-LGTLRGHENGVNSVAFSPDGYLLAS 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1818147686 663 TGKDNLLNAWRTPYGASIFQ-SKETSSVLSCDISTDDKYIVTGSGDKKATVYE 714
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
474-715 3.45e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.45  E-value: 3.45e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 474 LQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLAspTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNE 553
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA--TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 554 ILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQ---HdfSSQIFSLGYCPTGDWLAVGMENSHVEV 630
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTltgH--TGAVRSVAFSPDGKLLASGSADGTVRL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 631 LHASKPD-KYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASI-FQSKETSSVLSCDISTDDKYIVTGSGDK 708
Cdd:COG2319   231 WDLATGKlLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFSPDGKLLASGSDDG 310


                  ....*..
gi 1818147686 709 KATVYEV 715
Cdd:COG2319   311 TVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
423-675 1.06e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 1.06e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 423 RQINTLS-HGEVVCAVTISNPTKYVYTGGK-GCVKVWDISqpgNKNPVSQLDclQRDNYIRSVKLLPDGRTLIVGGEASN 500
Cdd:COG2319   153 KLLRTLTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 501 LSIWDLAspTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWT 580
Cdd:COG2319   228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 581 GGLDNTVRSWDLREGRQLQQHD-FSSQIFSLGYCPTGDWLAVGMENSHVEVLH-ASKPDKYQLHLHESCVLSLRFAACGK 658
Cdd:COG2319   306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGR 385

                         250
                  ....*....|....*..
gi 1818147686 659 WFVSTGKDNLLNAWRTP 675
Cdd:COG2319   386 TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
480-715 4.74e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 4.74e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 480 IRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPacYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQF 559
Cdd:COG2319    39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV--LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 560 QGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQ-HDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDK 638
Cdd:COG2319   117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1818147686 639 YQ-LHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSK-ETSSVLSCDISTDDKYIVTGSGDKKATVYEV 715
Cdd:COG2319   197 LRtLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 524-715 4.66e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.58  E-value: 4.66e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 524 CYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQ-HD 602
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTlTG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 603 FSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPD-KYQLHLHESCVLSLRFAACGKwFVSTGK-DNLLNAWRTPYGASI 680
Cdd:cd00200    92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKcLTTLRGHTDWVNSVAFSPDGT-FVASSSqDGTIKLWDLRTGKCV 170

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1818147686 681 --FQSkETSSVLSCDISTDDKYIVTGSGDKKATVYEV 715
Cdd:cd00200   171 atLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 555-715 1.17e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.56  E-value: 1.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 555 LVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREG---RQLQQHdfSSQIFSLGYCPTGDWLAVGMENSHVEVL 631
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 632 HASKPDK-YQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASI--FQSKeTSSVLSCDISTDDKYIVTGSGDK 708
Cdd:cd00200    79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttLRGH-TDWVNSVAFSPDGTFVASSSQDG 157


                  ....*..
gi 1818147686 709 KATVYEV 715
Cdd:cd00200   158 TIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
485-715 1.25e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 1.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 485 LLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPAcyALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTD 564
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVA--SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 565 GASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQ-HDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDK-YQLH 642
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLT 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1818147686 643 LHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQ-SKETSSVLSCDISTDDKYIVTGSGDKKATVYEV 715
Cdd:COG2319   160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
423-552 5.20e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 5.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 423 RQINTLS-HGEVVCAVTISNPTKYVYTGGKGC-VKVWDISqpgNKNPVSQLDclQRDNYIRSVKLLPDGRTLIVGGEASN 500
Cdd:COG2319   279 ELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGT 353

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1818147686 501 LSIWDLAspTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHN 552
Cdd:COG2319   354 VRLWDLA--TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 555-591 1.69e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.69e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1818147686  555 LVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWD 591
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
555-591 1.45e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.45e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1818147686 555 LVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWD 591
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
445-592 8.30e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.77  E-value: 8.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 445 YVYTGGKGCVKVWDisqPGNKNPVSQLDClqrDNYIRSVKLLPDGRTLIVGGEASN-LSIWDLAspTPRIKAEL-TSAAP 522
Cdd:COG3391    83 YVANSGSGRVSVID---LATGKVVATIPV---GGGPRGLAVDPDGGRLYVADSGNGrVSVIDTA--TGKVVATIpVGAGP 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 523 acYALAISPDSKVCFSCCSDGN-----IAVWDLHNEILVRQFQGHtDGASCIDISPDGSRLW--------TGGLDNTVRS 589
Cdd:COG3391   155 --HGIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVATIPVG-GGPVGVAVSPDGRRLYvanrgsntSNGGSNTVSV 231


                  ...
gi 1818147686 590 WDL 592
Cdd:COG3391   232 IDL 234
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 451-713 9.27e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 9.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 451 KGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPtprIKAELTSAAPACYALAIS 530
Cdd:PLN00181  457 EGLCKYLSFSKLRVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESI---IKDGRDIHYPVVELASRS 533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 531 PDSKVCF---------SCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDI-SPDGSRLWTGGLDNTVRSWDLREGRQLQQ 600
Cdd:PLN00181  534 KLSGICWnsyiksqvaSSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGT 613

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 601 HDFSSQIFSLGY-CPTGDWLAVGMENSHVEVLHASKPdkyQLHL-----HESCVLSLRFAACGKwFVSTGKDNLLNAWRT 674
Cdd:PLN00181  614 IKTKANICCVQFpSESGRSLAFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDL 689

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1818147686 675 PYGASIFQSKETSSVLS-------CDISTDDKYIVTGSGDKKATVY 713
Cdd:PLN00181  690 SMSISGINETPLHSFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 515-596 2.02e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 44.29  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 515 AELTSAAPACYALAISPDSKVCFSCcsdGNiavWD-------LHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTV 587
Cdd:pfam20426  75 AENVELGAQCFATLQTPSENFLISC---GN---WEnsfqvisLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTV 148


                  ....*....
gi 1818147686 588 RSWDLREGR 596
Cdd:pfam20426 149 MVWEVLRGR 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 523-549 4.99e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 4.99e-04
                           10        20
                   ....*....|....*....|....*..
gi 1818147686  523 ACYALAISPDSKVCFSCCSDGNIAVWD 549
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
487-627 5.65e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 5.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 487 PDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQgHTDGA 566
Cdd:COG3391    34 GPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIP-VGGGP 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1818147686 567 SCIDISPDGSRLW-TGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSH 627
Cdd:COG3391   113 RGLAVDPDGGRLYvADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSN 174
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 487-578 8.68e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 40.43  E-value: 8.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 487 PDGRTLI-VGGEASNLSIW--DLASPTPRikaELTSAAPACYALAISPD-SKVCFSCCSDG--NIAVWDLHNEILVRqfq 560
Cdd:COG0823    40 PDGRRIAfTSDRGGGPQIYvvDADGGEPR---RLTFGGGYNASPSWSPDgKRLAFVSRSDGrfDIYVLDLDGGAPRR--- 113

                          90
                  ....*....|....*...
gi 1818147686 561 gHTDGASCIDISPDGSRL 578
Cdd:COG0823   114 -LTDGPGSPSWSPDGRRI 130
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
423-627 1.11e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 41.82  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 423 RQINTL-SHGEVVCAVTISNPTKYVYTG--GKGCVKVWDISQPGNKNPVSQLDCL---------QRDNYIRSVKLLPDGR 490
Cdd:COG2706    83 TLLNTVsSGGASPCHLSVDPDGRFLFVAnyGGGSVSVFPIDADGSLGEPVQVIQHegsgpnperQEGPHAHSVVFDPDGR 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 491 TLIV---GgeASNLSIWDLASPTPRIKAELTSAAPA---CYALAISPDSKVCFSCCS-DGNIAVWDLHNE---------- 553
Cdd:COG2706   163 FLYVpdlG--TDRIYVYRLDPATGKLPEPPEVSLPPgsgPRHLAFHPNGRFAYVINElDSTVSVYAYDAAtgtltliqtv 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 554 -ILVRQFQGHTDGAScIDISPDGSRLWTG--GLDN-TVRSWDLREGR-QLQQH---------DFSsqiFSlgycPTGDWL 619
Cdd:COG2706   241 sTLPEDFTGENWAAD-IHISPDGRFLYVSnrGHNSiAVFAIDADGGKlTLVGHvptggkwprDFA---ID----PDGRFL 312


                  ....*...
gi 1818147686 620 AVGMENSH 627
Cdd:COG2706   313 LVANQKSD 320
WD40 pfam00400
WD domain, G-beta repeat;
525-549 3.16e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|....*
gi 1818147686 525 YALAISPDSKVCFSCCSDGNIAVWD 549
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
COG5276 COG5276
Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function ...
 489-593 7.59e-03

Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function unknown];


Pssm-ID: 444087 [Multi-domain]  Cd Length: 320  Bit Score: 39.15  E-value: 7.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818147686 489 GRTLIVGGEASNLSIWDLASPT-PRIKAELTSAAPACYALAISpDSKVCFSCCSDGNIAVWDLHNE---ILVRQFQghTD 564
Cdd:COG5276    29 GEYAYVAGGSNGLAIVDVSDPAnPVLVGSLPTPGGTWRDVKVS-GDYLYVASEGSEGLQIFDISDPanpKLVGRYD--TG 105

                          90       100       110
                  ....*....|....*....|....*....|
gi 1818147686 565 GASCIDISPDGSRLW-TGGLDNTVRSWDLR 593
Cdd:COG5276   106 GSGAHNIAVDGNYAYvAGGSDNGLVIVDIS 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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