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Conserved domains on  [gi|1814717666|ref|XP_032482674|]
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LOW QUALITY PROTEIN: colorectal mutant cancer protein [Phocoena sinus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MCC-bdg_PDZ pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the ...
589-652 8.19e-23

PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.


:

Pssm-ID: 463122 [Multi-domain]  Cd Length: 65  Bit Score: 92.76  E-value: 8.19e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1814717666  589 RLNSRIEHLKSQNDLLTITLEECKSNAEGMSMLVGKYESNATALRLALQYSEQCIEAYELLLAL 652
Cdd:pfam10506    1 RLQRRIEELKSQNELLSLTLEERKQQSEELSLLLGKYESNATALRLALEYSERCKEAYEVLLAL 64
EF-hand_7 pfam13499
EF-hand domain pair;
32-88 3.49e-10

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 56.88  E-value: 3.49e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1814717666   32 EERMRRLFQTCDGDGDGYISRNDLSMVCRQLNM-----EESVAEIMNQLGADENGKISFQDF 88
Cdd:pfam13499    1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEgeplsDEEVEELFKEFDLDKDGRISFEEF 62
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
796-1008 8.69e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.94  E-value: 8.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  796 QRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEELKEQRTRSLSSTSSG 875
Cdd:COG1196    263 AELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEEL 342
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  876 GKDKAGKESADAASpALSLAELRTAcsDSELAAEFANAIRRKEVKRPEFQELVSALERLTKSMKSDTEQSAESVNDLKRA 955
Cdd:COG1196    343 EEELEEAEEELEEA-EAELAEAEEA--LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL 419
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1814717666  956 NSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSR 1008
Cdd:COG1196    420 EEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
210-476 3.29e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 3.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  210 AALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERtTLRYEERITELHSIIAELNKKIDRLQGT 289
Cdd:COG1196    239 AELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAE-EYELLAELARLEQDIARLEERRRELEER 317
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  290 TIREEDEYSELRSELSQSQHEVNEDSRSVDQDQTSVSIPENQStmvtadmdncSDLNSELQRVLTGLENVVccrkksscS 369
Cdd:COG1196    318 LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL----------AEAEEALLEAEAELAEAE--------E 379
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  370 LSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLypNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKAT 449
Cdd:COG1196    380 ELEELAEELLEALRAAAELAAQLEELEEAEEALLERLE--RLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEE 457
                          250       260
                   ....*....|....*....|....*..
gi 1814717666  450 MNAIREERDRLRRRVRELQTRLQSVQA 476
Cdd:COG1196    458 EEALLELLAELLEEAALLEAALAELLE 484
 
Name Accession Description Interval E-value
MCC-bdg_PDZ pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the ...
589-652 8.19e-23

PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.


Pssm-ID: 463122 [Multi-domain]  Cd Length: 65  Bit Score: 92.76  E-value: 8.19e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1814717666  589 RLNSRIEHLKSQNDLLTITLEECKSNAEGMSMLVGKYESNATALRLALQYSEQCIEAYELLLAL 652
Cdd:pfam10506    1 RLQRRIEELKSQNELLSLTLEERKQQSEELSLLLGKYESNATALRLALEYSERCKEAYEVLLAL 64
EF-hand_7 pfam13499
EF-hand domain pair;
32-88 3.49e-10

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 56.88  E-value: 3.49e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1814717666   32 EERMRRLFQTCDGDGDGYISRNDLSMVCRQLNM-----EESVAEIMNQLGADENGKISFQDF 88
Cdd:pfam13499    1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEgeplsDEEVEELFKEFDLDKDGRISFEEF 62
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
32-90 2.67e-09

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 56.34  E-value: 2.67e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666   32 EERMRRLFQTCDGDGDGYISRNDLSMVCRQLNM-EESVAEIMNQLGADENGKISFQDFTR 90
Cdd:COG5126     68 EPFARAAFDLLDTDGDGKISADEFRRLLTALGVsEEEADELFARLDTDGDGKISFEEFVA 127
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
36-90 8.84e-08

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 49.85  E-value: 8.84e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1814717666   36 RRLFQTCDGDGDGYISRNDLSMVCRQLNM---EESVAEIMNQLGADENGKISFQDFTR 90
Cdd:cd00051      3 REAFRLFDKDGDGTISADELKAALKSLGEglsEEEIDEMIREVDKDGDGKIDFEEFLE 60
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
796-1008 8.69e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.94  E-value: 8.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  796 QRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEELKEQRTRSLSSTSSG 875
Cdd:COG1196    263 AELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEEL 342
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  876 GKDKAGKESADAASpALSLAELRTAcsDSELAAEFANAIRRKEVKRPEFQELVSALERLTKSMKSDTEQSAESVNDLKRA 955
Cdd:COG1196    343 EEELEEAEEELEEA-EAELAEAEEA--LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL 419
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1814717666  956 NSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSR 1008
Cdd:COG1196    420 EEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
210-476 3.29e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 3.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  210 AALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERtTLRYEERITELHSIIAELNKKIDRLQGT 289
Cdd:COG1196    239 AELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAE-EYELLAELARLEQDIARLEERRRELEER 317
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  290 TIREEDEYSELRSELSQSQHEVNEDSRSVDQDQTSVSIPENQStmvtadmdncSDLNSELQRVLTGLENVVccrkksscS 369
Cdd:COG1196    318 LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL----------AEAEEALLEAEAELAEAE--------E 379
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  370 LSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLypNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKAT 449
Cdd:COG1196    380 ELEELAEELLEALRAAAELAAQLEELEEAEEALLERLE--RLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEE 457
                          250       260
                   ....*....|....*....|....*..
gi 1814717666  450 MNAIREERDRLRRRVRELQTRLQSVQA 476
Cdd:COG1196    458 EEALLELLAELLEEAALLEAALAELLE 484
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
212-477 9.48e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.13  E-value: 9.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  212 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERttlryeeritelhsiIAELNKKIDRLQGTTI 291
Cdd:TIGR02169  296 IGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELERE---------------IEEERKRRDKLTEEYA 360
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  292 REEDEYSELRSELSQSQHEVNEDSRSVDQDQTSVSipenqstMVTADMDncsDLNSELQRVLTGLEnvvccRKKSSCSLS 371
Cdd:TIGR02169  361 ELKEELEDLRAELEEVDKEFAETRDELKDYREKLE-------KLKREIN---ELKRELDRLQEELQ-----RLSEELADL 425
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  372 VAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRdlypnLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMN 451
Cdd:TIGR02169  426 NAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQ-----LAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQAR 500
                          250       260
                   ....*....|....*....|....*.
gi 1814717666  452 AIREERDRLRRRVRELQTRLQSVQAT 477
Cdd:TIGR02169  501 ASEERVRGGRAVEEVLKASIQGVHGT 526
PTZ00184 PTZ00184
calmodulin; Provisional
39-103 2.75e-03

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 39.36  E-value: 2.75e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1814717666   39 FQTCDGDGDGYISRNDLSMVCRQLNM---EESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEE 103
Cdd:PTZ00184    17 FSLFDKDGDGTITTKELGTVMRSLGQnptEAELQDMINEVDADGNGTIDFPEFLTLMARKMKDTDSEE 84
MCC-bdg_PDZ pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the ...
925-985 2.93e-03

PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.


Pssm-ID: 463122 [Multi-domain]  Cd Length: 65  Bit Score: 37.30  E-value: 2.93e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1814717666  925 QELVSALERLTKSMKSDTEQSAESVNDLKRANSN---LVAAYEkakkkHQNKLKKLESQMMAMV 985
Cdd:pfam10506    7 EELKSQNELLSLTLEERKQQSEELSLLLGKYESNataLRLALE-----YSERCKEAYEVLLALV 65
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
807-863 9.22e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.05  E-value: 9.22e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1814717666  807 QELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEELKE 863
Cdd:PRK03918   231 KELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKE 287
 
Name Accession Description Interval E-value
MCC-bdg_PDZ pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the ...
589-652 8.19e-23

PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.


Pssm-ID: 463122 [Multi-domain]  Cd Length: 65  Bit Score: 92.76  E-value: 8.19e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1814717666  589 RLNSRIEHLKSQNDLLTITLEECKSNAEGMSMLVGKYESNATALRLALQYSEQCIEAYELLLAL 652
Cdd:pfam10506    1 RLQRRIEELKSQNELLSLTLEERKQQSEELSLLLGKYESNATALRLALEYSERCKEAYEVLLAL 64
EF-hand_7 pfam13499
EF-hand domain pair;
32-88 3.49e-10

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 56.88  E-value: 3.49e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1814717666   32 EERMRRLFQTCDGDGDGYISRNDLSMVCRQLNM-----EESVAEIMNQLGADENGKISFQDF 88
Cdd:pfam13499    1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEgeplsDEEVEELFKEFDLDKDGRISFEEF 62
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
32-90 2.67e-09

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 56.34  E-value: 2.67e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666   32 EERMRRLFQTCDGDGDGYISRNDLSMVCRQLNM-EESVAEIMNQLGADENGKISFQDFTR 90
Cdd:COG5126     68 EPFARAAFDLLDTDGDGKISADEFRRLLTALGVsEEEADELFARLDTDGDGKISFEEFVA 127
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
36-90 8.84e-08

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 49.85  E-value: 8.84e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1814717666   36 RRLFQTCDGDGDGYISRNDLSMVCRQLNM---EESVAEIMNQLGADENGKISFQDFTR 90
Cdd:cd00051      3 REAFRLFDKDGDGTISADELKAALKSLGEglsEEEIDEMIREVDKDGDGKIDFEEFLE 60
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
796-1008 8.69e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.94  E-value: 8.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  796 QRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEELKEQRTRSLSSTSSG 875
Cdd:COG1196    263 AELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEEL 342
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  876 GKDKAGKESADAASpALSLAELRTAcsDSELAAEFANAIRRKEVKRPEFQELVSALERLTKSMKSDTEQSAESVNDLKRA 955
Cdd:COG1196    343 EEELEEAEEELEEA-EAELAEAEEA--LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL 419
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1814717666  956 NSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSR 1008
Cdd:COG1196    420 EEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
751-980 2.64e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.39  E-value: 2.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  751 EDEQRLKDYIQQLRNDRAAVKLTMLELESihidplsydvkprgDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEK 830
Cdd:COG1196    288 AEEYELLAELARLEQDIARLEERRRELEE--------------RLEELEEELAELEEELEELEEELEELEEELEEAEEEL 353
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  831 KALELKLSTREAQEQAYLVHIEHLKSEVEELKEQRTRSLSSTSSGGKDKAGKESADAASpALSLAELRTAcsDSELAAEF 910
Cdd:COG1196    354 EEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEAL-LERLERLEEE--LEELEEAL 430
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  911 ANAIRRKEVKRPEFQELVSALERLTKSMKSDTEQSAESVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQ 980
Cdd:COG1196    431 AELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE 500
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
32-104 2.39e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 42.09  E-value: 2.39e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1814717666   32 EERMRRLFQTCDGDGDGYISRNDLsmvcrQLNMEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEV 104
Cdd:COG5126      4 RRKLDRRFDLLDADGDGVLERDDF-----EALFRRLWATLFSEADTDGDGRISREEFVAGMESLFEATVEPFA 71
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
210-476 3.29e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 3.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  210 AALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERtTLRYEERITELHSIIAELNKKIDRLQGT 289
Cdd:COG1196    239 AELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAE-EYELLAELARLEQDIARLEERRRELEER 317
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  290 TIREEDEYSELRSELSQSQHEVNEDSRSVDQDQTSVSIPENQStmvtadmdncSDLNSELQRVLTGLENVVccrkksscS 369
Cdd:COG1196    318 LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL----------AEAEEALLEAEAELAEAE--------E 379
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  370 LSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLypNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKAT 449
Cdd:COG1196    380 ELEELAEELLEALRAAAELAAQLEELEEAEEALLERLE--RLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEE 457
                          250       260
                   ....*....|....*....|....*..
gi 1814717666  450 MNAIREERDRLRRRVRELQTRLQSVQA 476
Cdd:COG1196    458 EEALLELLAELLEEAALLEAALAELLE 484
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
800-1005 8.87e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 8.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  800 LENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEELKEQRTRSLSSTSSGGKDK 879
Cdd:COG1196    225 LEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDI 304
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  880 A----GKESADAASPALSLAELRTACSDSELAAEFANAIRRKEVKRPEFQELVSALERLTKSMKSDTEQSAESVNDLKRA 955
Cdd:COG1196    305 ArleeRRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEEL 384
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1814717666  956 NSNLVAAyEKAKKKHQNKLKKLESQMMAMVERHEtqvRMLKQRIALLEEE 1005
Cdd:COG1196    385 AEELLEA-LRAAAELAAQLEELEEAEEALLERLE---RLEEELEELEEAL 430
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
212-477 9.48e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.13  E-value: 9.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  212 LASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERttlryeeritelhsiIAELNKKIDRLQGTTI 291
Cdd:TIGR02169  296 IGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELERE---------------IEEERKRRDKLTEEYA 360
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  292 REEDEYSELRSELSQSQHEVNEDSRSVDQDQTSVSipenqstMVTADMDncsDLNSELQRVLTGLEnvvccRKKSSCSLS 371
Cdd:TIGR02169  361 ELKEELEDLRAELEEVDKEFAETRDELKDYREKLE-------KLKREIN---ELKRELDRLQEELQ-----RLSEELADL 425
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  372 VAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRdlypnLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMN 451
Cdd:TIGR02169  426 NAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQ-----LAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQAR 500
                          250       260
                   ....*....|....*....|....*.
gi 1814717666  452 AIREERDRLRRRVRELQTRLQSVQAT 477
Cdd:TIGR02169  501 ASEERVRGGRAVEEVLKASIQGVHGT 526
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
209-300 1.55e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 1.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  209 LAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLR------YEERITELHSIIAELNKK 282
Cdd:COG4942     12 ALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALarriraLEQELAALEAELAELEKE 91
                           90
                   ....*....|....*...
gi 1814717666  283 IDRLQGTTIREEDEYSEL 300
Cdd:COG4942     92 IAELRAELEAQKEELAEL 109
PTZ00184 PTZ00184
calmodulin; Provisional
39-103 2.75e-03

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 39.36  E-value: 2.75e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1814717666   39 FQTCDGDGDGYISRNDLSMVCRQLNM---EESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEE 103
Cdd:PTZ00184    17 FSLFDKDGDGTITTKELGTVMRSLGQnptEAELQDMINEVDADGNGTIDFPEFLTLMARKMKDTDSEE 84
MCC-bdg_PDZ pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the ...
925-985 2.93e-03

PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.


Pssm-ID: 463122 [Multi-domain]  Cd Length: 65  Bit Score: 37.30  E-value: 2.93e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1814717666  925 QELVSALERLTKSMKSDTEQSAESVNDLKRANSN---LVAAYEkakkkHQNKLKKLESQMMAMV 985
Cdd:pfam10506    7 EELKSQNELLSLTLEERKQQSEELSLLLGKYESNataLRLALE-----YSERCKEAYEVLLALV 65
EFh_PEF_Group_I cd16180
Penta-EF hand, calcium binding motifs, found in Group I PEF proteins; The family corresponds ...
34-90 5.31e-03

Penta-EF hand, calcium binding motifs, found in Group I PEF proteins; The family corresponds to Group I PEF proteins that have been found not only in higher animals but also in lower animals, plants, fungi and protists. Group I PEF proteins include apoptosis-linked gene 2 protein (ALG-2), peflin and similar proteins. ALG-2, also termed programmed cell death protein 6 (PDCD6), is a widely expressed calcium-binding modulator protein associated with cell proliferation and death, as well as cell survival. It forms a homodimer in the cell or a heterodimer with its closest paralog peflin. Among the PEF proteins, ALG-2 can bind three Ca2+ ions through its EF1, EF3, and EF5 hands, where it is unique in that its EF5 hand binds Ca2+ ion in a canonical coordination. Peflin is a ubiquitously expressed 30-kD PEF protein containing five EF-hand motifs in its C-terminal domain and a longer N-terminal hydrophobic domain (NHB domain) than any other member of the PEF family. The NHB domain harbors nine repeats of a nonapeptide (A/PPGGPYGGP). Peflin may modulate the function of ALG-2 in Ca2+ signaling. It exists only as a heterodimer with ALG-2, and binds two Ca2+ ions through its EF1 and EF3 hands. Its additional EF5 hand is unpaired and does not bind Ca2+ ion but mediates the heterodimerization with ALG-2. The dissociation of heterodimer occurs in the presence of Ca2+.


Pssm-ID: 320055 [Multi-domain]  Cd Length: 164  Bit Score: 38.66  E-value: 5.31e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1814717666   34 RMRRLFQTCDGDGDGYISRNDLSMVCR-----QLNMeESVAEIMNQLGADENGKISFQDFTR 90
Cdd:cd16180      1 ELRRIFQAVDRDRSGRISAKELQRALSngdwtPFSI-ETVRLMINMFDRDRSGTINFDEFVG 61
EF-hand_6 pfam13405
EF-hand domain;
34-63 6.21e-03

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 35.23  E-value: 6.21e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1814717666   34 RMRRLFQTCDGDGDGYISRNDLSMVCRQLN 63
Cdd:pfam13405    1 ELREAFKLFDKDGDGKISLEELRKALRSLG 30
EFh_calglandulin_like cd16252
EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The ...
32-89 6.72e-03

EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The family corresponds to a group of uncharacterized calglandulin-like proteins. Although their biological function remain unclear, they show high sequence similarity with human calglandulin-like protein GAGLP, which is an ortholog of calglandulin from the venom glands of Bothrops insularis snake. Both GAGLP and calglandulin are putative Ca2+-binding proteins with four EF-hand motifs. However, members in this family contain only three EF-hand motifs. In this point, they may belong to the parvalbumin-like EF-hand family, which is characterized by the presence of three consecutive EF-hand motifs (helix-loop-helix).


Pssm-ID: 319995 [Multi-domain]  Cd Length: 106  Bit Score: 37.12  E-value: 6.72e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1814717666   32 EERMRRLFQTCDGDGDGYISRNDL---------SMVCRQLNMEEsvAEIMNQLG-ADENGKISFQDFT 89
Cdd:cd16252     36 EEAIRKAFQMLDKDKSGFIEWNEIkyilstvpsSMPVAPLSDEE--AEAMIQAAdTDGDGRIDFQEFS 101
PTZ00184 PTZ00184
calmodulin; Provisional
32-94 7.31e-03

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 38.20  E-value: 7.31e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1814717666   32 EERMRRLFQTCDGDGDGYISRNDLSMVCRQLN---MEESVAEIMNQLGADENGKISFQDFTRCRMQ 94
Cdd:PTZ00184    83 EEEIKEAFKVFDRDGNGFISAAELRHVMTNLGeklTDEEVDEMIREADVDGDGQINYEEFVKMMMS 148
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
807-863 9.22e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.05  E-value: 9.22e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1814717666  807 QELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEELKE 863
Cdd:PRK03918   231 KELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKE 287
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
813-1008 9.86e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 9.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  813 KEEMAELKAQLYLL-----EKEKKALELKLSTREAQEQAYLVHIEHLKSEVEELKEQRTRSLSSTSSGGKD--KAGKESA 885
Cdd:COG1196    219 KEELKELEAELLLLklrelEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEeyELLAELA 298
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1814717666  886 DAASPALSLAELRtacsdSELAAEFANAIRRKEVKRPEFQELVSALERLTKSMKSDTEQSAESVNDLKRANSNLVAAYEK 965
Cdd:COG1196    299 RLEQDIARLEERR-----RELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1814717666  966 AKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSR 1008
Cdd:COG1196    374 LAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERL 416
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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