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treacle protein isoform X3 [Camelus ferus]
Protein Classification
WD40 repeat domain-containing protein ( domain architecture ID 12218090 )
WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly
List of domain hits
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
317-873
5.27e-84
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 286.20
E-value: 5.27e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 317 TPA P PGKAGPAATQAKAGKPEEDSESSSEE D SDSEEE L PAAKTPL RV KPSGK I PQV K AASA APAKAS p RK R AP AA PPGK A 396
Cdd:pfam03546 1 TPA T PGKAGPAATQAKAGKPEEDSESSSEE E SDSEEE T PAAKTPL QA KPSGK T PQV R AASA PAKESP - RK G AP PV PPGK T 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 397 GP V A P QAQA R K Q EEDSESSS S E ESDSEG e A PAA VPQ TTS L AQ A K A LGKNSQV KA AS AL G L GPS A KGA V P G PPGK V GSAA A 476
Cdd:pfam03546 80 GP A A A QAQA G K P EEDSESSS E E SDSDGE - T PAA ATL TTS P AQ V K P LGKNSQV RP AS TV G K GPS G KGA N P A PPGK A GSAA P 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 477 Q a V KREEDS E S S SEAESD SD G E APTAA A SA QAK SL GK VP QVRPASGPAKG ---- P S QKAGP AT TQVK T ERSKE - DSETS E 551
Cdd:pfam03546 159 L - V QVGKKE E D S ESSSEE SD S E GEAPP A AT QAK PS GK IL QVRPASGPAKG aapa P P QKAGP VA TQVK A ERSKE d SESSE E 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 552 E SDSE D E T PAA V TPAQAK L A GR TPQTKASPRKGTPITP A SAKVPPV QA GTPAPWKAGTV S S L AC T SSPA M ARGAQRPEE N 631
Cdd:pfam03546 238 S SDSE E E A PAA A TPAQAK P A LK TPQTKASPRKGTPITP T SAKVPPV RV GTPAPWKAGTV T S P AC A SSPA V ARGAQRPEE D 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 632 SSSSEES D SEEETAPA T AVGQ V KSVGK SVP GKAASAPTKGPSGQGTAPV L PGK A G TVM AQVKAE V QE - DSE S S EESD N E K 710
Cdd:pfam03546 318 SSSSEES E SEEETAPA A AVGQ A KSVGK GLQ GKAASAPTKGPSGQGTAPV P PGK T G PAV AQVKAE A QE d SES S E EESD S E E 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 711 AA S T A AQVK T S V K S PQ T KAN L A ASRVA SAKGA V SA L GK G V T AAAQAK P GSPAK asgtratggarvgwrgrpssgpsldkg 790
Cdd:pfam03546 398 AA A T P AQVK A S G K T PQ A KAN P A PTKAS SAKGA A SA P GK V V A AAAQAK Q GSPAK --------------------------- 450
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 791 paq VKPP L RTPQ S S VV S GK GQ V S MT AVGKAVA A AAQ D Q Q GPV R GP E E DSES S E EE SD - SE G EAP T QAKPS V K L PQVRA S S 869
Cdd:pfam03546 451 --- VKPP A RTPQ N S AI S VR GQ A S VP AVGKAVA T AAQ A Q K GPV G GP Q E EDSE S S EE ES d SE E EAP A QAKPS G K T PQVRA A S 527
....
gi 1811043612 870 AP T K 873
Cdd:pfam03546 528 AP A K 531
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
753-1238
3.28e-04
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 45.70
E-value: 3.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 753 AAQAK P GS P AKASGT RA TGGA R VGW RG RPSSG P SL - D KGPAQVK PP LRT P QSSVVSGKGQVSMTAVGKAVAAA A QDQQGP 831
Cdd:PHA03247 2584 SRARR P DA P PQSARP RA PVDD R GDP RG PAPPS P LP p D THAPDPP PP SPS P AANEPDPHPPPTVPPPERPRDDP A PGRVSR 2663
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 832 V R GPEEDSESSEEE S DSEGEAPTQ A K P S V KLPQVR A SSA P TKGS P KKGAATAPPGKAG PP AAQ A RK Q eedsessseesds 911
Cdd:PHA03247 2664 P R RARRLGRAAQAS S PPQRPRRRA A R P T V GSLTSL A DPP P PPPT P EPAPHALVSATPL PP GPA A AR Q ------------- 2730
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 912 deevpa A V P PA qkegnsktassk TL APAPP EKK A KESSASSDEELPDSQVIKT P LIFVD P n RS PA GPAATPAQAQ A ASAP 991
Cdd:PHA03247 2731 ------ A S P AL ------------ PA APAPP AVP A GPATPGGPARPARPPTTAG P PAPAP P - AA PA AGPPRRLTRP A VASL 2791
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 992 RKA R A S ESTARSSSESE d ED V IPATQC L T PA VR -- TNVVTVPT AQP RTS P RASSNEESTPVSE G KK qe AP ATQ V TKTN P A 1069
Cdd:PHA03247 2792 SES R E S LPSPWDPADPP - AA V LAPAAA L P PA AS pa GPLPPPTS AQP TAP P PPPGPPPPSLPLG G SV -- AP GGD V RRRP P S 2868
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 1070 HL P ltqaalkvl A Q K ATESKS PP AKTSSSSGTDSALGTLPVTSP Q NTP aqakvtdk P KK P EV P TAKRAMAT P SGR P KAKA 1149
Cdd:PHA03247 2869 RS P --------- A A K PAAPAR PP VRRLARPAVSRSTESFALPPD Q PER -------- P PQ P QA P PPPQPQPQ P PPP P QPQP 2931
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 1150 SGTSDDSDDSSGSSSGSEEDTEG P QT A PSAHRP GA AASK R ETLVEETTAESSDD - E VVEP S QSL L S G YVTP R LTPAS S QA 1228
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGE P SG A VPQPWL GA LVPG R VAVPRFRVPQPAPS r E APAS S TPP L T G HSLS R VSSWA S SL 3011
490
....*....|
gi 1811043612 1229 SKASKAT P K P 1238
Cdd:PHA03247 3012 ALHEETD P P P 3021
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
3.30e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 3.30e-03
10 20 30
....*....|....*....|....*....|..
gi 1811043612 6 K R R EL LP LI YQH LL QA GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LL RN GY EET A ETLQKE SG LS 33
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
317-873
5.27e-84
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 286.20
E-value: 5.27e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 317 TPA P PGKAGPAATQAKAGKPEEDSESSSEE D SDSEEE L PAAKTPL RV KPSGK I PQV K AASA APAKAS p RK R AP AA PPGK A 396
Cdd:pfam03546 1 TPA T PGKAGPAATQAKAGKPEEDSESSSEE E SDSEEE T PAAKTPL QA KPSGK T PQV R AASA PAKESP - RK G AP PV PPGK T 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 397 GP V A P QAQA R K Q EEDSESSS S E ESDSEG e A PAA VPQ TTS L AQ A K A LGKNSQV KA AS AL G L GPS A KGA V P G PPGK V GSAA A 476
Cdd:pfam03546 80 GP A A A QAQA G K P EEDSESSS E E SDSDGE - T PAA ATL TTS P AQ V K P LGKNSQV RP AS TV G K GPS G KGA N P A PPGK A GSAA P 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 477 Q a V KREEDS E S S SEAESD SD G E APTAA A SA QAK SL GK VP QVRPASGPAKG ---- P S QKAGP AT TQVK T ERSKE - DSETS E 551
Cdd:pfam03546 159 L - V QVGKKE E D S ESSSEE SD S E GEAPP A AT QAK PS GK IL QVRPASGPAKG aapa P P QKAGP VA TQVK A ERSKE d SESSE E 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 552 E SDSE D E T PAA V TPAQAK L A GR TPQTKASPRKGTPITP A SAKVPPV QA GTPAPWKAGTV S S L AC T SSPA M ARGAQRPEE N 631
Cdd:pfam03546 238 S SDSE E E A PAA A TPAQAK P A LK TPQTKASPRKGTPITP T SAKVPPV RV GTPAPWKAGTV T S P AC A SSPA V ARGAQRPEE D 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 632 SSSSEES D SEEETAPA T AVGQ V KSVGK SVP GKAASAPTKGPSGQGTAPV L PGK A G TVM AQVKAE V QE - DSE S S EESD N E K 710
Cdd:pfam03546 318 SSSSEES E SEEETAPA A AVGQ A KSVGK GLQ GKAASAPTKGPSGQGTAPV P PGK T G PAV AQVKAE A QE d SES S E EESD S E E 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 711 AA S T A AQVK T S V K S PQ T KAN L A ASRVA SAKGA V SA L GK G V T AAAQAK P GSPAK asgtratggarvgwrgrpssgpsldkg 790
Cdd:pfam03546 398 AA A T P AQVK A S G K T PQ A KAN P A PTKAS SAKGA A SA P GK V V A AAAQAK Q GSPAK --------------------------- 450
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 791 paq VKPP L RTPQ S S VV S GK GQ V S MT AVGKAVA A AAQ D Q Q GPV R GP E E DSES S E EE SD - SE G EAP T QAKPS V K L PQVRA S S 869
Cdd:pfam03546 451 --- VKPP A RTPQ N S AI S VR GQ A S VP AVGKAVA T AAQ A Q K GPV G GP Q E EDSE S S EE ES d SE E EAP A QAKPS G K T PQVRA A S 527
....
gi 1811043612 870 AP T K 873
Cdd:pfam03546 528 AP A K 531
PHA03247
PHA03247 large tegument protein UL36; Provisional
217-649
1.64e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.94
E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 217 P AVK LP QVRA P P AP VKES P RR R V AP T P GKAGNVTPQV R G D TLTSAGKAKN P EEVSESSEEESESEEGA P AGTPSQVKASE 296
Cdd:PHA03247 2551 P PPP LP PAAP P A AP DRSV P PP R P AP R P SEPAVTSRAR R P D APPQSARPRA P VDDRGDPRGPAPPSPLP P DTHAPDPPPPS 2630
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 297 KTVQVRAASGPAKG T AGKGAT P APPGKA G PAATQAK A GKPEEDSES SS EEDSDSEEELPAAKTP L ---- RVK P SGKI P Q - 371
Cdd:PHA03247 2631 PSPAANEPDPHPPP T VPPPER P RDDPAP G RVSRPRR A RRLGRAAQA SS PPQRPRRRAARPTVGS L tsla DPP P PPPT P E p 2710
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 372 ----- V K A ASAA P AK A SP R KRA PA A P PGK A G P VA P QAQ A RKQEEDSESSSSEESDSEGE AP A A V P QTTSLAQAKALGKN S 446
Cdd:PHA03247 2711 aphal V S A TPLP P GP A AA R QAS PA L P AAP A P P AV P AGP A TPGGPARPARPPTTAGPPAP AP P A A P AAGPPRRLTRPAVA S 2790
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 447 QVKAASA L GLGPSAK --- G AV PG P PGKVGS AA AQ A VKREEDSESSSE A ESDSD G EA P TAAASAQAKSL G KVPQV RP A S GP 523
Cdd:PHA03247 2791 LSESRES L PSPWDPA dpp A AV LA P AAALPP AA SP A GPLPPPTSAQPT A PPPPP G PP P PSLPLGGSVAP G GDVRR RP P S RS 2870
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 524 A kg PSQK A G PA TTQ V KTERSKED S ETS E ESDSEDET P AAVTPA QA KLAGRTPQTKAS P RKGT P IT P ASAKVP P VQ A G T PA 603
Cdd:PHA03247 2871 P -- AAKP A A PA RPP V RRLARPAV S RST E SFALPPDQ P ERPPQP QA PPPPQPQPQPPP P PQPQ P PP P PPPRPQ P PL A P T TD 2948
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1811043612 604 P WK AG TV S SLA ctss P AMAR GA QR P EENSSSSEESDSEEETAP A T A 649
Cdd:PHA03247 2949 P AG AG EP S GAV ---- P QPWL GA LV P GRVAVPRFRVPQPAPSRE A P A 2990
PHA03247
PHA03247 large tegument protein UL36; Provisional
753-1238
3.28e-04
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 45.70
E-value: 3.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 753 AAQAK P GS P AKASGT RA TGGA R VGW RG RPSSG P SL - D KGPAQVK PP LRT P QSSVVSGKGQVSMTAVGKAVAAA A QDQQGP 831
Cdd:PHA03247 2584 SRARR P DA P PQSARP RA PVDD R GDP RG PAPPS P LP p D THAPDPP PP SPS P AANEPDPHPPPTVPPPERPRDDP A PGRVSR 2663
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 832 V R GPEEDSESSEEE S DSEGEAPTQ A K P S V KLPQVR A SSA P TKGS P KKGAATAPPGKAG PP AAQ A RK Q eedsessseesds 911
Cdd:PHA03247 2664 P R RARRLGRAAQAS S PPQRPRRRA A R P T V GSLTSL A DPP P PPPT P EPAPHALVSATPL PP GPA A AR Q ------------- 2730
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 912 deevpa A V P PA qkegnsktassk TL APAPP EKK A KESSASSDEELPDSQVIKT P LIFVD P n RS PA GPAATPAQAQ A ASAP 991
Cdd:PHA03247 2731 ------ A S P AL ------------ PA APAPP AVP A GPATPGGPARPARPPTTAG P PAPAP P - AA PA AGPPRRLTRP A VASL 2791
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 992 RKA R A S ESTARSSSESE d ED V IPATQC L T PA VR -- TNVVTVPT AQP RTS P RASSNEESTPVSE G KK qe AP ATQ V TKTN P A 1069
Cdd:PHA03247 2792 SES R E S LPSPWDPADPP - AA V LAPAAA L P PA AS pa GPLPPPTS AQP TAP P PPPGPPPPSLPLG G SV -- AP GGD V RRRP P S 2868
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 1070 HL P ltqaalkvl A Q K ATESKS PP AKTSSSSGTDSALGTLPVTSP Q NTP aqakvtdk P KK P EV P TAKRAMAT P SGR P KAKA 1149
Cdd:PHA03247 2869 RS P --------- A A K PAAPAR PP VRRLARPAVSRSTESFALPPD Q PER -------- P PQ P QA P PPPQPQPQ P PPP P QPQP 2931
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 1150 SGTSDDSDDSSGSSSGSEEDTEG P QT A PSAHRP GA AASK R ETLVEETTAESSDD - E VVEP S QSL L S G YVTP R LTPAS S QA 1228
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGE P SG A VPQPWL GA LVPG R VAVPRFRVPQPAPS r E APAS S TPP L T G HSLS R VSSWA S SL 3011
490
....*....|
gi 1811043612 1229 SKASKAT P K P 1238
Cdd:PHA03247 3012 ALHEETD P P P 3021
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
852-897
6.55e-04
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 44.29
E-value: 6.55e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1811043612 852 A P T QAKPS V K L PQVRA S SAP T K G SP K KGA ATA PPGK A GP P AAQA RK 897
Cdd:pfam03546 43 T P L QAKPS G K T PQVRA A SAP A K E SP R KGA PPV PPGK T GP A AAQA QA 88
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
3.30e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 3.30e-03
10 20 30
....*....|....*....|....*....|..
gi 1811043612 6 K R R EL LP LI YQH LL QA GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LL RN GY EET A ETLQKE SG LS 33
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
317-873
5.27e-84
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 286.20
E-value: 5.27e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 317 TPA P PGKAGPAATQAKAGKPEEDSESSSEE D SDSEEE L PAAKTPL RV KPSGK I PQV K AASA APAKAS p RK R AP AA PPGK A 396
Cdd:pfam03546 1 TPA T PGKAGPAATQAKAGKPEEDSESSSEE E SDSEEE T PAAKTPL QA KPSGK T PQV R AASA PAKESP - RK G AP PV PPGK T 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 397 GP V A P QAQA R K Q EEDSESSS S E ESDSEG e A PAA VPQ TTS L AQ A K A LGKNSQV KA AS AL G L GPS A KGA V P G PPGK V GSAA A 476
Cdd:pfam03546 80 GP A A A QAQA G K P EEDSESSS E E SDSDGE - T PAA ATL TTS P AQ V K P LGKNSQV RP AS TV G K GPS G KGA N P A PPGK A GSAA P 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 477 Q a V KREEDS E S S SEAESD SD G E APTAA A SA QAK SL GK VP QVRPASGPAKG ---- P S QKAGP AT TQVK T ERSKE - DSETS E 551
Cdd:pfam03546 159 L - V QVGKKE E D S ESSSEE SD S E GEAPP A AT QAK PS GK IL QVRPASGPAKG aapa P P QKAGP VA TQVK A ERSKE d SESSE E 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 552 E SDSE D E T PAA V TPAQAK L A GR TPQTKASPRKGTPITP A SAKVPPV QA GTPAPWKAGTV S S L AC T SSPA M ARGAQRPEE N 631
Cdd:pfam03546 238 S SDSE E E A PAA A TPAQAK P A LK TPQTKASPRKGTPITP T SAKVPPV RV GTPAPWKAGTV T S P AC A SSPA V ARGAQRPEE D 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 632 SSSSEES D SEEETAPA T AVGQ V KSVGK SVP GKAASAPTKGPSGQGTAPV L PGK A G TVM AQVKAE V QE - DSE S S EESD N E K 710
Cdd:pfam03546 318 SSSSEES E SEEETAPA A AVGQ A KSVGK GLQ GKAASAPTKGPSGQGTAPV P PGK T G PAV AQVKAE A QE d SES S E EESD S E E 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 711 AA S T A AQVK T S V K S PQ T KAN L A ASRVA SAKGA V SA L GK G V T AAAQAK P GSPAK asgtratggarvgwrgrpssgpsldkg 790
Cdd:pfam03546 398 AA A T P AQVK A S G K T PQ A KAN P A PTKAS SAKGA A SA P GK V V A AAAQAK Q GSPAK --------------------------- 450
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 791 paq VKPP L RTPQ S S VV S GK GQ V S MT AVGKAVA A AAQ D Q Q GPV R GP E E DSES S E EE SD - SE G EAP T QAKPS V K L PQVRA S S 869
Cdd:pfam03546 451 --- VKPP A RTPQ N S AI S VR GQ A S VP AVGKAVA T AAQ A Q K GPV G GP Q E EDSE S S EE ES d SE E EAP A QAKPS G K T PQVRA A S 527
....
gi 1811043612 870 AP T K 873
Cdd:pfam03546 528 AP A K 531
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
216-525
2.83e-07
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 55.08
E-value: 2.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 216 KPA V K L PQ VR A P P -------- APV K ES P R R RVA P T P G KAG N VT PQVRGDTLTS A GK A KN PEE V S E SSEE ESES EE G APA G 287
Cdd:pfam03546 255 KPA L K T PQ TK A S P rkgtpitp TSA K VP P V R VGT P A P W KAG T VT SPACASSPAV A RG A QR PEE D S S SSEE SESE EE T APA A 334
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 288 TPS Q V K ASE K TV Q VR AAS G P A KG TA G K G AT P A PPGK A GPA AT Q A KA gkpee DSESS SE EDSDSEEELP AA K TP LR VK P SG 367
Cdd:pfam03546 335 AVG Q A K SVG K GL Q GK AAS A P T KG PS G Q G TA P V PPGK T GPA VA Q V KA ----- EAQED SE SSEEESDSEE AA A TP AQ VK A SG 409
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 368 K I PQ V KA AS A APAKA S P rk RAP A AP PGK AGPV A P QA Q arkqeedsesssseesdse GEA PA A V PQTTSLA Q AK A LGKNS Q 447
Cdd:pfam03546 410 K T PQ A KA NP A PTKAS S A -- KGA A SA PGK VVAA A A QA K ------------------- QGS PA K V KPPARTP Q NS A ISVRG Q 468
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1811043612 448 VKAASA lglgpsakgavpgpp GK VGSA AAQA V K REEDSESSSEA ES DSDGEAPTAA A S AQAK SL GK V PQVR P AS G PAK 525
Cdd:pfam03546 469 ASVPAV --------------- GK AVAT AAQA Q K GPVGGPQEEDS ES SEEESDSEEE A P AQAK PS GK T PQVR A AS A PAK 531
PHA03247
PHA03247 large tegument protein UL36; Provisional
217-649
1.64e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.94
E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 217 P AVK LP QVRA P P AP VKES P RR R V AP T P GKAGNVTPQV R G D TLTSAGKAKN P EEVSESSEEESESEEGA P AGTPSQVKASE 296
Cdd:PHA03247 2551 P PPP LP PAAP P A AP DRSV P PP R P AP R P SEPAVTSRAR R P D APPQSARPRA P VDDRGDPRGPAPPSPLP P DTHAPDPPPPS 2630
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 297 KTVQVRAASGPAKG T AGKGAT P APPGKA G PAATQAK A GKPEEDSES SS EEDSDSEEELPAAKTP L ---- RVK P SGKI P Q - 371
Cdd:PHA03247 2631 PSPAANEPDPHPPP T VPPPER P RDDPAP G RVSRPRR A RRLGRAAQA SS PPQRPRRRAARPTVGS L tsla DPP P PPPT P E p 2710
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 372 ----- V K A ASAA P AK A SP R KRA PA A P PGK A G P VA P QAQ A RKQEEDSESSSSEESDSEGE AP A A V P QTTSLAQAKALGKN S 446
Cdd:PHA03247 2711 aphal V S A TPLP P GP A AA R QAS PA L P AAP A P P AV P AGP A TPGGPARPARPPTTAGPPAP AP P A A P AAGPPRRLTRPAVA S 2790
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 447 QVKAASA L GLGPSAK --- G AV PG P PGKVGS AA AQ A VKREEDSESSSE A ESDSD G EA P TAAASAQAKSL G KVPQV RP A S GP 523
Cdd:PHA03247 2791 LSESRES L PSPWDPA dpp A AV LA P AAALPP AA SP A GPLPPPTSAQPT A PPPPP G PP P PSLPLGGSVAP G GDVRR RP P S RS 2870
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 524 A kg PSQK A G PA TTQ V KTERSKED S ETS E ESDSEDET P AAVTPA QA KLAGRTPQTKAS P RKGT P IT P ASAKVP P VQ A G T PA 603
Cdd:PHA03247 2871 P -- AAKP A A PA RPP V RRLARPAV S RST E SFALPPDQ P ERPPQP QA PPPPQPQPQPPP P PQPQ P PP P PPPRPQ P PL A P T TD 2948
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1811043612 604 P WK AG TV S SLA ctss P AMAR GA QR P EENSSSSEESDSEEETAP A T A 649
Cdd:PHA03247 2949 P AG AG EP S GAV ---- P QPWL GA LV P GRVAVPRFRVPQPAPSRE A P A 2990
PRK07764
PRK07764 DNA polymerase III subunits gamma and tau; Validated
283-683
2.68e-04
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain]
Cd Length: 824
Bit Score: 45.75
E-value: 2.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 283 GAPA G TPSQVKAS E KTVQ V RAAS G PAKGT A GKG A TP AP PGKAG PAA TQAK A GKPEEDSESSSEEDSDS eeel PA AKT P LR 362
Cdd:PRK07764 369 DDER G LLARLERL E RRLG V AGGA G APAAA A PSA A AA AP AAAPA PAA AAPA A AAAPAPAAAPQPAPAPA ---- PA PAP P SP 444
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 363 VKPSGKIPQVKAAS AA pakasprkr AP A A P P GK A GPV AP QAQ A RKQEEDSESSSSEESDSEGE APAA VPQTTSL A Q ---- 438
Cdd:PRK07764 445 AGNAPAGGAPSPPP AA --------- AP S A Q P AP A PAA AP EPT A APAPAPPAAPAPAAAPAAPA APAA PAGADDA A T lrer 515
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 439 - AKA L GKNSQVKAASALG L G P S A K ga V P G PP G KV ------ GSAA A QAVKREEDS E SSSE A ESDSD G EAPTAA A SAQAKSL 511
Cdd:PRK07764 516 w PEI L AAVPKRSRKTWAI L L P E A T -- V L G VR G DT lvlgfs TGGL A RRFASPGNA E VLVT A LAEEL G GDWQVE A VVGPAPG 593
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 512 GKVPQVR PA SGPAKG P SQK A G PA TT ----- QVKTERSKEDSETS E E S DSEDETP AA VTPAQAKL A GRTPQTKASPRKGTP 586
Cdd:PRK07764 594 AAGGEGP PA PASSGP P EEA A R PA AP aapaa PAAPAPAGAAAAPA E A S AAPAPGV AA PEHHPKHV A VPDASDGGDGWPAKA 673
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 587 ITP A S A KV PP VQ A GTPAPWK AG TVSSLACTSSP A MARGA Q RPEENSSSSEESDSEEETA PA TAVGQVKSVGKSV P GKA A S 666
Cdd:PRK07764 674 GGA A P A AP PP AP A PAAPAAP AG AAPAQPAPAPA A TPPAG Q ADDPAAQPPQAAQGASAPS PA ADDPVPLPPEPDD P PDP A G 753
410
....*....|....*..
gi 1811043612 667 AP TKG P SGQGT AP VLPG 683
Cdd:PRK07764 754 AP AQP P PPPAP AP AAAP 770
PHA03247
PHA03247 large tegument protein UL36; Provisional
753-1238
3.28e-04
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 45.70
E-value: 3.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 753 AAQAK P GS P AKASGT RA TGGA R VGW RG RPSSG P SL - D KGPAQVK PP LRT P QSSVVSGKGQVSMTAVGKAVAAA A QDQQGP 831
Cdd:PHA03247 2584 SRARR P DA P PQSARP RA PVDD R GDP RG PAPPS P LP p D THAPDPP PP SPS P AANEPDPHPPPTVPPPERPRDDP A PGRVSR 2663
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 832 V R GPEEDSESSEEE S DSEGEAPTQ A K P S V KLPQVR A SSA P TKGS P KKGAATAPPGKAG PP AAQ A RK Q eedsessseesds 911
Cdd:PHA03247 2664 P R RARRLGRAAQAS S PPQRPRRRA A R P T V GSLTSL A DPP P PPPT P EPAPHALVSATPL PP GPA A AR Q ------------- 2730
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 912 deevpa A V P PA qkegnsktassk TL APAPP EKK A KESSASSDEELPDSQVIKT P LIFVD P n RS PA GPAATPAQAQ A ASAP 991
Cdd:PHA03247 2731 ------ A S P AL ------------ PA APAPP AVP A GPATPGGPARPARPPTTAG P PAPAP P - AA PA AGPPRRLTRP A VASL 2791
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 992 RKA R A S ESTARSSSESE d ED V IPATQC L T PA VR -- TNVVTVPT AQP RTS P RASSNEESTPVSE G KK qe AP ATQ V TKTN P A 1069
Cdd:PHA03247 2792 SES R E S LPSPWDPADPP - AA V LAPAAA L P PA AS pa GPLPPPTS AQP TAP P PPPGPPPPSLPLG G SV -- AP GGD V RRRP P S 2868
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 1070 HL P ltqaalkvl A Q K ATESKS PP AKTSSSSGTDSALGTLPVTSP Q NTP aqakvtdk P KK P EV P TAKRAMAT P SGR P KAKA 1149
Cdd:PHA03247 2869 RS P --------- A A K PAAPAR PP VRRLARPAVSRSTESFALPPD Q PER -------- P PQ P QA P PPPQPQPQ P PPP P QPQP 2931
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 1150 SGTSDDSDDSSGSSSGSEEDTEG P QT A PSAHRP GA AASK R ETLVEETTAESSDD - E VVEP S QSL L S G YVTP R LTPAS S QA 1228
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGE P SG A VPQPWL GA LVPG R VAVPRFRVPQPAPS r E APAS S TPP L T G HSLS R VSSWA S SL 3011
490
....*....|
gi 1811043612 1229 SKASKAT P K P 1238
Cdd:PHA03247 3012 ALHEETD P P P 3021
PHA03307
PHA03307 transcriptional regulator ICP4; Provisional
863-1145
4.75e-04
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain]
Cd Length: 1352
Bit Score: 44.78
E-value: 4.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 863 PQVRASSA P TKG SP KKGAA T A PP GKAG P PA A QARKQEEDSES S SEESDSDEEVP A AVP PA QKEGNSKTASS ktla P A P P E 942
Cdd:PHA03307 101 AREGSPTP P GPS SP DPPPP T P PP ASPP P SP A PDLSEMLRPVG S PGPPPAASPPA A GAS PA AVASDAASSRQ ---- A A L P L 176
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 943 KKAK E SSASSDEELPDSQVIKT P LIFVDPNRSPAG P AATP A QAQ A ASAP R K A RAS - ESTARS SS E SE DEDVIPATQCLT P 1021
Cdd:PHA03307 177 SSPE E TARAPSSPPAEPPPSTP P AAASPRPPRRSS P ISAS A SSP A PAPG R S A ADD a GASSSD SS S SE SSGCGWGPENEC P 256
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 1022 AV R TNVV T V PT AQPRT S PRASSNEEST P V S EGKKQEAPATQVTKTN P AHL P LTQAALKVLAQKATESK S PPAKT SSS SGT 1101
Cdd:PHA03307 257 LP R PAPI T L PT RIWEA S GWNGPSSRPG P A S SSSSPRERSPSPSPSS P GSG P APSSPRASSSSSSSRES S SSSTS SSS ESS 336
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1811043612 1102 DS A LGTLPVT ----- SP QNT P AQ A KVTDKP K K P EVPT A KRAM A TPS GRP 1145
Cdd:PHA03307 337 RG A AVSPGPS psrsp SP SRP P PP A DPSSPR K R P RPSR A PSSP A ASA GRP 385
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
852-897
6.55e-04
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 44.29
E-value: 6.55e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1811043612 852 A P T QAKPS V K L PQVRA S SAP T K G SP K KGA ATA PPGK A GP P AAQA RK 897
Cdd:pfam03546 43 T P L QAKPS G K T PQVRA A SAP A K E SP R KGA PPV PPGK T GP A AAQA QA 88
PRK07764
PRK07764 DNA polymerase III subunits gamma and tau; Validated
561-965
1.41e-03
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain]
Cd Length: 824
Bit Score: 43.44
E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 561 A A VTP A QAKL A GRT P QTKAS P RKGT P ITP A SAKVPPVQAGT PAP WK A GTVS S L A CTSSPAM A RGAQRPEEN S SSSEESDS 640
Cdd:PRK07764 392 G A PAA A APSA A AAA P AAAPA P AAAA P AAA A APAPAAAPQPA PAP AP A PAPP S P A GNAPAGG A PSPPPAAAP S AQPAPAPA 471
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 641 EEETAP A TAVGQVKSVGKSVPGK AA S A PTKG P S G QGT A PV L PGKAGTVM A Q V KAEVQEDSESS eesdne KAAS T AAQ V KT 720
Cdd:PRK07764 472 AAPEPT A APAPAPPAAPAPAAAP AA P A APAA P A G ADD A AT L RERWPEIL A A V PKRSRKTWAIL ------ LPEA T VLG V RG 545
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 721 SVKSPQTKANLA A S R V AS AKG A --- V S AL GK -- G VTAAAQ A KP G SPAK A S G tr AT G GARVGWR G R P SSGPSLDKGP A QVK 795
Cdd:PRK07764 546 DTLVLGFSTGGL A R R F AS PGN A evl V T AL AE el G GDWQVE A VV G PAPG A A G -- GE G PPAPASS G P P EEAARPAAPA A PAA 623
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 796 P P l RTPQSSVVSGKGQV S MTAVGKAV A AAAQDQQGP V rg P EEDSESSEEESDSE G E AP TQAK P SVKLPQVR A SSAPTKGS 875
Cdd:PRK07764 624 P A - APAPAGAAAAPAEA S AAPAPGVA A PEHHPKHVA V -- P DASDGGDGWPAKAG G A AP AAPP P APAPAAPA A PAGAAPAQ 700
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 876 P K - KG AAT A P P G K A GP PAAQ ARKQEEDSESS S EES D SDEEV P ---------- A A VPPAQKEGNSKT A SSKTL AP A P PEKK 944
Cdd:PRK07764 701 P A p AP AAT P P A G Q A DD PAAQ PPQAAQGASAP S PAA D DPVPL P pepddppdpa G A PAQPPPPPAPAP A AAPAA AP P P SPPS 780
410 420
....*....|....*....|.
gi 1811043612 945 AK E SS A SS D EELP D SQVIKTP 965
Cdd:PRK07764 781 EE E EM A ED D APSM D DEDRRDA 801
PHA03247
PHA03247 large tegument protein UL36; Provisional
852-1295
2.16e-03
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 43.00
E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 852 A PTQ A KPSVKLPQVRASSA P TKGSPKKGAAT - A P P G KAGP P AAQARKQEEDSES S SEES D SDEEV P A A V PPA qkegnskt 930
Cdd:PHA03247 2491 A AGA A PDPGGGGPPDPDAP P APSRLAPAILP d E P V G EPVH P RMLTWIRGLEELA S DDAG D PPPPL P P A A PPA -------- 2562
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 931 A SSKTLA P AP P EKKAK E SSAS S DEEL PD SQVIKT - P LIF VD PNRS P A GPA ATPAQAQAAS A ------ PRKAR A S E S --- T 1000
Cdd:PHA03247 2563 A PDRSVP P PR P APRPS E PAVT S RARR PD APPQSA r P RAP VD DRGD P R GPA PPSPLPPDTH A pdpppp SPSPA A N E P dph P 2642
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 1001 ARSSSES E DEDVI PA TQCLTPAV R TNVVTVPT -- AQ P RTS PR -------- A S SNEEST P VSEGKKQ E APATQVTKTN P AH 1070
Cdd:PHA03247 2643 PPTVPPP E RPRDD PA PGRVSRPR R ARRLGRAA qa SS P PQR PR rraarptv G S LTSLAD P PPPPPTP E PAPHALVSAT P LP 2722
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 1071 LPLTQ A ALKVL A QK A TESKSPPAKTSSSS G TDSALGTL P V T S -- P QNT P AQ A KVTDK P KKPEV P TAKRAMATPSGR P KAK 1148
Cdd:PHA03247 2723 PGPAA A RQASP A LP A APAPPAVPAGPATP G GPARPARP P T T A gp P APA P PA A PAAGP P RRLTR P AVASLSESRESL P SPW 2802
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 1149 ASGTSDDSDDSSGSSSGSEEDTE GP QTA P SAHR P G A AASKRETLVEETTAES S ----- D DEVVE PS Q S LLSGYVT P RLT P 1223
Cdd:PHA03247 2803 DPADPPAAVLAPAAALPPAASPA GP LPP P TSAQ P T A PPPPPGPPPPSLPLGG S vapgg D VRRRP PS R S PAAKPAA P ARP P 2882
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1811043612 1224 ASSQ A SK A SKATPKPDPN P S isstsitkdal D GKQEVE QPQA AGTMS P K - TGRREASTT P QK P QKGPGS P QAS 1295
Cdd:PHA03247 2883 VRRL A RP A VSRSTESFAL P P ----------- D QPERPP QPQA PPPPQ P Q p QPPPPPQPQ P PP P PPPRPQ P PLA 2944
PHA03247
PHA03247 large tegument protein UL36; Provisional
217-612
2.75e-03
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 42.62
E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 217 P AVKL P QVRA PP APVKES P R rrv A P T P GK A G N VTPQVRGD T LTSAGKAKNPEEVSES S EEESESEE G AP A GTP S QVKASE 296
Cdd:PHA03247 2608 P RGPA P PSPL PP DTHAPD P P --- P P S P SP A A N EPDPHPPP T VPPPERPRDDPAPGRV S RPRRARRL G RA A QAS S PPQRPR 2684
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 297 KTV q V R AAS G PAKGT A GKGAT P AP P GK A GP A ATQ A KAGK P EEDSESSSEEDSDSEEEL PA AKTPLRVKPSGKI P QVKAAS 376
Cdd:PHA03247 2685 RRA - A R PTV G SLTSL A DPPPP P PT P EP A PH A LVS A TPLP P GPAAARQASPALPAAPAP PA VPAGPATPGGPAR P ARPPTT 2763
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 377 A A P AKAS P r KR APAA P P GKAGPVAPQ A QARKQE E DSE S SSSEESDSEGEAPA A VPQTTSLAQ A KA L GKNSQVKAASA lgl 456
Cdd:PHA03247 2764 A G P PAPA P - PA APAA G P PRRLTRPAV A SLSESR E SLP S PWDPADPPAAVLAP A AALPPAASP A GP L PPPTSAQPTAP --- 2839
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811043612 457 g P SAK G AV P GPPGKV GS A A AQAVK R EEDSES S SE A ESDSDGEA P TAAASAQ A K S LGKVPQVR P ASG P AKG P SQK A G P ATT 536
Cdd:PHA03247 2840 - P PPP G PP P PSLPLG GS V A PGGDV R RRPPSR S PA A KPAAPARP P VRRLARP A V S RSTESFAL P PDQ P ERP P QPQ A P P PPQ 2918
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1811043612 537 QVKTERSKEDSETSEESDSEDET P A A V T PAQ A KLAGRTPQTKA s P RK G T p IT P ASAK VP PVQAGT PAP WKAGTV SS 612
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQP P L A P T TDP A GAGEPSGAVPQ - P WL G A - LV P GRVA VP RFRVPQ PAP SREAPA SS 2992
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
3.30e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 3.30e-03
10 20 30
....*....|....*....|....*....|..
gi 1811043612 6 K R R EL LP LI YQH LL QA GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LL RN GY EET A ETLQKE SG LS 33
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
