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Conserved domains on  [gi|1785346873|ref|XP_031752174|]
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proteasomal ATPase-associated factor 1 isoform X8 [Xenopus tropicalis]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-358 2.54e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 125.14  E-value: 2.54e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873  67 KVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMK 146
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 147 GHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevgtEGKL 226
Cdd:cd00200    91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SP-----------DGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 227 VVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFI-SSVGVLAGGLDGNIIHVDIRNPKSaVETVSWSETPVLSLVPF 304
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFS 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1785346873 305 RDTY--VASYGNGTCYI-PLKGSEQVLQLTGPNrQPVFQVAAWK--KLVYTCCRDGFIR 358
Cdd:cd00200   229 PDGYllASGSEDGTIRVwDLRTGECVQTLSGHT-NSVTSLAWSPdgKRLASGSADGTIR 286
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-358 2.54e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.14  E-value: 2.54e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873  67 KVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMK 146
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 147 GHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevgtEGKL 226
Cdd:cd00200    91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SP-----------DGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 227 VVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFI-SSVGVLAGGLDGNIIHVDIRNPKSaVETVSWSETPVLSLVPF 304
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFS 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1785346873 305 RDTY--VASYGNGTCYI-PLKGSEQVLQLTGPNrQPVFQVAAWK--KLVYTCCRDGFIR 358
Cdd:cd00200   229 PDGYllASGSEDGTIRVwDLRTGECVQTLSGHT-NSVTSLAWSPdgKRLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
68-358 1.09e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.79  E-value: 1.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873  68 VSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMKG 147
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 148 HRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVAEVGNAVNLGSPKET------PSNREVG 221
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTvrlwdlATGKLLR 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 222 T---------------EGKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNIIHVDIRN 283
Cdd:COG2319   241 TltghsgsvrsvafspDGRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAF-SPDGklLASGSDDGTVRLWDLAT 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 284 PKsAVETVSWSETPVLSLV--PFRDTYVASYGNGTCYI-PLKGSEQVLQLTGpNRQPVFQVAAWK--KLVYTCCRDGFIR 358
Cdd:COG2319   320 GK-LLRTLTGHTGAVRSVAfsPDGKTLASGSDDGTVRLwDLATGELLRTLTG-HTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 138-177 1.68e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1785346873  138 DGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 177
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
139-177 3.36e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 3.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1785346873 139 GSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 177
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 103-192 5.05e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.35  E-value: 5.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 103 LEGHTRDVFSCKFFPSGQEVL-SGGLDSLVKVWSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQG 181
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                          90
                  ....*....|.
gi 1785346873 182 ACIAVVDDSYS 192
Cdd:PTZ00421  201 TIVSSVEAHAS 211
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-358 2.54e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.14  E-value: 2.54e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873  67 KVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMK 146
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 147 GHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevgtEGKL 226
Cdd:cd00200    91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SP-----------DGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 227 VVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFI-SSVGVLAGGLDGNIIHVDIRNPKSaVETVSWSETPVLSLVPF 304
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFS 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1785346873 305 RDTY--VASYGNGTCYI-PLKGSEQVLQLTGPNrQPVFQVAAWK--KLVYTCCRDGFIR 358
Cdd:cd00200   229 PDGYllASGSEDGTIRVwDLRTGECVQTLSGHT-NSVTSLAWSPdgKRLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
68-358 1.09e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.79  E-value: 1.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873  68 VSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMKG 147
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 148 HRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVAEVGNAVNLGSPKET------PSNREVG 221
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTvrlwdlATGKLLR 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 222 T---------------EGKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNIIHVDIRN 283
Cdd:COG2319   241 TltghsgsvrsvafspDGRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAF-SPDGklLASGSDDGTVRLWDLAT 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 284 PKsAVETVSWSETPVLSLV--PFRDTYVASYGNGTCYI-PLKGSEQVLQLTGpNRQPVFQVAAWK--KLVYTCCRDGFIR 358
Cdd:COG2319   320 GK-LLRTLTGHTGAVRSVAfsPDGKTLASGSDDGTVRLwDLATGELLRTLTG-HTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
68-177 1.76e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 1.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873  68 VSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMKG 147
Cdd:COG2319   291 VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG 370

                          90       100       110
                  ....*....|....*....|....*....|
gi 1785346873 148 HRGSILDIAVVADGQNVISSGQDGTARLWD 177
Cdd:COG2319   371 HTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-177 1.94e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 1.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873  81 VSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMKGHRGSILDIAVVAD 160
Cdd:cd00200   193 LSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPD 272

                          90
                  ....*....|....*..
gi 1785346873 161 GQNVISSGQDGTARLWD 177
Cdd:cd00200   273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
68-358 2.52e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 2.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873  68 VSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMKG 147
Cdd:COG2319    39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 148 HRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevgtEGKLV 227
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF----------SP-----------DGKLL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 228 VLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG-VLAGGLDGNIIHV-DIRNPKsAVETVSWSETPVLSLVPF 304
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAF-SPDGkLLASGSADGTVRLwDLATGK-LLRTLTGHSGSVRSVAFS 255

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 305 RD-TYVASYG-NGTCYI-PLKGSEQVLQLTGPNRqPVFQVaAWK---KLVYTCCRDGFIR 358
Cdd:COG2319   256 PDgRLLASGSaDGTVRLwDLATGELLRTLTGHSG-GVNSV-AFSpdgKLLASGSDDGTVR 313
WD40 COG2319
WD40 repeat [General function prediction only];
74-358 1.65e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.10  E-value: 1.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873  74 SSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMKGHRGSIL 153
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 154 DIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevgtEGKLVVLARED 233
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF----------SP-----------DGKTLASGSAD 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 234 KSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNIIHVDIRNPKsAVETVSWSETPVLSLVPFRD-TYV 309
Cdd:COG2319   142 GTVRLWDLATGKLLRTLTGhSGAVTSVAF-SPDGklLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDgKLL 219

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1785346873 310 ASYG-NGTCYI-PLKGSEQVLQLTGPNRqPVFQVA--AWKKLVYTCCRDGFIR 358
Cdd:COG2319   220 ASGSaDGTVRLwDLATGKLLRTLTGHSG-SVRSVAfsPDGRLLASGSADGTVR 271
WD40 COG2319
WD40 repeat [General function prediction only];
68-138 1.01e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 1.01e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1785346873  68 VSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVND 138
Cdd:COG2319   333 VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 141-362 4.95e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 4.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 141 CLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPKetpsnrev 220
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA----------SAD-------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 221 gteGKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFISSVGVL-AGGLDGNIIHVDIRNPK---------SAVE 289
Cdd:cd00200    63 ---GTYLASGSSDKTIRLWDLETGECVRTLTGhTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKclttlrghtDWVN 139

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1785346873 290 TVSWSetpvlslvPFRDTYVASYGNGTCYI-PLKGSEQVLQLTGPNRqPVFQVaAW---KKLVYTCCRDGFIRKYEI 362
Cdd:cd00200   140 SVAFS--------PDGTFVASSSQDGTIKLwDLRTGKCVATLTGHTG-EVNSV-AFspdGEKLLSSSSDGTIKLWDL 206
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 138-177 1.68e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1785346873  138 DGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 177
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
139-177 3.36e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 3.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1785346873 139 GSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 177
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-135 2.75e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.75e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1785346873   98 EVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWS 135
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 103-192 5.05e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.35  E-value: 5.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 103 LEGHTRDVFSCKFFPSGQEVL-SGGLDSLVKVWSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQG 181
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                          90
                  ....*....|.
gi 1785346873 182 ACIAVVDDSYS 192
Cdd:PTZ00421  201 TIVSSVEAHAS 211
WD40 pfam00400
WD domain, G-beta repeat;
98-135 2.95e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.95e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1785346873  98 EVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWS 135
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 121-210 5.48e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 5.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873 121 EVLSGGLDSLVKVWSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQ-DGTARLWDSAQGACIAVVDDSYSPINAIAV 199
Cdd:PLN00181  547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSdDGSVKLWSINQGVSIGTIKTKANICCVQFP 626

                          90
                  ....*....|.
gi 1785346873 200 AEVGNAVNLGS 210
Cdd:PLN00181  627 SESGRSLAFGS 637
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 67-182 9.49e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.23  E-value: 9.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346873  67 KVSYLDISSGG-DLGVSSSTDQTFKVWEThNTEVkSVLEGHTRDVFSCKFFPS--GQEVLSGGLDSLVKVWSV-NDGSCL 142
Cdd:PLN00181  577 RVWSIDYSSADpTLLASGSDDGSVKLWSI-NQGV-SIGTIKTKANICCVQFPSesGRSLAFGSADHKVYYYDLrNPKLPL 654

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1785346873 143 ATMKGHRGSILDIAVVaDGQNVISSGQDGTARLWDSAQGA 182
Cdd:PLN00181  655 CTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSI 693
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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