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Conserved domains on  [gi|1785346871|ref|XP_031752173|]
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proteasomal ATPase-associated factor 1 isoform X7 [Xenopus tropicalis]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
94-362 5.27e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 5.27e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  94 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 173
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 174 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPKetpsnrevgte 253
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPD----------- 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 254 GKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNIIHVDIRNPKsAVETVSWSETPVLS 330
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAF-SPDGklLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRS 335

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1785346871 331 LV--PFRDTYVASYGNGTCYI-PLKGSEQVLQLTG 362
Cdd:COG2319   336 VAfsPDGKTLASGSDDGTVRLwDLATGELLRTLTG 370
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
94-362 5.27e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 5.27e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  94 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 173
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 174 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPKetpsnrevgte 253
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPD----------- 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 254 GKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNIIHVDIRNPKsAVETVSWSETPVLS 330
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAF-SPDGklLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRS 335

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1785346871 331 LV--PFRDTYVASYGNGTCYI-PLKGSEQVLQLTG 362
Cdd:COG2319   336 VAfsPDGKTLASGSDDGTVRLwDLATGELLRTLTG 370
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-364 1.11e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 1.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  94 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 173
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 174 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevgtE 253
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SP-----------D 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 254 GKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFI-SSVGVLAGGLDGNIIHVDIRNPKSaVETVSWSETPVLSL 331
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSV 225

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1785346871 332 VPFRDTY--VASYGNGTCYI-PLKGSEQVLQLTGPN 364
Cdd:cd00200   226 AFSPDGYllASGSEDGTIRVwDLRTGECVQTLSGHT 261
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 168-207 2.33e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.33e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1785346871  168 DGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 207
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
169-207 4.23e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 4.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1785346871 169 GSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 207
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 133-222 6.18e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.97  E-value: 6.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 133 LEGHTRDVFSCKFFPSGQEVL-SGGLDSLVKVWSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQG 211
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                          90
                  ....*....|.
gi 1785346871 212 ACIAVVDDSYS 222
Cdd:PTZ00421  201 TIVSSVEAHAS 211
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
94-362 5.27e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 5.27e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  94 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 173
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 174 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPKetpsnrevgte 253
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPD----------- 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 254 GKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNIIHVDIRNPKsAVETVSWSETPVLS 330
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAF-SPDGklLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRS 335

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1785346871 331 LV--PFRDTYVASYGNGTCYI-PLKGSEQVLQLTG 362
Cdd:COG2319   336 VAfsPDGKTLASGSDDGTVRLwDLATGELLRTLTG 370
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-364 1.11e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 1.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  94 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 173
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 174 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevgtE 253
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SP-----------D 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 254 GKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFI-SSVGVLAGGLDGNIIHVDIRNPKSaVETVSWSETPVLSL 331
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSV 225

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1785346871 332 VPFRDTY--VASYGNGTCYI-PLKGSEQVLQLTGPN 364
Cdd:cd00200   226 AFSPDGYllASGSEDGTIRVwDLRTGECVQTLSGHT 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-306 1.90e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.52  E-value: 1.90e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  94 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 173
Cdd:cd00200    92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 174 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAvaevgnavnlgspketpsnreVGTE 253
Cdd:cd00200   172 TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA---------------------FSPD 230

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1785346871 254 GKLVVLAREDKSLEGVSLHSRQSVFDFEGSDAF-NCCTFISSVGVLA-GGLDGNI 306
Cdd:cd00200   231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSvTSLAWSPDGKRLAsGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
92-324 4.78e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.86  E-value: 4.78e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  92 HIHGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSC 171
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 172 LATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevg 251
Cdd:COG2319   155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF----------SP---------- 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 252 tEGKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNI---------IHVDIRNPKSAVE 319
Cdd:COG2319   215 -DGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAF-SPDGrlLASGSADGTVrlwdlatgeLLRTLTGHSGGVN 292


                  ....*
gi 1785346871 320 TVSWS 324
Cdd:COG2319   293 SVAFS 297
WD40 COG2319
WD40 repeat [General function prediction only];
94-234 2.70e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 2.70e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  94 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 173
Cdd:COG2319   245 HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1785346871 174 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVAEVGN 234
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR 385
WD40 COG2319
WD40 repeat [General function prediction only];
94-207 4.85e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 4.85e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  94 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 173
Cdd:COG2319   287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1785346871 174 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 207
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-207 5.64e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 5.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  84 LSPYASFSHiHGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKV 163
Cdd:cd00200   167 GKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1785346871 164 WSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 207
Cdd:cd00200   246 WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 130-326 1.93e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 1.93e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 130 KSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSA 209
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 210 QGACIAVVDDSYSPINAIAVaevgnavnlgSPKetpsnrevgteGKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNC 288
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAF----------SPD-----------GRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNS 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1785346871 289 CTFISSVGVLAGGLDGNIIHV-DIRNPK---------SAVETVSWSET 326
Cdd:cd00200   141 VAFSPDGTFVASSSQDGTIKLwDLRTGKcvatltghtGEVNSVAFSPD 188
WD40 COG2319
WD40 repeat [General function prediction only];
92-332 2.19e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 2.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  92 HIHGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSC 171
Cdd:COG2319    33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 172 LATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevg 251
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF----------SP---------- 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 252 tEGKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG-VLAGGLDGNIIHV-DIRNPKsAVETVSWSETPV 328
Cdd:COG2319   173 -DGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAF-SPDGkLLASGSADGTVRLwDLATGK-LLRTLTGHSGSV 249


                  ....
gi 1785346871 329 LSLV 332
Cdd:COG2319   250 RSVA 253
WD40 COG2319
WD40 repeat [General function prediction only];
104-324 2.52e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 2.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 104 SSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMKGHRGSIL 183
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 184 DIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevgtEGKLVVLARED 263
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF----------SP-----------DGKTLASGSAD 141

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1785346871 264 KSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNIIHVDIRNPK---------SAVETVSWS 324
Cdd:COG2319   142 GTVRLWDLATGKLLRTLTGhSGAVTSVAF-SPDGklLASGSDDGTVRLWDLATGKllrtltghtGAVRSVAFS 213
WD40 COG2319
WD40 repeat [General function prediction only];
94-168 1.46e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 1.46e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1785346871  94 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVND 168
Cdd:COG2319   329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 168-207 2.33e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.33e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1785346871  168 DGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 207
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
169-207 4.23e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 4.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1785346871 169 GSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 207
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-346 4.66e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 4.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 171 CLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPKetpsnrev 250
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA----------SAD-------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 251 gteGKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFISSVGVL-AGGLDGNIIHVDIRNPK---------SAVE 319
Cdd:cd00200    63 ---GTYLASGSSDKTIRLWDLETGECVRTLTGhTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKclttlrghtDWVN 139

                         170       180
                  ....*....|....*....|....*..
gi 1785346871 320 TVSWSetpvlslvPFRDTYVASYGNGT 346
Cdd:cd00200   140 SVAFS--------PDGTFVASSSQDGT 158
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 128-165 3.75e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.75e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1785346871  128 EVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWS 165
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 133-222 6.18e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.97  E-value: 6.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 133 LEGHTRDVFSCKFFPSGQEVL-SGGLDSLVKVWSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQG 211
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                          90
                  ....*....|.
gi 1785346871 212 ACIAVVDDSYS 222
Cdd:PTZ00421  201 TIVSSVEAHAS 211
WD40 pfam00400
WD domain, G-beta repeat;
128-165 3.71e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1785346871 128 EVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWS 165
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 94-212 7.91e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 7.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871  94 HGKNVSYLDISSGG-DLGVSSSTDQTFKVWEThNTEVkSVLEGHTRDVFSCKFFPS--GQEVLSGGLDSLVKVWSV-NDG 169
Cdd:PLN00181  574 HEKRVWSIDYSSADpTLLASGSDDGSVKLWSI-NQGV-SIGTIKTKANICCVQFPSesGRSLAFGSADHKVYYYDLrNPK 651

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1785346871 170 SCLATMKGHRGSILDIAVVaDGQNVISSGQDGTARLWDSAQGA 212
Cdd:PLN00181  652 LPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSI 693
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 151-240 5.91e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 5.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346871 151 EVLSGGLDSLVKVWSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQ-DGTARLWDSAQGACIAVVDDSYSPINAIAV 229
Cdd:PLN00181  547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSdDGSVKLWSINQGVSIGTIKTKANICCVQFP 626

                          90
                  ....*....|.
gi 1785346871 230 AEVGNAVNLGS 240
Cdd:PLN00181  627 SESGRSLAFGS 637
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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