NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1785346865|ref|XP_031752170|]
View 

proteasomal ATPase-associated factor 1 isoform X6 [Xenopus tropicalis]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
83-377 1.57e-34

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 1.57e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865  83 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 162
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 163 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPKetpsnrevgte 242
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPD----------- 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 243 GKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNIIHVDIRNPKsAVETVSWSETPVLS 319
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAF-SPDGklLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRS 335

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1785346865 320 LV--PFRDTYVASYGNGTCYI-PLKGSEQVLQLTGpNRQPVFQVAAWK--KLVYTCCRDGFIR 377
Cdd:COG2319   336 VAfsPDGKTLASGSDDGTVRLwDLATGELLRTLTG-HTGAVTSVAFSPdgRTLASGSADGTVR 397
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
83-377 1.57e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 1.57e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865  83 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 162
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 163 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPKetpsnrevgte 242
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPD----------- 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 243 GKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNIIHVDIRNPKsAVETVSWSETPVLS 319
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAF-SPDGklLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRS 335

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1785346865 320 LV--PFRDTYVASYGNGTCYI-PLKGSEQVLQLTGpNRQPVFQVAAWK--KLVYTCCRDGFIR 377
Cdd:COG2319   336 VAfsPDGKTLASGSDDGTVRLwDLATGELLRTLTG-HTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-377 5.81e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 5.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865  83 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 162
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 163 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevgtE 242
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SP-----------D 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 243 GKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFI-SSVGVLAGGLDGNIIHVDIRNPKSaVETVSWSETPVLSL 320
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSV 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1785346865 321 VPFRDTY--VASYGNGTCYI-PLKGSEQVLQLTGPNrQPVFQVAAWK--KLVYTCCRDGFIR 377
Cdd:cd00200   226 AFSPDGYllASGSEDGTIRVwDLRTGECVQTLSGHT-NSVTSLAWSPdgKRLASGSADGTIR 286
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 2.70e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.70e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1785346865  157 DGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-196 4.89e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 4.89e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1785346865 158 GSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 196
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 122-211 5.66e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.35  E-value: 5.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 122 LEGHTRDVFSCKFFPSGQEVL-SGGLDSLVKVWSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQG 200
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                          90
                  ....*....|.
gi 1785346865 201 ACIAVVDDSYS 211
Cdd:PTZ00421  201 TIVSSVEAHAS 211
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
83-377 1.57e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 1.57e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865  83 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 162
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 163 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPKetpsnrevgte 242
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPD----------- 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 243 GKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNIIHVDIRNPKsAVETVSWSETPVLS 319
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAF-SPDGklLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRS 335

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1785346865 320 LV--PFRDTYVASYGNGTCYI-PLKGSEQVLQLTGpNRQPVFQVAAWK--KLVYTCCRDGFIR 377
Cdd:COG2319   336 VAfsPDGKTLASGSDDGTVRLwDLATGELLRTLTG-HTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-377 5.81e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 5.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865  83 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 162
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 163 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevgtE 242
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SP-----------D 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 243 GKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFI-SSVGVLAGGLDGNIIHVDIRNPKSaVETVSWSETPVLSL 320
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSV 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1785346865 321 VPFRDTY--VASYGNGTCYI-PLKGSEQVLQLTGPNrQPVFQVAAWK--KLVYTCCRDGFIR 377
Cdd:cd00200   226 AFSPDGYllASGSEDGTIRVwDLRTGECVQTLSGHT-NSVTSLAWSPdgKRLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
83-196 1.50e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 1.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865  83 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLA 162
Cdd:COG2319   287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1785346865 163 TMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 196
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
81-377 1.60e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 1.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865  81 HIHGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSC 160
Cdd:COG2319    33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 161 LATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevg 240
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF----------SP---------- 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 241 tEGKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG-VLAGGLDGNIIHV-DIRNPKsAVETVSWSETPV 317
Cdd:COG2319   173 -DGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAF-SPDGkLLASGSADGTVRLwDLATGK-LLRTLTGHSGSV 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1785346865 318 LSLVPFRD-TYVASYG-NGTCYI-PLKGSEQVLQLTGPNRqPVFQVaAWK---KLVYTCCRDGFIR 377
Cdd:COG2319   250 RSVAFSPDgRLLASGSaDGTVRLwDLATGELLRTLTGHSG-GVNSV-AFSpdgKLLASGSDDGTVR 313
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 73-196 7.00e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 7.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865  73 LSPYASFSHiHGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKV 152
Cdd:cd00200   167 GKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1785346865 153 WSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 196
Cdd:cd00200   246 WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
93-377 2.87e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 2.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865  93 SSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVNDGSCLATMKGHRGSIL 172
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 173 DIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPketpsnrevgtEGKLVVLARED 252
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF----------SP-----------DGKTLASGSAD 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 253 KSLEGVSLHSRQSVFDFEG-SDAFNCCTFiSSVG--VLAGGLDGNIIHVDIRNPKsAVETVSWSETPVLSLVPFRD-TYV 328
Cdd:COG2319   142 GTVRLWDLATGKLLRTLTGhSGAVTSVAF-SPDGklLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDgKLL 219

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1785346865 329 ASYG-NGTCYI-PLKGSEQVLQLTGPNRqPVFQVA--AWKKLVYTCCRDGFIR 377
Cdd:COG2319   220 ASGSaDGTVRLwDLATGKLLRTLTGHSG-SVRSVAfsPDGRLLASGSADGTVR 271
WD40 COG2319
WD40 repeat [General function prediction only];
83-157 8.46e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 8.46e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1785346865  83 HGKNVSYLDISSGGDLGVSSSTDQTFKVWETHNTEVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWSVND 157
Cdd:COG2319   329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 160-381 8.02e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.11  E-value: 8.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 160 CLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQGACIAVVDDSYSPINAIAVaevgnavnlgSPKetpsnrev 239
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA----------SAD-------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 240 gteGKLVVLAREDKSLEGVSLHSRQSVFDFEG-SDAFNCCTFISSVGVL-AGGLDGNIIHVDIRNPK---------SAVE 308
Cdd:cd00200    63 ---GTYLASGSSDKTIRLWDLETGECVRTLTGhTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKclttlrghtDWVN 139

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1785346865 309 TVSWSetpvlslvPFRDTYVASYGNGTCYI-PLKGSEQVLQLTGPNRqPVFQVaAW---KKLVYTCCRDGFIRKYEI 381
Cdd:cd00200   140 SVAFS--------PDGTFVASSSQDGTIKLwDLRTGKCVATLTGHTG-EVNSV-AFspdGEKLLSSSSDGTIKLWDL 206
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 2.70e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.70e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1785346865  157 DGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-196 4.89e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 4.89e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1785346865 158 GSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWD 196
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 117-154 4.29e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.29e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1785346865  117 EVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWS 154
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 122-211 5.66e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.35  E-value: 5.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 122 LEGHTRDVFSCKFFPSGQEVL-SGGLDSLVKVWSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQDGTARLWDSAQG 200
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                          90
                  ....*....|.
gi 1785346865 201 ACIAVVDDSYS 211
Cdd:PTZ00421  201 TIVSSVEAHAS 211
WD40 pfam00400
WD domain, G-beta repeat;
117-154 4.21e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 4.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1785346865 117 EVKSVLEGHTRDVFSCKFFPSGQEVLSGGLDSLVKVWS 154
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 83-201 7.89e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 7.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865  83 HGKNVSYLDISSGG-DLGVSSSTDQTFKVWEThNTEVkSVLEGHTRDVFSCKFFPS--GQEVLSGGLDSLVKVWSV-NDG 158
Cdd:PLN00181  574 HEKRVWSIDYSSADpTLLASGSDDGSVKLWSI-NQGV-SIGTIKTKANICCVQFPSesGRSLAFGSADHKVYYYDLrNPK 651

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1785346865 159 SCLATMKGHRGSILDIAVVaDGQNVISSGQDGTARLWDSAQGA 201
Cdd:PLN00181  652 LPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSI 693
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 140-229 5.98e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 5.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785346865 140 EVLSGGLDSLVKVWSVNDGSCLATMKGHRGSILDIAVVADGQNVISSGQ-DGTARLWDSAQGACIAVVDDSYSPINAIAV 218
Cdd:PLN00181  547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSdDGSVKLWSINQGVSIGTIKTKANICCVQFP 626

                          90
                  ....*....|.
gi 1785346865 219 AEVGNAVNLGS 229
Cdd:PLN00181  627 SESGRSLAFGS 637
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH