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Conserved domains on  [gi|1785412802|ref|XP_031748912|]
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oocyte zinc finger protein XlCOF7.1-like [Xenopus tropicalis]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 11577727)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-404 2.15e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 219 NYDKNSHQSPHKSeITKNILCGEYSCNESHKRLSYQSNLNRHQRTHTG-EKSFSCSECGKCFSDQSHLKTHYRT--HTGE 295
Cdd:COG5048   239 SLLSQSPSSLSSS-DSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGE 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 296 --KPFSC--SVCGKCFYCQSNLIRHKRTHTGEKPFSCVECGKCFIKQSDLDYHKRTHTREKPLSC----SECGKSFSCRS 367
Cdd:COG5048   318 slKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKndkkSETLSNSCIRN 397

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1785412802 368 SLNRHQR-----THTGEKP--FSCSECGKSFSQQYDLKIHSRTH 404
Cdd:COG5048   398 FKRDSNLslhiiTHLSFRPynCKNPPCSKSFNRHYNLIPHKKIH 441
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 88-121 1.05e-06

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


:

Pssm-ID: 143639  Cd Length: 40  Bit Score: 45.23  E-value: 1.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1785412802  88 IRCEDVSIYFSLEEWEYIKE-NKALYREGIKEEEE 121
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPaQRDLYRDVMLENYE 35
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-404 2.15e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 219 NYDKNSHQSPHKSeITKNILCGEYSCNESHKRLSYQSNLNRHQRTHTG-EKSFSCSECGKCFSDQSHLKTHYRT--HTGE 295
Cdd:COG5048   239 SLLSQSPSSLSSS-DSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGE 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 296 --KPFSC--SVCGKCFYCQSNLIRHKRTHTGEKPFSCVECGKCFIKQSDLDYHKRTHTREKPLSC----SECGKSFSCRS 367
Cdd:COG5048   318 slKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKndkkSETLSNSCIRN 397

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1785412802 368 SLNRHQR-----THTGEKP--FSCSECGKSFSQQYDLKIHSRTH 404
Cdd:COG5048   398 FKRDSNLslhiiTHLSFRPynCKNPPCSKSFNRHYNLIPHKKIH 441
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 88-121 1.05e-06

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 45.23  E-value: 1.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1785412802  88 IRCEDVSIYFSLEEWEYIKE-NKALYREGIKEEEE 121
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPaQRDLYRDVMLENYE 35
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-393 7.62e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 7.62e-06
                          10        20
                  ....*....|....*....|....*.
gi 1785412802 368 SLNRHQRTHTGEKPFSCSECGKSFSQ 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
KRAB smart00349
krueppel associated box;
91-118 2.31e-04

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 39.11  E-value: 2.31e-04
                           10        20
                   ....*....|....*....|....*....
gi 1785412802   91 EDVSIYFSLEEWEYIKE-NKALYREGIKE 118
Cdd:smart00349   4 EDVAVYFTQEEWEQLDPaQKNLYRDVMLE 32
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 91-118 3.35e-04

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 37.84  E-value: 3.35e-04
                          10        20
                  ....*....|....*....|....*....
gi 1785412802  91 EDVSIYFSLEEWEYIKEN-KALYREGIKE 118
Cdd:pfam01352   5 EDVAVDFTQEEWALLDPAqRNLYRDVMLE 33
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-404 2.15e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 219 NYDKNSHQSPHKSeITKNILCGEYSCNESHKRLSYQSNLNRHQRTHTG-EKSFSCSECGKCFSDQSHLKTHYRT--HTGE 295
Cdd:COG5048   239 SLLSQSPSSLSSS-DSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGE 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 296 --KPFSC--SVCGKCFYCQSNLIRHKRTHTGEKPFSCVECGKCFIKQSDLDYHKRTHTREKPLSC----SECGKSFSCRS 367
Cdd:COG5048   318 slKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKndkkSETLSNSCIRN 397

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1785412802 368 SLNRHQR-----THTGEKP--FSCSECGKSFSQQYDLKIHSRTH 404
Cdd:COG5048   398 FKRDSNLslhiiTHLSFRPynCKNPPCSKSFNRHYNLIPHKKIH 441
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 88-121 1.05e-06

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 45.23  E-value: 1.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1785412802  88 IRCEDVSIYFSLEEWEYIKE-NKALYREGIKEEEE 121
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPaQRDLYRDVMLENYE 35
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-393 7.62e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 7.62e-06
                          10        20
                  ....*....|....*....|....*.
gi 1785412802 368 SLNRHQRTHTGEKPFSCSECGKSFSQ 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
187-394 8.44e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 8.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 187 CSINPLTEQIQGTDTPTPIMGCSLNILEMKGNNYDKNSHQSPHKSEITKNILCgEYSCNESHKRLSYQSNLNRHQRT--H 264
Cdd:COG5048   236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSL-PIKSKQCNISFSRSSPLTRHLRSvnH 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 265 TGE--KSFSCSE--CGKCFSDQSHLKTHYRTHTGEKPFSCSVCGKCFYCQSNL-------IRHKRTHTGEKPFSCVECGK 333
Cdd:COG5048   315 SGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLSNSC 394

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1785412802 334 CFIKQSD--LDYHKRTHTREKPLSC--SECGKSFSCRSSLNRHQRTHTGEKPFSCSECGKSFSQQ 394
Cdd:COG5048   395 IRNFKRDsnLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-280 7.40e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.40e-05
                          10        20
                  ....*....|....*....|....*
gi 1785412802 256 NLNRHQRTHTGEKSFSCSECGKCFS 280
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 1.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.23e-04
                          10        20
                  ....*....|....*....|....*.
gi 1785412802 284 HLKTHYRTHTGEKPFSCSVCGKCFYC 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 270-292 1.33e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|...
gi 1785412802 270 FSCSECGKCFSDQSHLKTHYRTH 292
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
KRAB smart00349
krueppel associated box;
91-118 2.31e-04

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 39.11  E-value: 2.31e-04
                           10        20
                   ....*....|....*....|....*....
gi 1785412802   91 EDVSIYFSLEEWEYIKE-NKALYREGIKE 118
Cdd:smart00349   4 EDVAVYFTQEEWEQLDPaQKNLYRDVMLE 32
Semenogelin pfam05474
Semenogelin; This family consists of several mammalian secreted seminal proteins including ...
 220-404 2.86e-04

Semenogelin; This family consists of several mammalian secreted seminal proteins including semenogelin I and II. Freshly ejaculated human semen has the appearance of a loose gel in which the predominant structural protein components are the seminal vesicle secreted semenogelins (Sg). This family also includes seminal vesicle secretory protein 3A from mouse, which has been shown to be involved in the coagulation of semen resulting in the formation of the copulatory plug.


Pssm-ID: 368458 [Multi-domain]  Cd Length: 582  Bit Score: 43.33  E-value: 2.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 220 YDKNSHQsphkseiTKNILCGEYSCNESHKrLSYQSNLNRHQRTHTGEKSFSCSECGKCFSDQSHLKTHYRThtgEKPFS 299
Cdd:pfam05474 263 YNKNQHQ-------TKNLSQDQEHGRKAHK-ISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKS---QNQVT 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 300 CSVCGKCFYCQSNLIRHKRTHTGEKPFSCVECG------KCFIK-QSDLDYHKRTHTREK-PLSCSECG---KSFSCRSS 368
Cdd:pfam05474 332 IHSQDQEHGHKENKISYQSSSTEERHLNCGEKGiqkgvsKGSISiQTEEQIHGKSQNQVRiPSQAQEYGhkeNKISYQSS 411

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1785412802 369 LNRHQRTHTGEKPFSCSECGKSFSQQYDLKIHSRTH 404
Cdd:pfam05474 412 STEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQ 447
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 91-118 3.35e-04

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 37.84  E-value: 3.35e-04
                          10        20
                  ....*....|....*....|....*....
gi 1785412802  91 EDVSIYFSLEEWEYIKEN-KALYREGIKE 118
Cdd:pfam01352   5 EDVAVDFTQEEWALLDPAqRNLYRDVMLE 33
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-428 4.65e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 4.65e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1785412802 352 KPLSCSECGKSFSCRSSLNRHQRTHTGEKPFSCS--ECGKSFSQQYDLKIHSRTHALAKLFSCSecgKCFSKRSEFDCH 428
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-335 4.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.77e-04
                          10        20
                  ....*....|....*....|....
gi 1785412802 312 NLIRHKRTHTGEKPFSCVECGKCF 335
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-365 7.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.87e-04
                          10        20
                  ....*....|....*....|....*.
gi 1785412802 340 DLDYHKRTHTREKPLSCSECGKSFSC 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 382-404 1.43e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.43e-03
                          10        20
                  ....*....|....*....|...
gi 1785412802 382 FSCSECGKSFSQQYDLKIHSRTH 404
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
252-328 1.67e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 252 SYQSNLNRHQRTHTGE----KSFSCSECGKCFSDQSHLKTHYRTHTGEKPFSCSV--CGKCFYCQSNLIRHKRTHTGEKP 325
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91


                  ...
gi 1785412802 326 FSC 328
Cdd:COG5048    92 DLN 94
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 322-404 5.78e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 5.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 322 GEKPFSC--VECGKCFIKQSDLDYHKRThtrekplscSECGKSFSCRSSLNRHQRTHTGEKPFSCSECGKSFSQQYDLKI 399
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*
gi 1785412802 400 HsRTH 404
Cdd:COG5189   417 H-RKH 420
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-428 6.57e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 6.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412802 296 KPFSCSVCGKCFYCQSNLIRHKRTHTGEKPFSCvecgkcfikqsdldyhkrthtrekplSCSECGKSFSCRSSLNRHQRT 375
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQC--------------------------SYSGCDKSFSRPLELSRHLRT 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1785412802 376 HTGEKPFSCS-ECGKSFSQQYDLKIHSRTHALAKLFSCSECGKCFSKRSEFDCH 428
Cdd:COG5048    86 HHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPD 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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