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Conserved domains on  [gi|1779335748|ref|XP_031603159|]
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alpha- and gamma-adaptin-binding protein p34 [Oreochromis aureus]

Protein Classification

adaptin-binding domain-containing protein( domain architecture ID 10562885)

adaptin-binding domain-containing protein similar to fungal increased recombination centers protein 6 (IRC6) and mammalian alpha- and gamma-adaptin-binding protein p34 (AAGAB) that may be involved in endocytic recycling of growth factor receptors such as EGFR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adaptin_binding pfam10199
Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. ...
 162-300 1.04e-11

Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. It is known to interact with both alpha and gamma adaptin. It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane.


:

Pssm-ID: 462994  Cd Length: 96  Bit Score: 60.60  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779335748 162 ESTGVKRIVQALNANVWSSVEMKDGHNQgfglmsslvasrhnnprtcqdppssslpvegtvNNEEPNHTESTtntdtqee 241
Cdd:pfam10199   1 EKQGIERIVEILETHEWSNMELKSDDGS---------------------------------LQREKLSLEKA-------- 39

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1779335748 242 avVDAMTDLDIQELANLTTGDVDVDNFERLFTKLKEMKDKASSLPHEQRKVHAEKVAKA 300
Cdd:pfam10199  40 --DSQGQSLPNGKDLQDGDEELDVEDFENLLSKLKQARDMARELPDEERKEFAAKVAED 96
 
Name Accession Description Interval E-value
Adaptin_binding pfam10199
Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. ...
 162-300 1.04e-11

Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. It is known to interact with both alpha and gamma adaptin. It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane.


Pssm-ID: 462994  Cd Length: 96  Bit Score: 60.60  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779335748 162 ESTGVKRIVQALNANVWSSVEMKDGHNQgfglmsslvasrhnnprtcqdppssslpvegtvNNEEPNHTESTtntdtqee 241
Cdd:pfam10199   1 EKQGIERIVEILETHEWSNMELKSDDGS---------------------------------LQREKLSLEKA-------- 39

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1779335748 242 avVDAMTDLDIQELANLTTGDVDVDNFERLFTKLKEMKDKASSLPHEQRKVHAEKVAKA 300
Cdd:pfam10199  40 --DSQGQSLPNGKDLQDGDEELDVEDFENLLSKLKQARDMARELPDEERKEFAAKVAED 96
 
Name Accession Description Interval E-value
Adaptin_binding pfam10199
Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. ...
 162-300 1.04e-11

Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. It is known to interact with both alpha and gamma adaptin. It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane.


Pssm-ID: 462994  Cd Length: 96  Bit Score: 60.60  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779335748 162 ESTGVKRIVQALNANVWSSVEMKDGHNQgfglmsslvasrhnnprtcqdppssslpvegtvNNEEPNHTESTtntdtqee 241
Cdd:pfam10199   1 EKQGIERIVEILETHEWSNMELKSDDGS---------------------------------LQREKLSLEKA-------- 39

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1779335748 242 avVDAMTDLDIQELANLTTGDVDVDNFERLFTKLKEMKDKASSLPHEQRKVHAEKVAKA 300
Cdd:pfam10199  40 --DSQGQSLPNGKDLQDGDEELDVEDFENLLSKLKQARDMARELPDEERKEFAAKVAED 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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