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Conserved domains on  [gi|1777253978|ref|XP_031507410|]
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2-acylglycerol O-acyltransferase 1 [Papio anubis]

Protein Classification

2-acylglycerol O-acyltransferase family protein( domain architecture ID 11146611)

2-acylglycerol O-acyltransferase family protein such as 2-acylglycerol O-acyltransferase, which catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DAGAT pfam03982
Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is ...
47-334 1.90e-138

Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is catalyzed by the enzyme diacylglycerol acyltransferase (DAGAT).


:

Pssm-ID: 112781 [Multi-domain]  Cd Length: 297  Bit Score: 394.10  E-value: 1.90e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978  47 WFLYIPYLTWLYFDWHTPEQGGRRSSWIKNWTLWKHFKDYFPIHLIKTQDLDPSHNYIFGFHPHGILAAGAFGNFSTNYS 126
Cdd:pfam03982   9 WSLLVLYALWLFYDWNSPKRGGYRSNWARNWRIWKWFANYFPVKLHKTAELPPNRNYLFGYHPHGILSVGAFSNFSTNAT 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 127 DFKELFPGFTSYLHVLPLWFWCPVFREYMMSIGLVSVSKKSVSYVVSKEGGGNISVIVLGGAKESLDAHPGKFTLFIRQR 206
Cdd:pfam03982  89 GFMDKFPGIRPNICTLAGQFYTPFRREILLSLGLIEVSRESIEYVLDKCGKGRAVVLVVGGAAEALEAHPGKHTLTLKNR 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 207 KGFVKIALTHGASLVPVFSFGENELFKQVDNPEGSWIRTVQDKLQKIMGFALPLFHARGVFQ-YNFGLMPYRKAIHTVVG 285
Cdd:pfam03982 169 KGFVRIALKTGADLVPVYSFGENDVYKQWENPEGSRLRWVQEKLKRAIGFSPPIFHGRGVFNsYTFGLLPFRKPITTVVG 248
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1777253978 286 RPIPVRQILHPTEEQIEELHQTYMEELTKLFEEHKGKYGIPEHETLVLK 334
Cdd:pfam03982 249 APIEVTKTLNPTQEQIDELHGQYMEALRELFEEHKTKFGVPPDTDLVLN 297
 
Name Accession Description Interval E-value
DAGAT pfam03982
Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is ...
47-334 1.90e-138

Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is catalyzed by the enzyme diacylglycerol acyltransferase (DAGAT).


Pssm-ID: 112781 [Multi-domain]  Cd Length: 297  Bit Score: 394.10  E-value: 1.90e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978  47 WFLYIPYLTWLYFDWHTPEQGGRRSSWIKNWTLWKHFKDYFPIHLIKTQDLDPSHNYIFGFHPHGILAAGAFGNFSTNYS 126
Cdd:pfam03982   9 WSLLVLYALWLFYDWNSPKRGGYRSNWARNWRIWKWFANYFPVKLHKTAELPPNRNYLFGYHPHGILSVGAFSNFSTNAT 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 127 DFKELFPGFTSYLHVLPLWFWCPVFREYMMSIGLVSVSKKSVSYVVSKEGGGNISVIVLGGAKESLDAHPGKFTLFIRQR 206
Cdd:pfam03982  89 GFMDKFPGIRPNICTLAGQFYTPFRREILLSLGLIEVSRESIEYVLDKCGKGRAVVLVVGGAAEALEAHPGKHTLTLKNR 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 207 KGFVKIALTHGASLVPVFSFGENELFKQVDNPEGSWIRTVQDKLQKIMGFALPLFHARGVFQ-YNFGLMPYRKAIHTVVG 285
Cdd:pfam03982 169 KGFVRIALKTGADLVPVYSFGENDVYKQWENPEGSRLRWVQEKLKRAIGFSPPIFHGRGVFNsYTFGLLPFRKPITTVVG 248
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1777253978 286 RPIPVRQILHPTEEQIEELHQTYMEELTKLFEEHKGKYGIPEHETLVLK 334
Cdd:pfam03982 249 APIEVTKTLNPTQEQIDELHGQYMEALRELFEEHKTKFGVPPDTDLVLN 297
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
83-320 5.02e-56

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 181.33  E-value: 5.02e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978  83 FKDYFPIHLIKTQDLDPSHNYIFGFHPHGILA-AGAFGNFstnysDFKELFPGFTSYLHVLPLWFWCPVFREYMMSIGLV 161
Cdd:cd07987     1 HRKYFRVYEVRGLENIPDEGPALLVHPHGGLPiDGALLAA-----AFLLLFPGRLPRALADHFLFPLPGLRDLLRRLGAV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 162 SVSKKSVSYVVSKeggGNISVIVLGGAKESLDAHPGKFTLFIRQRKGFVKIALTHGASLVPVFSFGENELFKQVDNPEGS 241
Cdd:cd07987    76 PGSRENCVRLLRE---GELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDPDGP 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 242 WIRTVQDKLQkimgfalplfhargvfqynfglMPYRKAIHTVVGRPIPVRQ--ILHPTEEQIEELHQTYMEELTKLFEEH 319
Cdd:cd07987   153 VGKRLFRLLP----------------------LPRRLPLYPVFGEPIVVPRppIPDPPDEDVEELHQKYIAALRELIEKH 210

                  .
gi 1777253978 320 K 320
Cdd:cd07987   211 K 211
PLN02783 PLN02783
diacylglycerol O-acyltransferase
81-333 1.84e-45

diacylglycerol O-acyltransferase


Pssm-ID: 178380  Cd Length: 315  Bit Score: 157.09  E-value: 1.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978  81 KHFKDYFPIHLIKT--QDLDPSHNYIFGFHPHGIL--AAGAFGNFStnysdfkelfpGFT--SYLHVLP--LWFWCPVFR 152
Cdd:PLN02783   79 KYACAYFPVRLHVEdeEAFDPNRAYVFGYEPHSVLpiGVIALADLS-----------GFLplPKIRALAssAVFYTPFLR 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 153 EYMMSIGLVSVSKKSVSYVVSKeggGNISVIVLGGAKESLDAHPGKFTLFIRQRKGFVKIALTHGASLVPVFSFGENELF 232
Cdd:PLN02783  148 HIWTWLGLDPASRKNFTSLLKA---GYSCIIVPGGVQECLYMEHGSEVAYLKSRKGFVKIAMETGAPLVPVFCFGQTRAY 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 233 KQVdNPEGSWIrtvqDKLQKIMGFAlPLfhargVFQYNFGL-MPYRKAIHTVVGRPIPVRQILHPTEEQIEELHQTYMEE 311
Cdd:PLN02783  225 KWW-KPGGPLV----PKLSRAIGFT-PI-----VFWGRYGSpIPHRTPMHVVVGKPIEVKKNPQPSQEEVAEVLEQFVEA 293
                         250       260
                  ....*....|....*....|..
gi 1777253978 312 LTKLFEEHKGKYGIPEHETLVL 333
Cdd:PLN02783  294 LQDLFEKHKARAGYGDLELVVL 315
 
Name Accession Description Interval E-value
DAGAT pfam03982
Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is ...
47-334 1.90e-138

Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is catalyzed by the enzyme diacylglycerol acyltransferase (DAGAT).


Pssm-ID: 112781 [Multi-domain]  Cd Length: 297  Bit Score: 394.10  E-value: 1.90e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978  47 WFLYIPYLTWLYFDWHTPEQGGRRSSWIKNWTLWKHFKDYFPIHLIKTQDLDPSHNYIFGFHPHGILAAGAFGNFSTNYS 126
Cdd:pfam03982   9 WSLLVLYALWLFYDWNSPKRGGYRSNWARNWRIWKWFANYFPVKLHKTAELPPNRNYLFGYHPHGILSVGAFSNFSTNAT 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 127 DFKELFPGFTSYLHVLPLWFWCPVFREYMMSIGLVSVSKKSVSYVVSKEGGGNISVIVLGGAKESLDAHPGKFTLFIRQR 206
Cdd:pfam03982  89 GFMDKFPGIRPNICTLAGQFYTPFRREILLSLGLIEVSRESIEYVLDKCGKGRAVVLVVGGAAEALEAHPGKHTLTLKNR 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 207 KGFVKIALTHGASLVPVFSFGENELFKQVDNPEGSWIRTVQDKLQKIMGFALPLFHARGVFQ-YNFGLMPYRKAIHTVVG 285
Cdd:pfam03982 169 KGFVRIALKTGADLVPVYSFGENDVYKQWENPEGSRLRWVQEKLKRAIGFSPPIFHGRGVFNsYTFGLLPFRKPITTVVG 248
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1777253978 286 RPIPVRQILHPTEEQIEELHQTYMEELTKLFEEHKGKYGIPEHETLVLK 334
Cdd:pfam03982 249 APIEVTKTLNPTQEQIDELHGQYMEALRELFEEHKTKFGVPPDTDLVLN 297
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
83-320 5.02e-56

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 181.33  E-value: 5.02e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978  83 FKDYFPIHLIKTQDLDPSHNYIFGFHPHGILA-AGAFGNFstnysDFKELFPGFTSYLHVLPLWFWCPVFREYMMSIGLV 161
Cdd:cd07987     1 HRKYFRVYEVRGLENIPDEGPALLVHPHGGLPiDGALLAA-----AFLLLFPGRLPRALADHFLFPLPGLRDLLRRLGAV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 162 SVSKKSVSYVVSKeggGNISVIVLGGAKESLDAHPGKFTLFIRQRKGFVKIALTHGASLVPVFSFGENELFKQVDNPEGS 241
Cdd:cd07987    76 PGSRENCVRLLRE---GELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDPDGP 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 242 WIRTVQDKLQkimgfalplfhargvfqynfglMPYRKAIHTVVGRPIPVRQ--ILHPTEEQIEELHQTYMEELTKLFEEH 319
Cdd:cd07987   153 VGKRLFRLLP----------------------LPRRLPLYPVFGEPIVVPRppIPDPPDEDVEELHQKYIAALRELIEKH 210

                  .
gi 1777253978 320 K 320
Cdd:cd07987   211 K 211
PLN02783 PLN02783
diacylglycerol O-acyltransferase
81-333 1.84e-45

diacylglycerol O-acyltransferase


Pssm-ID: 178380  Cd Length: 315  Bit Score: 157.09  E-value: 1.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978  81 KHFKDYFPIHLIKT--QDLDPSHNYIFGFHPHGIL--AAGAFGNFStnysdfkelfpGFT--SYLHVLP--LWFWCPVFR 152
Cdd:PLN02783   79 KYACAYFPVRLHVEdeEAFDPNRAYVFGYEPHSVLpiGVIALADLS-----------GFLplPKIRALAssAVFYTPFLR 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 153 EYMMSIGLVSVSKKSVSYVVSKeggGNISVIVLGGAKESLDAHPGKFTLFIRQRKGFVKIALTHGASLVPVFSFGENELF 232
Cdd:PLN02783  148 HIWTWLGLDPASRKNFTSLLKA---GYSCIIVPGGVQECLYMEHGSEVAYLKSRKGFVKIAMETGAPLVPVFCFGQTRAY 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978 233 KQVdNPEGSWIrtvqDKLQKIMGFAlPLfhargVFQYNFGL-MPYRKAIHTVVGRPIPVRQILHPTEEQIEELHQTYMEE 311
Cdd:PLN02783  225 KWW-KPGGPLV----PKLSRAIGFT-PI-----VFWGRYGSpIPHRTPMHVVVGKPIEVKKNPQPSQEEVAEVLEQFVEA 293
                         250       260
                  ....*....|....*....|..
gi 1777253978 312 LTKLFEEHKGKYGIPEHETLVL 333
Cdd:PLN02783  294 LQDLFEKHKARAGYGDLELVVL 315
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
92-237 1.51e-09

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 56.65  E-value: 1.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777253978  92 IKTQDLDPSHNYIFGFHPHGILAAGAFGNFSTNYSdFKELFPGFTSYLHVLPLWFWCPVFREYMMSIGLVSVsKKSVSYV 171
Cdd:cd06551    16 VKGPPPPPGGGPVLFVSNHSSWWDGLILFLLLERG-LRRDVYGLMDEELLERYPFFTRLGAFSVDRDSPRSA-AKSLKYV 93
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1777253978 172 VSK-EGGGNISVIVLGGAKESLDAHPGKFtlfirqRKGFVKIALTHGASLVPVFSFGENELFKQVDN 237
Cdd:cd06551    94 ARLlSKPGSVVWIFPEGTRTRRDKRPLQF------KPGVAHLAEKAGVPIVPVALRYTFELFEQFPE 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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