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Conserved domains on  [gi|1776071076|ref|XP_031444044|]
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succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial isoform X2 [Phasianus colchicus]

Protein Classification

succinate--CoA ligase [ADP/GDP-forming] subunit alpha( domain architecture ID 11488210)

succinate--CoA ligase [ADP/GDP-forming] subunit alpha binds the substrates coenzyme A and phosphate as part of the heterodimeric enzyme succinyl-CoA synthetase that functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 28-329 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


:

Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 518.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  28 YSASRKNLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHL--GLPVFNSVKEAKEQTGASATVIYV 105
Cdd:PTZ00187   17 SSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKEAKKATGADASVIYV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 106 PPPFAAAAINEAIDAEMPLVVCITEGIPQQDMVRVKHRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVS 185
Cdd:PTZ00187   97 PPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKKGKIGIVS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 186 RSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENnsgPNAK 265
Cdd:PTZ00187  177 RSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWIKNN---PIKK 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1776071076 266 PVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYKEFEKRK 329
Cdd:PTZ00187  254 PVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 28-329 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 518.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  28 YSASRKNLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHL--GLPVFNSVKEAKEQTGASATVIYV 105
Cdd:PTZ00187   17 SSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKEAKKATGADASVIYV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 106 PPPFAAAAINEAIDAEMPLVVCITEGIPQQDMVRVKHRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVS 185
Cdd:PTZ00187   97 PPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKKGKIGIVS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 186 RSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENnsgPNAK 265
Cdd:PTZ00187  177 RSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWIKNN---PIKK 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1776071076 266 PVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYKEFEKRK 329
Cdd:PTZ00187  254 PVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 34-323 4.28e-170

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 473.78  E-value: 4.28e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  34 NLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAA 113
Cdd:COG0074     1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 114 INEAIDAEMPLVVCITEGIPQQDMVRVKhRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYE 193
Cdd:COG0074    81 ILEAIDAGIKLIVCITEGIPVLDMVRVK-RYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 194 AVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnaKPVVSFIAG 273
Cdd:COG0074   160 AVWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMT----KPVVAYIAG 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1776071076 274 LTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYK 323
Cdd:COG0074   236 RTAPPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKK 285
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 37-321 9.45e-156

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 437.62  E-value: 9.45e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  37 INKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAAINE 116
Cdd:TIGR01019   3 LDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAIFE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 117 AIDAEMPLVVCITEGIPQQDMVRVKhRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVH 196
Cdd:TIGR01019  83 AIDAGIELIVCITEGIPVHDMLKVK-RYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAVH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 197 QTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnaKPVVSFIAGLTA 276
Cdd:TIGR01019 162 QLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMS----KPVVGFIAGATA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1776071076 277 PPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTI 321
Cdd:TIGR01019 238 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELL 282
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 38-131 1.66e-37

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 129.25  E-value: 1.66e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  38 NKNTKVICQGFTGK--QGT-FHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAAI 114
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 1776071076 115 NEAIDAEMPLVVCITEG 131
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 37-132 4.51e-33

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 118.00  E-value: 4.51e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076   37 INKNTKVICQGFTGKQGTFHSQQA---LEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAA 113
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 1776071076  114 INEAIDAEMPLVVCITEGI 132
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 28-329 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 518.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  28 YSASRKNLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHL--GLPVFNSVKEAKEQTGASATVIYV 105
Cdd:PTZ00187   17 SSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKEAKKATGADASVIYV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 106 PPPFAAAAINEAIDAEMPLVVCITEGIPQQDMVRVKHRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVS 185
Cdd:PTZ00187   97 PPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKKGKIGIVS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 186 RSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENnsgPNAK 265
Cdd:PTZ00187  177 RSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWIKNN---PIKK 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1776071076 266 PVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYKEFEKRK 329
Cdd:PTZ00187  254 PVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 34-323 4.28e-170

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 473.78  E-value: 4.28e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  34 NLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAA 113
Cdd:COG0074     1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 114 INEAIDAEMPLVVCITEGIPQQDMVRVKhRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYE 193
Cdd:COG0074    81 ILEAIDAGIKLIVCITEGIPVLDMVRVK-RYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 194 AVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnaKPVVSFIAG 273
Cdd:COG0074   160 AVWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMT----KPVVAYIAG 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1776071076 274 LTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYK 323
Cdd:COG0074   236 RTAPPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKK 285
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 36-321 5.27e-170

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 473.89  E-value: 5.27e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  36 YINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAAIN 115
Cdd:PRK05678    4 LINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAADAIL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 116 EAIDAEMPLVVCITEGIPQQDMVRVKhRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAV 195
Cdd:PRK05678   84 EAIDAGIDLIVCITEGIPVLDMLEVK-AYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYEAV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 196 HQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnaKPVVSFIAGLT 275
Cdd:PRK05678  163 AQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANVT----KPVVGYIAGVT 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1776071076 276 APPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTI 321
Cdd:PRK05678  239 APPGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELL 284
PLN00125 PLN00125
Succinyl-CoA ligase [GDP-forming] subunit alpha
 30-331 2.40e-163

Succinyl-CoA ligase [GDP-forming] subunit alpha


Pssm-ID: 215066 [Multi-domain]  Cd Length: 300  Bit Score: 457.51  E-value: 2.40e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  30 ASRKNLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPF 109
Cdd:PLN00125    2 SPPPAVFVDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVAEAKAETKANASVIYVPPPF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 110 AAAAINEAIDAEMPLVVCITEGIPQQDMVRVKHRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGT 189
Cdd:PLN00125   82 AAAAILEAMEAELDLVVCITEGIPQHDMVRVKAALNRQSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 190 LTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnAKPVVS 269
Cdd:PLN00125  162 LTYEAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGTAEEDAAAFIKESGT---EKPVVA 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1776071076 270 FIAGLTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYKEFEKRKLL 331
Cdd:PLN00125  239 FIAGLTAPPGRRMGHAGAIVSGGKGTAQDKIKALREAGVTVVESPAKIGVAMLEVFKERGLL 300
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 37-321 9.45e-156

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 437.62  E-value: 9.45e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  37 INKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAAINE 116
Cdd:TIGR01019   3 LDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAIFE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 117 AIDAEMPLVVCITEGIPQQDMVRVKhRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVH 196
Cdd:TIGR01019  83 AIDAGIELIVCITEGIPVHDMLKVK-RYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAVH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 197 QTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnaKPVVSFIAGLTA 276
Cdd:TIGR01019 162 QLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMS----KPVVGFIAGATA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1776071076 277 PPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTI 321
Cdd:TIGR01019 238 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELL 282
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 38-131 1.66e-37

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 129.25  E-value: 1.66e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  38 NKNTKVICQGFTGK--QGT-FHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAAI 114
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 1776071076 115 NEAIDAEMPLVVCITEG 131
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 37-132 4.51e-33

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 118.00  E-value: 4.51e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076   37 INKNTKVICQGFTGKQGTFHSQQA---LEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAA 113
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 1776071076  114 INEAIDAEMPLVVCITEGI 132
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 184-316 2.85e-23

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 93.09  E-value: 2.85e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 184 VSRSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEED-AAAFLKE-NNSG 261
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGYGACEDpAGGLLKAiKEAR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1776071076 262 PNAKPVVSFIAGLTAPPGRRMGHagaiiaggkggakekIAALQSAGVIVSMSPAQ 316
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQ---------------AKALAESGVLIASSNNQ 120
PLN02522 PLN02522
ATP citrate (pro-S)-lyase
 69-327 1.73e-16

ATP citrate (pro-S)-lyase


Pssm-ID: 178137 [Multi-domain]  Cd Length: 608  Bit Score: 80.25  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  69 GGVSPGKG-------GKTHLGLPVFNSVKEA-KEQTGASATVIYVPPPFAAAAINEAIDAE-MPLVVCITEGIPQQDMVR 139
Cdd:PLN02522   42 GIINPGSEgfqklffGQEEIAIPVHGSIEAAcKAHPTADVFINFASFRSAAASSMEALKQPtIRVVAIIAEGVPESDTKQ 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 140 VkHRLLRQNNTRLVGPNCPGVINPGECKIG--------IMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSFCVGI 211
Cdd:PLN02522  122 L-IAYARANNKVVIGPATVGGIQAGAFKIGdtagtldnIIQCKLYRPGSVGFVSKSGGMSNEMYNVIARVTDGIYEGIAI 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 212 GGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKennSGPNAKPVVSFIAGLTA---PPGRRMGHAGAI 288
Cdd:PLN02522  201 GGDVFPGSTLSDHVLRFNNIPQIKMIVVLGELGGRDEYSLVEALK---QGKVSKPVVAWVSGTCArlfKSEVQFGHAGAK 277

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1776071076 289 IAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYKEFEK 327
Cdd:PLN02522  278 SGGDMESAQAKNKALKDAGAIVPTSFEALEAAIKETFEK 316
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
81-234 1.90e-12

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 67.84  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  81 LGLPVFNSVKEAKEqtgasaT----VIYVPPPFAAAAINEAIDAEMPLVVCIT--------EGIPQQDMVRvkhRLLRQN 148
Cdd:COG1042    55 LGLPCYPSVADLPE------PpdlaVIAVPAETVPDVVEECGEKGVKAAVVISagfaetgeEGAALEQELL---EIARRY 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 149 NTRLVGPNCPGVINPGeckIGIM----PGHIhKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSFCVGIGgdpfN--GTNFI 222
Cdd:COG1042   126 GMRLLGPNCLGLINPA---TGLNatfaPVPP-LPGNIALVSQSGALGTAILDWAAARGIGFSHFVSLG----NeaDVDFA 197

                         170
                  ....*....|..
gi 1776071076 223 DCLDVFLKDPHT 234
Cdd:COG1042   198 DLLDYLADDPDT 209
PRK06091 PRK06091
membrane protein FdrA; Validated
 74-234 2.51e-06

membrane protein FdrA; Validated


Pssm-ID: 180395 [Multi-domain]  Cd Length: 555  Bit Score: 48.89  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  74 GKGGKTHLGLPVFNSVKEAKEQT-GASATVIYVPPPFAAAAINEAIDAEMPlVVCITEGIPQQDMVRVKHRLlRQNNTRL 152
Cdd:PRK06091   93 AQGSGSSQSLTQVRRWDSACQKLpDANLALISVAGEYAAELAEQALDRNLN-VMMFSDNVTLEDEIRLKTRA-REKGLLV 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076 153 VGPNCpgvinpGECKIGIMP---GHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFN----GTNFIDCL 225
Cdd:PRK06091  171 MGPDC------GTAMIAGTPlafANVMPEGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGRDLSaevgGISALTAL 244


                  ....*....
gi 1776071076 226 DVFLKDPHT 234
Cdd:PRK06091  245 EMLSADEKS 253
CoA_binding_2 pfam13380
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 68-163 2.19e-05

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 433162 [Multi-domain]  Cd Length: 116  Bit Score: 42.91  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071076  68 VGGVSPGKggKTHLGLPVFNSVKEAKEQTGASatVIYVPPPFAAAAINEAIDAEMPLVVCITeGIPQQDMVRvkhrLLRQ 147
Cdd:pfam13380  30 VIPVNPKA--KEILGEPVYPSLADPPEPVDLV--DVFRPPEAVPEIVEEALALGAKAVWLQP-GIENEEAAA----IARA 100

                          90
                  ....*....|....*.
gi 1776071076 148 NNTRLVGPNCPGVINP 163
Cdd:pfam13380 101 AGIRVVGDRCLGVEHP 116
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 178-234 4.28e-05

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 42.84  E-value: 4.28e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1776071076 178 KGRIGIVSRSGTLTYEAVHQTTQVGLGQSFCVGIGgdpfNGT--NFIDCLDVFLKDPHT 234
Cdd:pfam13607   1 PGNIALVSQSGALGAALLDWARSRGIGFSKFVSLG----NEAdvDFADLLEYLADDPET 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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