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Conserved domains on  [gi|1776071072|ref|XP_031444043|]
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succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial isoform X1 [Phasianus colchicus]

Protein Classification

succinate--CoA ligase [ADP/GDP-forming] subunit alpha( domain architecture ID 11488210)

succinate--CoA ligase [ADP/GDP-forming] subunit alpha binds the substrates coenzyme A and phosphate as part of the heterodimeric enzyme succinyl-CoA synthetase that functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 57-358 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


:

Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 520.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  57 YSASRKNLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHL--GLPVFNSVKEAKEQTGASATVIYV 134
Cdd:PTZ00187   17 SSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKEAKKATGADASVIYV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 135 PPPFAAAAINEAIDAEMPLVVCITEGIPQQDMVRVKHRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVS 214
Cdd:PTZ00187   97 PPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKKGKIGIVS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 215 RSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENnsgPNAK 294
Cdd:PTZ00187  177 RSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWIKNN---PIKK 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1776071072 295 PVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYKEFEKRK 358
Cdd:PTZ00187  254 PVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 57-358 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 520.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  57 YSASRKNLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHL--GLPVFNSVKEAKEQTGASATVIYV 134
Cdd:PTZ00187   17 SSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKEAKKATGADASVIYV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 135 PPPFAAAAINEAIDAEMPLVVCITEGIPQQDMVRVKHRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVS 214
Cdd:PTZ00187   97 PPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKKGKIGIVS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 215 RSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENnsgPNAK 294
Cdd:PTZ00187  177 RSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWIKNN---PIKK 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1776071072 295 PVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYKEFEKRK 358
Cdd:PTZ00187  254 PVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 63-352 8.69e-171

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 476.86  E-value: 8.69e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  63 NLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAA 142
Cdd:COG0074     1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 143 INEAIDAEMPLVVCITEGIPQQDMVRVKhRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYE 222
Cdd:COG0074    81 ILEAIDAGIKLIVCITEGIPVLDMVRVK-RYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 223 AVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnaKPVVSFIAG 302
Cdd:COG0074   160 AVWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMT----KPVVAYIAG 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1776071072 303 LTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYK 352
Cdd:COG0074   236 RTAPPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKK 285
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 66-350 2.41e-156

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 440.32  E-value: 2.41e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  66 INKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAAINE 145
Cdd:TIGR01019   3 LDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAIFE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 146 AIDAEMPLVVCITEGIPQQDMVRVKhRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVH 225
Cdd:TIGR01019  83 AIDAGIELIVCITEGIPVHDMLKVK-RYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAVH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 226 QTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnaKPVVSFIAGLTA 305
Cdd:TIGR01019 162 QLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMS----KPVVGFIAGATA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1776071072 306 PPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTI 350
Cdd:TIGR01019 238 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELL 282
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 67-160 4.55e-38

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 131.56  E-value: 4.55e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  67 NKNTKVICQGFTGK--QGT-FHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAAI 143
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 1776071072 144 NEAIDAEMPLVVCITEG 160
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 66-161 4.40e-33

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 118.77  E-value: 4.40e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072   66 INKNTKVICQGFTGKQGTFHSQQA---LEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAA 142
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 1776071072  143 INEAIDAEMPLVVCITEGI 161
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 57-358 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 520.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  57 YSASRKNLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHL--GLPVFNSVKEAKEQTGASATVIYV 134
Cdd:PTZ00187   17 SSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKEAKKATGADASVIYV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 135 PPPFAAAAINEAIDAEMPLVVCITEGIPQQDMVRVKHRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVS 214
Cdd:PTZ00187   97 PPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKKGKIGIVS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 215 RSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENnsgPNAK 294
Cdd:PTZ00187  177 RSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWIKNN---PIKK 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1776071072 295 PVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYKEFEKRK 358
Cdd:PTZ00187  254 PVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 63-352 8.69e-171

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 476.86  E-value: 8.69e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  63 NLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAA 142
Cdd:COG0074     1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 143 INEAIDAEMPLVVCITEGIPQQDMVRVKhRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYE 222
Cdd:COG0074    81 ILEAIDAGIKLIVCITEGIPVLDMVRVK-RYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 223 AVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnaKPVVSFIAG 302
Cdd:COG0074   160 AVWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMT----KPVVAYIAG 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1776071072 303 LTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYK 352
Cdd:COG0074   236 RTAPPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKK 285
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 65-350 1.22e-170

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 476.59  E-value: 1.22e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  65 YINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAAIN 144
Cdd:PRK05678    4 LINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAADAIL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 145 EAIDAEMPLVVCITEGIPQQDMVRVKhRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAV 224
Cdd:PRK05678   84 EAIDAGIDLIVCITEGIPVLDMLEVK-AYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYEAV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 225 HQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnaKPVVSFIAGLT 304
Cdd:PRK05678  163 AQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANVT----KPVVGYIAGVT 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1776071072 305 APPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTI 350
Cdd:PRK05678  239 APPGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELL 284
PLN00125 PLN00125
Succinyl-CoA ligase [GDP-forming] subunit alpha
 59-360 9.18e-163

Succinyl-CoA ligase [GDP-forming] subunit alpha


Pssm-ID: 215066 [Multi-domain]  Cd Length: 300  Bit Score: 457.12  E-value: 9.18e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  59 ASRKNLYINKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPF 138
Cdd:PLN00125    2 SPPPAVFVDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVAEAKAETKANASVIYVPPPF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 139 AAAAINEAIDAEMPLVVCITEGIPQQDMVRVKHRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGT 218
Cdd:PLN00125   82 AAAAILEAMEAELDLVVCITEGIPQHDMVRVKAALNRQSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 219 LTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnAKPVVS 298
Cdd:PLN00125  162 LTYEAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGTAEEDAAAFIKESGT---EKPVVA 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1776071072 299 FIAGLTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYKEFEKRKLL 360
Cdd:PLN00125  239 FIAGLTAPPGRRMGHAGAIVSGGKGTAQDKIKALREAGVTVVESPAKIGVAMLEVFKERGLL 300
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 66-350 2.41e-156

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 440.32  E-value: 2.41e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  66 INKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAAINE 145
Cdd:TIGR01019   3 LDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAIFE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 146 AIDAEMPLVVCITEGIPQQDMVRVKhRLLRQNNTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVH 225
Cdd:TIGR01019  83 AIDAGIELIVCITEGIPVHDMLKVK-RYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAVH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 226 QTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKENNSgpnaKPVVSFIAGLTA 305
Cdd:TIGR01019 162 QLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMS----KPVVGFIAGATA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1776071072 306 PPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTI 350
Cdd:TIGR01019 238 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELL 282
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 67-160 4.55e-38

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 131.56  E-value: 4.55e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  67 NKNTKVICQGFTGK--QGT-FHSQQALEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAAI 143
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 1776071072 144 NEAIDAEMPLVVCITEG 160
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 66-161 4.40e-33

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 118.77  E-value: 4.40e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072   66 INKNTKVICQGFTGKQGTFHSQQA---LEYGTNLVGGVSPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAA 142
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 1776071072  143 INEAIDAEMPLVVCITEGI 161
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 213-345 1.46e-23

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 94.25  E-value: 1.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 213 VSRSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEED-AAAFLKE-NNSG 290
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGYGACEDpAGGLLKAiKEAR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1776071072 291 PNAKPVVSFIAGLTAPPGRRMGHagaiiaggkggakekIAALQSAGVIVSMSPAQ 345
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQ---------------AKALAESGVLIASSNNQ 120
PLN02522 PLN02522
ATP citrate (pro-S)-lyase
 98-356 2.98e-16

ATP citrate (pro-S)-lyase


Pssm-ID: 178137 [Multi-domain]  Cd Length: 608  Bit Score: 79.86  E-value: 2.98e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  98 GGVSPGKG-------GKTHLGLPVFNSVKEA-KEQTGASATVIYVPPPFAAAAINEAIDAE-MPLVVCITEGIPQQDMVR 168
Cdd:PLN02522   42 GIINPGSEgfqklffGQEEIAIPVHGSIEAAcKAHPTADVFINFASFRSAAASSMEALKQPtIRVVAIIAEGVPESDTKQ 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 169 VkHRLLRQNNTRLVGPNCPGVINPGECKIG--------IMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSFCVGI 240
Cdd:PLN02522  122 L-IAYARANNKVVIGPATVGGIQAGAFKIGdtagtldnIIQCKLYRPGSVGFVSKSGGMSNEMYNVIARVTDGIYEGIAI 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 241 GGDPFNGTNFIDCLDVFLKDPHTEGIILIGEIGGNAEEDAAAFLKennSGPNAKPVVSFIAGLTA---PPGRRMGHAGAI 317
Cdd:PLN02522  201 GGDVFPGSTLSDHVLRFNNIPQIKMIVVLGELGGRDEYSLVEALK---QGKVSKPVVAWVSGTCArlfKSEVQFGHAGAK 277

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1776071072 318 IAGGKGGAKEKIAALQSAGVIVSMSPAQLGSTIYKEFEK 356
Cdd:PLN02522  278 SGGDMESAQAKNKALKDAGAIVPTSFEALEAAIKETFEK 316
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
110-263 3.17e-12

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 67.84  E-value: 3.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 110 LGLPVFNSVKEAKEqtgasaT----VIYVPPPFAAAAINEAIDAEMPLVVCIT--------EGIPQQDMVRvkhRLLRQN 177
Cdd:COG1042    55 LGLPCYPSVADLPE------PpdlaVIAVPAETVPDVVEECGEKGVKAAVVISagfaetgeEGAALEQELL---EIARRY 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 178 NTRLVGPNCPGVINPGeckIGIM----PGHIhKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSFCVGIGgdpfN--GTNFI 251
Cdd:COG1042   126 GMRLLGPNCLGLINPA---TGLNatfaPVPP-LPGNIALVSQSGALGTAILDWAAARGIGFSHFVSLG----NeaDVDFA 197

                         170
                  ....*....|..
gi 1776071072 252 DCLDVFLKDPHT 263
Cdd:COG1042   198 DLLDYLADDPDT 209
PRK06091 PRK06091
membrane protein FdrA; Validated
 103-263 3.00e-06

membrane protein FdrA; Validated


Pssm-ID: 180395 [Multi-domain]  Cd Length: 555  Bit Score: 48.89  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 103 GKGGKTHLGLPVFNSVKEAKEQT-GASATVIYVPPPFAAAAINEAIDAEMPlVVCITEGIPQQDMVRVKHRLlRQNNTRL 181
Cdd:PRK06091   93 AQGSGSSQSLTQVRRWDSACQKLpDANLALISVAGEYAAELAEQALDRNLN-VMMFSDNVTLEDEIRLKTRA-REKGLLV 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072 182 VGPNCpgvinpGECKIGIMP---GHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFN----GTNFIDCL 254
Cdd:PRK06091  171 MGPDC------GTAMIAGTPlafANVMPEGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGRDLSaevgGISALTAL 244


                  ....*....
gi 1776071072 255 DVFLKDPHT 263
Cdd:PRK06091  245 EMLSADEKS 253
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 207-263 3.28e-05

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 43.22  E-value: 3.28e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1776071072 207 KGRIGIVSRSGTLTYEAVHQTTQVGLGQSFCVGIGgdpfNGT--NFIDCLDVFLKDPHT 263
Cdd:pfam13607   1 PGNIALVSQSGALGAALLDWARSRGIGFSKFVSLG----NEAdvDFADLLEYLADDPET 55
CoA_binding_2 pfam13380
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 97-192 3.30e-05

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 433162 [Multi-domain]  Cd Length: 116  Bit Score: 42.53  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776071072  97 VGGVSPGKggKTHLGLPVFNSVKEAKEQTGASatVIYVPPPFAAAAINEAIDAEMPLVVCITeGIPQQDMVRvkhrLLRQ 176
Cdd:pfam13380  30 VIPVNPKA--KEILGEPVYPSLADPPEPVDLV--DVFRPPEAVPEIVEEALALGAKAVWLQP-GIENEEAAA----IARA 100

                          90
                  ....*....|....*.
gi 1776071072 177 NNTRLVGPNCPGVINP 192
Cdd:pfam13380 101 AGIRVVGDRCLGVEHP 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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