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Conserved domains on  [gi|1743159278|ref|XP_030683301|]
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lactosylceramide alpha-2,3-sialyltransferase isoform X1 [Nomascus leucogenys]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 206-416 4.20e-156

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467711  Cd Length: 211  Bit Score: 439.56  E-value: 4.20e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 206 TCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 285
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 286 FNWLQAMVKNETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 365
Cdd:cd23983    81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1743159278 366 HLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 416
Cdd:cd23983   161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 206-416 4.20e-156

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 439.56  E-value: 4.20e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 206 TCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 285
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 286 FNWLQAMVKNETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 365
Cdd:cd23983    81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1743159278 366 HLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 416
Cdd:cd23983   161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 171-421 1.67e-94

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 284.88  E-value: 1.67e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 171 SKYNPPFgfrkfsSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVG 250
Cdd:pfam00777  16 SEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 251 NKTTIRMTYPEGAPLSDLEY------YSNDL-FVAVLFKSVDFNWLQAMVKNETLPF-WVRLFFWKQVaeKIPLQPKHFR 322
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYGNlgfshpRDPFVeFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 323 ILNPVIIKETAFDILQYSEPQSRfwgrdknVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQT 402
Cdd:pfam00777 165 FLHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYG 237

                         250
                  ....*....|....*....
gi 1743159278 403 MHNVTTETKFLLKLVKEGV 421
Cdd:pfam00777 238 VHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 206-416 4.20e-156

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 439.56  E-value: 4.20e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 206 TCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 285
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 286 FNWLQAMVKNETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 365
Cdd:cd23983    81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1743159278 366 HLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 416
Cdd:cd23983   161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 206-416 1.51e-119

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 346.59  E-value: 1.51e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 206 TCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 285
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 286 FNWLQAMVKNETLPFWVrlFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQsrfwGRDKNVPTIGVIAVVLAT 365
Cdd:cd23967    81 LLWLQAVIKGKKPNGKG--GFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG----KQGKNVPTTGIIAIVMAL 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1743159278 366 HLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 416
Cdd:cd23967   155 HYCDEVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 171-421 1.67e-94

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 284.88  E-value: 1.67e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 171 SKYNPPFgfrkfsSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVG 250
Cdd:pfam00777  16 SEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 251 NKTTIRMTYPEGAPLSDLEY------YSNDL-FVAVLFKSVDFNWLQAMVKNETLPF-WVRLFFWKQVaeKIPLQPKHFR 322
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYGNlgfshpRDPFVeFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 323 ILNPVIIKETAFDILQYSEPQSRfwgrdknVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQT 402
Cdd:pfam00777 165 FLHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYG 237

                         250
                  ....*....|....*....
gi 1743159278 403 MHNVTTETKFLLKLVKEGV 421
Cdd:pfam00777 238 VHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 206-416 2.00e-68

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 216.33  E-value: 2.00e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 206 TCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 285
Cdd:cd23981     1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 286 FNWLQAMVKNETlpfwVRLF--FWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEpQSRFWGRDkNVPTIGVIAVVL 363
Cdd:cd23981    81 FKWLKYIVYKEK----VSASdgFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPF-NNGLMGRG-NIPTLGSVAITM 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1743159278 364 ATHLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 416
Cdd:cd23981   155 ALHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 206-416 5.64e-66

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 209.91  E-value: 5.64e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 206 TCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSND-LFVAVLFKSV 284
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDtLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 285 DFNWLQAMVKNETLpfwVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSrfwgrDKNVPTIGVIAVVLA 364
Cdd:cd23982    81 DFYWLYEILSNEKR---VRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQRK-----KKQKPTTGLLAITLA 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1743159278 365 THLCDEVSLAGFGYDLNQ-PRTPLHYFDNQCMAAM-NFQtmHNVTTETKFLLKL 416
Cdd:cd23982   153 LHLCDEVHIAGFGYPDNGnSNQPIHYYNQITLKSMaNSG--HNLNAEAQAIQRL 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 207-416 5.64e-59

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 191.88  E-value: 5.64e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 207 CRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDF 286
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 287 NWLQAMVKNETlpfwVRLF-FWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEpqsRFWGRDKNV-PTIGVIAVVLA 364
Cdd:cd23984    82 RWLLDLLMGKK----VSAKgFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPK---RFPKEKKPKhPTTGIIAITLA 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1743159278 365 THLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 416
Cdd:cd23984   155 LHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 171-423 5.68e-40

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 144.71  E-value: 5.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 171 SKYNPPFGFRKFS-SKVQTLLELL--PEHDLPEHLKA--KTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGY 245
Cdd:cd23964    41 SHYKLPFGWGGLNrEVVERLLRNLnlTSSRYMFVLRGgrPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGF 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 246 SEHVGNKTTIRMTYPEGAPLSDLEYYSND---LFVAVLFKSVDFNWLQAMVKNETLPFWVRLFFWKQVAEKIPLQPKHFR 322
Cdd:cd23964   121 EKDVGTKTSFYTFFPESLHNSLLKHVPQDkdtKYLFIPFKIRDYDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATNVR 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 323 ILNPviiketafDILQYSEpqsRFWGRDKNV--PTIGVIAVVLATHLCDEVSLAGFGYDlnqPRTPLHYFDNQCMAAMNF 400
Cdd:cd23964   201 LLHP--------DFIRYLF---NRWLNSSTSyrPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTFVKFTVF 266

                         250       260
                  ....*....|....*....|...
gi 1743159278 401 QTMHNVTTETKFLLKLVKEGVVK 423
Cdd:cd23964   267 YANHDFTNERKLWRKLHEEGIIN 289
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 186-423 1.50e-30

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 118.92  E-value: 1.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 186 VQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 265
Cdd:cd23966    56 LEKLFQVVPGENPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVD 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 266 SDLEYYsndlFVAVLFKSVDFNWLQAMVKNETLpfwvrLFFWKQVAEKIPLQPKHFRILNPVIIKETAFdilQYSEPQSR 345
Cdd:cd23966   136 LDPGVH----LVLVPFKVLDLQWLISALTTGEI-----TRTYTPVKRFIKADKDKVLVINPAFIKYVHD---NWTEHHGR 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 346 FwgrdknvPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTplHYFDNQcMAAMNFQ--TMHNVTTETKFLLKLVKEGVVK 423
Cdd:cd23966   204 Y-------PSTGFLALIFALHICDEVSVFGFGADSKGNWH--HYWEKN-RSAGAFRktGVHDADFESDIIKKLAKEGKIR 273
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 210-416 1.53e-29

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 113.61  E-value: 1.53e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 210 CVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdlEYYSNDLfvavlfKSVDFNWL 289
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAG----FYLRGPR------CGCHPLPL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 290 QAMVKNETLPFWVRLFFWKQVAEKIPLQpkhfrilNPVIIKETAFDILQY---SEPQSR-FWGRDKNVPTIGVIAVVLAT 365
Cdd:cd19952    71 EEEVVLILSRAAAADFKRLKRRKKRHDN-------AVLLLTDPAPDLLSYvrkRLEKLGlKSFFGGNAPSSGLLAVLLAL 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1743159278 366 HLCDEVSLAGFGYD-LNQPRTPLHYFDNQCMAAMNfqTMHNVTTETKFLLKL 416
Cdd:cd19952   144 QLCDSVDLYGFGVDsGHAPKVPYHYYDLVEAEEGT--AVHSFDLEAELLRAL 193
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 135-423 1.01e-23

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 99.95  E-value: 1.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 135 CRPKFAETSMALLFEHRYSVDLLPFVQKAPKDSEAESKY-----NPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRR 209
Cdd:cd23979     3 CRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYwwmmlQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRCRR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 210 CVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdlEYYSNDLFVAVLFKSVDFNWL 289
Cdd:cd23979    83 CAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAK----NLPANVSFVLVPFKTLDLLWI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 290 QAMVKNETLPfwvrlFFWKQVAEKIPLQPKHFRILNPVIIKetaFDILQYSEPQSRFwgrdknvPTIGVIAVVLATHLCD 369
Cdd:cd23979   159 TSALSTGQIR-----FTYAPVKQFLRVDKDKVQIYNPAFFK---YIHDRWTEHHGRY-------PSTGMLVLFFALHVCD 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1743159278 370 EVSLAGFGYDlnQPRTPLHYFDNQCMAAMNFQT-MHNVTTETKFLLKLVKEGVVK 423
Cdd:cd23979   224 EVNVYGFGAD--SRGNWHHYWENNRYAGEFRKTgVHDADFEAHIIDMLAKAGKIK 276
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 171-423 2.03e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 98.87  E-value: 2.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 171 SKYNPPFGFRKFSSKVQTLLELLPEHDLPEHlkaKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVG 250
Cdd:cd23963    30 DVLYYSYFKKKTFKITKSLYELLPKTSPFSH---KRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 251 NKT--------TIRMTYPEGAPLSDLEYYSNDLfvAVLFKSVdfnwlqamvknetlpFWVRLFFWKQVAEKIPLQPKHFR 322
Cdd:cd23963   107 RKTnlttlnpsILKRRYNSLKKNRDRDKFLNRL--KEYNGSI---------------LWYPKFSFKSSTNLLLKAARALK 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 323 ILNPVIikETAFDILQYSEPQSRFWGRDKN--VPTIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDNqcMAA 397
Cdd:cd23963   170 KNGLNL--TVVYSNPEHFLAVQKFWKRRGLekRPSTGLYLVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYDD--LSP 245

                         250       260
                  ....*....|....*....|....*.
gi 1743159278 398 MNFQTMHNVTTETKFLLKLVKEGVVK 423
Cdd:cd23963   246 STKNKVHNMPEEFKLLRELHKKGVLK 271
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 135-416 5.66e-22

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 94.95  E-value: 5.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 135 CRPKFAETSMALLFEHRYSVDLLPFVQKA----PKDS-------EAESKYNppfgfrKFSSKVQTLLELLP-EHDLPEHL 202
Cdd:cd23980     3 CTTCIEEQRVSAWFDERFNRS*QPLLTAQnahlEEDTykwwlrlQREKKPK------NLNDTIRELFQVVPgNVDPLLEK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 203 KAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEgaplSDLEYYSNDLFVAVLFK 282
Cdd:cd23980    77 RLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPE----SFRELAQNVSMILVPFK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 283 SVDFNWLQAMVKNETLPfwvrlFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSepqsrfwGRdknVPTIGVIAVV 362
Cdd:cd23980   153 TLDLEWVISATTTGTIS-----HTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGH-------GR---YPSTGILSVI 217

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1743159278 363 LATHLCDEVSLAGFGYDlnQPRTPLHYFDNQCMAAMNFQT-MHNVTTETKFLLKL 416
Cdd:cd23980   218 FSLHVCDEVDLYGFGAD--SKGNWHHYWENNPSAGAFRKTgVHDGDFESNVTTIL 270
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 173-423 4.21e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 93.28  E-value: 4.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 173 YNPPFGFRKFS-SKVQTLLELLPEHDLPEHLKA-----KTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYS 246
Cdd:cd23973    43 FNPPFGFMGLNyTLVKEVVELIPKPKEQQLLALsppggDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 247 EHVGNKTTIrmtYPEGAP--LSDLEYYSNDLF-----------VAVLFKSVDFNWLQAMVKNETLPfwvRLFFWKQVAEK 313
Cdd:cd23973   123 EDVGTRTSF---YVHTAHsiTSSLMILQKRGFknipqdkdikyILFPEGPRDYQWLEALLKNKTIP---SGAYYGRRPRS 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 314 I---PLQPKHFRILNPviiketafDILQYSepQSRFWgRDKNV---------PTIGVIAVVLATHLCDEVSLAGF---GY 378
Cdd:cd23973   197 YfsgDFTEDKYLVLHP--------DFLRYV--KNRFL-RSKTLkgkywaiyrPTTGAFLLLTALHLCDTVSAYGFiteDY 265

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1743159278 379 DlnqpRTPLHYFDNQcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 423
Cdd:cd23973   266 R----KYPDHYYDKK-KTKLVFYINHDFRLEKKLWKRLHDEKIIK 305
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 202-416 2.26e-20

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 90.02  E-value: 2.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 202 LKAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLSDLEYYSNDL 275
Cdd:cd23968    40 ENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRlinsqiLSKPEFNFLTDPLYRNVTL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 276 FV--AVLFKSVDFNWLqamvKNETLPFWVRLFFWKQVaekIPLQPkhFRILNPVIIKEtAFDILQYSEPQSRFwgrdKNV 353
Cdd:cd23968   120 LVwdPSSYNVNLEKWY----KKPDFDFFPNYIKYRRR---HPEEP--FYLIDPRFLWR-LWDILQEYTPEKIK----PNP 185

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1743159278 354 PTIGVIAVVLATHLCDEVSLagFGYDLNQPRTPL-HYFDNQCMAAMNFQTMHNVTTETKFLLKL 416
Cdd:cd23968   186 PSSGFIGIVLMLHLCDWVDV--YEYVPSVRQTDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 188-423 4.78e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 89.76  E-value: 4.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 188 TLLELLPEHdlpEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplSD 267
Cdd:cd23970    52 NLRSLLPEV---SPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-----SI 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 268 LEYYSNDLFVavlfKSVDFNWLQAMVKNETLPFWVRLFFWKQVAEKiplqpkhFRILNPVIIK-------ETAF--DILQ 338
Cdd:cd23970   124 LEKYYNNLLT----IQDRNNFFLSLKKLDGAILWIPAFFFHTSATV-------TRTLVDFFVEhrgqlkvQLAWpgNIMQ 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 339 YSepqSRFWGRDKNVP---TIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDNQ-CMAAMNFQTMHNVTTETK 411
Cdd:cd23970   193 HV---NRYWKTKHLSPkrlSTGILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKKgTKFTTKWQESHQLPAEFV 269

                         250
                  ....*....|..
gi 1743159278 412 FLLKLVKEGVVK 423
Cdd:cd23970   270 LLYKMHGAGVLK 281
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 187-423 1.12e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 79.98  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 187 QTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplS 266
Cdd:cd23987    47 QNLYELLPR---TSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP-----S 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 267 DLEYYSNDLfvavlfksVDFNWLQAMVK-----NETLpFWVRLFFWKQVAEKIplqpkhfRILNPVIIK-----ETAFDI 336
Cdd:cd23987   119 VVQRAFEDL--------VNETWKEKFLQrlqslNGSI-LWIPAFMAKGGEERV-------EWVNDLILKhhinvRTAYPS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 337 LQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTET 410
Cdd:cd23987   183 LRLLHAVRGYWLTNKvhiKRPTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEF 262

                         250
                  ....*....|...
gi 1743159278 411 KFLLKLVKEGVVK 423
Cdd:cd23987   263 KALKNLHQQGALK 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 180-423 1.19e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 79.61  E-value: 1.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 180 RKFSSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVG--------N 251
Cdd:cd23988    40 RRTLNISQNLHSLLPE---VSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGtksdfitmN 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 252 KTTIRMTYPEGAPLSDLEYYSNDLfvAVLFKSVdfnwlqamvknetlpFWVRLFFWKQvaekiplQPKHFRILNPVIIK- 330
Cdd:cd23988   117 PSVVQRAFGGFRNESDREKFVHRL--SMLNDSV---------------LWIPAFMVKG-------GEKHVEWVNALILKn 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 331 ----ETAFDILQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDNQCMAAMNF 400
Cdd:cd23988   173 klkvRTAYPSLRLIHAVRGYWLTNKvniKRPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSN 252

                         250       260
                  ....*....|....*....|...
gi 1743159278 401 QTMHNVTTETKFLLKLVKEGVVK 423
Cdd:cd23988   253 AGPHRMPLEFKTLNVLHNRGALK 275
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 187-423 1.65e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 79.38  E-value: 1.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 187 QTLLELLPEHDlPehLKAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPls 266
Cdd:cd23969    47 QDLYQLLPEVS-P--LKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIP-- 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 267 dlEYYSNDLFVAVLFKSVDfnwlqamvknetlpfwvRLffwKQVAEKIPLQP--------KHFRILNPVIIKE-----TA 333
Cdd:cd23969   122 --HAYGDLVNATDKEKFVE-----------------RL---RQLGDSILWIPafvskggeEHVQWTNEIILKHklnvkTA 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 334 FDILQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDNQCMAAMNFQtmHNVT 407
Cdd:cd23969   180 YPPLRLNHAIRGYWLTTKfriKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLTTARP--HKMP 257

                         250
                  ....*....|....*.
gi 1743159278 408 TETKFLLKLVKEGVVK 423
Cdd:cd23969   258 EEFRALRSLHQRGALR 273
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 193-376 2.39e-15

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 75.51  E-value: 2.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 193 LPEHDLPEhlKAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLS 266
Cdd:cd23985    33 LPKKSLRE--EVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRlinsqlVTTEKHKFLK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 267 DLEYYSNDLFVavlfksvdfnWLQAmVKNETLPFWVRL----FF--WKQVAEKIPLQPkhFRILNPVIIKETaFDILQYS 340
Cdd:cd23985   111 DSLYNEGILIV----------WDPA-PYHSDIPEWYKNpdynFFenYKTYRRLNPNQP--FYILHPQMQWEL-WDIIQEN 176

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1743159278 341 EPQSrfwgRDKNVPTIGVIAVVLATHLCDEVSLAGF 376
Cdd:cd23985   177 SPEE----IQPNPPSSGMLGIILMMTLCDQVDVYEF 208
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 178-423 2.25e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 73.06  E-value: 2.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 178 GFRKFSSKV-QTLLELLPEhDLPehLKAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEgYSEHVGNKT--- 253
Cdd:cd23971    37 GERKKTITVnEKLFSMLPK-ESP--FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTnlv 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 254 -------TIRMTYPEGAPLS---DLEYYSNDLFVAVLFksvdfnwlqAMVKNETLPFwvRLFFwkqVAEKIPLQPKHFrI 323
Cdd:cd23971   113 tanpsilREKFHNLKKRRRPfveRMKVYGNALLLLPAF---------SYTSNTEPSL--RALY---TLEDFGSPQKVL-F 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 324 LNPviiketafdilQYSEPQSRFWgRDKNVPTI----GVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDNQcma 396
Cdd:cd23971   178 FNP-----------EYLRNLSRYW-KSKGLKARrlstGLMLVSAALELCENVHLYGFwpfSTDLDGNPISHHYYDNV--- 242

                         250       260
                  ....*....|....*....|....*..
gi 1743159278 397 aMNFQTMHNVTTETKFLLKLVKEGVVK 423
Cdd:cd23971   243 -LPKKGVHAMPEEFLRYLKLHSQGVLR 268
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 171-423 5.30e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 72.55  E-value: 5.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 171 SKYNPPFGFRKFSSK-VQTLLELLPEHD----LPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGY 245
Cdd:cd23972    41 SQRKVPYGWKGLSHQvVASTLSLLNDSAnaklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGF 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 246 SEHVGNKTTIR-----------MTY--------PEGaplSDLEYysndLFVAVLFKsvDFNWLQAMVKNETLPF------ 300
Cdd:cd23972   121 EEDVGTKTSFYgftvntmknslISYwnlgftrtPQG---QDLQY----IFIPSDIR--DYVMLRSAILGVPVPEgldkgd 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 301 -WVRLFFWKQVAEKiplqpkhFRILNPVIIKETAFDILQySEPQSRFWGrDKNVPTIGVIAVVLATHLCDEVSLAGFGYD 379
Cdd:cd23972   192 rPHKYFGPEASAKK-------FKLLHPDFISYLTDRFLK-SKLLNTHYG-HLYMPSTGALMLLTALHTCDQVSAYGFITS 262

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1743159278 380 lNQPRTPLHYFDNQcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 423
Cdd:cd23972   263 -NYWKFSDHYYERK-KKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 208-425 3.55e-13

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 69.48  E-value: 3.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 208 RRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEgaPLSDLEYYSNDlfvAVLFKSVdfn 287
Cdd:cd23986    50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ--ILTNPNHHFID---SSLYKDV--- 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 288 wlqAMVKNETLPFWVRLFFW------------KQVAEKIPLQPkhFRILNPVIIKETaFDILQYSEPQSrfwgRDKNVPT 355
Cdd:cd23986   122 ---ILVAWDPAPYSANLHKWykkpdynlftpyVQYRKRNPNQP--FYILHPKFIWQL-WDIIQENTQEK----IQPNPPS 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1743159278 356 IGVIAVVLATHLCDEVSLAGFGYDLNQprTPL-HYFDNQCMAAMNFQTMHNVTTEtKFLLKLVKEGVVKDL 425
Cdd:cd23986   192 SGFIGILIMMSMCREVHVYEYIPSVRQ--TDLcHYHERYYDAACTLGAYHPLLYE-KLLIQRMNKGTEDDL 259
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 207-391 4.26e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 65.34  E-value: 4.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 207 CRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMtypegaplsdleyysndlfvaVLFKSVDF 286
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRV---------------------VSHSSLPR 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 287 NWLQAMVKNETLPFWVRLFFW-------KQVAEKIP----LQPKH----FRILNPVIIKETAFDILQY---SEPQSRFWg 348
Cdd:cd23965    60 LLRNAILLLAGTRAPTVVVFWgpetkmnKDGAGKYNllrsLSKKYpdveFYSLTPEKMDYADELFEKEtgkSRIKSGTW- 138

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1743159278 349 rdknvPTIGVIAVVLATHLCDEVSLAGFGYD-----LNQPRTPLHYFD 391
Cdd:cd23965   139 -----LSTGWFTMLLALDVCDEIKVYGMVPEnycreHPNSKVPYHYYE 181
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 207-423 1.39e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 65.16  E-value: 1.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 207 CRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIrMTYPEGAPLSDLEYYSNDLFVAV------- 279
Cdd:cd23974    84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSF-YTFSTNTLMNSLRAYAGVGFNGPpqsketr 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 280 -LF---KSVDFNWLQAMVKNETL---------PfwvRLFFWKQV-AEKiplqpkhFRILNPviiketafDILQYSepQSR 345
Cdd:cd23974   163 yIFlpdHDRDYLLVKAALTHTPIdrgrdkskrP---SKYFGKDVtAEK-------FKIYHP--------DFIRYL--RNR 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 346 F-WG-------RDKNVPTIGVIAVVLATHLCDEVSLAGF---GYDLNQPrtplHYFDNQcMAAMNFQTMHNVTTETKFLL 414
Cdd:cd23974   223 FlWSpilntkqRDIYRPSTGAVMLLAALHTCDQVSAYGFmtpDYGKYSD----HYYDKT-YHKVVFYANHDLRLEMQLWQ 297


                  ....*....
gi 1743159278 415 KLVKEGVVK 423
Cdd:cd23974   298 KLHKAGLIK 306
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 200-391 1.75e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 61.04  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 200 EHLKAKT-CRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTypegaPLSDLEYysndlfva 278
Cdd:cd23976     7 DHKPLKMhCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-----AHSSIQR-------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 279 VLFKSvdfNWLQAMVKNETLPFWVRLFFWKQVAEKipLQPKHFRILNPVIIKETAFDI-----LQYSEPQSRFWGRDKNV 353
Cdd:cd23976    74 ILRNR---NELLNVSQGTVFIFWGPSNYMRRDGKG--LVYNNLQLMNQILPKLKVYTItrhkmLQFDELFKRETGKDRKI 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1743159278 354 P----TIGVIAVVLATHLCDEVSLAG-----FGYDLNQPRTPLHYFD 391
Cdd:cd23976   149 SntwlSTGWFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 207-257 7.89e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 58.71  E-value: 7.89e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1743159278 207 CRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRM 257
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 207-265 1.29e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 58.33  E-value: 1.29e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1743159278 207 CRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 265
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPL 59
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 208-423 6.81e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 56.69  E-value: 6.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 208 RRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEG-YSEHVGNKTT--------IRMTYPE----GAP-LSDLEYYSN 273
Cdd:cd23991    65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNlvtanpsiISIKYAKlnerRKPfLETVSVYGD 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 274 DLFvavLFKSVDFNwlqamvKNETLPFWVRLFFWKQVAEKIPLqpkhfrILNPVIIKETAfdilqysepqsRFWgRDKNV 353
Cdd:cd23991   145 AFL---LLPAFSYR------SNTALSFKVYYTLEDFKAKQKVI------FFHPIYLKHLA-----------QFW-RSKGV 197

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1743159278 354 P----TIGVIAVVLATHLCDEVSLAGF-GYDLNQPRTPL--HYFDNQcMAAMNFqtmHNVTTETKFLLKLVKEGVVK 423
Cdd:cd23991   198 QvyrlSTGLMITSAALELCEEVKLYGFwPFSKNTEGKPIshHYYDNQ-LPKPGF---HSMPKEFYQLLQLHSKGILK 270
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 207-265 2.99e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 51.09  E-value: 2.99e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1743159278 207 CRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 265
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPL 59
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 187-392 6.69e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 50.61  E-value: 6.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 187 QTLLELLPEhDLPEHlkAKTCRRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPV-EGYSEHVGNKTTIRMTYPEgapl 265
Cdd:cd23990    47 SEIFKMFPK-DMPYS--RSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPS---- 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 266 sdleyysndlFVAVLFKSVDfNWLQamvknetlPFWVRLffwkQVAEKIP-LQPKHFRILNPVIIKETAFDILQYSEPQ- 343
Cdd:cd23990   120 ----------IITERFHKLE-KWRR--------PFYEVL----QVYENASvVLPAFYNTRNTDVSIRVKYVLDDFESQQa 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1743159278 344 ------------SRFWGRD---KNVPTIGVIAVVLATHLCDEVSLAGF-GYDLNQPRTPL--HYFDN 392
Cdd:cd23990   177 vyyfhpqyllnvSRFWLRQgvrAKRISSGLMLVTAALELCEEVHLYGFwAFPMNPSGIFIthHYYDN 243
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 208-423 8.38e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 47.13  E-value: 8.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 208 RRCVVIGSGGILHGLELGHTLNQFDIVIRLNSAPV-EGYSEHVGNKTTIRMTYPEgapLSDLEYYSNDLFVAVLFKSV-- 284
Cdd:cd23989    64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQLVTANPS---IIDKRFQNLLWSRKSFVESMkv 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743159278 285 ---DFNWLQAM-VKNETLP-FWVrlffWKQVAEKIPLQPKHFRilNPVIIKETafdilqysepqSRFW-GRD---KNVPT 355
Cdd:cd23989   141 ygrSYIYMPAFsMKTGTDPsLRV----YYTLADVGANQTVLFA--NPNFLRNV-----------GKFWkSKGvhaKRLST 203

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1743159278 356 iGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDNQcmaaMNFQTMHNVTTETKFLLKLVKEGVVK 423
Cdd:cd23989   204 -GLFLVSAALGLCEEVTIYGfwpFSVDLDERTISHHYYDNV----LPDSGFHAMPEEFLQLWHLHKSGVLR 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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