Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189717  53 PTPFPNSFKCFTCENAGDNYNCNRWAEDKWCPQNTQYCLTVHHFTSHGRSTSITKKCASRSECHFVGCHHSRDSEHTECR 132
Cdd:pfam16975   1 TTPYPSGFKCFTCEAADDNYCCNRWAPDWCCPRTTYYCTTHHFMSHGGSSVSVTKRCATEEECLVGGCHHRDDGGHEVCS 80

                          90       100
                  ....*....|....*....|....*.
gi 1743189717 133 SCCEGMICNVELPTNHTNAVFAVMHA 158
Cdd:pfam16975  81 SCCEGNICNVVLPNNTTAAVFATTSP 106

Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189717  53 PTPFPNSFKCFTCENAGDNYNCNRWAEDKWCPQNTQYCLTVHHFTSHGRSTSITKKCASRSECHFVGCHHSRDSEHTECR 132
Cdd:pfam16975   1 TTPYPSGFKCFTCEAADDNYCCNRWAPDWCCPRTTYYCTTHHFMSHGGSSVSVTKRCATEEECLVGGCHHRDDGGHEVCS 80

                          90       100
                  ....*....|....*....|....*.
gi 1743189717 133 SCCEGMICNVELPTNHTNAVFAVMHA 158
Cdd:pfam16975  81 SCCEGNICNVVLPNNTTAAVFATTSP 106

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189717   62 CFTCENAGDNyNCNRWAEdkwCPQNTQYCLTVH-HFTSHGRSTSITKKCASRSECHFVGCHHSRDSEHTECRSCCEGMIC 140
Cdd:smart00134   3 CYSCTGNPDS-SCSSEEE---CRSPDDVCLTVVaEVISDSRGSVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTDLC 78

                   ....*.
gi 1743189717  141 NVELPT 146
Cdd:smart00134  79 NAAGPG 84

Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189717  53 PTPFPNSFKCFTCENAGDNYNCNRWAEDKWCPQNTQYCLTVHHFTSHGRSTSITKKCASRSECHFVGCHHSRDSEHTECR 132
Cdd:pfam16975   1 TTPYPSGFKCFTCEAADDNYCCNRWAPDWCCPRTTYYCTTHHFMSHGGSSVSVTKRCATEEECLVGGCHHRDDGGHEVCS 80

                          90       100
                  ....*....|....*....|....*.
gi 1743189717 133 SCCEGMICNVELPTNHTNAVFAVMHA 158
Cdd:pfam16975  81 SCCEGNICNVVLPNNTTAAVFATTSP 106

extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 6 (LYPD6)-like family; The LYPD6-like family includes LYPD6 and LYPD6B. LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6B (also called LYPD7) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it acts on nAChRs in a subtype- and stoichiometry-dependent manner. LYPD6B modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398, but not its wild-type sequence. LYPD6B also activates AP1 (PMA)-mediated transcriptional activation. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189717  60 FKCFTCENAGDNYNCNRWAEDKWCPQNTQYCLTVHHFTSHGRSTSITKKCASRSECH--FVGCHHSRDSEHTECRSCCEG 137
Cdd:cd23567     1 ITCFTCENKTDNYECNRWAIDRPCPQGTSYCYTVHVMDSRGRSVSVTKKCATPSECTpnTVGCRDSTDTGHTVCISCCDG 80

                  ....*...
gi 1743189717 138 MICNVELP 145
Cdd:cd23567    81 SYCNVEVP 88

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189717  61 KCFTCENAGDNYNCNRWAEDKWCPQNTQYCLTVHHFTSHGrSTSITKKCASRSECHFVGCHHSRDSEHTECRSCCEGMIC 140
Cdd:cd00117     2 KCYQCNSSNDPNCCNSSPTLVTCSSPETFCRKIVGKVGGG-ETLVIRGCATECECGCTECCSGTGTSGTTCTSCCDTDLC 80

                  .
gi 1743189717 141 N 141
Cdd:cd00117    81 N 81

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189717  59 SFKCFTCENAGDNYNCNRWAEdkwCPQNTQYCLTV--HHFTSHGRSTSITKKCASRseCHFVgchhSRDSEHTECR-SCC 135
Cdd:cd23575     2 SLKCYTCVSAHSNSDCLTETN---CSSSDTYCKTLvaSASGGSGSLTTITKWCASS--CTPS----TRTVEGTKVTvSCC 72

                  ....*..
gi 1743189717 136 EGMICNV 142
Cdd:cd23575    73 QTDLCNV 79

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189717  58 NSFKCFTCENAGDNYNCNRWAEdkwCPQNTQYCLTVHHFTSHGRST--SITKKCASRSECHFVGCHHSRDSehtecRSCC 135
Cdd:cd23543     1 HSLYCYTCENQSSNWNCLKPTK---CSDNDKYCVTTVASGGTGSSSgvRITKKCSPKCPETNVNIGIASVS-----TSCC 72

                  ....*.
gi 1743189717 136 EGMICN 141
Cdd:cd23543    73 QSSLCN 78