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Conserved domains on  [gi|1726076681|ref|XP_030318186|]
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A-kinase anchor protein 10, mitochondrial isoform X3 [Calypte anna]

Protein Classification

regulator of G-protein signaling domain-containing protein( domain architecture ID 10171674)

regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 100-337 6.25e-93

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


:

Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 283.96  E-value: 6.25e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 100 LSKTLEQVLQDNVALPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKQQETVSASPSG 179
Cdd:cd08735     1 LSKTLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSAAWSRIRAHSLNTVKHSSLEEPVSPSLDRKVLESKSTD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 180 LLEERLEDSGAVhllrtkpvaldkkdrtgnsqnhvlpgqgsdnpsvlclsksetdqqesskltvsnrnspssalkdlsgK 259
Cdd:cd08735    81 SLSQRLTDDDDE-------------------------------------------------------------------K 93

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1726076681 260 LMKSIERDAVSTFTKYISPDAAKPIPITEAMRNDIVAKICGEDGQVDPNCFVTAQSVVFNAMEQEHFSEFLRSHHFCK 337
Cdd:cd08735    94 SMKSIERDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVDPNCFVEAQSFVFSAMEQDHFTEFLRSHFFCK 171
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 353-473 4.17e-76

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


:

Pssm-ID: 188676  Cd Length: 121  Bit Score: 238.40  E-value: 4.17e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 353 ILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSQLAAKEGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDSVRLEIE 432
Cdd:cd08721     1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1726076681 433 SNICREGGPLPNCFTTPLRQAWTTMETVFLPGFLSSNLYYK 473
Cdd:cd08721    81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 588-632 3.86e-17

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


:

Pssm-ID: 214003  Cd Length: 45  Bit Score: 75.16  E-value: 3.86e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1726076681 588 AMKKWVQGNTDEAQEEMAWRIAKMIVNDVMQQAQCEQPSEKVTKL 632
Cdd:cd12804     1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45
 
Name Accession Description Interval E-value
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 100-337 6.25e-93

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 283.96  E-value: 6.25e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 100 LSKTLEQVLQDNVALPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKQQETVSASPSG 179
Cdd:cd08735     1 LSKTLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSAAWSRIRAHSLNTVKHSSLEEPVSPSLDRKVLESKSTD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 180 LLEERLEDSGAVhllrtkpvaldkkdrtgnsqnhvlpgqgsdnpsvlclsksetdqqesskltvsnrnspssalkdlsgK 259
Cdd:cd08735    81 SLSQRLTDDDDE-------------------------------------------------------------------K 93

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1726076681 260 LMKSIERDAVSTFTKYISPDAAKPIPITEAMRNDIVAKICGEDGQVDPNCFVTAQSVVFNAMEQEHFSEFLRSHHFCK 337
Cdd:cd08735    94 SMKSIERDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVDPNCFVEAQSFVFSAMEQDHFTEFLRSHFFCK 171
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 353-473 4.17e-76

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 238.40  E-value: 4.17e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 353 ILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSQLAAKEGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDSVRLEIE 432
Cdd:cd08721     1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1726076681 433 SNICREGGPLPNCFTTPLRQAWTTMETVFLPGFLSSNLYYK 473
Cdd:cd08721    81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 350-474 6.81e-24

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 96.95  E-value: 6.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681  350 LADILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSqlaakegQYDGQEAQNDAMILYDKYFSLQATHPLGFDDSVRL 429
Cdd:smart00315   2 LESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKK-------AEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLRE 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1726076681  430 EIESNICrEGGPLPNCFTTPLRQAWTTMETVFLPGFLSSNLYYKY 474
Cdd:smart00315  75 KIEENLE-SEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 588-632 3.86e-17

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


Pssm-ID: 214003  Cd Length: 45  Bit Score: 75.16  E-value: 3.86e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1726076681 588 AMKKWVQGNTDEAQEEMAWRIAKMIVNDVMQQAQCEQPSEKVTKL 632
Cdd:cd12804     1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 262-338 1.18e-14

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 70.38  E-value: 1.18e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1726076681  262 KSIERDAVSTFTKYISPDAAKPIPITEAMRNDIVAKICGEdgQVDPNCFVTAQSVVFNAMEQEHFSEFLRSHHFCKY 338
Cdd:smart00315  44 EERIAKAREIYDKFLSPNAPKEVNLDSDLREKIEENLESE--EPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 350-474 1.37e-09

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 56.08  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 350 LADILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSQLAAKegqydgqEAQNDAMILYDKYFSLQATHPLGFDDSVRL 429
Cdd:pfam00615   2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDE-------ERLKKAKEIYNEFLAPGSPKEINLDSDLRE 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1726076681 430 EIESNICREggPLPNCFTTPLRQAWTTMETVFLPGFLSSNLYYKY 474
Cdd:pfam00615  75 EIRENLEKE--PTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 259-332 2.58e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 49.54  E-value: 2.58e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1726076681 259 KLMKSIE---RDAVSTFTKYISPDAAKPIPITEAMRNDIVAKICGEdgqVDPNCFVTAQSVVFNAMEQEHFSEFLRS 332
Cdd:pfam00615  38 KKADPDEerlKKAKEIYNEFLAPGSPKEINLDSDLREEIRENLEKE---PTRDLFDEAQAEVYELMEKDSYPRFLKS 111
 
Name Accession Description Interval E-value
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 100-337 6.25e-93

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 283.96  E-value: 6.25e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 100 LSKTLEQVLQDNVALPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKQQETVSASPSG 179
Cdd:cd08735     1 LSKTLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSAAWSRIRAHSLNTVKHSSLEEPVSPSLDRKVLESKSTD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 180 LLEERLEDSGAVhllrtkpvaldkkdrtgnsqnhvlpgqgsdnpsvlclsksetdqqesskltvsnrnspssalkdlsgK 259
Cdd:cd08735    81 SLSQRLTDDDDE-------------------------------------------------------------------K 93

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1726076681 260 LMKSIERDAVSTFTKYISPDAAKPIPITEAMRNDIVAKICGEDGQVDPNCFVTAQSVVFNAMEQEHFSEFLRSHHFCK 337
Cdd:cd08735    94 SMKSIERDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVDPNCFVEAQSFVFSAMEQDHFTEFLRSHFFCK 171
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 353-473 4.17e-76

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 238.40  E-value: 4.17e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 353 ILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSQLAAKEGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDSVRLEIE 432
Cdd:cd08721     1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1726076681 433 SNICREGGPLPNCFTTPLRQAWTTMETVFLPGFLSSNLYYK 473
Cdd:cd08721    81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 354-473 1.64e-24

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 98.62  E-value: 1.64e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 354 LFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSQLAAKEgqydgqEAQNDAMILYDKYFSLQATHPLGFDDSVRLEIES 433
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDE------ELKSKAKEIYDKYISKDAPKEINIPESIREEIEE 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1726076681 434 NICREgGPLPNCFTTPLRQAWTTMETVFLPGFLSSNLYYK 473
Cdd:cd07440    75 NLEEP-YPDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 350-474 6.81e-24

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 96.95  E-value: 6.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681  350 LADILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSqlaakegQYDGQEAQNDAMILYDKYFSLQATHPLGFDDSVRL 429
Cdd:smart00315   2 LESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKK-------AEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLRE 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1726076681  430 EIESNICrEGGPLPNCFTTPLRQAWTTMETVFLPGFLSSNLYYKY 474
Cdd:smart00315  75 KIEENLE-SEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 108-337 1.14e-19

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 84.75  E-value: 1.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 108 LQDNVALPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRirahslntvkqsslaepvspskqqetvsaspsglleerled 187
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSD----------------------------------------- 39

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 188 sgavhllrtkpvaldkkdrtgnsqnhvlpgqgsdnpsvlclsksetdqqesskltvsnrnspssalkdlsgklmKSIERD 267
Cdd:cd07440    40 --------------------------------------------------------------------------EELKSK 45

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 268 AVSTFTKYISPDAAKPIPITEAMRNDIVAKICGEDgqVDPNCFVTAQSVVFNAMEQEHFSEFLRSHHFCK 337
Cdd:cd07440    46 AKEIYDKYISKDAPKEINIPESIREEIEENLEEPY--PDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 588-632 3.86e-17

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


Pssm-ID: 214003  Cd Length: 45  Bit Score: 75.16  E-value: 3.86e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1726076681 588 AMKKWVQGNTDEAQEEMAWRIAKMIVNDVMQQAQCEQPSEKVTKL 632
Cdd:cd12804     1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 262-338 1.18e-14

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 70.38  E-value: 1.18e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1726076681  262 KSIERDAVSTFTKYISPDAAKPIPITEAMRNDIVAKICGEdgQVDPNCFVTAQSVVFNAMEQEHFSEFLRSHHFCKY 338
Cdd:smart00315  44 EERIAKAREIYDKFLSPNAPKEVNLDSDLREKIEENLESE--EPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 350-473 7.07e-12

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 64.01  E-value: 7.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 350 LADILFCESALFYFSEYMEKEDAVNVLQFWLAADNF-----------------QSQLAAKEGQYDGQEA----------- 401
Cdd:cd08735     5 LEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFksaawsrirahslntvkHSSLEEPVSPSLDRKVleskstdslsq 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 402 --------------QNDAMILYDKYFSLQATHPLGFDDSVRLEIESNICREGGPL-PNCFTTPLRQAWTTMETVFLPGFL 466
Cdd:cd08735    85 rltddddeksmksiERDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVdPNCFVEAQSFVFSAMEQDHFTEFL 164


                  ....*..
gi 1726076681 467 SSNLYYK 473
Cdd:cd08735   165 RSHFFCK 171
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 267-337 1.20e-09

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 56.20  E-value: 1.20e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1726076681 267 DAVSTFTKYISPDAAKPIPITEAMRNDIVAKICGEDGQVdPNCFVTAQSVVFNAMEQEHFSEFLRSHHFCK 337
Cdd:cd08721    52 DAMIIYDKYFSLQATEPLGFDDKTRLEVESNICREGGPL-PSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 350-474 1.37e-09

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 56.08  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 350 LADILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSQLAAKegqydgqEAQNDAMILYDKYFSLQATHPLGFDDSVRL 429
Cdd:pfam00615   2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDE-------ERLKKAKEIYNEFLAPGSPKEINLDSDLRE 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1726076681 430 EIESNICREggPLPNCFTTPLRQAWTTMETVFLPGFLSSNLYYKY 474
Cdd:pfam00615  75 EIRENLEKE--PTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 567-612 3.59e-09

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


Pssm-ID: 214003  Cd Length: 45  Bit Score: 52.82  E-value: 3.59e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1726076681 567 FIRESEPEPDvkKSKGSMFSQAMKKWVQGNTDEAQEEMAWRIAKMI 612
Cdd:cd12804     2 FKKWVQPEPD--EAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 259-332 2.58e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 49.54  E-value: 2.58e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1726076681 259 KLMKSIE---RDAVSTFTKYISPDAAKPIPITEAMRNDIVAKICGEdgqVDPNCFVTAQSVVFNAMEQEHFSEFLRS 332
Cdd:pfam00615  38 KKADPDEerlKKAKEIYNEFLAPGSPKEINLDSDLREEIRENLEKE---PTRDLFDEAQAEVYELMEKDSYPRFLKS 111
RGS_SNX13 cd08719
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; ...
 353-473 1.73e-06

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.


Pssm-ID: 188674  Cd Length: 135  Bit Score: 47.79  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 353 ILFCESALFYFSEYMEKEDAVNVLQFWLAADNF----QSQL-AAKEGQYDGQEAQNDAM--------ILYDKYFSLQATH 419
Cdd:cd08719     1 ILVNNVALSYFIDFMQSVGGQAYLFFWLTVEGYrvsaEQQLsELHLRQRGGEHQRSDVYemlraaalNIYDQYLSEKASP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1726076681 420 PLGFDDSVRLEIESNIcREGGPLPNCFTTPLRQAWTTMET--VFLPGFLSSNLYYK 473
Cdd:cd08719    81 RVPLDDSLVKKLLNRL-RNDTPSDLWFDDIQQKVFDIMQEdeRFYPAFKKSPAYVK 135
RGS_SNX14 cd08722
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; ...
 353-472 3.05e-06

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX14 (Sorting Nexin14) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX14 is believed to regulates membrane trafficking in motor neurons.


Pssm-ID: 188677  Cd Length: 127  Bit Score: 46.95  E-value: 3.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 353 ILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSQ-LAAKEGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDSVRLEI 431
Cdd:cd08722     1 ILDDQRLLFPFMQFLKEEGAVHLLQFCLTVEDFNRRiLNPDLTDEEKQSLHKEAQEIYKTYFLPEAPDRIHFPPDIVEEI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1726076681 432 ESNIcrEGGPLPNCF---TTPLRQAW----TTMETVFLPGFLSSNLYY 472
Cdd:cd08722    81 KQIL--EGGPEKIVKlrtSRPLFEAYehvySLLESVFCPLFCHSDEYF 126
RGS_PX cd08729
Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in ...
 358-473 5.81e-06

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188684  Cd Length: 136  Bit Score: 46.31  E-value: 5.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 358 SALFYFSEYMEKEDAVNVLQFWLAADNFQSQLAAKEGQYDGQEAQ---------NDAMILYDKYFSLQATH---PLGFDD 425
Cdd:cd08729     5 SSLSYFMEFMDRRNRSQLVQFWLVVEGFKNPLEDTENDYSLDSSQsrswidsdkEDIAMIYETYFSDPSPSlnvPKASRD 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1726076681 426 SVRLEIesNICREGGPLP------NCFTTPLRQAWTTMETVFLPGFLSSNLYYK 473
Cdd:cd08729    85 PIRLFL--NAGVNASPNEqyrkarRAVLMAQRAVYEEMEEEDFPEFKKSELFYK 136
RGS_RGS14 cd08743
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...
 359-471 5.88e-06

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.


Pssm-ID: 188697  Cd Length: 129  Bit Score: 46.18  E-value: 5.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 359 ALFYFSEYMEKEDAVNVLQFWLAADNFQsQLAAKEGQYDGQEAQNdamiLYDKYFSLQATHPLGFDDSVRleIESNICRE 438
Cdd:cd08743    20 GVEYFTEFLKKEFSAENVNFWKACERFQ-QIPASDTQQLAQEARK----IYNEFLSSSSQSPVNIDQQAW--IGEDMLAT 92

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1726076681 439 ggPLPNCFTTPLRQAWTTMETVFLPGFLSSNLY 471
Cdd:cd08743    93 --PSPDMFRAQQLQIFNLMKFDSYARFVKSPLY 123
RGS_R12-like cd08706
Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS ...
 362-471 7.32e-06

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.


Pssm-ID: 188661  Cd Length: 113  Bit Score: 45.39  E-value: 7.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 362 YFSEYMEKE-DAVNVLqFWLAADNFQSQLAAKEGQydgQEAQNdamiLYDKYFSLQATHPLGFDDSVRLEIEsnICREgg 440
Cdd:cd08706    13 YFTEFLKKEfSEENIL-FWQACEKFKKIPDKKQLV---QEARE----IYDTFLSSKASSPVNIDSQAQLAEE--MLEE-- 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1726076681 441 PLPNCFTTPLRQAWTTMETVFLPGFLSSNLY 471
Cdd:cd08706    81 PHPDMFQKQQLQIFNLMKFDSYSRFLKSPLY 111
RGS_RGS2 cd08709
Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of ...
 352-471 2.06e-05

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.


Pssm-ID: 188664  Cd Length: 114  Bit Score: 44.27  E-value: 2.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 352 DILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSQLAAkegqydgQEAQNDAMILYDKYFSLQATHPLGFDDSVRLEI 431
Cdd:cd08709     3 ELLASKYGVAAFRAFLKSEFSEENIEFWLACEDFKKTKSP-------QKLTSKAKKIYTDFIEKEAPKEINIDFQTKTLI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1726076681 432 ESNICReggPLPNCFTTPLRQAWTTMETVFLPGFLSSNLY 471
Cdd:cd08709    76 AQNIQE---ATSGCFTAAQKRVYSLMENNSYPRFLESEFY 112
RGS_RGS3 cd08713
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of ...
 363-473 5.73e-05

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.


Pssm-ID: 188668  Cd Length: 114  Bit Score: 42.93  E-value: 5.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 363 FSEYMEKEDAVNVLQFWLAADNF-----QSQLAAKegqydgqeaqndAMILYDKYFSLQATHPLGFDDSVRLEIESNIcr 437
Cdd:cd08713    14 FRAFLQTEFSEENLEFWLACEEYkkiksQSKMASR------------AKKIFAEYIAIQSCKEVNLDSYTREHTKENL-- 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1726076681 438 eGGPLPNCFTTPLRQAWTTMETVFLPGFLSSNLYYK 473
Cdd:cd08713    80 -QNPTRGCFDLAQKRIYGLMEKDSYPRFLRSDLYQD 114
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 272-332 6.18e-05

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 42.61  E-value: 6.18e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1726076681 272 FTKYISPDAAKPIPITEAMRNDIVAKIcgedGQVDPNCFVTAQSVVFNAMEQEHFSEFLRS 332
Cdd:cd08716    53 FASYIQPQAPREINIDSPTRKAIIRNI----QEPTQSCFDEAQRIVYMHMERDSYPRFLES 109
RGS_RGS21 cd08723
Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...
 353-473 1.01e-04

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.


Pssm-ID: 188678  Cd Length: 111  Bit Score: 41.97  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 353 ILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSQlaakegqYDGQEAQNDAMILYDKYFSLQATHPLGFDDSVRLEIE 432
Cdd:cd08723     1 LLANQAGLDAFRTFLKSEFSEENVEFWLACEDFKKT-------KSSTEIALKAQMIYSEFIQADAPKEINIDFHTRDLIS 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1726076681 433 SNICReggPLPNCFTTPLRQAWTTMETVFLPGFLSSNLYYK 473
Cdd:cd08723    74 QNISE---PTLKCFDEAQSLIYCLMAKDSFPRFLKSEVYKK 111
RGS_RGS1 cd08715
Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of ...
 272-335 2.31e-04

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.


Pssm-ID: 188670  Cd Length: 114  Bit Score: 41.09  E-value: 2.31e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1726076681 272 FTKYISPDAAKPIPITEAMRNDIVAKIcgedGQVDPNCFVTAQSVVFNAMEQEHFSEFLRSHHF 335
Cdd:cd08715    52 YKEFVQSDAAKQINIDFRTRESTAKKI----KAPTPTCFDEAQKVIYILMERDSYPRFLKSDIY 111
RGS_RGS17 cd08744
Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator ...
 363-471 2.80e-04

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.


Pssm-ID: 188698  Cd Length: 118  Bit Score: 40.87  E-value: 2.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 363 FSEYMEKEDAVNVLQFWLAADNFQSQLAAKEgqydgqeAQNDAMILYDKYFSLQATHPLGFDDSVRLEIESNICregGPL 442
Cdd:cd08744    18 FREFLRTEYSEENLLFWLACEDLKKEQNKKV-------IEEKARLIYEDYISILSPKEVSLDSRVREVINRNLL---DPN 87

                          90       100
                  ....*....|....*....|....*....
gi 1726076681 443 PNCFTTPLRQAWTTMETVFLPGFLSSNLY 471
Cdd:cd08744    88 PHMYEDAQLQIYTLMHRDSFPRFLNSQIY 116
RGS_RGS21 cd08723
Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...
 263-337 5.81e-04

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.


Pssm-ID: 188678  Cd Length: 111  Bit Score: 40.04  E-value: 5.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1726076681 263 SIERDAVSTFTKYISPDAAKPIPITEAMRNDIVAKIcgedGQVDPNCFVTAQSVVFNAMEQEHFSEFLRSHHFCK 337
Cdd:cd08723    41 EIALKAQMIYSEFIQADAPKEINIDFHTRDLISQNI----SEPTLKCFDEAQSLIYCLMAKDSFPRFLKSEVYKK 111
RGS_RGS12 cd08742
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of ...
 362-471 6.40e-04

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.


Pssm-ID: 188696  Cd Length: 115  Bit Score: 40.04  E-value: 6.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 362 YFSEYMEKEDAVNVLQFWLAADNFQSQLAakegqYDGQEAQNDAMILYDKYFSLQATHPLGFDDSVRLeiESNICRegGP 441
Cdd:cd08742    13 YFSEFLRKEFSEENILFWQACEYFNHVPA-----HDKKELSYRAREIFSKFLCSKATTPVNIDSQAQL--ADDILN--AP 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 1726076681 442 LPNCFTTPLRQAWTTMETVFLPGFLSSNLY 471
Cdd:cd08742    84 HPDMFKEQQLQIFNLMKFDSYTRFLKSPLY 113
RGS_RGS1 cd08715
Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of ...
 350-473 9.79e-04

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.


Pssm-ID: 188670  Cd Length: 114  Bit Score: 39.16  E-value: 9.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 350 LADILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQSQlaakegqyDGQEAQNDAMILYDKYFSLQATHPLGFDDSVRl 429
Cdd:cd08715     1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDYKKT--------ESDLLPCKAEEIYKEFVQSDAAKQINIDFRTR- 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1726076681 430 eiESNICREGGPLPNCFTTPLRQAWTTMETVFLPGFLSSNLYYK 473
Cdd:cd08715    72 --ESTAKKIKAPTPTCFDEAQKVIYILMERDSYPRFLKSDIYLN 113
RGS_SNX25 cd08720
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; ...
 362-473 1.13e-03

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX25 (Sorting Nexin 25) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX25 is a member of the Dopamine receptors (DAR) signalplex and regulates the trafficking of D1 and D2 DARs.


Pssm-ID: 188675  Cd Length: 110  Bit Score: 38.93  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 362 YFSEYMEKEDAVNVLQFWLAADNFQSQLAAKEGQYDGQeaqndamiLYDKYFSLQaTHPLGFDDSVRLEIESNICREGGp 441
Cdd:cd08720    10 YLSQFLERMDSQALIGFWEAVEELRSANKSEWHQLGAE--------IFYTFIVEP-TAEIKVDKSLRKRIEQFLLGDKG- 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1726076681 442 lPNCFTTPLRQAWTTMETVFLPGFLSSNLYYK 473
Cdd:cd08720    80 -PEVFYEVQENVVETLEEKYYPSFVVSDQYKQ 110
RGS_RGS20 cd08746
Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator ...
 353-471 1.24e-03

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.


Pssm-ID: 188700 [Multi-domain]  Cd Length: 167  Bit Score: 39.97  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 353 ILFCESALFYFSEYMEKEDAVNVLQFWLAADNFQsqlaaKEGQYDGQEAQndAMILYDKYFSLQATHPLGFDDSVRLEIE 432
Cdd:cd08746    57 LMLTPAGRNAFREFLRTEFSEENMLFWMACEELK-----KEANKSVIEEK--ARIIYEDYISILSPKEVSLDSRVREVIN 129

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1726076681 433 SNICReggPLPNCFTTPLRQAWTTMETVFLPGFLSSNLY 471
Cdd:cd08746   130 RNMLE---PSQHTFDDAQLQIYTLMHRDSYPRFMNSAIY 165
RGS_PX cd08729
Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in ...
 108-139 2.16e-03

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188684  Cd Length: 136  Bit Score: 38.60  E-value: 2.16e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1726076681 108 LQDNVALPYFIQFMELRRMEHLVKFWLEAESF 139
Cdd:cd08729     1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGF 32
RGS_SNX13 cd08719
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; ...
 107-185 2.47e-03

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.


Pssm-ID: 188674  Cd Length: 135  Bit Score: 38.55  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 107 VLQDNVALPYFIQFMELRRMEHLVKFWLEAESFhsttwsRIRA-HSLNTVKQSSLAEPVSPSKQQETVSASPSGLLEERL 185
Cdd:cd08719     1 ILVNNVALSYFIDFMQSVGGQAYLFFWLTVEGY------RVSAeQQLSELHLRQRGGEHQRSDVYEMLRAAALNIYDQYL 74
RGS_RGS14 cd08743
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...
 94-178 3.36e-03

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.


Pssm-ID: 188697  Cd Length: 129  Bit Score: 38.09  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681  94 EETKSSLSKTLEQVLQDNVALPYFIQFMELRRMEHLVKFWLEAESFHSTTWS----------RIRAHSLNTVKQSslaeP 163
Cdd:cd08743     1 EKSVASWAVSFERLLQDPLGVEYFTEFLKKEFSAENVNFWKACERFQQIPASdtqqlaqearKIYNEFLSSSSQS----P 76

                          90
                  ....*....|....*...
gi 1726076681 164 VSPSKQQ---ETVSASPS 178
Cdd:cd08743    77 VNIDQQAwigEDMLATPS 94
RGS_RZ-like cd08718
Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of ...
 362-471 5.00e-03

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.


Pssm-ID: 188673  Cd Length: 118  Bit Score: 37.44  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726076681 362 YFSEYMEKEDAVNVLQFWLAADNFQSQlaakegqYDGQEAQNDAMILYDKYFSLQATHPLGFDDSVRLEIESNICReggP 441
Cdd:cd08718    17 VFREFLRTEYSEENMLFWLACEELKKE-------ANKHVIEEKARLIYEDYISILSPKEVSLDSRVREVINRNMLE---P 86

                          90       100       110
                  ....*....|....*....|....*....|
gi 1726076681 442 LPNCFTTPLRQAWTTMETVFLPGFLSSNLY 471
Cdd:cd08718    87 SPHTFDDAQLQIYTLMHRDSYPRFLNSAIY 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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