NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720406773|ref|XP_030108862|]
View 

uncharacterized protein LOC100041677 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 8.42e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 8.42e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720406773  12 LLTFKDVALYFSLEEWECLSFAQRTLYMDVMLENYNNLLFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-465 8.75e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 8.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 220 THQIHLSIHQGIHAEEKIYKCSECDKCFTHKSHLNIHQRIHTGENPYKCSECDKCFKHKFSFSMHQRIHTGEKPYKCSEC 299
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 300 DKCFTQKSHLSVHQRIHTGE-------KPYKCSECDKCFTHKSHLNSHQR--IHTGE--KPYKCSE--CDKCFTKNGSLR 366
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 367 IHQRIHTGENPYKCSECDKCFTHKSNLNI----HQRIHTGEKPYKCSECDKCFT-------HKSHLNSHQRIHTGEKPYK 435
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCirnfkrdSNLSLHIITHLSFRPYNCK 420

                         250       260       270
                  ....*....|....*....|....*....|
gi 1720406773 436 CSECDKCFTRKFHLSIHQRIHTGENPYKCS 465
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
476-500 2.85e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.85e-03
                          10        20
                  ....*....|....*....|....*
gi 1720406773 476 NLNIHQRIHTGEKPYKCSECDKCFT 500
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-529 6.01e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 504 SLRIHQRIHTGENPYKCSECDKCFTR 529
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 8.42e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 8.42e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720406773  12 LLTFKDVALYFSLEEWECLSFAQRTLYMDVMLENYNNLLFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-55 1.62e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 1.62e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720406773   13 LTFKDVALYFSLEEWECLSFAQRTLYMDVMLENYNNLLFVENH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 3.31e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.20  E-value: 3.31e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720406773  13 LTFKDVALYFSLEEWECLSFAQRTLYMDVMLENYNNLLF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-465 8.75e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 8.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 220 THQIHLSIHQGIHAEEKIYKCSECDKCFTHKSHLNIHQRIHTGENPYKCSECDKCFKHKFSFSMHQRIHTGEKPYKCSEC 299
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 300 DKCFTQKSHLSVHQRIHTGE-------KPYKCSECDKCFTHKSHLNSHQR--IHTGE--KPYKCSE--CDKCFTKNGSLR 366
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 367 IHQRIHTGENPYKCSECDKCFTHKSNLNI----HQRIHTGEKPYKCSECDKCFT-------HKSHLNSHQRIHTGEKPYK 435
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCirnfkrdSNLSLHIITHLSFRPYNCK 420

                         250       260       270
                  ....*....|....*....|....*....|
gi 1720406773 436 CSECDKCFTRKFHLSIHQRIHTGENPYKCS 465
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
420-445 7.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.87e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 420 HLNSHQRIHTGEKPYKCSECDKCFTR 445
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
476-500 2.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.85e-03
                          10        20
                  ....*....|....*....|....*
gi 1720406773 476 NLNIHQRIHTGEKPYKCSECDKCFT 500
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-529 6.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 504 SLRIHQRIHTGENPYKCSECDKCFTR 529
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 8.42e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 8.42e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720406773  12 LLTFKDVALYFSLEEWECLSFAQRTLYMDVMLENYNNLLFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-55 1.62e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 1.62e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720406773   13 LTFKDVALYFSLEEWECLSFAQRTLYMDVMLENYNNLLFVENH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 3.31e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.20  E-value: 3.31e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720406773  13 LTFKDVALYFSLEEWECLSFAQRTLYMDVMLENYNNLLF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-465 8.75e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 8.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 220 THQIHLSIHQGIHAEEKIYKCSECDKCFTHKSHLNIHQRIHTGENPYKCSECDKCFKHKFSFSMHQRIHTGEKPYKCSEC 299
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 300 DKCFTQKSHLSVHQRIHTGE-------KPYKCSECDKCFTHKSHLNSHQR--IHTGE--KPYKCSE--CDKCFTKNGSLR 366
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 367 IHQRIHTGENPYKCSECDKCFTHKSNLNI----HQRIHTGEKPYKCSECDKCFT-------HKSHLNSHQRIHTGEKPYK 435
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCirnfkrdSNLSLHIITHLSFRPYNCK 420

                         250       260       270
                  ....*....|....*....|....*....|
gi 1720406773 436 CSECDKCFTRKFHLSIHQRIHTGENPYKCS 465
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
236-547 1.35e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 236 KIYKCSECDKCFTHKSHLNIHQRIHTGENPYKCS--ECDKCFKHKFSFSMHQRIHTGEKPYKCSecDKCFTQKSHLSVHQ 313
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 314 RIHTGEKPykcSECDKCFTHKSHLNSHQRIHtgEKPYKCSECDKCFTKNGSLRIHQRIHTGENPYKCS--ECDKCFTHKS 391
Cdd:COG5048   110 LSSSSSNS---NDNNLLSSHSLPPSSRDPQL--PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 392 NLNIHQRIHTGEKPYKCSECDKCFTHKSHLNSHQRIHTGEKPYKCSECDKCFTRKFHLSIHQRIHTGENPYKCSECDKCF 471
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 472 TQKSNLNIHQRIHTGE-------KPYKCSECDKCFTEKGSLRIHQR--IHTGEN--PYKCSE--CDKCFTRKFHLSIHQK 538
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESlkPFSCPYslCGKLFSRNDALKRHIL 344


                  ....*....
gi 1720406773 539 IHTGEKPYK 547
Cdd:COG5048   345 LHTSISPAK 353
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-541 1.71e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 166 SKHKVMVKRNNTGVNPYKCS--EFDKYLTQREKLQSQQRIYHGKKPYRSSKsdkcfthQIHLSIHQGIHAEEKIYKCSEC 243
Cdd:COG5048    46 LEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSK-------SLPLSNSKASSSSLSSSSSNSN 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 244 DKCFTHKSHLNIHQRIHTGENPYKCSECDKCFKHKFSFSMHQRIHTGEKPYKCSECDKCFTQKSHLSV--HQRIHTGEKP 321
Cdd:COG5048   119 DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLliSSNVSTSIPS 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 322 YKCSECDKCFTHKSHLNSHQRIHTGEKPYKCSECDKCFTKNGSLRIHQRIHTGENPYKCSECDKCFTHKSNLNIHQRIHT 401
Cdd:COG5048   199 SSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 402 GE-------KPYKCSECDKCFTHKSHLNSHQR--IHTGE--KPYKCSE--CDKCFTRKFHLSIHQRIHTGENPYKC--SE 466
Cdd:COG5048   279 DSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLN 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 467 CDKCFTQKSNLNIHQRI--HTGEKPYKCSECDKCFTEKGSLR-------IHQRIHTGENPYKCSECDKCFTRKFHLSIHQ 537
Cdd:COG5048   359 SSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRdsnlslhIITHLSFRPYNCKNPPCSKSFNRHYNLIPHK 438


                  ....
gi 1720406773 538 KIHT 541
Cdd:COG5048   439 KIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-520 6.49e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 6.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 207 KKPYRSSKSDKCFTHQIHLSIHQGIHAEEKIYKCS--ECDKCFTHKSHLNIHQRIHTGENPYKCSECDKCFKHKFSFSMH 284
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 285 qrihtGEKPYKCSECDKCFTQKSHLSVHQRIHtgEKPYKCSECDKCFTHKSHLNSHQRIHTGEKPYKCS--ECDKCFTKN 362
Cdd:COG5048   111 -----SSSSSNSNDNNLLSSHSLPPSSRDPQL--PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 363 GSLRIHQRIHTGENPYKCSECDKCFTHKSNLNIHQRIHTGEKPYKCSECDKCFTHKSHLNSHQRIHTGEKPYKCSECDKC 442
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 443 F--TRKFHLSIHQRIHTGE-----NPYKCSECDKCFTQKSNLNIHQR--IHTGE--KPYKCSE--CDKCFTEKGSLRIHQ 509
Cdd:COG5048   264 SlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330
                  ....*....|.
gi 1720406773 510 RIHTGENPYKC 520
Cdd:COG5048   344 LLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
420-445 7.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.87e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 420 HLNSHQRIHTGEKPYKCSECDKCFTR 445
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 403-508 8.95e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 8.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 403 EKPYKCSECDKCFTHKSHLN---SHQRIHT-GEKPYKCS--ECDKCFTRKFHLSIHqRIHtgenpykcSECDKCFTQKSN 476
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNidtPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPS 385

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720406773 477 LNIHQRIHTGEKPYKCSECDKCFTEKGSLRIH 508
Cdd:COG5189   386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 290-368 1.24e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 290 GEKPYKCS--ECDKCFTQKSHLSVHqRIHtgekpykcSECDKCFTHKSHLNSHQRIHTGEKPYKCSECDKCFTKNGSLRI 367
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720406773 368 H 368
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
336-361 1.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 336 HLNSHQRIHTGEKPYKCSECDKCFTK 361
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
392-417 1.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 392 NLNIHQRIHTGEKPYKCSECDKCFTH 417
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
308-333 1.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 308 HLSVHQRIHTGEKPYKCSECDKCFTH 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
476-500 2.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.85e-03
                          10        20
                  ....*....|....*....|....*
gi 1720406773 476 NLNIHQRIHTGEKPYKCSECDKCFT 500
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 319-424 3.99e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406773 319 EKPYKCSECDKCFTHKSHLN---SHQRIHT-GEKPYKCS--ECDKCFTKNGSLRIHqRIHTGENPYKCSECDKcfthksn 392
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNidtPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP------- 386

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720406773 393 lNIHQRIHTGEKPYKCSECDKCFTHKSHLNSH 424
Cdd:COG5189   387 -EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
252-277 5.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 252 HLNIHQRIHTGENPYKCSECDKCFKH 277
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
280-305 5.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.67e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 280 SFSMHQRIHTGEKPYKCSECDKCFTQ 305
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
364-389 5.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 364 SLRIHQRIHTGENPYKCSECDKCFTH 389
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-529 6.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 504 SLRIHQRIHTGENPYKCSECDKCFTR 529
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 378-400 7.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.88e-03
                          10        20
                  ....*....|....*....|...
gi 1720406773 378 YKCSECDKCFTHKSNLNIHQRIH 400
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 238-260 7.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.95e-03
                          10        20
                  ....*....|....*....|...
gi 1720406773 238 YKCSECDKCFTHKSHLNIHQRIH 260
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 322-344 7.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.95e-03
                          10        20
                  ....*....|....*....|...
gi 1720406773 322 YKCSECDKCFTHKSHLNSHQRIH 344
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 406-428 7.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.95e-03
                          10        20
                  ....*....|....*....|...
gi 1720406773 406 YKCSECDKCFTHKSHLNSHQRIH 428
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 462-484 8.77e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.77e-03
                          10        20
                  ....*....|....*....|...
gi 1720406773 462 YKCSECDKCFTQKSNLNIHQRIH 484
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
448-473 9.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.92e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406773 448 HLSIHQRIHTGENPYKCSECDKCFTQ 473
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH